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26421“…Although this immunotolerogenic environment is favorable in the setting of organ transplantation, it is detrimental in chronic infectious liver diseases like hepatitis B or C, malaria, schistosomiasis or tumorigenesis, leading to pathogen persistence and weak anti-tumor effects. …”
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26422por Ruan, Ju-Xin, Li, Jian-Xu, Fang, Xin, Wang, Ling-Jian, Hu, Wen-Li, Chen, Xiao-Ya, Yang, Chang-Qing“…Artemisia annua, an annual herb used in traditional Chinese medicine, produces a wealth of monoterpenes and sesquiterpenes, including the well-known sesquiterpene lactone artemisinin, an active ingredient in the treatment for malaria. Here we report three new monoterpene synthases of A. annua. …”
Publicado 2016
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26423A Toxoplasma gondii Ortholog of Plasmodium GAMA Contributes to Parasite Attachment and Cell Invasion“…IMPORTANCE Toxoplasma gondii is a successful human pathogen in the same phylum as malaria-causing Plasmodium parasites. Invasion of a host cell is an essential process that begins with secretion of adhesive proteins onto the parasite surface for attachment and subsequent penetration of the host cell. …”
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26424“…An interesting way to move forward in integrating the micro- and macro-level assessment might be by integrating computable general equilibrium (CGE) models as part of the evaluation framework, as was recently performed for pandemic flu and malaria vaccination.…”
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26425por Blagborough, A.M., Musiychuk, K., Bi, H., Jones, R.M., Chichester, J.A., Streatfield, S., Sala, K.A., Zakutansky, S.E., Upton, L.M., Sinden, R.E., Brian, I., Biswas, S., Sattabonkot, J., Yusibov, V.“…Malaria transmission blocking (TB) vaccines (TBVs) directed against proteins expressed on the sexual stages of Plasmodium parasites are a potentially effective means to reduce transmission. …”
Publicado 2016
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26426Desiccation tolerance in Anopheles coluzzii: the effects of spiracle size and cuticular hydrocarbonspor Arcaz, Arthur C., Huestis, Diana L., Dao, Adama, Yaro, Alpha S., Diallo, Moussa, Andersen, John, Blomquist, Gary J., Lehmann, Tovi“…The African malaria mosquitoes Anopheles gambiae and Anopheles coluzzii range over forests and arid areas, where they withstand dry spells and months-long dry seasons, suggesting variation in their desiccation tolerance. …”
Publicado 2016
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26427por Le Gonidec, Erwan, Maquart, Marianne, Duron, Sandrine, Savini, Hélène, Cazajous, Geraldine, Vidal, Pierre-Olivier, Chenilleau, Marie-Caroline, Roseau, Jean-Baptiste, Benois, Alain, Dehan, Céline, Kugelman, Jeffrey, Leparc-Goffart, Isabelle, Védy, Serge“…Based on these results we have determined that screening for Malaria and the presence of the arthralgia, gastro-intestinal symptoms and lymphopenia < 1,000cell/ mm3 allows for negative predictive value and specificity of diagnosis in isolated areas superior to 80% up to day 6. …”
Publicado 2016
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26428por Chaurio, Ricardo A., Pacheco, M. Andreína, Cornejo, Omar E., Durrego, Ester, Stanley, Craig E., Castillo, Andreína I., Herrera, Sócrates, Escalante, Ananias A.“…Transmission-blocking (TB) vaccines are considered an important tool for malaria control and elimination. Among all the antigens characterized as TB vaccines against Plasmodium vivax, the ookinete surface proteins Pvs28 and Pvs25 are leading candidates. …”
Publicado 2016
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26429por Ghashghaeinia, Mehrdad, Giustarini, Daniela, Koralkova, Pavla, Köberle, Martin, Alzoubi, Kousi, Bissinger, Rosi, Hosseinzadeh, Zohreh, Dreischer, Peter, Bernhardt, Ingolf, Lang, Florian, Toulany, Mahmoud, Wieder, Thomas, Mojzikova, Renata, Rossi, Ranieri, Mrowietz, Ulrich“…The specific G6PDH inhibitory effect of these compounds may be exploited for the treatment of human diseases with high NADPH and GSH consumption rates, including malaria, trypanosomiasis, cancer or obesity.…”
Publicado 2016
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26430por Crosnier, Cécile, Iqbal, Zamin, Knuepfer, Ellen, Maciuca, Sorina, Perrin, Abigail J., Kamuyu, Gathoni, Goulding, David, Bustamante, Leyla Y., Miles, Alistair, Moore, Shona C., Dougan, Gordon, Holder, Anthony A., Kwiatkowski, Dominic P., Rayner, Julian C., Pleass, Richard J., Wright, Gavin J.“…Population-based genome sequencing of Plasmodium falciparum, the parasite responsible for the most severe form of malaria, has highlighted two related polymorphic genes called dblmsp and dblmsp2, which encode Duffy binding-like (DBL) domain-containing proteins located on the merozoite surface but whose function remains unknown. …”
