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25621por Aly, Mussa Manuel, Ali, Sadia, Muianga, Argentina Felisbela, Monteiro, Vanessa, Gallego, Jorge Galano, Weyer, Jacqueline, Falk, Kerstin I., Paweska, Janusz Tadeusz, Cliff, Julie, Gudo, Eduardo Samo“…Laboratory testing revealed IgM antibodies against Chikungunya virus. Malaria tests were consistently negative. CONCLUSIONS: This report suggests that Chikungunya might cause unsuspected severe disease in febrile patients in Mozambique and provides insights for the improvement of national protocols for management of febrile patients in Mozambique. …”
Publicado 2017
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25622“…Members of this epigenetic gene ensemble may constitute another set of potential targets for vector control and enable further reductions in the burden of human malaria, by analogy to recent success in development of small molecule antagonists for mammalian epigenetic machinery.…”
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25623por Ch’ng, Jun-Hong, Sirel, Madle, Zandian, Arash, del Pilar Quintana, Maria, Chun Leung Chan, Sherwin, Moll, Kirsten, Tellgren-Roth, Asa, Nilsson, IngMarie, Nilsson, Peter, Qundos, Ulrika, Wahlgren, Mats“…Variable surface antigens of Plasmodium falciparum have been a major research focus since they facilitate parasite sequestration and give rise to deadly malaria complications. Coupled with its potential use as a vaccine candidate, the recent suggestion that the repetitive interspersed families of polypeptides (RIFINs) mediate blood group A rosetting and influence blood group distribution has raised the research profile of these adhesins. …”
Publicado 2017
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25624“…OBJECTIVE: H omalium letestui Pellegr (Flacourtiaceae) has been traditionally used by the Ibibios of Southern Nigeria to treat stomach ulcer, malaria and other inflammatory diseases and Yorubas of western Nigeria as an antidote. …”
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25625“…Here, we addressed the question of whether artesunate (ART), a drug currently used in the treatment of malaria, enhances the killing response of glioblastoma cells to temozolomide (TMZ), which is the first-line therapeutic for GBM. …”
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25626“…The anti-mitochondrial effects of artemisinin were later confirmed with purified mitochondria from malaria parasites. Inside some cells heme appears to be a primary reducing agent and reduction of ARTs by heme can induce a relatively nonspecific cellular damage. …”
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25627por Yang, Yihao, Zhang, Ya, Qu, Xin, Xia, Junfeng, Li, Dongqi, Li, Xiaojuan, Wang, Yu, He, Zewei, Li, Su, Zhou, Yonghong, Xie, Lin, Yang, Zuozhang“…The DEGs in metastatic OS compared with primary OS were significantly enriched in the arachidonic acid metabolism, malaria, and chemokine signaling pathways. Finally, we employed quantitative real-time polymerase chain reaction (qRT-PCR) to validate the expression levels of candidate DEGs and the results indicated that our bioinformatics approach was acceptable. …”
Publicado 2016
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25628por Wang, Weisi, Li, Qiang, Wei, Yufen, Xue, Jian, Sun, Xiao, Yu, Yang, Chen, Zhuo, Li, Shizhu, Duan, Liping“…Malaria and schistosomiasis are two of the most socioeconomically devastating parasitic diseases in tropical and subtropical countries. …”
Publicado 2017
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25629“…In this study, we screened the Pathogen Box chemical library (Medicines for Malaria Venture, Switzerland) in an effort to identify novel antifungal compounds. …”
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25630por Kim, Young-Jin, Lee, Ji Young, Kim, Hyun-Ju, Kim, Do-Hoon, Lee, Tae Hee, Kang, Mi Suk, Choi, You-Kyung, Lee, Hye Lim, Kim, Jaieun, An, Hyo-Jin, Park, Wansu“…PMR is used to treat dizziness, spermatorrhea, sores, and scrofula as well as chronic malaria traditionally in China and Korea. The anti-tumor property of emodin was already reported. …”
Publicado 2017
