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26381por Knapp, Jennifer, Macdonald, Michael, Malone, David, Hamon, Nicholas, Richardson, Jason H.“…Malaria vector control technology has remained largely static for decades and there is a pressing need for innovative control tools and methodology to radically improve the quality and efficiency of current vector control practices. …”
Publicado 2015
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26382por Doll, Tais A.P.F., Neef, Tobias, Duong, Nha, Lanar, David E., Ringler, Philippe, Müller, Shirley A., Burkhard, Peter“…Successful vaccine development remains a huge challenge for infectious diseases such as malaria, HIV and influenza. As a novel way to present antigenic epitopes to the immune system, we have developed icosahedral self-assembling protein nanoparticles (SAPNs) to serve as a prototypical vaccine platform for infectious diseases. …”
Publicado 2015
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26383“…Plasmodium falciparum is an apicomplexan parasite and the etiological agent of severe human malaria. The complex P. falciparum life cycle is supported by a diverse repertoire of surface proteins including the family of 6-Cys s48/45 antigens. …”
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26384por Pulcini, Serena, Staines, Henry M., Lee, Andrew H., Shafik, Sarah H., Bouyer, Guillaume, Moore, Catherine M., Daley, Daniel A., Hoke, Matthew J., Altenhofen, Lindsey M., Painter, Heather J., Mu, Jianbing, Ferguson, David J. P., Llinás, Manuel, Martin, Rowena E., Fidock, David A., Cooper, Roland A., Krishna, Sanjeev“…Mutations in the Plasmodium falciparum chloroquine resistance transporter, PfCRT, are the major determinant of chloroquine resistance in this lethal human malaria parasite. Here, we describe P. falciparum lines subjected to selection by amantadine or blasticidin that carry PfCRT mutations (C101F or L272F), causing the development of enlarged food vacuoles. …”
Publicado 2015
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26385por Torgerson, Paul R., Hagan, José E., Costa, Federico, Calcagno, Juan, Kane, Michael, Martinez-Silveira, Martha S., Goris, Marga G. A., Stein, Claudia, Ko, Albert I., Abela-Ridder, Bernadette“…The study findings indicate that highest burden estimates occur in resource-poor tropical countries, which include regions of Africa where the burden of leptospirosis has been under-appreciated and possibly misallocated to other febrile illnesses such as malaria.…”
Publicado 2015
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26386por Pinto-Almeida, António, Mendes, Tiago, Armada, Ana, Belo, Silvana, Carrilho, Emanuel, Viveiros, Miguel, Afonso, Ana“…BACKGROUND: Schistosomiasis is a neglected disease caused by a trematode of the genus Schistosoma that is second only to malaria in public health significance in Africa, South America, and Asia. …”
Publicado 2015
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26387por Asampong, Emmanuel, Dwuma-Badu, Kwaku, Stephens, Judith, Srigboh, Roland, Neitzel, Richard, Basu, Niladri, Fobil, Julius N.“…These included physical injuries, chest and respiratory tract associated symptoms, malaria, headaches, body pains and stomach discomfort. …”
Publicado 2015
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26388“…Intriguingly, traps baited with 1-octen-3-ol captured significantly more females of the malaria mosquito, Anopheles gambiae, and the yellow fever mosquito, Aedes aegypti, than control traps, but failed to attract the southern house mosquito, Culex quinquefasciatus. …”
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26389“…There is an ongoing need for new adjuvants to facilitate development of vaccines against HIV, tuberculosis, malaria and cancer, amongst many others. Unfortunately, the most potent adjuvants are often associated with toxicity and safety issues. …”
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26390por Enwere, Godwin C., Paranjape, Gandhali, Kulkarni, Prasad S., Ginde, Manisha, Hartmann, Katharina, Viviani, Simonetta, Chaumont, Julie, Martellet, Lionel, Makadi, Marie-Francoise, Ivinson, Karen, Marchetti, Elisa, Herve, Jacques, Kertson, Kim, LaForce, F. Marc, Preziosi, Marie-Pierre“…These challenges included the need for uniformity of methods, timely reporting in the context of frequent communication problems, occurrence of seasonal diseases such as malaria and rotavirus diarrhea, and healthcare systems that required improvement. …”
Publicado 2015
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26391por Woolhouse, Mark E. J., Thumbi, Samuel M., Jennings, Amy, Chase-Topping, Margo, Callaby, Rebecca, Kiara, Henry, Oosthuizen, Marinda C., Mbole-Kariuki, Mary N., Conradie, Ilana, Handel, Ian G., Poole, E. Jane, Njiiri, Evalyne, Collins, Nicola E., Murray, Gemma, Tapio, Miika, Auguet, Olga Tosas, Weir, Willie, Morrison, W. Ivan, Kruuk, Loeske E. B., Bronsvoort, B. Mark de C., Hanotte, Olivier, Coetzer, Koos, Toye, Philip G.“…These findings can be generalized to many other infectious diseases, including human malaria, and illustrate how co-infections can play a key role in determining population-level patterns of morbidity and mortality due to parasite infections.…”
