“…Initially, small, black or brown macules appear on sun-exposed areas. They later merge to form large hyperpigmented patches. …”
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“…We also observed significant loss of stereocilia on hair cells in the cristae and macule up to 1 month after blast-wave exposure; damage that is likely permanent. …”
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“…Results: Typically, a solitary cutaneous mastocytoma presents as an indurated, erythematous, yellow-brown or reddish-brown macule, papule, plaque or nodule, usually measuring up to 5 cm in diameter. …”
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“…BACKGROUND: Neurofibromatosis type 1 (NF1) is an autosomal dominant disorder with equal sex incidence that is characterized by neurofibromas, café‐au‐lait macules, axillary freckling, optic pathway tumor, distinctive osseous lesion, and iris Lisch nodules. …”
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“…BACKGROUND AND OBJECTIVES: Café‐au‐lait spots, also known as café‐au‐lait macules (CALMs), are a common pigmentary disorder. …”
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“…This case was characterized by café-au-lait macules, discrete cutaneous neurofibromas, nodular neurofibromas, multiple jejunal tumours, and ascending colon cancer. …”
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“…Neurofibromatosis type 1 (NF1) is a progressive neurocutaneous disorder in humans, mainly characterized by café-au-lait macules (CALMs) and neurofibromas. NF1 is caused by variants of the neurofibromin 1 gene (NF1), which encodes a Ras-GTPase-activating protein called neurofibromin. …”
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“…INTRODUCTION: Pigmented purpuric dermatosis (PPD) describes a cutaneous eruption that presents with asymptomatic or pruritic macules, and petechiae with red and brown pigmentation. …”
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“…Skin inspection revealed hypochromic macules. Respiratory and cardiovascular examinations were normal, as well as laboratorial tests and chest radiography. …”
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“…The most common presence of confetti macules indicates these as characteristic, although not pathognomonic, of chemical leucoderma. …”
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“…The results of 17 studies showed variability in oral lesions associated with COVID-19, including ulcerations, aphthous-like lesions, and macules. The tongue, lips, and palate were the most frequent anatomical locations. …”
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“…Among them, pigmentary mosaicism of hyperpigmented type (OR = 2.76, P = 0.02) and café-au-lait macules (CALMs) (OR = 2.40, P = 0.001) were the most prevalent with hyperpigmented pigmentary mosaicism showing a higher association with autism. …”
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“…Three different pathogenic variants of the NF1 gene were found in three probands who mainly complained of café-au-lait macules (CALMs), including one frameshift variant c.5072_5073insTATAACTGTAACTCCTGGGTCAGGGAGTACACCAA:p.Tyr1692Ilefs in exon 37, one missense variant c.3826C > T:p.Arg1276Ter in exon 28, and one splicing variant c.4110 + 1G > T at the first base downstream of the 3′-end of exon 30. …”
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“…She subsequently developed worsening erythema and bullae on her palms and soles, as well as reddish macules on her back and chest wall. Histopathological evaluation of the chest wall lesions revealed extensive eosinophilic epidermal necrosis and separation of the epidermis from the dermis. …”
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“…BACKGROUND: Dyschromatosis universalis hereditaria (DUH) is a rare genodermatosis characterized by hyper‐ and hypo‐pigmented macules on the face, trunk, and extremities. The condition causes severe cosmetic problem which can lead to significant psychological distress to the patients and bear a negative impact on society. …”
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“…Physical examination revealed a 20/10 cm mass at the base of the left labia majora, soft in consistency, painless, mobile in relation to the deep plane, and dotted with a hypochromic cicatricial macule (A and B). Endoanal examination found non reducible hemorrhoidal packets (B). …”
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“…CONTEXT: Vitiligo is an acquired pigmentary disorder of the skin that is characterized by circumscribed, depigmented macules, and patches. AIMS: To compare the therapeutic efficacy and safety of microneedling combined with topical 5-fluorouracil solution versus microneedling alone on stable patches of vitiligo. …”
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“…The most frequently occurring lesions were café-au-lait macules, followed by neurofibromas and intertriginous freckling. …”
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“…Oral clinical examination revealed a well-circumscribed brownish macule on the hard palatal mucosa, adjacent to the left first primary upper molar. …”
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“…She had hypomelanotic macules, facial angiofibroma, and a shagreen patch. …”
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