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25631por Näsström, Elin, Parry, Christopher M, Vu Thieu, Nga Tran, Maude, Rapeephan R, de Jong, Hanna K, Fukushima, Masako, Rzhepishevska, Olena, Marks, Florian, Panzner, Ursula, Im, Justin, Jeon, Hyonjin, Park, Seeun, Chaudhury, Zabeen, Ghose, Aniruddha, Samad, Rasheda, Van, Tan Trinh, Johansson, Anders, Dondorp, Arjen M, Thwaites, Guy E, Faiz, Abul, Antti, Henrik, Baker, Stephen“…Here, we performed mass spectrometry on plasma from Bangladeshi and Senegalese patients with culture confirmed typhoid fever, clinically suspected typhoid, and other febrile diseases including malaria. After applying supervised pattern recognition modelling, we could significantly distinguish metabolite profiles in plasma from the culture confirmed typhoid patients. …”
Publicado 2017
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25632por Hoekou, Yao Patrick, Tchacondo, Tchadjobo, Karou, Simplice Damintoti, Yerbanga, Rakiswende Serge, Achoribo, Elom, Da, Ollo, Atakpama, Wouyo, Batawila, Komlan“…A previous ethnobotanical survey on the latex plants of the Maritime region of the country revealed that this plant was included in several recipes curing malaria and microbial infections. Therefore, this study aimed to seek for the effectiveness of the ethanolic extract of the plant in the treatment of these diseases. …”
Publicado 2017
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25633por Wessells, K. Ryan, Ouédraogo, Césaire T., Young, Rebecca R., Faye, M. Thierno, Brito, Alex, Hess, Sonja Y.“…Common risk factors associated with MN status included gravidity, mid-upper-arm circumference, geophagy, malaria, and result of the woman’s last pregnancy. …”
Publicado 2017
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25634“…Facility-based surveillance is unlikely to be effective in detecting EIDs due to a combination of clinical care practices and the time constraints associated with individual episodes of illness, particularly in the resource-limited settings of rural West Africa, where febrile illness due to malaria is common and specific diagnostic assays are largely unavailable. …”
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25635por Jain, Sonia, Bose, Anjali, Bastia, Banajit, Sharma, Hritika, Sachdeva, Ruchi, Jain, Arun K., Pal, Rahul“…Hemolysis-associated anemia is characteristic of diseases such as atherosclerosis, lupus, malaria, and leishmaniasis; the toxic effects of free hemoglobin (Hb) have been extensively described. …”
Publicado 2017
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25636“…Apicomplexan parasites cause a variety of important infectious diseases, including malaria, toxoplasma encephalitis, and severe diarrhea due to Cryptosporidium. …”
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25637por Kumar, Sudhir, Kumar, Manish, Ekka, Roseleen, Dvorin, Jeffrey D., Paul, Aditya S., Madugundu, Anil K., Gilberger, Tim, Gowda, Harsha, Duraisingh, Manoj T., Keshava Prasad, T. S., Sharma, Pushkar“…Calcium Dependent Protein Kinases are key effectors of calcium signaling in malaria parasite. PfCDPK1 is critical for asexual development of Plasmodium falciparum, but its precise function and substrates remain largely unknown. …”
Publicado 2017
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25638por Li, Lin, Josef, Brinckmann A., Liu, Bing, Zheng, Sihao, Huang, Linfang, Chen, Shilin“…Artemisinin is the first-line drug for anti-malaria recommended by the World Health Organization (WHO). …”
Publicado 2017
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25639por Cubi, Roger, Vembar, Shruthi S., Biton, Anne, Franetich, Jean‐Francois, Bordessoulles, Mallaury, Sossau, Daniel, Zanghi, Gigliola, Bosson‐Vanga, Henriette, Benard, Magalie, Moreno, Alicia, Dereuddre‐Bosquet, Nathalie, Le Grand, Roger, Scherf, Artur, Mazier, Dominique“…Dormant liver stage forms (hypnozoites) of the malaria parasite Plasmodium vivax present major hurdles to control and eradicate infection. …”
Publicado 2017
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25640por Yamthe, Lauve Rachel Tchokouaha, Fokou, Patrick Valere Tsouh, Mbouna, Cedric Derick Jiatsa, Keumoe, Rodrigue, Ndjakou, Bruno Lenta, Djouonzo, Paul Toukam, Mfopa, Alvine Ngoutane, Legac, Jennifer, Tsabang, Nole, Gut, Jiri, Rosenthal, Philip J., Boyom, Fabrice Fekam“…These results support traditional claims for A. muricata and A. reticulata in the treatment of malaria. Given their limited cytotoxicity profile, their extracts qualify as promising starting points for antimalarial drug discovery.…”
Publicado 2015
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