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25761“…Presently, the principal tools to combat malaria are restricted to killing the parasite in infected people and killing the mosquito vector to thwart transmission. …”
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25762por Chan, Emily Ying Yang, Sham, Tiffany Sze Tung, Shahzada, Tayyab Salim, Dubois, Caroline, Huang, Zhe, Liu, Sida, Hung, Kevin K.C., Tse, Shelly L.A., Kwok, Kin On, Chung, Pui-Hong, Kayano, Ryoma, Shaw, Rajib“…Although prevention against mosquito-borne diseases, notably malaria, has been well-studied, research on other vectors and VBDs remains limited. …”
Publicado 2020
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25763por Tsamesidis, Ioannis, Reybier, Karine, Marchetti, Giuseppe, Pau, Maria Carmina, Virdis, Patrizia, Fozza, Claudio, Nepveu, Francoise, Low, Philip S., Turrini, Francesco Michelangelo, Pantaleo, Antonella“…Although artemisinin-based combination therapies (ACTs) treat Plasmodium falciparum malaria effectively throughout most of the world, the recent expansion of ACT-resistant strains in some countries of the Greater Mekong Subregion (GMS) further increased the interest in improving the effectiveness of treatment and counteracting resistance. …”
Publicado 2020
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25764“…Geospatial modeling, using data from the Malaria Atlas Project, together with census data, permits quantification of the huge global discrepancies in temporal access to burn care between high-income and low-resource settings. …”
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25765“…BACKGROUND: The ability of cluster-randomized trials to capture mass or indirect effects is one reason for their increasing use to test interventions against vector-borne diseases such as malaria and dengue. For the same reason, however, the independence of clusters may be compromised if the distances between clusters is too small to ensure independence. …”
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25766por Ullah, Najeeb, Andaleeb, Hina, Mudogo, Celestin Nzanzu, Falke, Sven, Betzel, Christian, Wrenger, Carsten“…Plasmodium species are protozoan parasites causing the deadly malaria disease. They have developed effective resistance mechanisms against most antimalarial medication, causing an urgent need to identify new antimalarial drug targets. …”
Publicado 2020
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25767por Zhang, Xiao-lei, Li, Zhuo-ming, Ye, Jian-tao, Lu, Jing, Ye, Lingyu Linda, Zhang, Chun-xiang, Liu, Pei-qing, Duan, Dayue D“…Chloroquine phosphate and its derivative hydroxychloroquine, which have been used in the treatment and prevention of malaria and autoimmune diseases for decades, were found to inhibit SARS-CoV-2 infection with high potency in vitro and have shown clinical and virologic benefits in COVID-19 patients. …”
Publicado 2020
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25768por Jenner, Adrianne L., Aogo, Rosemary A., Davis, Courtney L., Smith, Amber M., Craig, Morgan“…Modeling of the epidemic dynamics of malaria at the within-host and between-host level has afforded the development of more effective vaccination and antimalarial therapies. …”
Publicado 2020
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25769A machine learning approach to define antimalarial drug action from heterogeneous cell-based screenspor Ashdown, George W., Dimon, Michelle, Fan, Minjie, Sánchez-Román Terán, Fernando, Witmer, Kathrin, Gaboriau, David C. A., Armstrong, Zan, Ando, D. Michael, Baum, Jake“…We have developed a semi-supervised machine learning approach, combining human- and machine-labeled training data from mixed human malaria parasite cultures. Designed for high-throughput and high-resolution screening, our semi-supervised approach is robust to natural parasite morphological heterogeneity and correctly orders parasite developmental stages. …”
Publicado 2020
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25770“…Here, we demonstrate that a paired family member, gooseberry, has acquired paired-like expression in the malaria mosquito Anopheles stephensi. Anopheles-gooseberry CRISPR-Cas9 knock-out mutants display pair-rule phenotypes and alteration of target gene expression similar to what is seen in Drosophila and beetle paired mutants. …”
