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25201por Roy, Soumya“…Theories such as warm climate, weaker strain of the virus, and cross-protection by malaria have been popularly put forward. One such interesting theory is that since the general people of the low- income countries are mostly habituated to dwell in lesser hygienic condition and with lesser medical attention throughout their lifetime; hence, they have naturally acquired better immunity and more resilience against many infective diseases. …”
Publicado 2020
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25202por Mathieu, Luana C, Cox, Horace, Early, Angela M, Mok, Sachel, Lazrek, Yassamine, Paquet, Jeanne-Celeste, Ade, Maria-Paz, Lucchi, Naomi W, Grant, Quacy, Udhayakumar, Venkatachalam, Alexandre, Jean SF, Demar, Magalie, Ringwald, Pascal, Neafsey, Daniel E, Fidock, David A, Musset, Lise“…These data place local malaria control efforts at risk in the Guiana Shield.…”
Publicado 2020
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25203por Rolfes, Verena, Ribeiro, Lucas Secchim, Hawwari, Ibrahim, Böttcher, Lisa, Rosero, Nathalia, Maasewerd, Salie, Santos, Marina Lima Silva, Próchnicki, Tomasz, Silva, Camila Meirelles de Souza, Wanderley, Carlos Wagner de Souza, Rothe, Maximilian, Schmidt, Susanne V., Stunden, H. James, Bertheloot, Damien, Rivas, Magali Noval, Fontes, Cor Jesus, Carvalho, Luzia Helena, Cunha, Fernando Queiroz, Latz, Eicke, Arditi, Moshe, Franklin, Bernardo Simoes“…Platelets influence IL-1β production in vivo, and blood platelet counts correlate with plasmatic IL-1β levels in malaria. Furthermore, we reveal an enriched platelet gene signature among the highest-expressed transcripts in IL-1β-driven autoinflammatory diseases. …”
Publicado 2020
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25204“…Most studies focused on malaria and fever (n = 47) followed by health services coverage (n = 38). …”
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25205por Voloshin, Vitaly, Kröner, Christian, Seniya, Chandrabhan, Murray, Gregory P. D., Guy, Amy, Towers, Catherine E., McCall, Philip J., Towers, David P.“…Recent innovations in optical imaging systems and associated signal processing have enabled detailed characterization of nocturnal mosquito behaviour around bednets and improvements in bednet design, a global essential for protecting populations against malaria. Nonetheless, there remain challenges around ease of use for large-scale in situ recordings and extracting data reliably in the critical areas of the bednet where the optical signal is attenuated. …”
Publicado 2020
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25206por Huang, Hurng-Wern, Bow, Yung-Ding, Wang, Chia-Yih, Chen, Yen-Chun, Fu, Pei-Rong, Chang, Kuo-Feng, Wang, Tso-Wen, Tseng, Chih-Hua, Chen, Yeh-Long, Chiu, Chien-Chih“…Quinoline derivatives show biological activity against HIV, malaria, bacteriuria, and cancer. DFIQ is a novel synthetic quinoline derivative that induces cell death in both in vitro and in vivo zebrafish xenograft models. …”
Publicado 2020
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25207Synthesis and biological evaluation of novel quinoline-piperidine scaffolds as antiplasmodium agentspor Van de Walle, Tim, Boone, Maya, Van Puyvelde, Julie, Combrinck, Jill, Smith, Peter J., Chibale, Kelly, Mangelinckx, Sven, D’hooghe, Matthias“…The parasitic disease malaria places almost half of the world’s population at risk of infection and is responsible for more than 400,000 deaths each year. …”
Publicado 2020
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25208por Rosenke, Kyle, Jarvis, Michael A., Feldmann, Friederike, Schwarz, Benjamin, Okumura, Atsushi, Lovaglio, Jamie, Saturday, Greg, Hanley, Patrick W., Meade-White, Kimberly, Williamson, Brandi N., Hansen, Frederick, Perez-Perez, Lizette, Leventhal, Shanna, Tang-Huau, Tsing-Lee, Nason, Martha, Callison, Julie, Haddock, Elaine, Scott, Dana, Sewell, Graham, Bosio, Catharine M., Hawman, David, de Wit, Emmie, Feldmann, Heinz“…When used for prophylaxis or treatment neither the standard human malaria dose (6.5 mg/kg) nor a high dose (50 mg/kg) of HCQ had any beneficial effect on clinical disease or SARS-CoV-2 kinetics (replication/shedding) in the Syrian hamster disease model. …”
Publicado 2020
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25209por Araujo, Maisa da Silva, dos Santos, Najara Akira Costa, Andrade, Alice Oliveira, Castro, Raphael Brum, Bastos, Alessandra da Silva, Resadore, Fábio, Pereira-da-Silva, Luiz Hidelbrando, Medeiros, Jansen Fernandes“…BACKGROUND: Nyssorhynchus deaneorum is a potential malaria vector because it has been shown to be competent to transmit Plasmodium vivax and Plasmodium falciparum, and because it exhibits antropophilic and endophilic behaviors in some regions of the Amazon. …”