Publicado 2016
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26431por Anand, Gaurav, Reddy, K. Sony, Pandey, Alok Kumar, Mian, Syed Yusuf, Singh, Hina, Mittal, Shivani Arora, Amlabu, Emmanuel, Bassat, Quique, Mayor, Alfredo, Chauhan, Virander Singh, Gaur, Deepak“…Erythrocyte invasion by Plasmodium falciparum merozoites is central to blood-stage infection and malaria pathogenesis. This intricate process is coordinated by multiple parasite adhesins that bind erythrocyte receptors and mediate invasion through several alternate pathways. …”
Publicado 2016
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26432por Voss, Christiane, Ehrenman, Karen, Mlambo, Godfree, Mishra, Satish, Kumar, Kota Arun, Sacci, John B., Sinnis, Photini, Coppens, Isabelle“…These observations reveal that Plasmodium ATG8 is a key effector in the development of merozoites by controlling microneme clearance and apicoplast proliferation and that dysregulation in ATG8 levels is detrimental for malaria infectivity.…”
Publicado 2016
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26433Quantitative insertion-site sequencing (QIseq) for high throughput phenotyping of transposon mutantspor Bronner, Iraad F., Otto, Thomas D., Zhang, Min, Udenze, Kenneth, Wang, Chengqi, Quail, Michael A., Jiang, Rays H.Y., Adams, John H., Rayner, Julian C.“…The approach was developed using piggyBac mutants in the human malaria parasite Plasmodium falciparum but should be applicable to many other eukaryotic genomes. …”
Publicado 2016
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26434por Alemu, Fekadu Mazengia, Yalew, Alemayehu Worku, Fantahun, Mesganaw, Ashu, Eta Ebasi“…Covariates principally included malnutrition and other co-morbidities such as malaria and HIV. CONCLUSIONS AND PUBLIC HEALTH IMPLICATIONS: There is growing evidence in published literature suggesting that ART might be causing adverse birth outcomes among pregnant women in developing countries. …”
Publicado 2015
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26435por Madan, Jason, Ades, Anthony E., Price, Malcolm, Maitland, Kathryn, Jemutai, Julie, Revill, Paul, Welton, Nicky J.“…We illustrate the methods using an example of fluid resuscitation in African children with severe malaria.…”
Publicado 2014
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26436por Bromley, Mike, Johns, Anna, Davies, Emma, Fraczek, Marcin, Mabey Gilsenan, Jane, Kurbatova, Natalya, Keays, Maria, Kapushesky, Misha, Gut, Marta, Gut, Ivo, Denning, David W., Bowyer, Paul“…Recent estimates of the global burden of fungal disease suggest that that their incidence has been drastically underestimated and that mortality may rival that of malaria or tuberculosis. Azoles are the principal class of antifungal drug and the only available oral treatment for fungal disease. …”
Publicado 2016
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26437por Sambili, Benatus, Kimambo, Ronald, Peng, Yun, Ishunga, Elison, Matasha, Edna, Matumu, Godfrey, Noronha, Rita, Ngilangwa, David P.“…Malaria and iron-deficient anemia during pregnancy pose considerable risks for the mother and newborn. …”
Publicado 2016
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26438por Wang, Chuan, Hart, Matthew, Chui, Cecilia, Ajuogu, Augustine, Brian, Iona J., de Cassan, Simone C., Borrow, Persephone, Draper, Simon J., Douglas, Alexander D.“…There is great interest in the development of Ab-inducing subunit vaccines targeting infections, including HIV, malaria, and Ebola. We previously reported that adenovirus vectored vaccines are potent in priming Ab responses, but uncertainty remains regarding the optimal approach for induction of humoral immune responses. …”
Publicado 2016
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26439por Vembar, Shruthi Sridhar, Seetin, Matthew, Lambert, Christine, Nattestad, Maria, Schatz, Michael C., Baybayan, Primo, Scherf, Artur, Smith, Melissa Laird“…The application of next-generation sequencing to estimate genetic diversity of Plasmodium falciparum, the most lethal malaria parasite, has proved challenging due to the skewed AT-richness [∼80.6% (A + T)] of its genome and the lack of technology to assemble highly polymorphic subtelomeric regions that contain clonally variant, multigene virulence families (Ex: var and rifin). …”
Publicado 2016
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26440por Shrivastava, Manisha, Shah, Nehal, Navaid, Seema, Agarwal, Kalpana, Sharma, Gourav“…The maximum number of donors deferred (28.2%) due to a history of jaundice (permanent) followed by 19.4% due to low hemoglobin (temporary). History of malaria, intake of medicines, infections, underweight, last blood donation within 3 months (temporary deferral), and history of heart and lung diseases, diabetes, and with suspicious identity (permanent deferral) were other major causes identified. …”
Publicado 2016
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