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25341por Rehman, Aqeeb Ur, Ahmed, Aleena, Zaheer, Zaofsha, Ahmed, Bakhtawar, Lucke-Wold, Brandon“…The global death toll from lack of access to basic surgical care is three times as much as for tuberculosis, HIV and malaria combined. Patients dying of curable neurosurgical conditions solely because of inadequacy or absence of neurosurgical infrastructure is an issue deserving immediate attention and action. …”
Publicado 2023
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25342por Mathur, Varsha, Salomaki, Eric D, Wakeman, Kevin C, Na, Ina, Kwong, Waldan K, Kolisko, Martin, Keeling, Patrick J“…Apicomplexans and related lineages comprise many obligate symbionts of animals; some of which cause notorious diseases such as malaria. They evolved from photosynthetic ancestors and transitioned into a symbiotic lifestyle several times, giving rise to species with diverse non-photosynthetic plastids. …”
Publicado 2023
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25343por Aborode, Abdullahi Tunde, Huang, Helen, Wireko, Andrew Awuah, Mehta, Aashna, Kalmanovich, Jacob, Abdul‐Rahman, Toufik, Sikora, Vladyslav, Awaji, Aeshah A.“…However, the burden of infectious diseases such as malaria creates a significant burden on public health resources that are dedicated to COVID‐19 surveillance, testing, and vaccination access. …”
Publicado 2022
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25344por Gao, Xinna, Bai, Yue, Sun, Peng, Gao, Huimin, Yang, Lan, Zhang, Dong, Zhao, Yifan, Ma, Yue“…Introduction: Artemisinin (1) is a milestone compound in malaria treatment, and it exhibits a broad scope of bioactivities. …”
Publicado 2023
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25345por Mullany, Luke C., van Boetzelaer, Elburg W., Gutman, Julie R., Steinhardt, Laura C., Ngoy, Pascal, Barbera Lainez, Yolanda, Wittcoff, Alison, Harvey, Steven A., Ho, Lara S.“…Children in both arms were assessed again at day 8, and classified as a clinical failure if fever (caregiver-reported), malaria, diarrhea, pneumonia, or decline of health status (development of danger signs, hospitalization, or death) was noted (failure definition 1). …”
Publicado 2018
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25346por Chen, Mengni, Dong, Ying, Deng, Yan, Xu, Yanchun, Liu, Yan, Zhang, Canglin, Huang, Herong“…BACKGROUND: Eighteen imported ovale malaria cases imported from Myanmar and various African countries have been reported in Yunnan Province, China from 2013 to 2018. …”
Publicado 2020
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25347por Hartley, Mary-Anne, Hofmann, Natalie, Keitel, Kristina, Kagoro, Frank, Antunes Moniz, Clara, Mlaganile, Tarsis, Samaka, Josephine, Masimba, John, Said, Zamzam, Temba, Hosiana, Gonzalez, Iveth, Felger, Ingrid, Genton, Blaise, D’Acremont, Valérie“…BACKGROUND: Low-density (LD) Plasmodium infections are missed by standard malaria rapid diagnostic tests (standard mRDT) when the blood antigen concentration is below the detection threshold. …”
Publicado 2020
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25348“…The serum vitamin D level of visceral leishmaniasis patient was affected by HIV (B -9.43 [95% CI: − 10.92 - -7.94]), DDS (B 16.24 [95% CI: 14.89–17.58]), malaria (B -0.61 [95% CI: − 3.37 - -3.37]), and family size (B -1.15 [95% CI: − 2.03 - -0.28]). …”
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25349por Xu, Qinwen, Liu, Sihong, Kassegne, Kokouvi, Yang, Bo, Lu, Jiachen, Sun, Yifan, Zhong, Wenli, Zhang, Miaosa, Liu, Yaobao, Zhu, Guoding, Cao, Jun, Cheng, Yang“…BACKGROUND: Merozoite surface protein 1 (MSP1) plays an essential role in erythrocyte invasion by malaria parasites. The C-terminal 19-kDa region of MSP1 has long been considered one of the major candidate antigens for a malaria blood-stage vaccine against Plasmodium falciparum. …”
Publicado 2021
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25350por Coppée, Romain, Mama, Atikatou, Sarrasin, Véronique, Kamaliddin, Claire, Adoux, Lucie, Palazzo, Lawrence, Ndam, Nicaise Tuikue, Letourneur, Franck, Ariey, Frédéric, Houzé, Sandrine, Clain, Jérôme“…BACKGROUND: Whole-genome sequencing (WGS) is becoming increasingly helpful to assist malaria control programmes. A major drawback of this approach is the large amount of human DNA compared to parasite DNA extracted from unprocessed whole blood. …”
Publicado 2022
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25351por Stone, Will, Mahamar, Almahamoudou, Smit, Merel J, Sanogo, Koualy, Sinaba, Youssouf, Niambele, Sidi M, Sacko, Adama, Keita, Sekouba, Dicko, Oumar M, Diallo, Makonon, Maguiraga, Seydina O, Samake, Siaka, Attaher, Oumar, Lanke, Kjerstin, ter Heine, Rob, Bradley, John, McCall, Matthew B B, Issiaka, Djibrilla, Traore, Sekou F, Bousema, Teun, Drakeley, Chris, Dicko, Alassane“…METHODS: In this four-arm, single-blind, phase 2, randomised controlled trial, participants were recruited at the Clinical Research Unit of the Malaria Research and Training Centre of the University of Bamako in Mali. …”