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25771por Lopes, V. L., Costa, F. V., Rodrigues, R. A., Braga, É. M., Pichorim, M., Moreira, P. A.“…For two years, we monthly sampled birds in a tropical coastal ecosystem to avian malaria molecular diagnosis. The studied networks exhibited high specialization, medium modularity, with low niche overlap among parasites lineages. …”
Publicado 2020
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25772por Ishaq, Uzma, Malik, Jahanzeb, Asif, Maliha, Zaib, Hina, Haider, Iqbal, Zahid, Tayyaba, Abdul Sattar, Rana, Ikram, Umar“…Methods This case-control study, done at Fauji Foundation Hospital, Pakistan, included patients with symptoms suggestive of typhoid fever, culture, or serology positive for typhoid fever and excluded patients who had been previously diagnosed with malaria and dengue hemorrhagic fever. After flagging cultures and serology, the records were viewed for leukocyte counts. …”
Publicado 2020
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25773por Zhao, Dan, Mu, Hai-Jun, Shi, Hai Bing, Bi, Hong Xia, Jiang, Yun Fei, Liu, Guo Hua, Zheng, Hong Yan, Liu, Bo“…Kyoto Encyclopedia of Genes and Genomes analysis revealed that DEGs were enriched in pathways related to “Malaria,” “Cell cycle,” and “IL-17 signaling pathway.” …”
Publicado 2020
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25774“…(1) Background: Hydroxychloroquine is used to treat malaria and autoimmune diseases, and its potential use against COVID-19 is currently under investigation. …”
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25775por Maitland, Kathryn, Kiguli, Sarah, Olupot-Olupot, Peter, Opoka, Robert O., Chimalizeni, Yami, Alaroker, Florence, Uyoga, Sophie, Kyeyune-Byabazaire, Dorothy, M’baya, Bridon, Bates, Imelda, Williams, Thomas N., Munube, Deogratias, Mbanya, Dora, Molyneux, Elizabeth M., South, Annabelle, Walker, A. Sarah, Gibb, Diana M., George, Elizabeth C.“…Among all 3196 children receiving an initial transfusion there was no evidence that nutritional status, presence of shock, malaria parasite burden or sickle cell disease status influenced outcomes or modified the interaction with fever status on volume required. …”
Publicado 2021
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25776por Posuwan, Nawarat, Wanlapakorn, Nasamon, Sintusek, Palittiya, Wasitthankasem, Rujipat, Poovorawan, Kittiyod, Vongpunsawad, Sompong, Poovorawan, Yong“…Viral hepatitis is a global problem with mortality comparable to HIV, tuberculosis and malaria. The WHO aims to eliminate hepatitis B (HBV) and hepatitis C (HCV) by 2030. …”
Publicado 2020
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25777por Szentiványi, Tamara, Markotter, Wanda, Dietrich, Muriel, Clément, Laura, Ançay, Laurie, Brun, Loïc, Genzoni, Eléonore, Kearney, Teresa, Seamark, Ernest, Estók, Peter, Christe, Philippe, Glaizot, Olivier“…We tested the presence of three distinct vector-borne microorganisms in both bat blood and bat flies: Bartonella bacteria, malaria-like Polychromophilus sp. (Apicomplexa), and Trypanosoma sp. …”
Publicado 2020
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25778por Hoh, Boon-Peng, Zhang, Xiaoxi, Deng, Lian, Yuan, Kai, Yew, Chee-Wei, Saw, Woei-Yuh, Hoque, Mohammad Zahirul, Aghakhanian, Farhang, Phipps, Maude E, Teo, Yik-Ying, Subbiah, Vijay Kumar, Xu, Shuhua“…Owing to the long history of endemic malaria in NB, the putative signature of positive selection is postulated to be driven by Plasmodium parasite infection. …”
Publicado 2020
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25779“…Some of these life-threatening diseases are malaria, which is caused by protozoan parasites of the genus Plasmodium and transmitted by Anopheles mosquitoes; dengue fever, which is caused by an arbovirus mainly transmitted by Aedes aegypti; and West Nile fever, which is caused by an arbovirus transmitted by Culex spp. …”
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25780por Mulaw Belete, Tafere“…Therefore, repurposing the existing drugs that were used for the treatment of malaria, Ebola, and influenza helps rapid drug development for COVID-19. …”
Publicado 2020
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