“…Model performance (c-statistic) and implementation outcomes (acceptability, adoption, appropriateness, feasibility, fidelity, penetration, sustainability) were evaluated after 6 months by indicators and implementation instruments (NoMAD; MIDI). RESULTS: The adherence to the prognostic model (c-statistic 0.85 (95%CI 0.81–0.90)) was 95% (n = 1021). …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…This was done by conducting interviews with the municipality officials based on the measurement instrument for determinants of implementation (MIDI). These data from multiple sources and perspectives were integrated and analyzed to form a total picture of the determinants (barriers and facilitators to implementation in the municipality context). …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Here, the RNA and protein of epididymis of Duroc pigs at different postnatal development stages were extracted by using commercial RNeasy Midi kit and extraction buffer (7 M Urea, 2 M thiourea, 3% CHAPS, and 1 mM PMSF) combined with sonication, respectively, which were further subjected to transcriptomic and proteomic profiling. …”
Enlace del recurso
Enlace del recurso

“…DNA was extracted using four extraction kits (Qiagen DNeasy PowerSoil, Qiagen DNeasy PowerSoil Pro, Qiagen RNeasy PowerSoil Total RNA/DNA extraction/elution and Favorgen FavorPrep Soil DNA Isolation Midi Kit) and three sediment volumes (0.25, 2, and 5 g). …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Small circular DNA viruses from the Anneloviridae (Torque teno midi virus 8, TTV-like mini virus 19 and 26) and Cycloviridae families (Human associated cyclovirus 10), Human betaherpesvirus 6, were found to be significantly more abundant in samples from deceased and hospitalized patients compared to samples from ambulatory individuals. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…A cross-sectional survey was performed among the physiotherapists (PTs) of the first five GLA:D® Switzerland certification courses, using the Measurement Instrument for Determinants of Innovations (MIDI) to identify the facilitators and barriers. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…In each debonded group, three cleanup techniques (n = 6 each) were tested, including (I) diamond bur (TC11EF, MANI, Tochigi, Japan) and One-Gloss (Midi, Shofu, Kyoto, Japan), (II) a Super-Snap disk (Shofu, Kyoto, Japan), and (III) One-Gloss polisher. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Les enregistrements étaient effectués le matin, l'après-midi en présence de patients, la nuit sans patients. …”
Enlace del recurso
Enlace del recurso

“…La période d'enregistrement s'est déroulée pendant 6 périodes de 24 heures continues, chacune étant divisée en trois sessions ; la première le matin accueillant des patients SARS-CoV-2 négatifs (C-), la deuxième l'après-midi accueillant des patients SARS-CoV-2 positifs (C+), la troisième sur la nuit sans patients après le bio-nettoyage (N). …”
Enlace del recurso
Enlace del recurso

“…We then implement regression analyses using MIDIS and obtain the following results: First, MIDIS is strongly correlated with available mobility statistics, at least for high income countries. …”
Enlace del recurso
Enlace del recurso

“…Genetic deletion of one, two, or even three alleles encoding insulin in mice does not necessarily lead to diabetes. Yet MIDY patients are INS-gene heterozygotes; inheritance of even one MIDY allele, causes diabetes. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…In mutant INS gene–induced diabetes of youth (MIDY), characterized by insulin deficiency, MIDY proinsulin mutants misfold and fail to exit the endoplasmic reticulum (ER). …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Recently, missense mutations upstream of preproinsulin’s signal peptide (SP) cleavage site were reported to cause mutant INS gene-induced diabetes of youth (MIDY). Our objective was to understand the molecular pathogenesis using metabolic labeling and assays of proinsulin export and insulin and C-peptide production to examine the earliest events of insulin biosynthesis, highlighting molecular mechanisms underlying β-cell failure plus a novel strategy that might ameliorate the MIDY syndrome. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…METHODS: We analyzed liver samples of a genetically diabetic pig model (MIDY) and of wild-type (WT) littermate controls by RNA sequencing, proteomics, and targeted metabolomics/lipidomics. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…The MIDIS process is based on high aspect ratio bulk micromachining of single-crystal silicon layer that is vacuum encapsulated between two other silicon handle wafers. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Emerging evidence indicates that proinsulin misfolding is not only the molecular basis of mutant INS-gene–induced diabetes of youth (MIDY) but also an important contributor in the development and progression of T2D. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…METHODS: We will use a three-armed randomized controlled trial design to determine the impact of MIDY on peak consumption of alcohol among young people. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Toxic misfolding of proinsulin variants in β-cells defines a monogenic diabetes syndrome, designated mutant INS-gene induced diabetes of the young (MIDY). In our first study (previous article in this issue), we described a one-disulfide peptide model of a proinsulin folding intermediate and its use to study such variants. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…OBJECTIVE: To gain mechanistic insights into adverse effects of maternal hyperglycemia on the liver of neonates, we performed a multi-omics analysis of liver tissue from piglets developed in genetically diabetic (mutant INS gene induced diabetes of youth; MIDY) or wild-type (WT) pigs. METHODS: Proteome, metabolome and lipidome profiles of liver and clinical parameters of serum samples from 3-day-old WT piglets (n = 9) born to MIDY mothers (PHG) were compared with those of WT piglets (n = 10) born to normoglycemic mothers (PNG). …”
Enlace del recurso
Enlace del recurso
Enlace del recurso