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661por Radbruch, Moritz, Pischon, Hannah, Ostrowski, Anja, Volz, Pierre, Brodwolf, Robert, Neumann, Falko, Unbehauen, Michael, Kleuser, Burkhard, Haag, Rainer, Ma, Nan, Alexiev, Ulrike, Mundhenk, Lars, Gruber, Achim D.“…Dendritic hPG-amid-C18-mPEG core-multishell nanocarriers (CMS) represent a novel class of unimolecular micelles that hold great potential as drug transporters, e.g., to facilitate topical therapy in skin diseases. …”
Publicado 2017
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662por Li, Pan, Zhou, Junhui, Huang, Pingsheng, Zhang, Chuangnian, Wang, Weiwei, Li, Chen, Kong, Deling“…Well-defined cationic and acid-responsive copolymers, monomethoxy poly(ethylene glycol)-block-poly(2-(diisopropyl amino) ethyl methacrylate)-block-poly(2-(guanidyl) ethyl methacrylate) (mPEG-b-PDPA-b-PGEM, PEDG) were synthesized by reversible addition-fragmentation chain transfer polymerization of 2-(diisopropylamino)ethyl methacrylate) and N-(tert-butoxycarbonyl) amino ethyl methacrylate monomers, followed by deprotection of tert-butyl protective groups and guanidinylation of obtained primary amines. (1)H NMR, (13)C NMR and GPC results indicated the successful synthesis of well-defined PEDG copolymers. …”
Publicado 2017
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663por Cai, Chenlei, Xie, Yuexia, Wu, liangliang, Chen, Xiaojing, Liu, Hongmei, Zhou, Yan, Zou, Hanbing, Liu, Dejun, Zhao, Yanan, Kong, Xianming, Liu, Peifeng“…Therefore, we constructed monomethoxy (polyethylene glycol)-poly(D,L-lactide-co-glycolide)-poly(L-lysine)-lactobionic acid- anti-vascular endothelial growth factor antibody (mPEG-PLGA-PLL-LA/VEGFab or PEAL-LA/VEGFab) nanoparticles (NPs) with highly specific targeting properties as carriers to restore the expression of miR-99a both in vitro and in vivo, to inhibit HCC progression. …”
Publicado 2017
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664por Wu, Meng-Huang, Shih, Ming-Hung, Hsu, Wei-Bin, Dubey, Navneet Kumar, Lee, Wen-Fu, Lin, Tsai-Yu, Hsieh, Meng-Yow, Chen, Chin-Fu, Peng, Kuo-Ti, Huang, Tsung-Jen, Shi, Chung-Sheng, Guo, Ren-Shyang, Cai, Chang-Jhih, Chung, Chiu-Yen, Wong, Chung-Hang“…A ketorolac-embedded 2, 2'-Bis (2-oxazolin) (BOX) linking methoxy-poly(ethylene glycol) and poly(lactide-co-glycolide) (mPEG-PLGA) diblock copolymer (BOX copolymer) was synthesized as keto-hydrogel based on optimal sol-gel phase transition and in vitro drug release profile. …”
Publicado 2017
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665por Xu, Shan, Du, Xiaobo, Feng, Gang, Zhang, Yu, Li, Jie, Lin, Binwei, Yang, Linglin, Fu, Shaozhi, Wu, Jingbo“…BACKGROUND AND PURPOSE: We aimed to explore the anti-tumor effect and mechanism of the combination of cisplatin (DDP)-containing thermosensitive hydrogel (PEG-PCL-PEG, or PECE) and paclitaxel (PTX)-loaded MPEG-PCL polymeric micelles called PDMP on human cervical carcinoma (HeLa) cell. …”
Publicado 2017
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666por Luukinen, Hanna, Hammarén, Milka Marjut, Vanha-aho, Leena-Maija, Svorjova, Aleksandra, Kantanen, Laura, Järvinen, Sampsa, Luukinen, Bruno Vincent, Dufour, Eric, Rämet, Mika, Hytönen, Vesa Pekka, Parikka, Mataleena“…At 24 h post-infection, HKLm priming leads to a significant increase in the expression levels of macrophage-expressed gene 1 (mpeg1), tumor necrosis factor α (tnfa) and nitric oxide synthase 2b (nos2b), whereas superoxide dismutase 2 (sod2) expression is downregulated, implying that HKLm priming increases the number of macrophages and boosts intracellular killing mechanisms. …”
Publicado 2018
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667por Chang, Ming-Hsiang, Pai, Chin-Ling, Chen, Ying-Chen, Yu, Hsiu-Ping, Hsu, Chia-Yen, Lai, Ping-Shan“…In this study, a clinically therapeutic antibody cetuximab (C225) was conjugated to the surface of methoxy poly(ethylene glycol)-b-poly(lactide) (mPEG-b-PLA) micelles via thiol-maleimide coupling to allow tumor-targetable chlorin e6 (Ce6) delivery. …”
Publicado 2018
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668por Nik, Maryam Ebrahimi, Malaekeh-Nikouei, Bizhan, Amin, Mohamadreza, Hatamipour, Mahdi, Teymouri, Manouchehr, Sadeghnia, Hamid Reza, Iranshahi, Mehrdad, Jaafari, Mahmoud Reza“…In this study, a pegylated liposomal Gba (PLGba) with HSPC/Cholesterol/mPEG(2000)-DSPE (56.2, 38.3, 5.3% molar ratio) was developed by the thin film hydration plus extrusion and calcium acetate gradient remote loading method, to address the issue of poor Gba solubility. …”
Publicado 2019
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669por Hong, Jingyi, Xiao, Xiaojun, Gao, Qichan, Li, Shanshan, Jiang, Bei, Sun, Xizhuo, Ran, Pixin, Yang, Pingchang“…METHODS: We proposed an oral administration strategy to treat FA by co-delivering food allergen epitope fragment (peptide: IK) and adjuvant R848 (TLR7 ligand) in the mPEG–PDLLA nanoparticles (PPLA-IK/R848 NPs). The generation of tolerogenic dendritic cells (DCs) and regulatory T cells (Tregs) induced by PPLA-IK/R848 NPs were evaluated in vitro and in vivo. …”