Publicado 2022
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25352por Stepniewska, Kasia, Allen, Elizabeth N., Humphreys, Georgina S., Poirot, Eugenie, Craig, Elaine, Kennon, Kalynn, Yilma, Daniel, Bousema, Teun, Guerin, Philippe J., White, Nicholas J., Price, Ric N., Raman, Jaishree, Martensson, Andreas, Mwaiswelo, Richard O., Bancone, Germana, Bastiaens, Guido J. H., Bjorkman, Anders, Brown, Joelle M., D’Alessandro, Umberto, Dicko, Alassane A., El-Sayed, Badria, Elzaki, Salah-Eldin, Eziefula, Alice C., Gonçalves, Bronner P., Hamid, Muzamil Mahdi Abdel, Kaneko, Akira, Kariuki, Simon, Khan, Wasif, Kwambai, Titus K., Ley, Benedikt, Ngasala, Billy E., Nosten, Francois, Okebe, Joseph, Samuels, Aaron M., Smit, Menno R., Stone, Will J. R., Sutanto, Inge, Ter Kuile, Feiko, Tine, Roger C., Tiono, Alfred B., Drakeley, Chris J., Gosling, Roly, Stergachis, Andy, Barnes, Karen I., Chen, Ingrid“…BACKGROUND: In 2012, the World Health Organization (WHO) recommended single low-dose (SLD, 0.25 mg/kg) primaquine to be added as a Plasmodium (P.) falciparum gametocytocide to artemisinin-based combination therapy (ACT) without glucose-6-phosphate dehydrogenase (G6PD) testing, to accelerate malaria elimination efforts and avoid the spread of artemisinin resistance. …”
Publicado 2022
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25353por Zahouli, Julien Z. B., Edi, Constant A. V., Yao, Laurence A., Lisro, Emmanuelle G., Adou, Marc, Koné, Inza, Small, Graham, Sternberg, Eleanore D., Koudou, Benjamin G.“…BACKGROUND: Due to the rapid expansion of pyrethroid-resistance in malaria vectors in Africa, Global Plan for Insecticide Resistance Management (GPIRM) has recommended the development of long-lasting insecticidal nets (LLINs), containing insecticide mixtures of active ingredients with different modes of action to mitigate resistance and improve LLIN efficacy. …”
Publicado 2023
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25354por Tu, Yifan, Li, Xiaodong, Fu, Yuanzheng, Chen, Yunyun, Fang, Hui, Li, Yuan, Gu, Ying, Zhang, Jiawei“…Isocorydine (ICD) is a type of isoquinoline alkaloid originating from Corydalis edulis, which has been used to relieve spasm, dilate blood vessels, and treat malaria as well as hypoxia in clinic. However, its effect on inflammation and underlying mechanisms remains unclear. …”
Publicado 2023
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25355por Ashton, Trent D., Dans, Madeline G., Favuzza, Paola, Ngo, Anna, Lehane, Adele M., Zhang, Xinxin, Qiu, Deyun, Chandra Maity, Bikash, De, Nirupam, Schindler, Kyra A., Yeo, Tomas, Park, Heekuk, Uhlemann, Anne-Catrin, Churchyard, Alisje, Baum, Jake, Fidock, David A., Jarman, Kate E., Lowes, Kym N., Baud, Delphine, Brand, Stephen, Jackson, Paul F., Cowman, Alan F., Sleebs, Brad E.“…Finally, we observed that optimized frontrunner analogue WJM-921 demonstrates oral efficacy in a mouse model of malaria.…”
Publicado 2023
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25356por Niba, Juste Ongeh, Ngasa, Stewart Ndutard, Chang, Neh, Sanji, Eric, Awa, Anne-Marie, Dingana, Therence Nwana, Sama, Carlson Babila, Tchouda, Leticia, Julius, Mekolle Enongene“…Participants observed an increase in complications due to malaria, malnutrition and a rise in maternal and infant mortality. …”
Publicado 2022
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25357por Chakraborty, Monoswi, Choudhury, Mohua Chakraborty, Chakraborty, Indraneel, Saberwal, Gayatri“…The drugs were for the conditions B-cell Lymphoma, Chronic Myeloid Leukemia, Gaucher disease Type 1, Malaria, Myeloma and Pulmonary Arterial Hypertension. …”
Publicado 2022
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25358“…Typical examples are the unsuccessful conduct of the Ebola vaccine trial and the initial refusal of parents to allow their children to receive the recently piloted malaria vaccine in Ghana. Therefore, this study explored participants’ views on factors affecting trust in clinical trials conduct in Ghana. …”
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25359por Giuliano, Christopher J., Wei, Kenneth J., Harling, Faye M., Waldman, Benjamin S., Farringer, Madeline A., Boydston, Elizabeth A., Lan, Tammy C. T., Thomas, Raina W., Herneisen, Alice L., Sanderlin, Allen G., Coppens, Isabelle, Dvorin, Jeffrey D., Lourido, Sebastian“…This compound exhibited antiparasitic activity against T. gondii and Plasmodium falciparum, the most lethal agent of malaria. Taken together, we present the first complete survey of an apicomplexan genome during infection of an animal host, and point to novel interfaces of host-parasite interaction that may offer new avenues for treatment.…”
Publicado 2023
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25360“…Chloroquine phosphate (CQP) is used for malaria treatment. As it is facing increasing resistance, it needs continuous monitoring using sensitive and specific detection methods. …”
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