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441por Miyagawa, S, Harada, M, Matsumaru, D, Tanaka, K, Inoue, C, Nakahara, C, Haraguchi, R, Matsushita, S, Suzuki, K, Nakagata, N, Ng, R C-L, Akita, K, Lui, V C-H, Yamada, G“…The expression of bone morphogenetic protein (Bmp) genes, such as Bmp4 and Bmp7, was also ectopically induced in the epithelia of the URS in the β-catenin GOF mutants. The expression of the Msx2 gene and phosphorylated-Smad1/5/8, possible readouts of Bmp signaling, was also increased in the mutants. …”
Publicado 2014
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442por Aurrekoetxea, Maitane, Irastorza, Igor, García-Gallastegui, Patricia, Jiménez-Rojo, Lucia, Nakamura, Takashi, Yamada, Yoshihiko, Ibarretxe, Gaskon, Unda, Fernando J.“…During tooth morphogenesis, Fibroblast growth factor4 (Fgf4), Fibroblast growth factor10 (Fgf10), Muscle segment homeobox 1 (Msx-1), Bone Morphogenetic protein 4 (Bmp4), and Dickkopf WNT signaling pathway inhibitor 1 (Dkk-1) were overexpressed in first molars cultured with BIO. …”
Publicado 2016
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443por Zheng, Yunfei, Cai, Jinglei, Hutchins, Andrew Paul, Jia, Lingfei, Liu, Pengfei, Yang, Dandan, Chen, Shubin, Ge, Lihong, Pei, Duanqing, Wei, Shicheng“…This loss of odontogenic potential was accompanied by widespread transcriptomic alteration and, specifically, the downregulation of some dental mesenchyme-specific genes, such as Pax9, Msx1, and Pdgfrα. To prolong the odontogenic potential of mDMCs in vitro, we then cultured mDMCs in a serum-free medium with Knockout Serum Replacement (KSR) and growth factors (fibroblastic growth factor 2 and epidermal growth factor). …”
Publicado 2016
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444por Salvi, Alessandro, Giacopuzzi, Edoardo, Bardellini, Elena, Amadori, Francesca, Ferrari, Lia, De Petro, Giuseppina, Borsani, Giuseppe, Majorana, Alessandra“…In this study, we enrolled 16 individuals affected by tooth agenesis, prevalently hypodontia, and we carried out direct Sanger sequencing of paired box 9 (PAX9) and Msh homeobox 1 (MSX1) genes in 9 subjects. Since no mutations were identified, we performed whole exome sequencing (WES) in the members of 5 families to identify causative gene mutations either novel or previously described. …”
Publicado 2016
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445por Yu, Yanqin, Zuo, Xianbo, He, Miao, Gao, Jinping, Fu, Yuchuan, Qin, Chuanqi, Meng, Liuyan, Wang, Wenjun, Song, Yaling, Cheng, Yong, Zhou, Fusheng, Chen, Gang, Zheng, Xiaodong, Wang, Xinhuan, Liang, Bo, Zhu, Zhengwei, Fu, Xiazhou, Sheng, Yujun, Hao, Jiebing, Liu, Zhongyin, Yan, Hansong, Mangold, Elisabeth, Ruczinski, Ingo, Liu, Jianjun, Marazita, Mary L., Ludwig, Kerstin U., Beaty, Terri H., Zhang, Xuejun, Sun, Liangdan, Bian, Zhuan“…We identify 41 SNPs within 26 loci that achieve genome-wide significance, 14 of which are novel (RAD54B, TMEM19, KRT18, WNT9B, GSC/DICER1, PTCH1, RPS26, OFCC1/TFAP2A, TAF1B, FGF10, MSX1, LINC00640, FGFR1 and SPRY1). These 26 loci collectively account for 10.94% of the heritability for NSCLP in Chinese population. …”
Publicado 2017
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446“…This aberrant mTORC1 signalling within the ciliary margin in particular leads to a reduction in the number of cells that express Pax6, Bmp4 and Msx1. Sustained mTORC1 signalling also induces a decrease in ciliary margin progenitor cell proliferation and a consequent failure of ciliary body and iris development in postnatal animals. …”
