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25601por Wiesner, Jochen, Ziemann, Christina, Hintz, Martin, Reichenberg, Armin, Ortmann, Regina, Schlitzer, Martin, Fuhst, Rainer, Timmesfeld, Nina, Vilcinskas, Andreas, Jomaa, Hassan“…In previous studies, FR-900098 was shown to possess potent antimalarial activity in vitro and in a murine malaria model. In order to provide a basis for further preclinical and clinical development, we studied the acute toxicity and genotoxicity of FR-900098. …”
Publicado 2016
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25602“…Vaccinia virus (VACV)-derived vectors are popular candidates for vaccination against diseases such as HIV-1, malaria and tuberculosis. However, their genomes encode a multitude of proteins with immunomodulatory functions, several of which reduce the immunogenicity of these vectors. …”
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25603por Chen, Shicheng, Zhao, Jiangchao, Joshi, Deepak, Xi, Zhiyong, Norman, Beth, Walker, Edward D.“…Consistent presence of certain predominant bacteria (Elizabethkingia, Asaia, Pseudomonas, and Enterobacteriaceae) suggests they would be useful for paratransgenesis to control malaria infection, particularly when coupled to a Wolbachia-based intervention strategy.…”
Publicado 2016
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25604por Angleró-Rodríguez, Yesseinia I., Blumberg, Benjamin J., Dong, Yuemei, Sandiford, Simone L., Pike, Andrew, Clayton, April M., Dimopoulos, George“…While this type of immunomodulatory mechanism has already been demonstrated in other host-pathogen interaction systems, this is the first report of a mosquito-associated fungus that can suppress the mosquito’s innate immune system in a way that would favor Plasmodium infection and possibly malaria transmission.…”
Publicado 2016
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25605por Banfi, Felipe Finger, Guedes, Karla de Sena, Andrighetti, Carla Regina, Aguiar, Ana Carolina, Debiasi, Bryan Wender, Noronha, Janaina da Costa, Rodrigues, Domingos de Jesus, Júnior, Gerardo Magela Vieira, Sanchez, Bruno Antonio Marinho“…The drug-resistance of malaria parasites is the main problem in the disease control. …”
Publicado 2016
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25606por GOMES, Margarete do Socorro Mendonça, VIEIRA, José Luiz Fernandes, CASSIANO, Gustavo Capatti, MUSSET, Lise, LEGRAND, Eric, NACHER, Mathieu, COUTO, Vanja Suely Calvosa D'Almeida, MACHADO, Ricardo Luiz Dantas, COUTO, Álvaro Augusto Ribeiro D'Almeida“…Malaria is a major health problem for people who live on the border between Brazil and French Guiana. …”
Publicado 2016
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25607por Miles, Alistair, Iqbal, Zamin, Vauterin, Paul, Pearson, Richard, Campino, Susana, Theron, Michel, Gould, Kelda, Mead, Daniel, Drury, Eleanor, O'Brien, John, Ruano Rubio, Valentin, MacInnis, Bronwyn, Mwangi, Jonathan, Samarakoon, Upeka, Ranford-Cartwright, Lisa, Ferdig, Michael, Hayton, Karen, Su, Xin-zhuan, Wellems, Thomas, Rayner, Julian, McVean, Gil, Kwiatkowski, Dominic“…The malaria parasite Plasmodium falciparum has a great capacity for evolutionary adaptation to evade host immunity and develop drug resistance. …”
Publicado 2016
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25608por Tong, Yunli, Liu, Yuting, Zheng, Hongming, Zheng, Liang, Liu, Wenqin, Wu, Jinjun, Ou, Rilan, Zhang, Guiyu, Li, Fangyuan, Hu, Ming, Liu, Zhongqiu, Lu, Linlin“…Non-small-cell lung cancer (NSCLC) is the most prevalent malignancy worldwide given its high incidence, considerable mortality, and poor prognosis. The anti-malaria compounds artemisinin (ART), dihydroartemisinin (DHA), and artesunate (ARTS) reportedly have anti-cancer potential, although the underlying mechanisms remain unclear. …”
Publicado 2016
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25609por Cheng, Yang, Lu, Feng, Wang, Bo, Li, Jian, Han, Jin-Hee, Ito, Daisuke, Kong, Deok-Hoon, Jiang, Lubin, Wu, Jian, Ha, Kwon-Soo, Takashima, Eizo, Sattabongkot, Jetsumon, Cao, Jun, Nyunt, Myat Htut, Kyaw, Myat Phone, Desai, Sanjay A., Miller, Louis H., Tsuboi, Takafumi, Han, Eun-Taek“…Plasmodium vivax, a major agent of malaria in both temperate and tropical climates, has been thought to be unable to infect humans lacking the Duffy (Fy) blood group antigen because this receptor is critical for erythrocyte invasion. …”
Publicado 2016
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25610por Kim, Seung-Hun, Liu, Chun-Yen, Fan, Po-Wei, Hsieh, Chang-Heng, Lin, Hsuan-Yuan, Lee, Ming-Chung, Fang, Kang“…Merr., were used to cure patients suffering from infectious diseases such as malaria. Recent advances revealed that the herb could also be a useful cancer therapy agent. …”
Publicado 2016
