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61“…Mannuronan C-5 epimerase (MC5E) and carbohydrate sulfotransferase (CST) are crucial enzymes for alginate and sulfated CWPS, respectively. …”
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62por Tauber, Marie, Basso, Lilian, Martin, Jeremy, Bostan, Luciana, Pinto, Marlene Magalhaes, Thierry, Guilhem R., Houmadi, Raïssa, Serhan, Nadine, Loste, Alexia, Blériot, Camille, Kamphuis, Jasper B.J., Grujic, Mirjana, Kjellén, Lena, Pejler, Gunnar, Paul, Carle, Dong, Xinzhong, Galli, Stephen J., Reber, Laurent L., Ginhoux, Florent, Bajenoff, Marc, Gentek, Rebecca, Gaudenzio, Nicolas“…MC1 are preferentially enriched in the bladder, MC2 in the lungs, and MC4, MC6, and MC7 in the skin. Conversely, MC3 and MC5 are shared by most organs but not skin. This comprehensive analysis offers valuable insights into the natural diversity of MC subtypes in both mice and humans.…”
Publicado 2023
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63por Guadarrama-Avila, Tania Marel, Ramírez-Trujillo, José Augusto, Rodríguez-Ocampo, Thania Gisel, Peña-Chora, Guadalupe, Arenas-Sosa, Iván, Hernández-Velázquez, Víctor Manuel“…Oscheius myriophila, an entomopathogenic nematode (EPN), was monitored for its performance when produced in vivo, as well as its development using Galleria mellonella larvae, using the MC5-2014 strain isolated from soil samples in the municipality of Tepalcingo, Morelos, México. …”
Publicado 2023
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64“…RESULTS: In the connector area, von Mises stress in MPa were approximately identical in the specimens with ZB (at molar connector (MC): 4.75 and at premolar connector (PC): 6.40) and without ZB (MC: 5.50, PC: 6.68), and considerable differences were not recognized. …”
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65por Møller, Cathrine Laustrup, Kjøbsted, Rasmus, Enriori, Pablo J., Jensen, Thomas Elbenhardt, Garcia-Rudaz, Cecilia, Litwak, Sara A., Raun, Kirsten, Wojtaszewski, Jørgen, Wulff, Birgitte Schjellerup, Cowley, Michael A.“…The melanocortin system includes five G-protein coupled receptors (family A) defined as MC1R-MC5R, which are stimulated by endogenous agonists derived from proopiomelanocortin (POMC). …”
Publicado 2016
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66por Montero-Melendez, Trinidad, Forfar, Rachel A. E., Cook, Jennifer M., Jerman, Jeffrey C., Taylor, Debra L., Perretti, Mauro“…The non-steroidal anti-inflammatory drug fenoprofen, but not the similar compound ibuprofen, presented PAM activity at MC(3), MC(4), and MC(5) receptors. In a model of inflammatory arthritis, fenoprofen afforded potent inhibition while ibuprofen was nearly inactive. …”
Publicado 2016
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67por Schlasner, Katherine N., Ericson, Mark D., Doering, Skye R., Freeman, Katie T., Weinrich, Mary, Haskell-Luevano, Carrie“…The five melanocortin receptors (MC1R–MC5R) are involved in numerous biological pathways, including steroidogenesis, pigmentation, and food intake. …”
Publicado 2019
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68por Ericson, Mark D., Freeman, Katie T., LaVoi, Travis M., Donow, Haley M., Santos, Radleigh G., Giulianotti, Marc A., Pinilla, Clemencia, Houghten, Richard A., Haskell-Luevano, Carrie“…Two additional fragments, featuring molecular weights below 300 Da, were also identified that possessed full agonist efficacy and micromolar potencies at the mMC5R. These SAR experiments may be useful in generating new small-molecule ligands and chemical probes for the melanocortin receptors to help elucidate their roles in vivo and as therapeutic lead compounds.…”
Publicado 2023
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69por Huang, Lei, Zhang, Huijuan, Hong, Yongbo, Liu, Shixia, Li, Dayong, Song, Fengming“…Whereas OsMC3, OsMC4, and OsMC7 were evenly distributed in the cells, OsMC5, OsMC6, and OsMC8 were localized in cytoplasm. …”
Publicado 2015
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70por Getting, S. J., Kaneva, M., Bhadresa, Y., Renshaw, D., Leoni, Giovanna, Patel, H. B., Kerrigan, M. J. P., Locke, I. C.“…Their biological effects are mediated via seven transmembrane G-protein-coupled receptors, of which five have been cloned, identified, and termed MC(1) to MC(5). Adrenocorticotrophic hormone represents the parent molecule of the melanocortins; the first 13 amino acids of which (termed a-MSH) have been shown to be the most pharmacologically active region of the parent hormone. …”
