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    Temperament and major depressive disorder
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    by Villanueva, Rosa
    Published 2013
    “…We survey studies which relate abnormal neurogenesis to major depressive disorder. Clinically, descriptive gene and protein expression analysis and genetic and functional studies revised here show that individual alterations of a complex signaling network, which includes the hypothalamic-pituitary-adrenal axis; the production of neurotrophins and growth factors; the expression of miRNAs; the production of proinflammatory cytokines; and, even, the abnormal delivery of gastrointestinal signaling peptides, are able to induce major mood alterations. …”
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    Neurobiology of Major Depressive Disorder
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    “…Omic sciences coupled with novel computational approaches such as machine intelligence offer completely new approaches to major depressive disorder (MDD) research. The complexity of MDD's pathophysiology is being integrated into studies examining MDD's biology within the omic fields. …”
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    Lipidomics in Major Depressive Disorder
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    “…It has been discovered that neuronal dysfunction is a key factor in the development of major depressive disorder (MDD). PubMed and Google Scholar databases were searched with keywords such as ‘SUMO’, ‘neuronal plasticity’, and ‘depression’ to obtain relevant scientific literature. …”
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    SUMOylation and Major Depressive Disorder
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    by Han, Laura K. M., Dinga, Richard, Hahn, Tim, Ching, Christopher R. K., Eyler, Lisa T., Aftanas, Lyubomir, Aghajani, Moji, Aleman, André, Baune, Bernhard T., Berger, Klaus, Brak, Ivan, Filho, Geraldo Busatto, Carballedo, Angela, Connolly, Colm G., Couvy-Duchesne, Baptiste, Cullen, Kathryn R., Dannlowski, Udo, Davey, Christopher G., Dima, Danai, Duran, Fabio L. S., Enneking, Verena, Filimonova, Elena, Frenzel, Stefan, Frodl, Thomas, Fu, Cynthia H. Y., Godlewska, Beata R., Gotlib, Ian H., Grabe, Hans J., Groenewold, Nynke A., Grotegerd, Dominik, Gruber, Oliver, Hall, Geoffrey B., Harrison, Ben J., Hatton, Sean N., Hermesdorf, Marco, Hickie, Ian B., Ho, Tiffany C., Hosten, Norbert, Jansen, Andreas, Kähler, Claas, Kircher, Tilo, Klimes-Dougan, Bonnie, Krämer, Bernd, Krug, Axel, Lagopoulos, Jim, Leenings, Ramona, MacMaster, Frank P., MacQueen, Glenda, McIntosh, Andrew, McLellan, Quinn, McMahon, Katie L., Medland, Sarah E., Mueller, Bryon A., Mwangi, Benson, Osipov, Evgeny, Portella, Maria J., Pozzi, Elena, Reneman, Liesbeth, Repple, Jonathan, Rosa, Pedro G. P., Sacchet, Matthew D., Sämann, Philipp G., Schnell, Knut, Schrantee, Anouk, Simulionyte, Egle, Soares, Jair C., Sommer, Jens, Stein, Dan J., Steinsträter, Olaf, Strike, Lachlan T., Thomopoulos, Sophia I., van Tol, Marie-José, Veer, Ilya M., Vermeiren, Robert R. J. M., Walter, Henrik, van der Wee, Nic J. A., van der Werff, Steven J. A., Whalley, Heather, Winter, Nils R., Wittfeld, Katharina, Wright, Margaret J., Wu, Mon-Ju, Völzke, Henry, Yang, Tony T., Zannias, Vasileios, de Zubicaray, Greig I., Zunta-Soares, Giovana B., Abé, Christoph, Alda, Martin, Andreassen, Ole A., Bøen, Erlend, Bonnin, Caterina M., Canales-Rodriguez, Erick J., Cannon, Dara, Caseras, Xavier, Chaim-Avancini, Tiffany M., Elvsåshagen, Torbjørn, Favre, Pauline, Foley, Sonya F., Fullerton, Janice M., Goikolea, Jose M., Haarman, Bartholomeus C. M., Hajek, Tomas, Henry, Chantal, Houenou, Josselin, Howells, Fleur M., Ingvar, Martin, Kuplicki, Rayus, Lafer, Beny, Landén, Mikael, Machado-Vieira, Rodrigo, Malt, Ulrik F., McDonald, Colm, Mitchell, Philip B., Nabulsi, Leila, Otaduy, Maria Concepcion Garcia, Overs, Bronwyn J., Polosan, Mircea, Pomarol-Clotet, Edith, Radua, Joaquim, Rive, Maria M., Roberts, Gloria, Ruhe, Henricus G., Salvador, Raymond, Sarró, Salvador, Satterthwaite, Theodore D., Savitz, Jonathan, Schene, Aart H., Schofield, Peter R., Serpa, Mauricio H., Sim, Kang, Soeiro-de-Souza, Marcio Gerhardt, Sutherland, Ashley N., Temmingh, Henk S., Timmons, Garrett M., Uhlmann, Anne, Vieta, Eduard, Wolf, Daniel H., Zanetti, Marcus V., Jahanshad, Neda, Thompson, Paul M., Veltman, Dick J., Penninx, Brenda W. J. H., Marquand, Andre F., Cole, James H., Schmaal, Lianne
    Published 2020
    “…Major depressive disorder (MDD) is associated with an increased risk of brain atrophy, aging-related diseases, and mortality. …”
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    Brain aging in major depressive disorder: results from the ENIGMA major depressive disorder working group
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    “…BACKGROUND: The impact of treatment‐resistant depression (TRD) or prior suicidal ideation/suicide attempt (SI/SA) on mortality by suicide among patients with major depressive disorder (MDD) is not well known. This retrospective, observational, descriptive cohort study characterized real‐world rates of suicide‐specific mortality among patients with MDD with or without TRD or SI/SA. …”
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    Suicide‐specific mortality among patients with treatment‐resistant major depressive disorder, major depressive disorder with prior suicidal ideation or suicide attempts, or major depressive disorder alone
