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121por Chu, BingYang, Zhang, Lan, Qu, Ying, Chen, XiaoXin, Peng, JinRong, Huang, YiXing, Qian, ZhiYong“…And all lyophilized DTX-loaded MPEG-PCLA micelles except MPEG-PCL micelles were readily re-dissolved in normal saline at 25 °C. …”
Publicado 2016
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122por Hou, Zemin, Zhou, Wencheng, Guo, Xi, Zhong, Rui, Wang, Ao, Li, Jiehua, Cen, Ying, You, Chao, Tan, Hong, Tian, Meng“…Interestingly, the protein adsorption was affected and dependent on the chain conformation, with lowest adsorption for PCL(30)-MPEG, which also has the loWest phagocytosis. The stability of the micelles was in the order of PCL(40)-MPEG>PCL(30)-MPEG>PCL(20)-MPEG which was dependent on the PCL chain length. …”
Publicado 2022
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123por Liu, Wenguang, Liu, Bing, Zhang, Gege, Yao, Gaoyou, Zhang, Yang, Cen, Xitong, He, Maoxian“…In this study, a homolog of Mpeg1 (Ct-Mpeg1) was identified in C. tritonis. The predicted protein of Ct-Mpeg1 contains several structural features known in Mpegs, including a membrane attack complex/perforin (MACPF) domain and single transmembrane region. …”
Publicado 2022
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124por Shen, Ming, Chen, Chuanrong, Guo, Qianqian, Wang, Quan, Liao, Jinghan, Wang, Liting, Yu, Jian, Xue, Man, Duan, Yourong, Zhang, Jiali“…Here, a methoxy poly(ethylene glycol) (mPEG)‐masked CD44×PD‐L1/CD3 trispecific T‐cell nanoengager loaded with the STING agonist c‐di‐AMP (CDA) (PmTriTNE@CDA) for the treatment of triple‐negative breast cancer (TNBC) is rationally designed. …”
Publicado 2022
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125por Xing, Lingxi, Shi, Qiusheng, Zheng, Kailiang, Shen, Ming, Ma, Jing, Li, Fan, Liu, Yang, Lin, Lizhou, Tu, Wenzhi, Duan, Yourong, Du, Lianfang“…The three-block copolymer methoxy polyethylene glycol-polylacticco-glycolic acid-polylysine (mPEG-PLGA-PLL) constituted the skeleton of the NPs. …”
Publicado 2016
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126“…The Poly (ethylene glycol) methyl ether-block-poly (lactide-co-glycolide) (mPEG-PLGA) nanoparticles carrying acetyltanshinone IIA (ATA), a novel anti-breast cancer agent, were prepared by ultrasonic emulsion method to enhance the bioavailability and reduce the toxicity. …”
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127por Zhai, Yinglei, Zhou, Xing, Zhang, Zhiqiang, Zhang, Lei, Wang, Dianyu, Wang, Xinhui, Sun, Wei“…DOX was chemically conjugated with the polymer via acid-cleavable imine bonds to obtain a novel pH-sensitive DOX prodrug (mPEG-PCL-Imi-DOX). mPEG-PCL-Imi-DOX (24.2 wt % DOX content) formed micelles with an average diameter of 125 nm through a simple solvent evaporation method. …”
Publicado 2018
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128por Chen, Daquan, Liu, Wanhui, Shen, Yan, Mu, Hongjie, Zhang, Yanchun, Liang, Rongcai, Wang, Aiping, Sun, Kaoxiang, Fu, Fenghua“…However, a slight ABC phenomenon was brought about by repeated injection of mPEG-CHEMS liposomes and was accompanied by only a slightly increased uptake in the liver, and repeated injection of mPEG-Hz-CHEMS liposomes did not induce the ABC phenomenon and there was no increase in liver accumulation. …”
Publicado 2011
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129por Papotto, Pedro Henrique, Marengo, Eliana Blini, Sardinha, Luiz Roberto, Carvalho, Karina Inácio, de Carvalho, Ana Eduarda Zulim, Castillo-Mendez, Sheyla, Jank, Carina Calixto, Vanhove, Bernard, Goldberg, Anna Carla, Rizzo, Luiz Vicente“…Thus, we evaluated the efficacy of mPEG PV1-Fab’ (PV1), a novel selective CD28 antagonist monovalent Fab fragment in the treatment of Experimental Autoimmune Uveitis (EAU). …”
Publicado 2017
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130por Bikiaris, Nikolaos D., Ainali, Nina Maria, Christodoulou, Evi, Kostoglou, Margaritis, Kehagias, Thomas, Papasouli, Emilia, Koukaras, Emmanuel N., Nanaki, Stavroula G.“…This PTX-Fe-BTC nanocomposite was further encapsulated into a mPEG-PCL matrix, a typical aliphatic amphiphilic copolyester synthesized in our lab, whose biocompatibility was validated by in vitro cytotoxicity tests toward human umbilical vein endothelial cells (HUVEC). …”
Publicado 2020
