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721por Zhu, Jingyi, Yang, Junxing, Zhao, Lingzhou, Zhao, Pingping, Yang, Jiqin, Zhao, Jinhua, Miao, Wenjun“…Alkoxyphenyl acylsulfonamide (APAS), a typical functional group that could achieve improved cellular uptake of its modified nanoparticles, was utilized to conjugate onto the functional PEI pre-modified with polyethylene glycol (PEG) with terminal groups of monomethyl ether and N-hydroxysuccinimide (mPEG-NHS), PEG with terminal groups of maleimide and succinimidyl valerate (MAL-PEG-SVA) through sulfydryl of APAS and MAL moiety of MAL-PEG-SVA. …”
Publicado 2021
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722por Liu, Jinlu, Yang, Ling, Yuan, Xin, Xiong, Meimei, Zhu, Jiao, Wu, Wenbi, Ren, Min, Long, Jianlin, Xu, Xuewen, Gou, Maling“…Recently, we designed a nonviral nanocarrier iRGD/DOTAP/MPEG-PDLLA (iDPP) that could deliver gene targetedly to melanoma efficiently without obvious adverse effects. …”
Publicado 2021
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723por Chen, Zhou, Hu, Yue, Mao, Xinggang, Nie, Dan, Zhao, Hui, Hou, Zheng, Li, Mingkai, Meng, Jingru, Luo, Xiaoxing, Xue, Xiaoyan“…RESULTS: Here, we designed a series of dendritic poly-peptides (DPP1 to DPP12) to encapsulate ASOs to form DSPE-mPEG2000 decorated ASOs/DPP nanoparticles (DP-AD1 to DP-AD12) and observed that amphipathic DP-AD2, 3, 7 or 8 with a positive charge ≥ 8 showed great efficiency to deliver ASOs into bacteria, but only the two histidine residues contained DP-AD7 and DP-AD8 significantly inhibited the bacterial growth and the targeted gene expression of tested bacteria in vitro. …”
Publicado 2022
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724por Fresco-Cala, Beatriz, López-Lorente, Ángela I., Batista, Alex D., Dinc, Mehmet, Bansmann, Joachim, Behm, R. Jürgen, Cárdenas, Soledad, Mizaikoff, Boris“…The latter was achieved by non-covalent linking of the protein to the iAuNP surface using a PEG without reactive termination (i.e., methoxy PEG thiol, mPEG-SH, Mn=800). Alternatively, covalent anchoring points were generated by modifying the iAuNPs with a bifunctional PEG (i.e., thiol PEG amine, SH-PEG-NH(2)) followed by the addition of glutaraldehyde. …”
Publicado 2022
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725por Priwitaningrum, Dwi L., Pednekar, Kunal, Gabriël, Alexandros V., Varela-Moreira, Aida A., Le Gac, Severine, Vellekoop, Ivo, Storm, Gert, Hennink, Wim E., Prakash, Jai“…PTX-PMCs (77 nm) based on a amphiphilic block copolymer of mPEG-b-p(HPMAm-Bz) and PTX-PNPs (159 nm) based on poly(lactic-co-glycolic acid) were prepared, which had an encapsulation efficiency (EE%) of 81 ± 15% and 45 ± 8%, respectively. 3D homospheroids of mouse 4T1 breast cancer cells and heterospheroids of NIH3T3 fibroblasts and 4T1 (5:1 ratio) were prepared and characterized with high content two-photon microscopy and immunostaining. …”
Publicado 2023
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726por Palau, Marta, Muñoz, Estela, Gusta, Muriel F., Larrosa, Nieves, Gomis, Xavier, Gilabert, Joan, Almirante, Benito, Puntes, Victor, Texidó, Robert, Gavaldà, Joan“…First, we synthesized highly monodispersed silver nanoparticles (AgNPs) of approximately 17 nm, and we functionalized them with mercaptopoly(ethylene glycol) carboxylic acid (mPEG-COOH) and amikacin (AK). Second, we evaluated the antibacterial activity of this treatment (AgNPs_mPEG_AK) alone and in combination with hyperthermia against planktonic and biofilm-growing strains. …”
