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26621por Thakkar, Nilay, Green, Justin A., Koh, Gavin C. K. W., Duparc, Stephan, Tenero, David, Goyal, Navin“…Food and Drug Administration (FDA) for the radical cure of acute Plasmodium vivax malaria, which is the first new treatment in almost 60 years. …”
Publicado 2018
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26622“…RESULTS: The spectrum of diseases that presented with bleeding was 47 patients with malaria (23.5%) followed by 36 acute undifferentiated febrile illness (18.0%), 33 dengue (16.5%), 30 leptospirosis (15.0%), 31 acute fulminant hepatitis (15.5%), 14 sepsis (7.0%), and the rest nine miscellaneous causes. …”
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26623por Mulatier, Margaux, Porciani, Angélique, Nadalin, Louis, Ahoua Alou, Ludovic Phamien, Chandre, Fabrice, Pennetier, Cédric, Dormont, Laurent, Cohuet, Anna“…(Giles) (Diptera: Culicidae) and Aedes albopictus (Skuse) (Diptera: Culicidae), respective vectors of malaria parasites and arboviruses such as dengue, chikungunya, and Zika viruses. …”
Publicado 2018
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26624por Horumpende, Pius G., Said, Sophia H., Mazuguni, Festo S., Antony, Magreth L., Kumburu, Happiness H., Sonda, Tolbert B., Mwanziva, Charles E., Mshana, Stephen E., Mmbaga, Blandina T., Kajeguka, Debora C., Chilongola, Jaffu O.“…The most common symptoms that led to self-medication were cough (51.17%), headache/ fever/ malaria (25.57%) and diarrhoea (21.59%). The most common reasons for self-medication were emergency illness (24.00%), health facility charges (20.33%), proximity of pharmacy to home (17.00%) and no reason (16.66%). …”
Publicado 2018
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26625“…INTRODUCTION: The use of antimalarial chloroquine in malaria-endemic regions of Africa is rampant and it is not uncommon to find individuals taken the drug concurrent with alcohol. …”
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26626por Pant, A., Kumar, R., Wani, N. A., Verma, S., Sharma, R., Pande, V., Saxena, A. K., Dixit, R., Rai, R., Pandey, K. C.“…Collectively, for the first time we provide a framework for blocking the allosteric site of crucial haemoglobinases of the human malaria parasite. Targeting the allosteric site could provide high selectivity and less vulnerable to drug resistance.…”
Publicado 2018
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26627“…Documented infectious complications were dominated by malaria (27.5%). Decompensated anemia accounted for 30.4%. …”
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26628por Bae, Su-Jin, Choi, Jae-Won, Park, Byung-Joon, Lee, Jina, Jo, Eun-Kyeong, Lee, Young-Ha, Kim, Sung-Bae, Yuk, Jae-Min“…Stellaria dichotoma var. lanceolata (SdLv), a member of the Caryophyllaceae, is a traditional herbal medicine that has been used to treat fever, night sweats, and malaria in East Asia. Inflammation plays an essential role in both host defense and pathogenesis during infection by diverse intracellular pathogens. …”
Publicado 2018
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26629“…Seizure management must occur simultaneously with the diagnostic assessment, which should include addressing life threatening causes (e.g. hypoglycaemia, malaria) and with attention given to the most likely aetiology in a particular region or setting. …”
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26630“…Dihydroartemisinin (DHA), the primary of artemisinin extracted from the traditional Chinese medicine Artemisia annua, has been used in malaria treatment for a long time. Recently, many studies have indicated that, in addition to antimalarial effects, DHA also exhibits anticancer activity in certain types of neoplasms, including ovarian cancer. …”
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26631por Cheng, Qianqian, Liu, Jian, Pei, Yujun, Zhang, Yaolin, Zhou, Dawang, Pan, Weiqing, Zhang, Jiyan“…However, its contribution to T cell-mediated immunity to blood-stage malaria remains unclear. Here using an experimental model induced by Plasmodium yoelii 17XNL, and conditional knockout mice with T cell-specific deficiency of crucial components of neddylation pathway, we demonstrate activation of neddylation in T cells during blood-stage Plasmodium infection is essential for parasite control and host survival. …”
Publicado 2018