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131por Huang, Chan, Su, Xuan, Zhou, Da-Lei, Xu, Bo-Heng, Liu, Qing, Zhang, Xiao, Tang, Tao, Yang, Xin-Hua, Ye, Zu-Lu, He, Cai-Yun“…A nomogram combining two lncRNAs, lnc-MPEG1-1:1 and lnc-ABCA12-5:2, with age, T stage, histological type, and predicted LN metastasis was developed. …”
Publicado 2022
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132por Bhowmick, Sirsendu, Thanusha, A. V., Kumar, Arun, Scharnweber, Dieter, Rother, Sandra, Koul, Veena“…The aim of this study was to investigate the efficacy of a skin substitute composed of mPEG–PCL–grafted-gelatin (Bio-Syn)/hyaluronan/chondroitin sulfate/sericin and to study its in vitro biocompatibility with human fibroblasts, human keratinocytes and hMSCs in terms of cellular adhesion and proliferation (∼5–6 fold). mPEG–PCL was grafted into a gelatin backbone via a Michael addition reaction to prepare Bio-Syn and it was characterized using ATR-FTIR, (1)H NMR and TNBS assay. …”
Publicado 2018
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133“…Simulations on the prodrug release process showed that the prodrug unimolecular micelles assembled by β-CD-P[CL(30)-co-(ACL-g-DOX)(8)-SS-MPEG(49)](21) would provide good dual pH/reduction-responsive DOX release performance.…”
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134por Tousi, Marziyeh Shalchi, Sepehri, Houri, Khoee, Sepideh, Farimani, Mahdi Moridi, Delphi, Ladan, Mansourizadeh, Fariba“…The results indicated that eupatorin was successfully entrapped in Fe(3)O(4)@mPEG-b-PLGA nanoparticles with an efficacy of (90.99 ± 2.1)%. …”
Publicado 2021
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135“…In this study, the acid-responsive methoxy poly(ethylene oxide)-hydrazone-poly(ε-caprolactone) copolymers, mPEG-Hz-b-PCL, were synthesized. The structure was characterized by (1)H NMR. …”
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136por Su, Chia-Yu, Chen, Michael, Chen, Ling-Chun, Ho, Yuan-Soon, Ho, Hsiu-O, Lin, Shyr-Yi, Chuang, Kuo-Hsiang, Sheu, Ming-Thau“…Anti-mPEG/anti-human epidermal growth factor receptor 2 (HER2) bispecific antibodies (BsAbs) non-covalently bound to a docetaxel (DTX)-loaded mPEGylated lecithin-stabilized micellar drug delivery system (L(sb)MDDs) were endowed with active targetability to improve the chemotherapeutic efficacy of DTX. …”
Publicado 2018
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137por Ho, Kai-Wen, Chen, I.-J.u, Cheng, Yi-An, Liao, Tzu-Yi, Liu, En-Shuo, Chen, Huei-Jen, Lu, Yun-Chi, Su, Yu-Cheng, Roffler, Steve R., Huang, Bo-Cheng, Liu, Hui-Ju, Huang, Ming-Yii, Chen, Chiao-Yun, Cheng, Tian-Lu“…METHODS: In this study, we developed a humanized bispecific antibody (BsAbs: CD20 Ab-mPEG scFv) which retains the clinical anti-CD20 whole antibody (Ofatumumab) and is fused with an anti-mPEG single chain antibody (scFv) that can target the systemic liquid tumor cells. …”
Publicado 2021
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138por López-Serrano, Sergi, Cordoba, Lorena, Pérez-Maillo, Mónica, Pleguezuelos, Patricia, Remarque, Edmond J., Ebensen, Thomas, Guzmán, Carlos A., Christensen, Dennis, Segalés, Joaquim, Darji, Ayub“…This study aimed to evaluate the immune response and protection correlates against influenza virus (IV) infection in pigs vaccinated with the novel NG34 HA1 vaccine candidate adjuvanted with either CAF(®)01 or CDA/αGalCerMPEG (αGCM). Two groups of six pigs each were vaccinated intramuscularly twice with either NG34 + CAF(®)01 or NG34 + CDA/αGCM. …”
Publicado 2021
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139por Wang, Huafen, He, Huanhuan, Zhang, Jiaxiang, Liu, Juntao, Zhuang, Yuwei, Yin, Yuanyuan, Ren, Zhiyong, Fu, Yang, He, Suqin“…Novel monomethoxy poly(ethylene glycol) (mPEG) modified hydroxylated tung oil (HTO), denoted as mPEG-HTO-mPEG, was designed and synthesized for drug delivery. mPEG-HTO-mPEG consists of a hydroxylated tung oil center joined by two mPEG blocks via a urethane linkage. …”
Publicado 2023
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140“…HM-3 was modified with four different types of PEG with different molecular weights (ALD-mPEG(5k), ALD-mPEG(10k), SC-mPEG(10k) and SC-mPEG(20k)), resulting in four modified products (ALD-mPEG(5k)-HM-3, ALD-mPEG(10k)-HM-3, SC-mPEG(10k)-HM-3 and SC-mPEG(20k)-HM-3, respectively). …”
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