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25611por Maeda, Hiroki, Hatta, Takeshi, Alim, M Abdul, Tsubokawa, Daigo, Mikami, Fusako, Matsubayashi, Makoto, Miyoshi, Takeharu, Umemiya-Shirafuji, Rika, Kawazu, Shin-ichiro, Igarashi, Ikuo, Mochizuki, Masami, Tsuji, Naotoshi, Tanaka, Tetsuya“…Tick-borne babesiosis is a well-recognized malaria-like disease that occurs worldwide and recently has attracted increased attention as an emerging zoonosis. …”
Publicado 2016
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25612por Baragaña, Beatriz, Norcross, Neil R., Wilson, Caroline, Porzelle, Achim, Hallyburton, Irene, Grimaldi, Raffaella, Osuna-Cabello, Maria, Norval, Suzanne, Riley, Jennifer, Stojanovski, Laste, Simeons, Frederick R. C., Wyatt, Paul G., Delves, Michael J., Meister, Stephan, Duffy, Sandra, Avery, Vicky M., Winzeler, Elizabeth A., Sinden, Robert E., Wittlin, Sergio, Frearson, Julie A., Gray, David W., Fairlamb, Alan H., Waterson, David, Campbell, Simon F., Willis, Paul, Read, Kevin D., Gilbert, Ian H.“…Improvement of the pharmacokinetic profile led to several compounds showing excellent oral efficacy in the P. berghei malaria mouse model with ED(90) values below 1 mg/kg when dosed orally for 4 days. …”
Publicado 2016
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25613“…Such mechanisms include blockade of antibiotic cytosolic extrusion in the cases of Pneumococci, Mycobacterium tuberculosis, Plasmodium falciparum malaria, or Schistosoma mansoni; blockade of the calcineurin/calmodulin pathway (in immunosuppressed patients allowing for lower dosage of cyclosporine); stabilization of calcium movement at the level of sarcoplasmic reticulum by which shock (vasopressor instability) is prevented; or of cytosolic calcium influx and cell death (in the case of allograft acute tubular necrosis). …”
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25614por Fontana, Mary F., de Melo, Gabrielly L., Anidi, Chioma, Hamburger, Rebecca, Kim, Chris Y., Lee, So Youn, Pham, Jennifer, Kim, Charles C.“…Dynamic regulation of leukocyte population size and activation state is crucial for an effective immune response. In malaria, Plasmodium parasites elicit robust host expansion of macrophages and monocytes, but the underlying mechanisms remain unclear. …”
Publicado 2016
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25615por Ansah, Evelyn K., Whitty, Christopher JM, Bart-Plange, Constance, Gyapong, Margaret“…Ghana was among nine countries piloting the Global Fund Affordable Medicines Facility – malaria (AMFm). AMFm aimed to: increase artemisinin combination therapy (ACT) affordability; increase ACT availability; increase ACT use; and ‘crowd out’ artemisinin monotherapies. …”
Publicado 2016
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25616por Gorouhi, Mohammad Amin, Vatandoost, Hassan, Oshaghi, Mohammad Ali, Raeisi, Ahmad, Enayati, Ahmad Ali, Mirhendi, Hossein, Hanafi-Bojd, Ahmad Ali, Abai, Mohammad Reza, Salim-Abadi, Yaser, Rafi, Fatemeh“…BACKGROUND: Anopheles mosquitoes are an important group of arthropods due to their role in transmission of malaria. The present study was conducted for determination of susceptibility status of Anopheles stephensi to different imagicides collected from malarious area in Chabahar city, Iran. …”
Publicado 2016
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25617“…CASE PRESENTATION: A 16 year old female Muslim from the Extreme North of Cameroon with no significant past history, was treated for severe malaria and associated refractory vomiting using intravenous quinine and metoclopramide respectively. …”
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25618“…A common assumption about malaria, dengue, and other mosquito-borne infections is that the two main components of the risk of human infection—the rate at which people are bitten (human biting rate) and the proportion of mosquitoes that are infectious—are positively correlated. …”
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25619por Espinosa, Diego A., Vega-Rodriguez, Joel, Flores-Garcia, Yevel, Noe, Amy R., Muñoz, Christian, Coleman, Russell, Bruck, Torben, Haney, Keith, Stevens, Alex, Retallack, Diane, Allen, Jeff, Vedvick, Thomas S., Fox, Christopher B., Reed, Steven G., Howard, Randall F., Salman, Ahmed M., Janse, Chris J., Khan, Shahid M., Zavala, Fidel, Gutierrez, Gabriel M.“…Using a newly developed rodent malaria chimeric parasite expressing the P. falciparum CelTOS (PfCelTOS), we evaluated the protective effect of in vivo immune responses elicited by vaccination and assessed the neutralizing capacity of monoclonal antibodies specific against PfCelTOS. …”
Publicado 2017
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25620por Waldecker, Mailin, Dasanna, Anil K., Lansche, Christine, Linke, Marco, Srismith, Sirikamol, Cyrklaff, Marek, Sanchez, Cecilia P., Schwarz, Ulrich S., Lanzer, Michael“…The contribution of vesiculation to the malaria‐protective function of hemoglobin S is discussed.…”
Publicado 2016
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