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25241“…INTRODUCTION: Prevention of malaria in pregnancy (MIP) with the use of insecticide treated nets (ITNs) is no doubt one of the major interventions aimed at reducing maternal and infant morbidity and mortality rates. …”
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25242por Nofal, Stephanie D., Patel, Avnish, Blackman, Michael J., Flueck, Christian, Baker, David A.“…Guanylyl cyclases (GCs) synthesize cyclic GMP (cGMP) and, together with cyclic nucleotide phosphodiesterases, are responsible for regulating levels of this intracellular messenger which mediates myriad functions across eukaryotes. In malaria parasites (Plasmodium spp), as well as their apicomplexan and ciliate relatives, GCs are associated with a P4-ATPase-like domain in a unique bifunctional configuration. …”
Publicado 2021
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25243“…Chloroquine (CQ) and its metabolite hydroxychloroquine (HCQ) are mainly used to prevent and treat malaria and rheumatic diseases. They are also used in several countries to treat SARS-CoV-2 infection inducing COVID-19. …”
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25244por Fraser, Merryn, Jing, Weidong, Bröer, Stefan, Kurth, Florian, Sander, Leif-Erik, Matuschewski, Kai, Maier, Alexander G.“…The human malaria parasite Plasmodium falciparum relies on lipids to survive; this makes its lipid metabolism an attractive drug target. …”
Publicado 2021
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25245“…Carboxamides bearing sulphonamide functionality have been shown to exhibit significant lethal effect on Plasmodium falciparum, the causative agent of human malaria. Here we report the synthesis of thirty-two new drug-like sulphonamide pyrolidine carboxamide derivatives and their antiplasmodial and antioxidant capabilities. …”
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25246por Eba, Kasahun, Duchateau, Luc, Olkeba, Beekam Kebede, Boets, Pieter, Bedada, Dechasa, Goethals, Peter L. M., Mereta, Seid Tiku, Yewhalaw, Delenasaw“…A selection of mosquito predators has the potential to control Anopheles mosquito larvae, suggesting that they can be used as complementary approach in an integrated malaria vector control strategy.…”
Publicado 2021
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25247por González-Cardenete, Miguel A., Rivas, Fatima, Basset, Rachel, Stadler, Marco, Hering, Steffen, Padrón, José M., Zaragozá, Ramón J., Dea-Ayuela, María Auxiliadora“…The biological profiling of these compounds was investigated against a panel of six human solid tumor cell lines (HBL-100, A549, HeLa, T-47D, SW1573 and WiDr), four parasitic Leishmania species (L. donovani, L. infantum, L. guyanensis and L. amazonensis) and two malaria strains (3D7 and K1). Furthermore, the capacity of the compounds to modulate gamma-aminobutyric acid type A (GABA(A)) receptors (α(1)β(2)γ(2s)) is also described. …”
Publicado 2021
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25248por Rafael, Míriam Silva, Bridi, Leticia Cegatti, Sharakhov, Igor V., Marinotti, Osvaldo, Sharakhova, Maria V., Timoshevskiy, Vladimir, Guimarães-Marques, Giselle Moura, Santos, Valéria Silva, da Silva, Carlos Gustavo Nunes, Astolfi-Filho, Spartaco, Tadei, Wanderli Pedro“…SIMPLE SUMMARY: Anopheles darlingi mosquitoes are the main vectors of malaria in the Brazilian Amazon. To assign genomic DNA sequences to chromosomes of this species, we performed fluorescence in situ hybridization of DNA probes with salivary glands polytene chromosomes. …”
Publicado 2021
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25249por Kalungi, Allan, Kinyanda, Eugene, Akena, Dickens Howard, Kaleebu, Pontiano, Bisangwa, Innocent M.“…In addition to other potential explanations for the few cases and deaths of COVID-19 such as the population socio-demographics, early lockdown measures and the possibility of under reporting, we hypothesize in this mini review that individuals with a recent history of malaria infection may be protected against infection or severe form of COVID-19. …”
Publicado 2021
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25250por Nuwagira, Edwin, Yekosani, Mitala, Abraham, Birungi, Atwine, Raymond, Caleb, Tuhumwire, Baluku, Joseph Baruch“…He was initially treated for malaria with no improvement. His final diagnosis was rifampicin-resistant tuberculosis following Xpert(®) MTB/RIF Ultra (Xpert-Ultra) assay performed on a fine needle aspirate of the scrotal mass. …”
Publicado 2021