Publicado 2020
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25210por Batiha, Gaber El-Saber, Olatunde, Ahmed, El-Mleeh, Amany, Hetta, Helal F., Al-Rejaie, Salim, Alghamdi, Saad, Zahoor, Muhammad, Magdy Beshbishy, Amany, Murata, Toshihiro, Zaragoza-Bastida, Adrian, Rivero-Perez, Nallely“…Combination chemotherapies of artemisia extract or its isolated active constituents with the currently available antibabesial or anti-malarial drugs are now documented to relieve malaria and piroplasmosis infections. The current review examines the phytoconstituents, toxic and biological activities of A. absinthium.…”
Publicado 2020
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25211por Abubakar, Umar F., Adam, Ruqayya, Mukhtar, Muhammad M., Muhammad, Abdullahi, Yahuza, Adamu A., Ibrahim, Sulaiman S.“…Malaria control relies on first-line treatments that use artemisinin-combination therapies (ACT). …”
Publicado 2020
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25212por Hilarión-Gaitán, Liliana, Díaz-Jiménez, Diana, Cotes-Cantillo, Karol, Castañeda-Orjuela, Carlos“…In this population, 82.31 cases of Plasmodium falciparum malaria per 100,000 affiliates were reported more than those reported in the contributory regime. …”
Publicado 2019
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25213por Ambegaonkar, Abhijit A., Kwak, Kihyuck, Sohn, Haewon, Manzella-Lapeira, Javier, Brzostowski, Joseph, Pierce, Susan K.“…Chronic human infectious diseases, including malaria, are associated with a large expansion of a phenotypically and transcriptionally distinct subpopulation of B cells distinguished by their high expression of a variety of inhibitory receptors including FcγRIIB. …”
Publicado 2020
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25214por Solarin, Olusola, Mohammed, Sulma I., Ndlovu, Ntokozo, Vanderpuye, Verna, Olaiya, Victoria“…Beyond the imperative of evidence-based interventions, Africans carry a disproportionately heavy burden of certain diseases, including prostate cancer, sickle cell anemia, and malaria. It therefore provides opportunity for efficient recruitment of participants for trials for such diseases. …”
Publicado 2020
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25215por Wang, Li-lei, Yu, Li-li, Zhou, Ying, Wu, Mei-li, Teng, Fei-xiang, Wang, Nan, Cui, Yu-bao“…To better understand the structure and role of mite aquaporin, we constructed a tertiary structure for DerfAQP1 by homology modeling from the X-ray structure of malaria aquaporin PfAQP (Protein Data Bank code No. 3C02) and conducted molecular dynamics simulation. …”
Publicado 2020
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25216por Shinzawa, Naoaki, Nishi, Tsubasa, Hiyoshi, Fumiya, Motooka, Daisuke, Yuda, Masao, Iwanaga, Shiroh“…Malaria is caused by infection with Plasmodium parasites and is a major public health concern. …”
Publicado 2020
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25217“…These ten well-characterized drugs, previously used to treat malaria and Ebola infections, were screened based on their interactions with the SARS-CoV-2 ACE2 receptor and 3C-like protease. …”
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25218“…Mixtures of drugs often have greater therapeutic value than any of their constituent drugs alone, and such combination therapies are widely used to treat diseases such as cancer, malaria, and viral infections. However, developing useful drug mixtures is challenging due to complex interactions between drugs. …”
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25219por Ospina, Juan David“…In parasitology, investigations carried out with parasites such as Leishmania spp. allowed the acquisition of aptamers that recognize the polyA-binding protein LiPABP and may have potential applications in research and diagnosis and even as therapeutic agents. Regarding malaria, aptamers have been obtained that allow the identification of infected erythrocytes or inhibit the formation of rosettes, along with those that provide promising alternatives for diagnosis by specifically detecting the protein lactate dehydrogenase (PfLDH). …”
Publicado 2020
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25220por Cox, Shereen“…These drugs are approved for use by patients with systemic lupus erythematosus (SLE), rheumatoid arthritis, and malaria. The demand for these products has increased, and the stocks are depleting for the patient population for whom the drugs are intended initially. …”
Publicado 2020
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