Publicado 2019
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670Polymeric micelles loading with ursolic acid enhancing anti-tumor effect on hepatocellular carcinomapor Zhou, Meiling, Yi, Youping, Liu, Li, Lin, Yan, Li, Jian, Ruan, Jinghua, Zhong, Zhirong“…We took a diblock copolymer of methoxy poly (ethylene glycol)-poly(L-lactic acid) (mPEG-PLA) as carrier material to prepare UA-PMs by the thin-film dispersion method. …”
Publicado 2019
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671por Oddone, Natalia, Boury, Frank, Garcion, Emmanuel, Grabrucker, Andreas M., Martinez, M. Carmen, Da Ros, Federica, Janaszewska, Anna, Forni, Flavio, Vandelli, Maria Angela, Tosi, Giovanni, Ruozi, Barbara, Duskey, Jason T.“…In this work, we designed a new ROS-responsive prodrug by using Melphalan (MPH) covalently coupled with methoxy polyethylene glycol (mPEG) through a ROS-cleavable group thioketal (TK), demonstrating the capacity to self-assembly into nanosized micelles. …”
Publicado 2020
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672por Phan, Quang Tien, Tan, Wen Hui, Liu, Ranran, Sundaram, Sudha, Buettner, Anita, Kneitz, Susanne, Cheong, Benedict, Vyas, Himanshu, Mathavan, Sinnakaruppan, Schartl, Manfred, Winkler, Christoph“…Ectopic expression of Cxcl9l recruits mpeg1-positive macrophages to bone matrix and triggers their differentiation into osteoclasts. …”
Publicado 2020
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673por Chen, Enrui, Han, Shangcong, Song, Bo, Xu, Lisa, Yuan, Haicheng, Liang, Mingtao, Sun, Yong“…MATERIALS AND METHODS: We here reported a tumoral microenvironment responsive multistage drug delivery system (NPs-EPI/HAase) which was formed layer by layer via electrostatic interaction with epirubicin (EPI)-loaded PEG-b-poly(2-(diisopropylamino)ethyl methacrylate)-b-poly(2-guanidinoethylmethacrylate) (mPEG-PDPA-PG, PEDG) micelles (NPs-EPI) and hyaluronidase (HAase). …”
Publicado 2020
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674“…The mutation frequencies of 11 genes (MYD88[L265P], SGK1, MPEG1, TP53, SPEN, NOTCH1, ETV6, TNFRSF14, MGA, CIITA, and PIM1) significantly differed between the high‐ and low‐risk groups. …”
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675por Mirhadi, Elaheh, Mashreghi, Mohammad, Askarizadeh, Anis, Mehrabian, Amin, Alavizadeh, Seyedeh Hoda, Arabi, Leila, Badiee, Ali, Jaafari, Mahmoud Reza“…Some formulations had mPEG(2000)-DSPE and cholesterol. After extrusion, the external phase was exchanged with sodium bicarbonate to create a pH gradient. …”
Publicado 2022
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676por Song, Chenghua, Zhang, Jia, Wen, Ruichao, Li, Qingshan, Zhou, Jiaxuan, Xiaoli liu, Wu, Zheng, Lv, Yi, Wu, Rongqian“…By a single emulsification method, a representative HCC targeted-therapeutic drug sorafenib (SF) was encapsulated into the pH-triggered positive-charged mPEG5K-PAE10K (PP) nanoparticles, followed by condensing of negative-charged Tim-3 siRNA. …”
Publicado 2022
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677“…More importantly, a targeted delivery of mPEG-PCL-g-PDMAEMA nanoparticles/miR-190 complexes (PECgD NPs/miR-190) to the pancreas significantly ameliorated hyperglycemia, decreased fasting serum insulin levels, and improved glucose tolerance in diabetic mice. …”
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678por Jiao, Fang, Dehez, François, Ni, Tao, Yu, Xiulian, Dittman, Jeremy S., Gilbert, Robert, Chipot, Christophe, Scheuring, Simon“…Perforin-2 (PFN2, MPEG1) is a pore-forming protein that acts as a first line of defense in the mammalian immune system, rapidly killing engulfed microbes within the phagolysosome in macrophages. …”
Publicado 2022
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679por Timmers, Matt, Weterings, Jimmy, van Geijn, Michiel, Bell, Roel, Lenting, Peter E., Rijcken, Cristianne J.F., Vermonden, Tina, Hennink, Wim E., Liskamp, Rob M.J.“…Hereafter, API release from CCPMs based on mPEG-b-pHPMAmLac block copolymers was investigated. …”
Publicado 2022
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680por Zakaria, Mohamed Y., Zaki, Islam, Alhomrani, Majid, Alamri, Abdulhakeem S., Abdulaziz, Osama, Abourehab, Mohammed A.S.“…(F4) with desirability value (0.772), picked to be the optimal formula, which is fabricated utilizing 35 mg compritol as the lipidic core and 60 mg 1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-[amino(polyethylene glycol)-2000] (DSPE-Mpeg-2000). The dominance of the F4 relative to RSV dispersion was affirmed by the data acquired from ex-vivo and pharmacokinetic studies. …”
Publicado 2022
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