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Malaria
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26081por Slavic, Ksenija, Straschil, Ursula, Reininger, Luc, Doerig, Christian, Morin, Christophe, Tewari, Rita, Krishna, Sanjeev“…We found that the rodent malaria parasite orthologue, P. berghei hexose transporter (PbHT) gene, was similarly refractory to knockout attempts. …”
Publicado 2010
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26082por Simba, Daudi O, Kakoko, Deodatus C, Warsame, Marian, Premji, Zul, Gomes, Melba F, Tomson, Goran, Johansson, Eva“…BACKGROUND: Malaria kills. A single rectal dose of artesunate before referral can reduce mortality and prevent permanent disability. …”
Publicado 2010
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26083por Wang, Ping, Wang, Qi, Yang, Yonghong, Coward, James K., Nzila, Alexis, Sims, Paul F.G., Hyde, John E.“…Unusually for a eukaryote, the malaria parasite Plasmodium falciparum expresses dihydrofolate synthase (DHFS) and folylpolyglutamate synthase (FPGS) as a single bifunctional protein. …”
Publicado 2010
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26084por Cuamba, Nelson, Morgan, John C., Irving, Helen, Steven, Andrew, Wondji, Charles S.“…BACKGROUND: Although Anopheles funestus is difficult to rear, it is crucial to analyse field populations of this malaria vector in order to successfully characterise mechanisms of insecticide resistance observed in this species in Africa. …”
Publicado 2010
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26085“…Lessons can be learnt from the management of diseases such as tuberculosis and malaria in terms of planning the switch to combination treatment. …”
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26086“…Developing countries, where malaria is one of the most prevalent diseases, still rely on traditional medicine as a source for the treatment of this disease. …”
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26087por Chertemps, Thomas, Mitri, Christian, Perrot, Sylvie, Sautereau, Jean, Jacques, Jean-Claude, Thiery, Isabelle, Bourgouin, Catherine, Rosinski-Chupin, Isabelle“…BACKGROUND: Invasion of the mosquito salivary glands by Plasmodium is a critical step for malaria transmission. From a SAGE analysis, we previously identified several genes whose expression in salivary glands was regulated coincident with sporozoite invasion of salivary glands. …”
Publicado 2010
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26088por Veiga, Maria Isabel, Ferreira, Pedro Eduardo, Schmidt, Berit Aydin, Ribacke, Ulf, Björkman, Anders, Tichopad, Ales, Gil, José Pedro“…BACKGROUND: Multi-drug resistant Plasmodium falciparum is a major obstacle to malaria control and is emerging as a complex phenomenon. …”
Publicado 2010
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26089por Boele van Hensbroek, Michaël, Calis, Job C. J., Phiri, Kamija S., Vet, Raymond, Munthali, Francis, Kraaijenhagen, Rob, van den Berg, Henk, Faragher, Brian, Bates, Imelda, Molyneux, Malcolm E.“…In the final model, nutritional and infectious factors, including malaria, were directly or indirectly associated with RCPF, but not with haemolysis. …”
Publicado 2010
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26090por Bhalla, Ashish, Suri, Vika, Varma, Subhash, Sharma, Navneet, Mahi, Sushil, Singh, Paramjeet, Khandelwal, Niranjan K“…These were followed by cerebral malaria, leptospirosis, and brain abscess as the cause of febrile encephalopathy in adults. …”
Publicado 2010
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26091por Mnyone, Ladslaus L, Koenraadt, Constantianus JM, Lyimo, Issa N, Mpingwa, Monica W, Takken, Willem, Russell, Tanya L“…BACKGROUND: Entomopathogenic fungi, Metarhizium anisopliae and Beauveria bassiana, are promising bio-pesticides for application against adult malaria mosquito vectors. An understanding of the behavioural responses of mosquitoes towards these fungi is necessary to guide development of fungi beyond the 'proof of concept' stage and to design suitable intervention tools. …”
Publicado 2010
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26092por Linard, Catherine, Alegana, Victor A, Noor, Abdisalan M, Snow, Robert W, Tatem, Andrew J“…Comparison tests between the new dataset and existing population datasets revealed important differences in population size distributions, and in population at risk of malaria estimates. These differences are particularly important in more densely populated areas and strongly depend on the settlement data used in the modelling approach. …”
Publicado 2010
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26093por Weetman, David, Wilding, Craig S., Steen, Keith, Morgan, John C., Simard, Frédéric, Donnelly, Martin J.“…We quantified and investigated the impacts of these key variables in a large-scale association study of a strongly selected trait of medical importance: pyrethroid resistance in the African malaria vector Anopheles gambiae. METHODOLOGY/PRINCIPAL FINDINGS: We genotyped ≈1500 resistance-phenotyped wild mosquitoes from Ghana and Cameroon using a 1536-SNP array enriched for candidate insecticide resistance gene SNPs. …”
Publicado 2010
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26094“…BACKGROUND: Artemether-lumefantrine is one of the most widely used anti-malarial drug combinations in the world with excellent tolerability and cure rates in adult and paediatric patients with uncomplicated falciparum malaria. The aim of this study was to evaluate the pharmacokinetics of artemether and its active metabolite, dihydroartemisinin, in healthy Pakistani volunteers. …”
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26095“…BACKGROUND: Malaria is the most prominent disease in the Democratic Republic of the Congo (DRC), and long-lasting insecticide-treated nets (LLINs) have been distributed free of charge since 2006 to combat the disease. …”
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26096“…Gullain Barre syndrome, Parkinson’s disease, and cerebral malaria were relatively rare causes of neurologic admissions in this study. …”
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26097por Lambin, Eric F, Tran, Annelise, Vanwambeke, Sophie O, Linard, Catherine, Soti, Valérie“…The case studies concern West Nile virus transmission in Senegal, tick-borne encephalitis incidence in Latvia, sandfly abundance in the French Pyrenees, Rift Valley Fever in the Ferlo (Senegal), West Nile Fever and the risk of malaria re-emergence in the Camargue, and rodent-borne Puumala hantavirus and Lyme borreliosis in Belgium. …”
Publicado 2010
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26098por van Herpen, Teun W. J. M., Cankar, Katarina, Nogueira, Marilise, Bosch, Dirk, Bouwmeester, Harro J., Beekwilder, Jules“…Here the potential of this plant is explored for rapid production of precursors of artemisinin, a sesquiterpenoid compound that is used for malaria treatment. METHODOLOGY/PRINCIPAL FINDINGS: Biosynthetic genes leading to artemisinic acid, a precursor of artemisinin, were combined and expressed in N. benthamiana by agro-infiltration. …”
Publicado 2010
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26099por Beiersmann, Claudia, De Allegri, Manuela, Tiendrebéogo, Justin, Yé, Maurice, Jahn, Albrecht, Mueller, Olaf“…BACKGROUND: Insecticide-treated nets (ITNs) have been confirmed to be a very effective tool in malaria control. Two different delivery strategies for roll-out of ITN programmes have been the focus of debate in the last years: free distribution and distribution through commercial marketing systems. …”
Publicado 2010
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26100por Mnyone, Ladslaus L., Kirby, Matthew J., Mpingwa, Monica W., Lwetoijera, Dickson W., Knols, Bart G. J., Takken, Willem, Koenraadt, Constantianus J. M., Russell, Tanya L.“…An understanding of host–pathogen interaction with respect to these physiological characteristics of the host is essential if we are to develop fungal formulations capable of reducing malaria transmission under field conditions. Here, two independent bioassays were conducted to study the effect of age and blood-feeding status on fungal infection and survival of Anopheles gambiae s.s. …”
Publicado 2010
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