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449por Buckley, Matthew T., Racimo, Fernando, Allentoft, Morten E., Jensen, Majken K., Jonsson, Anna, Huang, Hongyan, Hormozdiari, Farhad, Sikora, Martin, Marnetto, Davide, Eskin, Eleazar, Jørgensen, Marit E., Grarup, Niels, Pedersen, Oluf, Hansen, Torben, Kraft, Peter, Willerslev, Eske, Nielsen, RasmusEnlace del recurso
Publicado 2017
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450por Koch, Anastasia S., Brites, Daniela, Stucki, David, Evans, Joanna C., Seldon, Ronnett, Heekes, Alexa, Mulder, Nicola, Nicol, Mark, Oni, Tolu, Mizrahi, Valerie, Warner, Digby F., Parkhill, Julian, Gagneux, Sebastien, Martin, Darren P., Wilkinson, Robert J.Enlace del recurso
Publicado 2017
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451por Yuan, Qiuping, Zhao, Min, Tandon, Bhavna, Maili, Lorena, Liu, Xiaoming, Zhang, Anqi, Baugh, Evan H., Tran, Tam, Silva, Renato M., Hecht, Jacqueline T., Swindell, Eric C., Wagner, Daniel S., Letra, Ariadne“…Furthermore, mRNA expression levels of additional tooth development genes were directly correlated with wnt10a expression; expression of msx1, dlx2b, eda, and axin2 was decreased upon wnt10a knockdown, and increased upon wnt10a overexpression. …”
Publicado 2017
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452“…Interestingly, exposure of YAP(−/−) hESCs to Activin induces cardiac mesoderm markers (BAF60c and HAND1) without activating Wnt-dependent cardiac inhibitor genes (CDX2 and MSX1). Moreover, canonical Wnt target genes are up-regulated only modestly, if at all, under these conditions. …”
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453“…The expanded TM cells were small cuboidal cells expressing TM markers such as AQP1, MGP, CHI3L1, and AnkG, embryonic stem cell (ESC) markers such as Oct4, Sox2, Nanog, and ABCG2, and neural crest (NC) markers such as p75NTR, FOXD3, Sox9, Sox10, and MSX1. Although expanded cells lost expression of these markers after passage, the cells regained the markers when Passage 2 cells were seeded on 3D Matrigel through activation of canonical BMP signaling. …”
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455por Baalsrud, Helle Tessand, Tørresen, Ole Kristian, Solbakken, Monica Hongrø, Salzburger, Walter, Hanel, Reinhold, Jakobsen, Kjetill S, Jentoft, SisselEnlace del recurso
Publicado 2018
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456por Casas-Marce, Mireia, Marmesat, Elena, Soriano, Laura, Martínez-Cruz, Begoña, Lucena-Perez, Maria, Nocete, Francisco, Rodríguez-Hidalgo, Antonio, Canals, Antoni, Nadal, Jordi, Detry, Cleia, Bernáldez-Sánchez, Eloísa, Fernández-Rodríguez, Carlos, Pérez-Ripoll, Manuel, Stiller, Mathias, Hofreiter, Michael, Rodríguez, Alejandro, Revilla, Eloy, Delibes, Miguel, Godoy, José A.Enlace del recurso
Publicado 2017
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457por Peng, Fen, Widmann, Scott, Wünsche, Andrea, Duan, Kristina, Donovan, Katherine A, Dobson, Renwick C J, Lenski, Richard E, Cooper, Tim FEnlace del recurso
Publicado 2018
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459por Li, Mingai, Xu, Jia, Algarra Alarcon, Alberto, Carlin, Silvia, Barbaro, Enrico, Cappellin, Luca, Velikova, Violeta, Vrhovsek, Urska, Loreto, Francesco, Varotto, ClaudioEnlace del recurso
Publicado 2017
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460por Barbosa, Camilo, Trebosc, Vincent, Kemmer, Christian, Rosenstiel, Philip, Beardmore, Robert, Schulenburg, Hinrich, Jansen, GuntherEnlace del recurso
Publicado 2017
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