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1“…We show that Msx1(−)(/)(−);Msx2(−)(/)(−) mutant embryos have defects in PGC migration as well as a reduced number of PGCs. …”
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2“…BACKGROUND: Msx1 and Msx2, which belong to the highly conserved Nk family of homeobox genes, display overlapping expression patterns and redundant functions in multiple tissues and organs during vertebrate development. …”
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4“…MSX2 homeoprotein controls several stages of the ameloblast life cycle. …”
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6por Vieux-Rochas, Maxence, Bouhali, Kamal, Mantero, Stefano, Garaffo, Giulia, Provero, Paolo, Astigiano, Simonetta, Barbieri, Ottavia, Caratozzolo, Mariano F., Tullo, Apollonia, Guerrini, Luisa, Lallemand, Yvan, Robert, Benoît, Levi, Giovanni, Merlo, Giorgio R.“…The Dlx and Msx homeodomain transcription factors play important roles in the control of limb development. …”
Publicado 2013
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7por Liang, Hao, Zhang, Qian, Lu, Junjie, Yang, Genling, Tian, Na, Wang, Xiaojie, Tan, Yi, Tan, Dongmei“…Notably, however, treatment with the MSX2 overexpression plasmid and the MSX2 siRNAs had no effect on the mRNA expression levels of β-catenin. …”
Publicado 2016
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8“…Colorectal cancer patients with diabetes had the high risks of total mortality. High expression of MSX2 is related to development of diabetes. There are few reports about the clinical implications and function of MSX2 in colorectal cancer (CRC). …”
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9“…Research has identified an association between mutations in MSX1, PAX9, EDA, AXIN2, WNT10A, WNT10B and LRP6 and human tooth agenesis. …”
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10por Son, Myung Jin, Rho, Seung Bae, Kim, Kwangbae, Oh, Mijung, Son, Chaeyeon, Song, Sang Yong, Park, Kyoungsook“…Previously, we demonstrated that the homeoprotein Msx1 interaction with p53 inhibited tumor growth by inducing apoptosis. …”
Publicado 2020
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11por Cheng, Su-Li, Behrmann, Abraham, Shao, Jian-Su, Ramachandran, Bindu, Krchma, Karen, Bello Arredondo, Yoanna, Kovacs, Attila, Mead, Megan, Maxson, Robert, Towler, Dwight A.“…Aortic Msx2 and Msx1 were decreased by 95% and 34% in SM22-Cre;Msx1(fl/fl);Msx2(fl/fl);LDLR(−/−) animals versus Msx1(fl/fl);Msx2(fl/fl);LDLR(−/−) controls, respectively. …”
Publicado 2014
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12“…A homozygous mutation was identified in 3’-UTR of MSX1 gene in the proband. The parents of the patient had no dental and nail anomalies.…”
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13por Zheng, Jinglei, Yu, Miao, Liu, Haochen, Cai, Tao, Feng, Hailan, Liu, Yang, Han, Dong“…The goal of this study was to identify MSX1 gene variants in multiple Chinese families with nonsyndromic oligodontia and analyse the functional influence of these variants. …”
Publicado 2021
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14por Eppich, Simon, Kuhn, Christina, Schmoeckel, Elisa, Mayr, Doris, Mahner, Sven, Jeschke, Udo, Gallwas, Julia, Heidegger, Helene Hildegard“…The aim of this study was to examine the MSX1 expression in healthy endometrial tissue throughout the different phases to gain more insight on the mechanics of MSX-regulation in the female reproductive system. …”
Publicado 2023
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15por Coudert, Amélie E., Pibouin, Laurence, Vi-Fane, Brigitte, Thomas, Bethan L., Macdougall, Mary, Choudhury, Anuradha, Robert, Benoît, Sharpe, Paul T., Berdal, Ariane, Lezot, Frédéric“…The spatial and temporal expression patterns of S, AS transcripts and protein are consistent with a role of AS RNA in the regulation of Msx1 expression in timely controlled developmental sites. …”
Publicado 2005
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16por Gremel, G, Ryan, D, Rafferty, M, Lanigan, F, Hegarty, S, Lavelle, M, Murphy, I, Unwin, L, Joyce, C, Faller, W, McDermott, E W, Sheahan, K, Ponten, F, Gallagher, W M“…BACKGROUND: The homeobox containing transcription factor MSX2 is a key regulator of embryonic development and has been implicated to have a role in breast and pancreatic cancer. …”
Publicado 2011
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17“…Msx1 and Msx2 encode homeodomain transcription factors that play a role in several embryonic developmental processes. …”
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18por Vandersmissen, Ine, Craps, Sander, Depypere, Maarten, Coppiello, Giulia, van Gastel, Nick, Maes, Frederik, Carmeliet, Geert, Schrooten, Jan, Jones, Elizabeth A.V., Umans, Lieve, Devlieger, Roland, Koole, Michel, Gheysens, Olivier, Zwijsen, An, Aranguren, Xabier L., Luttun, Aernout“…MSX1 was specifically up-regulated in remodeling collateral arteries. …”
Publicado 2015
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19“…The fibers showing morphological plasticity selectively expressed Msx1 mRNA and protein. The uptake of morpholino antisense oligonucleotides directed to Msx1 led to a specific decrease in expression of Msx1 protein in myonuclei and marked inhibition of cellularisation and fragmentation. …”
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20por Hornbachner, Ruth, Lackner, Andreas, Papuchova, Henrieta, Haider, Sandra, Knöfler, Martin, Mechtler, Karl, Latos, Paulina A.“…Depletion of MSX2 resulted in activation of the syncytiotrophoblast transcriptional program, while forced expression of MSX2 blocked it. …”
Publicado 2021
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