Publicado 2023
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727“…Four video encoders, motion-JPEG (M-JPEG), MPEG-4 (MP4), Advanced Video Coding (AVC or H.264) and High Efficiency Video Coding (HEVC or H.265) were investigated. …”
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728por Tsui, Sam-Mui, Lam, Wai-Man, Lam, Tin-Lun, Chong, Hiu-Chi, So, Pui-Kin, Kwok, Sui-Yi, Arnold, Simon, Cheng, Paul Ning-Man, Wheatley, Denys N, Lo, Wai-Hung, Leung, Yun-Chung“…RESULTS: Methoxypolyethylene glycol-succinimidyl propionate (mPEG-SPA 5,000) coupled with very high affinity under mild conditions. …”
Publicado 2009
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729por Sárvári, Miklós, Hrabovszky, Erik, Kalló, Imre, Solymosi, Norbert, Tóth, Kinga, Likó, István, Széles, János, Mahó, Sándor, Molnár, Béla, Liposits, Zsolt“…E2 regulated the expression of sixteen genes, including down-regulation of complement C3 and C4b, Ccl2, Tgfb1, macrophage expressed gene Mpeg1, RT1-Aw2, Cx3cr1, Fcgr2b, Cd11b, Tlr4 and Tlr9, and up-regulation of defensin Np4 and RatNP-3b, IgG-2a, Il6 and ER gene Esr1. …”
Publicado 2011
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730por Hershfield, Michael S, Ganson, Nancy J, Kelly, Susan J, Scarlett, Edna L, Jaggers, Denise A, Sundy, John S“…Ab to pegloticase and 10 kDa mPEG were monitored by enzyme linked immunosorbent assay and specificity was further defined. …”
Publicado 2014
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731por Zhao, Lingzhou, Zhu, Jingyi, Gong, Jiali, Song, Ningning, Wu, Shan, Qiao, Wenli, Yang, Jiqin, Zhu, Meilin, Zhao, Jinhua“…RESULTS: This multifunctional nanocomplex was manufactured using branched polyethylenimine (PEI) as a template to sequentially conjugate with methoxypolyethylene glycol (mPEG), glioma-targeting peptide chlorotoxin (CTX), and diethylenetriaminepentaacetic acid (DTPA) for (99m)Tc radiolabeling on the surface of PEI. …”
Publicado 2020
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732por Hou, Xingyu, Zhong, Dan, Li, Yunkun, Mao, Hongli, Yang, Jun, Zhang, Hu, Luo, Kui, Gong, Qiyong, Gu, Zhongwei“…Herein, a novel dual-responsive multi-pocket nanoparticle was conveniently constructed through self-assembly and cross-linking of amphiphilic methoxypolyethylene glycol-lipoic acid (mPEG-LA) conjugates to enhance tumor penetration and antitumor efficacy. …”
Publicado 2021
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733por Hong, Weiyong, Gao, Ying, Lou, Bang, Ying, Sanjun, Wu, Wenchao, Ji, Xugang, Yu, Nan, Jiao, Yunlong, Wang, Haiying, Zhou, Xuefeng, Li, Anqin, Guo, Fangyuan, Yang, Gensheng“…METHODS: The amphiphilic tri-chaintricarballylic acid-poly (ε-caprolactone)-methoxypolyethylene glycol (Tri-CL-mPEG) and the enzyme-targeted tetra-chain pentaerythritol-poly (ε-caprolactone)-polypeptide (PET-CL-P) were synthesized. …”
Publicado 2021
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734por Al-Ani, Mena, Elemam, Noha Mousaad, Hachim, Ibrahim Y, Raju, Tom K, Muhammad, Jibran Sualeh, Hachim, Mahmood Y, Bendardaf, Riyad, Maghazachi, Azzam A“…Our combined bioinformatics and qRT-PCR analyses show increased mRNA expression of Atp6v0d2, C3, C3ar1, Ccl3, Ccl6, Cd74, Clec7a, Cybb, H2-Aa, Hspb1, Lilr4b, Lilrb4a, Mpeg1, Ms4a4a, Ms4a6c, Saa3, Serpina3n and Timp1, at HCS. …”
Publicado 2021
