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  1. 4221
    por So, Kum-Kang, Kim, Dae-Hyuk
    Publicado 2017
    “…In silico analysis of the promoter region of the cryparin gene revealed the presence of binding motifs related to downstream transcription factors of CWI, HOG1, and pheromone responsive pathways including MADS-box- and Ste12-binding domains. Real-time reverse transcriptase PCR analyses indicated that both CpRlm1, an ortholog of yeast RLM1 in the CWI pathway, and cpst12, an ortholog of yeast STE12 in the mating pathway, showed significantly reduced transcription levels in the mutant strains showing lower cryparin production in C. prasitica. …”
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    Role of MAPK Signaling Pathways in Regulating the Hydrophobin Cryparin in the Chestnut Blight Fungus Cryphonectria parasitica
  2. 4222
    “…In Arabidopsis thaliana, ovule identity is redundantly conferred by the homeotic D-class genes SHATTERPROOF1 (SHP1), SHP2 and SEEDSTICK (STK), phylogenetically related to the MADS-domain regulatory gene AGAMOUS (AG), essential in floral organ specification. …”
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    Ovule identity mediated by pre-mRNA processing in Arabidopsis
  3. 4223
    “…Dominant FRI inhibits flowering by activating the expression of the MADS box transcriptional repressor FLOWERING LOCUS C (FLC), which represses flowering prior to vernalization. …”
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    Sequence variation and functional analysis of a FRIGIDA orthologue (BnaA3.FRI) in Brassica napus
  4. 4224
    por Honjo, Ken, Tracey, W. Daniel
    Publicado 2018
    “…Blocking the transcriptional output of the BMP pathway with dominant negative Mad suppressed nociceptive hypersensitivity that was induced by interfering with hiw. …”
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    BMP signaling downstream of the Highwire E3 ligase sensitizes nociceptors
  5. 4225
    “…This function of 53BP1 requires interactions with PTIP3 and RIF14–9, the latter also recruiting REV7/MAD2L2 to break sites10,11. How 53BP1-pathway proteins shield DNA ends is unknown but two models best explain their action: in one model, the 53BP1 complex strengthens the nucleosomal barrier to end-resection nucleases12,13, whereas in a second model, 53BP1 recruits effector proteins with end-protection activity. …”
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    The Shieldin complex mediates 53BP1-dependent DNA repair
  6. 4226
    “…Surprisingly, knockdown of key SAC proteins, Mad2 and Mps1, suppressed developmental defects associated with San depletion. …”
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    Absence of the Spindle Assembly Checkpoint Restores Mitotic Fidelity upon Loss of Sister Chromatid Cohesion
  7. 4227
    “…KEGG analyses indicated down regulated genes in the Poly-PN group included oocyte meiosis related genes, such as PPP2R1B, YWHAZ, MAD2L1, SPDYC, SKP1 and CDC27, together with genes associated with RNA processing, such as SF3B1, LOC645691, MAGOHB, PHF5A, PRPF18, DDX5, THOC1 and BAT1. …”
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    Transcriptome profiling of human oocytes experiencing recurrent total fertilization failure
  8. 4228
    “…We also highlight new emerging therapies targeting the adhesion and migration of leukocytes into the inflamed intestinal mucosa by blocking selectively different subunits of α(4)β(7) integrins or binding alternative adhesion molecules like MAdCAM-1. Drugs reducing the circulating lymphocytes by sequestering them in secondary lymphoid organs (sphingosine-1-phosphate (S1P) receptor modulators) are also discussed. …”
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    Immunotherapy in inflammatory bowel disease: Novel and emerging treatments
  9. 4229
    “…We found Grevillea homologs of all lineages of MADS-box genes involved in floral organ identity. …”
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    Unraveling the Developmental and Genetic Mechanisms Underpinning Floral Architecture in Proteaceae
  10. 4230
    “…This resulted in impaired dynamic adhesion to MAdCAM-1. Internalized β7 integrin localized in endosomes and re-expression of β7 was dependent on de novo protein synthesis. …”
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    Cellular Mechanisms of Etrolizumab Treatment in Inflammatory Bowel Disease
  11. 4231
    “…Coronal measurements comprised the mechanical lateral distal femoral angle (mLDFA), mechanical medial proximal tibial angle (mMPTA) and mechanical axis deviation (MAD), measured from standing teleoroentgenograms of the lower extremities. …”