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25251“…It has been proven that consumption of un-safe drinking water is one of the major cause of prevalence of water borne diseases like diarrhea, gastroenteritis, typhoid fever and malaria etc. in study area. Community water supply and sanitation projects should be encouraged; government should provide filter plants in all regions of the country so that people could have easy approach to safe drinking water.…”
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25252por Ayoola, Adeola Oluwakemi, Zhang, Bao-Lin, Meisel, Richard P, Nneji, Lotanna M, Shao, Yong, Morenikeji, Olanrewaju B, Adeola, Adeniyi C, Ng’ang’a, Said I, Ogunjemite, Babafemi G, Okeyoyin, Agboola O, Roos, Christian, Wu, Dong-Dong“…Genomic scans suggest that immunity genes such as AKT3 and IL13 (possibly involved in simian immunodeficiency virus defense), and G6PD, a gene involved in malaria resistance, are under positive natural selection. …”
Publicado 2020
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25253por Bogale, Haikel N., Pascini, Tales V., Kanatani, Sachie, Sá, Juliana M., Wellems, Thomas E., Sinnis, Photini, Vega-Rodríguez, Joel, Serre, David“…Despite the critical role of Plasmodium sporozoites in malaria transmission, we still know little about the mechanisms underlying their development in mosquitoes. …”
Publicado 2021
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25254por Nurkanto, Arif, Jeelani, Ghulam, Santos, Herbert J., Rahmawati, Yulia, Mori, Mihoko, Nakamura, Yumi, Goto, Kana, Saikawa, Yoko, Annoura, Takeshi, Tozawa, Yuzuru, Sakura, Takaya, Inaoka, Daniel Ken, Shiomi, Kazuro, Nozaki, Tomoyoshi“…In Plasmodium falciparum, the most deadly among Plasmodium species that cause malaria, CoA and its biosynthetic pathway have been proven to be indispensable. …”
Publicado 2021
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25255por Maclean, Andrew E., Bridges, Hannah R., Silva, Mariana F., Ding, Shujing, Ovciarikova, Jana, Hirst, Judy, Sheiner, Lilach“…The Apicomplexa, important pathogens of humans causing diseases such as toxoplasmosis and malaria, depend on their mETC in every known stage of their complicated life cycles. …”
Publicado 2021
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25256por Park, Ju-Hyoung, Ahn, Eun-Kyung, Hwang, Min Hee, Park, Young Jin, Cho, Young-Rak, Ko, Hye-Jin, Jeong, Wonsik, Yang, Seung Hwan, Seo, Dong-Wan, Oh, Joa Sub“…Amomum tsao-ko Crevost et Lemaire (Zingiberaceae) is a medicinal herb found in Southeast Asia that is used for the treatment of malaria, abdominal pain, dyspepsia, etc. The aim of this study was to investigate the effect of an ethanol extract of Amomum tsao-ko (EAT) on obesity and hyperlipidemia in C57BL/6 mice fed a high-carbohydrate diet (HCD). …”
Publicado 2021
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25257por Ferreira, Letícia Tiburcio, Borba, Joyce V. B., Moreira-Filho, José Teófilo, Rimoldi, Aline, Andrade, Carolina Horta, Costa, Fabio Trindade Maranhão“…With about 400,000 annual deaths worldwide, malaria remains a public health burden in tropical and subtropical areas, especially in low-income countries. …”
Publicado 2021
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25258por Daron, Josquin, Boissière, Anne, Boundenga, Larson, Ngoubangoye, Barthelemy, Houze, Sandrine, Arnathau, Celine, Sidobre, Christine, Trape, Jean-François, Durand, Patrick, Renaud, François, Fontaine, Michael C., Prugnolle, Franck, Rougeron, Virginie“…Plasmodium vivax is the most common and widespread human malaria parasite. It was recently proposed that P. vivax originates from sub-Saharan Africa based on the circulation of its closest genetic relatives (P. vivax-like) among African great apes. …”
Publicado 2021
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25259“…Male and female gametocytes are sexual precursor cells essential for mosquito transmission of malaria parasite. Differentiation of gametocytes into fertile gametes (known as gametogenesis) relies on the gender‐specific transcription program. …”
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25260por Jumani, Rajiv S., Blais, Johanne, Tillmann, Hanns-Christian, Segal, Florencia, Wetty, Dean, Ostermeier, Christian, Nuber, Natko, Lakshman, Jay, Aziz, Natasha, Chandra, Richa, Chen, Wilbur H., Chappell, Cynthia L., Diagana, Thierry T., Manjunatha, Ujjini H.“…Recently, novel therapeutic agents have been discovered through high-throughput phenotypic and target-based screening strategies, repurposing malaria hits, etc., and these agents have a promising preclinical in vitro and in vivo anti-Cryptosporidium efficacy. …”
Publicado 2021
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