Publicado 2009
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71por del Rocio Castro-Ortega, Iveth, Caspeta-Mandujano, Juan Manuel, Suárez-Rodríguez, Ramón, Peña-Chora, Guadalupe, Ramírez-Trujillo, José Augusto, Cruz-Pérez, Karina, Sosa, Iván Arenas, Hernández–Velázquez, Víctor Manuel“…A survey of entomopathogenic nematodes was conducted in sugar cane crops in a total of 14 soils, and positive results were obtained for strain MC5-2014 in the municipality of Tepalcingo, Morelos, in soil with a sandy loam texture and a pH of 6.4. …”
Publicado 2020
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72por Wang, Meng, Zhai, Yue, Lei, Xiaowei, Xu, Jing, Jiang, Bopei, Kuang, Zhe, Zhang, Cong, Liu, Shangyun, Bian, Shan, Yang, Xiao-Mei, Zan, Tao, Jin, Li-Na, Li, Qingfeng, Zhang, Chao“…The Melanocortin Receptor Accessory Protein 2 (MRAP2), a small single transmembrane protein broadly expressed in multiple tissues, has been defined as a vital endocrine modulator of five melanocortin receptors (MC1R–MC5R) and several other GPCRs in the regulation of central neuronal activities and peripheral energy balance. …”
Publicado 2022
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73por Zhang, Wei, Li, Xiaojin, Jiang, Yao, Zhou, Mei, Liu, Linqing, Su, Shiguang, Xu, Chengliang, Li, Xueting, Wang, Chonglong“…We also identified several potential selective sweep regions associated with domestication characteristics among Anhui pigs, including reproduction-associated genes (CABS1, INSL6, MAP3K12, IGF1R, INSR, LIMK2, PATZ1, MAPK1), lipid- and meat-related genes (SNX19, MSTN, MC5R, PRKG1, CREBBP, ADCY9), and ear size genes (MSRB3 and SOX5). …”
Publicado 2022
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74“…Acute co-ablation of C/EBPα and C/EBPβ in sebaceous glands resulted in severe morphological defects, and sebocyte differentiation was blocked as determined by lack of sebum production and reduced expression of stearoyl-CoA desaturase (SCD3) and melanocortin 5 receptor (MC5R), two markers of terminal sebocyte differentiation. …”
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75por Lee, Jae Meen, Nam, Kyoung Hyup, Lee, In Sook, Park, Se Kyung, Choi, Byung Kwan, Han, In Ho“…Of the 10 segments exhibiting MC, 5 had DHs at the same level (50.0%). Accordingly, DH was strongly associated with MC (p=0.000). …”
Publicado 2013
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76“…Best performed Bacillus subtilis isolates Sb4-23, Mc5-Re2, and Mc2-Re2, which were further studied for their mode of action with regard to direct effects by bacterial metabolites or repellents, and plant mediated effects. …”
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77por Messias, Rafael da Silva, Galli, Vanessa, Silva, Sérgio Delmar dos Anjos e, Rombaldi, Cesar Valmor“…The carotenoid content in grains varied from 10.03, in the white variety MC5, to 61.50 μg·g(−1), in the yellow-to-orange variety MC3, and the major carotenoids detected were lutein and zeaxanthin. …”
Publicado 2014
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78por Yang, Zheng-Ting, Wang, Mei-Jing, Sun, Ling, Lu, Sun-Jie, Bi, Dong-Ling, Sun, Le, Song, Ze-Ting, Zhang, Shuang-Shuang, Zhou, Shun-Fan, Liu, Jian-Xiang“…Transcriptional regulation analysis and ChIP-qPCR reveal that NAC089 plays important role in regulating downstream genes involved in PCD, such as NAC094, MC5 and BAG6. Furthermore, NAC089 is up-regulated by ER stress, which is directly controlled by bZIP28 and bZIP60. …”
Publicado 2014
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79por Gragnoli, Claudia“…We hypothesize that HPA axis hyperactivation may be due to variants in the genes of the CRH receptors (CRHR1, CRHR2), corticotropin receptors (or melanocortin receptors, MC1R-MC5R), glucocorticoid receptor (NR3C1), mineralocorticoid receptor (NR3C2), and of the FK506 binding protein 51 (FKBP5), and that these variants may be partially responsible for the clinical association of depression, T2D and MetS. …”
Publicado 2014
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80por Huang, Hei-Jen, Chen, Shu-Ling, Chang, Yen-Ting, Chyuan, Jong-Ho, Hsieh-Li, Hsiu Mei“…The in vitro results show that the order of the neuroprotective effect is MC5, MC3, MC2, and MC5523 under hyperglycemia or tau hyperphosphorylation. …”
Publicado 2018
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