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25781por Zhou, Guofa, Yu, Leonard, Wang, Xiaoming, Zhong, Daibin, Lee, Ming-chieh, Kibret, Solomon, Yan, Guiyun“…Rapidly increasing pyrethroid insecticide resistance and changes in vector biting and resting behavior pose serious challenges in malaria control. Mosquito repellents, especially spatial repellents, have received much attention from industry. …”
Publicado 2020
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25782por Zapletal, Josef, Najmitabrizi, Neda, Erraguntla, Madhav, Lawley, Mark A., Myles, Kevin M., Adelman, Zach N.“…Gene drive systems have long been sought to modify mosquito populations and thus combat malaria and dengue. Powerful gene drive systems have been developed in laboratory experiments, but may never be used in practice unless they can be shown to be acceptable through rigorous field-based testing. …”
Publicado 2021
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25783por Mühleip, Alexander, Kock Flygaard, Rasmus, Ovciarikova, Jana, Lacombe, Alice, Fernandes, Paula, Sheiner, Lilach, Amunts, Alexey“…In Apicomplexa causing diseases such as malaria and toxoplasmosis, an unusual cristae morphology has been observed, but its structural basis is unknown. …”
Publicado 2021
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25784por Papadopoulos, Konstantinos I., Sutheesophon, Warachaya, Manipalviratn, Somjate, Aw, Tar-Choon“…We posit that the evolutionary protective effect of the HbE and other thalassemic variants against malaria and the dengue virus may extend its advantage to resistance to COVID-19 infection, as HbE heterozygote population prevalence appears to be positively correlated with immunity to COVID-19. …”
Publicado 2021
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25785por Soares de Melo, Candice, Singh, Vinayak, Myrick, Alissa, Simelane, Sandile B., Taylor, Dale, Brunschwig, Christel, Lawrence, Nina, Schnappinger, Dirk, Engelhart, Curtis A., Kumar, Anuradha, Parish, Tanya, Su, Qin, Myers, Timothy G., Boshoff, Helena I. M., Barry, Clifton E., Sirgel, Frederick A., van Helden, Paul D., Buchanan, Kirsteen I., Bayliss, Tracy, Green, Simon R., Ray, Peter C., Wyatt, Paul G., Basarab, Gregory S., Eyermann, Charles J., Chibale, Kelly, Ghorpade, Sandeep R.“…[Image: see text] Phenotypic screening of a Medicines for Malaria Venture compound library against Mycobacterium tuberculosis (Mtb) identified a cluster of pan-active 2-pyrazolylpyrimidinones. …”
Publicado 2021
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25786por Oringanje, Chioma, Delacruz, Lillian R., Han, Yunan, Luckhart, Shirley, Riehle, Michael A.“…In summary, this work identifies midgut AMPK activity as an important regulator of metabolism, reproduction, and innate immunity in An. stephensi, a highly invasive and important malaria vector species.…”
Publicado 2021
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25787“…FUNDING: The study was supported by a grant to author DB by the President's Malaria Initiative (PMI) -CDC CoAg 6NU2GGH001876…”
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25788por Ou, Tianling, Mou, Huihui, Zhang, Lizhou, Ojha, Amrita, Choe, Hyeryun, Farzan, Michael“…Hydroxychloroquine, used to treat malaria and some autoimmune disorders, potently inhibits viral infection of SARS coronavirus (SARS-CoV-1) and SARS-CoV-2 in cell-culture studies. …”
Publicado 2021
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25789por Rashidi, Sajad, Mansouri, Reza, Ali-Hassanzadeh, Mohammad, Mojtahedi, Zahra, Shafiei, Reza, Savardashtaki, Amir, Hamidizadeh, Nasrin, Karimazar, Mohammadreza, Nguewa, Paul, Manzano-Román, Raúl“…In recent years, the mTOR pathway has been highlighted in different diseases such as diabetes, cancer, and infectious and parasitic diseases including leishmaniasis, toxoplasmosis, and malaria. The current review underlines the implications of mTOR signals and intricate networks on pathogen infections and the modulation of this master regulator by parasites. …”
Publicado 2021
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25790“…Hemolysis is a pathological feature of several diseases of diverse etiology such as hereditary anemias, malaria, and sepsis. A major complication of hemolysis involves the release of large quantities of hemoglobin into the blood circulation and the subsequent generation of harmful metabolites like labile heme. …”
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25791por Mathur, Varsha, Kwong, Waldan K, Husnik, Filip, Irwin, Nicholas A T, Kristmundsson, Árni, Gestal, Camino, Freeman, Mark, Keeling, Patrick J“…The phylum Apicomplexa consists largely of obligate animal parasites that include the causative agents of human diseases such as malaria. Apicomplexans have also emerged as models to study the evolution of nonphotosynthetic plastids, as they contain a relict chloroplast known as the apicoplast. …”