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    “…OBJECTIVES: Evaluating the quality of remission in a group of patients followed for major depressive disorder at the Arrazi Hospital in Salé. METHODS: Cross-sectional study in adult patients followed up in consultation for major depressive disorder according to DSM-V criteria and having been under treatment for at least 2 months. …”
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    quality of remission in the major depressive disorder
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    by Flint, Jonathan
    Published 2023
    “…The genetic dissection of major depressive disorder (MDD) ranks as one of the success stories of psychiatric genetics, with genome-wide association studies (GWAS) identifying 178 genetic risk loci and proposing more than 200 candidate genes. …”
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    The genetic basis of major depressive disorder
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    by Goldstein, David J
    Published 2007
    “…Approximately 10% of the 1139 patients with major depressive disorder in placebo-controlled trials discontinued treatment due to an adverse event, compared to 4% of the 777 patients receiving placebo. …”
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    Duloxetine in the treatment of major depressive disorder
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    “…Major depressive disorder (MDD) is among the most incapacitating conditions in the world. …”
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    Desvenlafaxine in the treatment of major depressive disorder
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    “…Specifically, this study tested whether the presentation of facial expressions of emotion affects subsequent processing of affective material in participants with major depressive disorder (MDD) and healthy controls (CTL). …”
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    Affective priming in major depressive disorder
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    “…BACKGROUND: Major depressive disorder (MDD) is associated with abnormalities in financial reward processing. …”
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    Temporal discounting in major depressive disorder
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    by Rucker, James JH, McGuffin, Peter
    Published 2014
    “…An intriguing recent study examines the role of miR-1202, a glutamate receptor regulating microRNA, in regulating major depressive disorder.…”
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    Chipping away at major depressive disorder
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    “…BACKGROUND: This study aims to evaluate the efficacy of Xiaoyaosan (XYS) for treatment of major depressive disorder (MDD) and to review the studies on antidepressant mechanisms of XYS. …”
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    Effect of Xiaoyaosan on major depressive disorder
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    “…Major depressive disorder (MDD) is a chronic disease whose neurological basis and pathophysiology remain poorly understood. …”
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    Epigenetic Modifications of Major Depressive Disorder
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    by Mullen, Sandra
    Published 2018
    “…Major depressive disorder (MDD) is one of the most common psychiatric disorders of childhood and adolescence, but because of symptom variation from the adult criteria, it is often unrecognized and untreated. …”
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    Major depressive disorder in children and adolescents
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    “…A total of 201 patients with major depressive disorder from four hospitals in Malaysia were followed up for 5 years to determine the prognostic factors of recurrent major depressive disorder that could potentially contribute to improving the management of MDD patients. …”
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    Predictors of recurrence of major depressive disorder
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    “…OBJECTIVE: To identify factors associated with major depressive disorder (MDD) in detention officers. METHODS: This cross-sectional study included all detention officers from the largest prison complex in the state of Bahia, Brazil. …”
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    Major depressive disorder in detention officers
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    “…Variation in DNA methylation (DNAm) is associated with lifestyle factors such as smoking and body mass index (BMI) but there has been little research exploring its ability to identify individuals with major depressive disorder (MDD). Using penalised regression on genome-wide CpG methylation, we tested whether DNAm risk scores (MRS), trained on 1223 MDD cases and 1824 controls, could discriminate between cases (n = 363) and controls (n = 1417) in an independent sample, comparing their predictive accuracy to polygenic risk scores (PRS). …”
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    Epigenetic prediction of major depressive disorder
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    “…This study aimed to assess the effect of insomnia on the prognosis of patients with major depressive disorder (MDD). METHODS: We divided the patients into three groups according to the Insomnia Severity Index (ISI) scores. …”
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    Effect of insomnia in the major depressive disorder
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