Publicado 2015
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26392“…The mean packed cell volume in subjects with sickle cell anaemia was 8.8±1.5%; the only case of haemoglobin SC had packed cell volume of 20%, while the non-sickle cell disease patients had a normal PCV. Malaria was present in 80.4% of them. CONCLUSION: Febrile convulsion remains a common cause of hospitalisation. …”
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26393por Ranasinghe, Shamika, Ansumana, Rashid, Bockarie, Alfred S., Bangura, Umaru, Jimmy, David Henry, Stenger, David A., Jacobsen, Kathryn H.“…The bed net use rate significantly increased (p < 0.01) from before the campaign to after the universal LLIN distribution campaign in all demographic, socioeconomic, and health behaviour groups, even though reported use during the campaign dropped significantly. CONCLUSION: Future malaria prevention efforts will need to promote consistent use of LLINs and address any remaining disparities in insecticide-treated bed net (ITN) use.…”
Publicado 2015
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26394por do Carmo, Dominique F. M., Amaral, Ana Claudia F., Machado, Marta, Lopes, Dinora, Echevarria, Aurea, Rosário, Virgílio E., Silva, Jefferson Rocha de A.“…BACKGROUND: Ampelozizyphus amazonicus Ducke, a plant that is widely used by the population of the Amazonian region to prevent and treat malaria, was investigated in this work, which describes, for the first time, the antiplasmodial activity of its extracts and associates this activity with its isolated constituents. …”
Publicado 2015
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26395por Cross, James H., Bradbury, Richard S., Fulford, Anthony J., Jallow, Amadou T., Wegmüller, Rita, Prentice, Andrew M., Cerami, Carla“…However, iron lies at the center of host-pathogen competition for nutritional resources and recent trials of iron administration in African and Asian children have resulted in significant excesses of serious adverse events including hospitalizations and deaths. Increased rates of malaria, respiratory infections, severe diarrhea and febrile illnesses of unknown origin have all been reported, but the mechanisms are unclear. …”
Publicado 2015
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26396por Domínguez-Bernal, Gustavo, Horcajo, Pilar, Orden, José A., Ruiz-Santa-Quiteria, José A., De La Fuente, Ricardo, Ordóñez-Gutiérrez, Lara, Martínez-Rodrigo, Abel, Mas, Alicia, Carrión, Javier“…The leishmanioses represent the second-largest parasitic killer in the world after malaria. Recently, we succeeded in generating a plasmid DNA (pCMV-HISA70m2A) and demonstrated that immunized mice were protected against L. major challenge. …”
Publicado 2015
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26397por Macpherson, Eleanor E, Adams, Emily R, Bockarie, Moses J, Hollingsworth, T Deirdre, Kelly-Hope, Louise A, Lehane, Mike, Kovacic, Vanja, Harrison, Robert A, Paine, Mark JI, Reimer, Lisa J, Torr, Stephen J“…LSTM and its partners are world leaders in developing and delivering interventions to control vector-borne NTDs and malaria, particularly in hard-to-reach settings in Africa. …”
Publicado 2015
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26398por Shahi, Preeti, Trebicz-Geffen, Meirav, Nagaraja, Shruti, Alterzon-Baumel, Sharon, Hertz, Rivka, Methling, Karen, Lalk, Michael, Ankri, Serge“…Entamoeba histolytica is an obligate protozoan parasite of humans, and amebiasis, an infectious disease which targets the intestine and/or liver, is the second most common cause of human death due to a protozoan after malaria. Although amebiasis is usually asymptomatic, E. histolytica has potent pathogenic potential. …”
Publicado 2016
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26399por Okebe, Joseph, Mwesigwa, Julia, Agbla, Schadrac C., Sanya-Isijola, Frank, Abubakar, Ismaela, D’Alessandro, Umberto, Jaye, Assan, Bojang, Kalifa“…The study defines reference intervals for haematological and biochemistry parameters and examines the effect of seasonality in malaria transmission. METHODS: Blood samples collected from clinically healthy children, aged 12–59 months, in two surveys during the dry and wet season in the Upper River region of The Gambia were processed and the data analysed to generate reference intervals based on the 2.5(th) and 97.5(th) percentiles of the data. …”
Publicado 2016
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26400por Raiten, Daniel J, Neufeld, Lynnette M, De-Regil, Luz-Maria, Pasricha, Sant-Rayn, Darnton-Hill, Ian, Hurrell, Richard, Murray-Kolb, Laura E, Nair, K Madhavan, Wefwafwa, Terry, Kupka, Roland, Phall, Modou Cheyassin, Sakr Ashour, Fayrouz A“…Recent reports indicate potential increased adverse risks when iron is provided in areas with high infection burdens (e.g., malaria). This paradox has weakened iron intervention programs. …”
Publicado 2016
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