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26632“…Quinine was first isolated in 1820 and is still acknowledged in the therapy of chloroquine-resistant falciparum malaria; in lower dosage quinine has been used as treatment for leg cramps since the 1940s. …”
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26633por Boechat, Núbia, Pinheiro, Luiz C. S., Silva, Thiago S., Aguiar, Anna C. C., Carvalho, Alcione S., Bastos, Monica M., Costa, Carolina C. P., Pinheiro, Sergio, Pinto, Angelo C., Mendonça, Jorge S., Dutra, Karen D. B., Valverde, Alessandra L., Santos-Filho, Osvaldo A., Ceravolo, Isabela P., Krettli, Antoniana U.“…According to the World Health Organization, half of the World’s population, approximately 3.3 billion people, is at risk for developing malaria. Nearly 700,000 deaths each year are associated with the disease. …”
Publicado 2012
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26634por Lansche, Christine, Dasanna, Anil K., Quadt, Katharina, Fröhlich, Benjamin, Missirlis, Dimitris, Tétard, Marilou, Gamain, Benoit, Buchholz, Bernd, Sanchez, Cecilia P., Tanaka, Motomu, Schwarz, Ulrich S., Lanzer, Michael“…Sickle cell trait, a common hereditary blood disorder, protects carriers from severe disease in infections with the human malaria parasite Plasmodium falciparum. Protection is associated with a reduced capacity of parasitized erythrocytes to cytoadhere to the microvascular endothelium and cause vaso-occlusive events. …”
Publicado 2018
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26635por Zhong, Yijun, Li, Ling, Hao, Xiaolong, Fu, Xueqing, Ma, Yanan, Xie, Lihui, Shen, Qian, Kayani, Sadaf, Pan, Qifang, Sun, Xiaofen, Tang, Kexuan“…Artemisinin is well known for its irreplaceable curative effect on the devastating parasitic disease, Malaria. This sesquiterpenoid is specifically produced in Chinese traditional herbal plant Artemisia annua. …”
Publicado 2018
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26636por Neveu, Gaëlle, Dupuy, Florian, Ladli, Meriem, Barbieri, Daniela, Naissant, Bernina, Richard, Cyrielle, Martins, Rafael M., Lopez-Rubio, Jose-Juan, Bachmann, Anna, Verdier, Frédérique, Lavazec, Catherine“…Plasmodium falciparum gametocytes, the sexual stages responsible for malaria parasite transmission, develop in the human bone marrow parenchyma in proximity to the erythroblastic islands. …”
Publicado 2018
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26637por Demas, Allison R., Sharma, Aabha I., Wong, Wesley, Early, Angela M., Redmond, Seth, Bopp, Selina, Neafsey, Daniel E., Volkman, Sarah K., Hartl, Daniel L., Wirth, Dyann F.“…Drug resistance is an obstacle to global malaria control, as evidenced by the recent emergence and rapid spread of delayed artemisinin (ART) clearance by mutant forms of the PfKelch13 protein in Southeast Asia. …”
Publicado 2018
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26638por Jones, William, Kulma, Katarzyna, Bensch, Staffan, Cichoń, Mariusz, Kerimov, Anvar, Krist, Miloš, Laaksonen, Toni, Moreno, Juan, Munclinger, Pavel, Slater, Fred M., Szöllősi, Eszter, Visser, Marcel E., Qvarnström, Anna“…In this study, we investigate how haemosporidian (avian malaria) prevalence and lineage diversity vary in two, closely related species of passerine birds; the pied flycatcher Ficedula hypoleuca and the collared flycatcher F. albicollis in both allopatry and sympatry. …”
Publicado 2018
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26639por Loesbanluechai, Duangkamon, Kotanan, Namfon, de Cozar, Cristina, Kochakarn, Theerarat, Ansbro, Megan R., Chotivanich, Kesinee, White, Nicholas J., Wilairat, Prapon, Lee, Marcus C.S., Gamo, Francisco Javier, Sanz, Laura Maria, Chookajorn, Thanat, Kümpornsin, Krittikorn“…Artemisinin derivatives and their partner drugs in artemisinin combination therapies (ACTs) have played a pivotal role in global malaria mortality reduction during the last two decades. …”
Publicado 2018
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26640por Papathanos, Philippos Aris, Bourtzis, Kostas, Tripet, Frederic, Bossin, Hervé, Virginio, Jair Fernandes, Capurro, Margareth Lara, Pedrosa, Michelle Cristine, Guindo, Amadou, Sylla, Lakamy, Coulibaly, Mamadou B., Yao, Franck Adama, Epopa, Patric Stephane, Diabate, Abdoulaye“…A number of programs targeting Aedes and Anopheles mosquitoes, vectors of human arboviruses and malaria respectively, are currently being developed or deployed in many parts of the world. …”
Publicado 2018
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