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  1. 441
    por Naik, Piyu Parth
    Publicado 2021
    “…It typically begins as a tan-brown macule or patch, but it can progress to a variegated pigmentation with dark black color or even amelanotic characteristics. …”
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    Diagnosis and Management of Lentigo Maligna: Clinical Presentation and Comprehensive Review
  2. 442
    “…NF1 patients show high phenotypic variabilities, including cafe-au-lait macules, freckling, or other neoplastic or non-neoplastic features. …”
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    Impacts of NF1 Gene Mutations and Genetic Modifiers in Neurofibromatosis Type 1
  3. 443
    “…Prurigo pigmentosa is a rare inflammatory skin disease characterized by an unexpected onset of diffuse erythematous papules and macules usually on the chest, neck, and back. These generally resolve, leaving reticular hyperpigmentation. …”
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    A Case of Exfoliative Vesiculobullous Prurigo Pigmentosa Cured by Doxycycline and Topical Tacrolimus
  4. 444
    “…A variety of black-pigmented lesions of the oral cavity can be found, ranging from harmless benign lesions such as melanotic macule, smoker’s melanosis, amalgam/graphite tattoos, and pigmented nevus to a life-threatening oral malignant melanoma. …”
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    A Large Oral Melanoma: A Case Report of a Rare but Aggressive Malignancy
  5. 445
    “…The patient had multiple renal cysts, angiomyolipoma, hypomelanotic macules, shagreen patch, subependymal giant cell astrocytoma, multiple cortical tubers, and subependymal nodules. …”
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    TSC2/PKD1 contiguous deletion syndrome in a pregnant woman: A case report
  6. 446
    “…Benign lymphangioendothelioma (BL) is a rare, poorly identified, slow-growing benign vascular lesion characterized by asymptomatic, solitary, well-demarcated macules, or by mildly infiltrated plaque. We report a case of an atypical BL that arose as a tender, protuberant, flesh-colored mass with cyanotic vesicles, and then progressed to a persistent exudative wound after two incomplete excisions. …”
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    Surgical Treatment for Benign Lymphangioendothelioma After Two Incomplete Excisions: A Case Report and Literature Review
  7. 447
    “…The plant Carpobrotus edulis has traditionally been known for its wide applications in diseases, especially vitiligo, which is characterized by patches and white macules caused by the loss of melanocytes. One of the chemical treatments for vitiligo consists mainly of skin repigmentation and usually leads to a non-durable effect by inhibiting the Janus kinase (JAK) signal transduction (STAT pathway). …”
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    A Bioinformatic Study on the Potential Anti-Vitiligo Activity of a Carpobrotus edulis Compound
  8. 448
    “…Legius syndrome presents as an autosomal dominant condition characterized by café-au-lait macules with or without freckling and sometimes a Noonan-like appearance and/or learning difficulties. …”
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    Legius Syndrome in Fourteen Families
  9. 449
    “…A dermatological examination of the patient showed 142 hyperpigmented macules, the largest of which was 1 cm × 1 cm and the smallest was 0.2 cm × 0.2 cm in size, diffusely scattered to the skin and oral mucosa. …”
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    A CASE WITH POSTCHEMOTHERAPY ERUPTIVE COMPOUND NEVUS
  10. 450
    “…Of note, rare spotty amelanotic macules presenting as skin ivory spots (SIS) was reported on any part of the body. …”
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    The Skin Ivory Spot. A Possible Indicator for Skinfield Photo-Carcinogenesis in Recreational Sunbed Addicts
  11. 451
    “…Clinical features are café-au-lait macules, intertriginous freckling, dermal neurofibroma, iris hamartoma (Lisch nodules), and learning disability. …”
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    Neurofibromatosis Type 1 Complicated by Atypical Coarctation of the Thoracic Aorta
  12. 452
    por Gündüz, Özge, Aytekin, Aslı
    Publicado 2012
    “…After six weeks of treatment with tretinoin 0.025% and 4% erythromycin jel topically, the appearance of black macules was significantly reduced. Treatment had to be terminated due to her pregnancy, and the lesions recurred within 1 month. …”
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    Trichostasis Spinulosa Confirmed by Standard Skin Surface Biopsy
  13. 453
    “…CASE PRESENTATION: We report a Chinese TSC family with two siblings presenting with multiple hypomelanotic macules, cardiac rhabdomyomas and cortical tubers associated with a small subependymal nodule. …”
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    A novel TSC2 missense variant associated with a variable phenotype of tuberous sclerosis complex: case report of a Chinese family
  14. 454
    “…Prurigo pigmentosa is a unique cutaneous inflammatory disorder characterized by a sudden onset of pruritic and erythematous macules, urticarial papules, and plaques that may coalesce to form a reticulated pattern. …”
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    Prurigo Pigmentosa: A Clinicopathological Report of Three Middle Eastern Patients
  15. 455
    “…These lesions typically appear abruptly as a solitary macule, papule, or plaque that continuously evolves as it undergoes regression. …”
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    Lichen planus-like keratosis: clinical applicability of in vivo reflectance confocal microscopy for an indeterminate cutaneous lesion
  16. 456
    “…BACKGROUND: Neurofibromatosis is an autosomal dominant disorder of the nerves, resulting in café-au-lait spots, axillary freckling, macules, and neurofibromas throughout the nervous system. …”
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    Utility of MRI neurography in neurofibromatosis type I: Case example and review of MRI neurography literature
  17. 457
    “…On physical examination, he demonstrated numerous 1-2 mm red/brown, non-blanching, petechial macules scattered on the bilateral anterior lower legs, thighs, trunk, arms, hands, and feet with facial sparing. …”
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    Diet-induced Pigmented Purpuric Dermatosis Confirmed with a Rechallenge Response
  18. 458
    “…Physical examination showed confluent non-palpable purpuric macules covering the dorsum of both feet and medial malleolus, giving rise to dusky erythema in some areas. …”
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    A Case of Intertriginous and Flexural Exanthema caused by Amoxicillin
  19. 459
    por Cohen, Philip R
    Publicado 2019
    “…The endogenous conditions include not only benign (angioleiomyoma, hemangioma, melanocytic macule, and varicosities) and malignant (ovarian carcinoma) tumors but also reactive lesions (intravascular papillary endothelial hyperplasia and mucocele) and systemic disorders (argyria, cyanosis, methemoglobinemia, primary adrenal insufficiency, and thrombocytosis). …”
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    Acquired Asymptomatic Blue Tongue: A Report of Exogenous Agent-associated Tongue Dyschromia and Review of Blue Tongue Etiologies
  20. 460
    “…CASE PRESENTATION: We report a case of a 28-year-old Chinese woman with freckle-like hyperpigmented macules in a sun-exposed area who is prone to develop basal cell carcinomas. …”
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    Identification of a novel DDB2 mutation in a Chinese Han family with Xeroderma pigmentosum group E:a case report and literature review
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