Publicado 2020
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25792por Robbers, Gianna, Vogel, Joshua P., Mola, Glen, Bolgna, John, Homer, Caroline S. E.“…There was a lack of data available on other indicators such as the adolescent birth rate, postnatal care provided to women and newborns, intermittent preventative treatment to prevent malaria in pregnancy and treatment to prevent mother-to-child transmission of HIV. …”
Publicado 2019
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25793“…A diverse set of cellular and inter-organellar signaling changes have been implicated in chemoresistance, but it is still unclear what processes lead to chemoresistance and effective strategies to overcome chemoresistance are lacking. The anti-malaria drugs, chloroquine (CQ) and its derivative hydroxychloroquine (HCQ) are being used for the treatment of various cancers and CQ and HCQ are used in combination with chemotherapeutic drugs to enhance their anti-cancer effects. …”
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25794por Naqvi, Rubina“…RESULTS: In medical AKI there has been found a rise in toxic rhabdomyolysis, vivax malaria and dengue infection during later part of study. …”
Publicado 2021
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25795por Ramyasoma, Hewawasam Patuwatha Badathuruge Kalindu Dulanja, Gunawardene, Yasanthi Illika Nilmini Silva, Hapugoda, Menaka, Dassanayake, Ranil Samantha“…BACKGROUND: Genetic modification offers opportunities to introduce artificially created molecular defence mechanisms to vector mosquitoes to counter diseases causing pathogens such as the dengue virus, malaria parasite, and Zika virus. RNA interference is such a molecular defence mechanism that could be used for this purpose to block the transmission of pathogens among human and animal populations. …”
Publicado 2021
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25796“…Anophensin, the albicin ortholog from An. stephensi, is only weakly active as an inhibitor of the AP, suggesting that the SG7 family may play a different functional role in this species and other species of the subgenus Cellia, containing the major malaria vectors in Africa and Asia. Crystal structures of albicin and SG7.AF reveal a novel four-helix bundle arrangement that is stabilized by an N-terminal hydrogen bonding network. …”
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25797por Koreny, Ludek, Zeeshan, Mohammad, Barylyuk, Konstantin, Tromer, Eelco C., van Hooff, Jolien J. E., Brady, Declan, Ke, Huiling, Chelaghma, Sara, Ferguson, David J. P., Eme, Laura, Tewari, Rita, Waller, Ross F.“…We reporter-tagged and observed the expression and location of several conoid complex proteins in the malaria model P. berghei and revealed equivalent structures in all of its zoite forms, as well as evidence of molecular differentiation between blood-stage merozoites and the ookinetes and sporozoites of the mosquito vector. …”
Publicado 2021
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25798por Clark, Martha A., Kanjee, Usheer, Rangel, Gabriel W., Chery, Laura, Mascarenhas, Anjali, Gomes, Edwin, Rathod, Pradipsinh K., Brugnara, Carlo, Ferreira, Marcelo U., Duraisingh, Manoj T.“…The structural integrity of the host red blood cell (RBC) is crucial for propagation of Plasmodium spp. during the disease-causing blood stage of malaria infection. To assess the stability of Plasmodium vivax-infected reticulocytes, we developed a flow cytometry-based assay to measure osmotic stability within characteristically heterogeneous reticulocyte and P. vivax-infected samples. …”
Publicado 2021
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25799por Talyuli, Octavio A. C., Bottino-Rojas, Vanessa, Polycarpo, Carla R., Oliveira, Pedro L., Paiva-Silva, Gabriela O.“…They are vectors of a plethora of infectious agents that cause potentially fatal diseases like Malaria, Dengue fever, Leishmaniasis, and Lyme disease. …”
Publicado 2021
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25800por Nielsen, Carolyn M., Ogbe, Ane, Pedroza-Pacheco, Isabela, Doeleman, Susanne E., Chen, Yue, Silk, Sarah E., Barrett, Jordan R., Elias, Sean C., Miura, Kazutoyo, Diouf, Ababacar, Bardelli, Martino, Dabbs, Rebecca A., Barfod, Lea, Long, Carole A., Haynes, Barton F., Payne, Ruth O., Minassian, Angela M., Bradley, Todd, Draper, Simon J., Borrow, Persephone“…Using samples from clinical trials performed with the malaria vaccine candidate antigen Plasmodium falciparum merozoite protein (PfRH5), we compare the frequency, phenotype, and gene expression profiles of PfRH5-specific circulating Tfh (cTfh) cells elicited by two leading human vaccine delivery platforms: heterologous viral vector prime boost and protein with AS01(B) adjuvant. …”
Publicado 2021
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