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735por Jia, Fan, Li, Yunhao, Deng, Xiongwei, Wang, Xuan, Cui, Xinyue, Lu, Jianqing, Pan, Zian, Wu, Yan“…RESULTS: In the present work, curcumin (Cur) and small interfering RNA targeting lncRNA CCAT1(siCCAT1) were co-incorporated into polymeric hybrid nanoparticles (CSNP), which was constructed by self-assembling method with two amphiphilic copolymers, polyethyleneimine-poly (d, l-lactide) (PEI-PDLLA) and 1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-[methoxy (polyethylene glycol) (DSPE-mPEG). Owing to the multicolor fluorescence characteristics of PEI-PDLLA, the constructed CSNP could be served as a theranostic nanomedicine for synchronous therapy and imaging both in vitro and in vivo. …”
Publicado 2021
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736por Xie, Xiaoting, Wei, Jiemao, Zhang, Bin, Xiong, Wei, He, Zhiyi, Zhang, Yayun, Gao, Chenghao, Zhao, Yuandi, Liu, Bo“…METHODS: In this study, a bilayer hydrogel based on genetically engineered polypeptide AC(10)A and AC(10)ARGD was prepared by self-assembly. Ag(2)S QDs@DSPE-mPEG(2000)-Ce6/Aptamer (AD-Ce6/Apt) was loaded in the top layer AC(10)A hydrogel (AA) for antibacterial, and bone marrow-derived mesenchymal stem cells (BMSCs) were loaded in the lower layer AC(10)ARGD hydrogel (MAR) for bone healing. …”
Publicado 2022
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737por Zhu, Duan, Zhou, Mi, Zhang, Houli, Gong, Liang, Hu, Jianlin, Luo, Hu, Zhou, Xiangdong“…The key genes and their upstream regulators comprised a gene panel, including EOMES, LTF, CSF1R, HLA-DRA, IRF8 and MPEG1. Compared with the healthy controls, the panel had an area under the curve (AUC) of 0.900 and 0.914 for sepsis-alone group and sepsis-induced ARDS group, respectively. …”
Publicado 2023
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738por Wang, Zhixiong, Zhu, Menglin, Dong, Runyu, Cao, Danping, Li, Yanna, Chen, Zhiqiang, Cai, Juan, Zuo, Xueliang“…However, the effectiveness of TH-302 in gastric cancer combined immunotherapy remains unclear. METHODS: We designed mPEG-PLGA-encapsulated TH-302 (TH-302 NPs) to target the hypoxic area of tumour tissues. …”
Publicado 2023
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739por Xu, Pengfei, Werner, Jens-Uwe, Milerski, Sebastian, Hamp, Carmen M., Kuzenko, Tatjana, Jähnert, Markus, Gottmann, Pascal, de Roy, Luisa, Warnecke, Daniela, Abaei, Alireza, Palmer, Annette, Huber-Lang, Markus, Dürselen, Lutz, Rasche, Volker, Schürmann, Annette, Wabitsch, Martin, Knippschild, Uwe“…Furthermore, histological satellite cell evaluation showed lower satellite cell numbers in the obese model upon injury. Ankrd1, C3ar1, Ccl8, Mpeg1, and Myog expression levels were also verified by qPCR. …”
Publicado 2018
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740por D’Alessandro, Giuseppina, Quaglio, Deborah, Monaco, Lucia, Lauro, Clotilde, Ghirga, Francesca, Ingallina, Cinzia, De Martino, Michela, Fucile, Sergio, Porzia, Alessandra, Di Castro, Maria Amalia, Bellato, Federica, Mastrotto, Francesca, Mori, Mattia, Infante, Paola, Turano, Paola, Salmaso, Stefano, Caliceti, Paolo, Di Marcotullio, Lucia, Botta, Bruno, Ghini, Veronica, Limatola, Cristina“…After the orthotopic GL261 cells injection in the right striatum of C57BL6 mice and the intranasal (IN) GlaB/mPEG(5kDa)-Cholane treatment, the tumor growth was evaluated. …”
Publicado 2019
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