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    The reliability of full-length lower limb radiographic alignment measurements in skeletally immature youth
  12. 4232
    “…The trigger of autocatalytic ethylene production regulated by a dual positive feedback loop circuit derived from a NAC gene and three MADS genes results in metabolic processes that induce changes in the primary metabolism of bananas. …”
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    The Starch Is (Not) Just Another Brick in the Wall: The Primary Metabolism of Sugars During Banana Ripening
  13. 4233
    “…Three cases known to provide transgender primary care and represent different primary care models in Ontario, Canada (i.e., family health team, community health centre, fee-for service physician) were explored. The NoMAD survey, a tool to measure implementation processes, and qualitative interviews with primary care practitioners and allied healthcare staff were administered. …”
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    “Primary care is primary care”: Use of Normalization Process Theory to explore the implementation of primary care services for transgender individuals in Ontario
  14. 4234
    “…Frequencies of msp-1 allelic types were statistically comparable between the studied groups (p>0.05), and were respectively 93.54% vs 87.5% for K1, 60% vs 54.83% for MAD20 and 41.93% vs 22.5% for RO33 while frequencies of msp-2 allelic types were significantly highest in the microscopy group for FC27 (41.93% vs 10%, Fisher’s Exact Test, p = 0.001) and 3D7 (61.29% vs 32.5%, Fisher’s Exact Test, p = 0.02). …”
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    Low genetic diversity and complexity of submicroscopic Plasmodium falciparum infections among febrile patients in low transmission areas in Senegal
  15. 4235
    “…The K1 family has shown the trend of predominance (41%), followed by Mad20 (35%). Comparatively to msp-2, 49.6% and 48.8% fragments belonged to 3D7 and FC27 respectively. …”
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    Genetic diversity of Plasmodium falciparum infection among children with uncomplicated malaria living in Pointe-Noire, Republic of Congo
  16. 4236
    “…Virus‐induced gene silencing (VIGS) of OAGL6‐2 in L complex resulted in smaller lips and the down‐regulation of Oncidium OnAAF. VIGS of PeMADS9 in L complex resulted in the enlarged lips and up‐regulation of Phalaenopsis PaAAF. …”
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    A tetraspanin gene regulating auxin response and affecting orchid perianth size and various plant developmental processes
  17. 4237
    “…Here, we also found that transcription factor MADS, NFY, HSF, MYB/C and WRKY might play a crucial role in male fertility under the high temperature condition. …”
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    Transcriptomic analysis reveals the mechanism of thermosensitive genic male sterility (TGMS) of Brassica napus under the high temperature inducement
  18. 4238
    “…In the single-ascending-dose (SAD) phase, mean tebipenem plasma concentrations increased in a linear and dose proportional manner for doses of 100 to 900 mg and were comparable in the fasted and fed states for the 300- and 600-mg doses. In the MAD phase, tebipenem maximum concentration (C(max)) was reached within 1.5 h and was dose proportional on day 1 and higher than dose proportional (2.7-fold) on day 14. …”
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    Safety, Pharmacokinetics, and Food Effect of Tebipenem Pivoxil Hydrobromide after Single and Multiple Ascending Oral Doses in Healthy Adult Subjects
  19. 4239
    “…Furthermore, overexpression of BoTGG1 delayed flowering by promoting the expression of FLOWERING LOCUS C (FLC), which encodes a MADS-box transcription factor known as floral repressor. …”
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    Overexpressing the Myrosinase Gene TGG1 Enhances Stomatal Defense Against Pseudomonas syringae and Delays Flowering in Arabidopsis
  20. 4240
    “…Additionally, Sma- and Mad-related protein (SMAD)3 and SMAD4 are the downstream signaling transducers that mediate the biological response induced by TGF-β1. …”
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    TGF-β1 Increases GDNF Production by Upregulating the Expression of GDNF and Furin in Human Granulosa-Lutein Cells
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