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26781por Hooft, Anneka, Nabukalu, Doreen, Mwanga-Amumpaire, Juliet, Gardiner, Michael A., Sundararajan, Radhika“…Febrile illnesses, such as malaria and pneumonia, are among the most common causes of mortality in children younger than 5 years in Uganda outside of the neonatal period. …”
Publicado 2020
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26782“…Descriptive statistics and Chisquare test at α=0.05 were used for data analysis. RESULTS: Perceived malaria (52.4%), acne (36.2%), menstrual pain (17.0%) and depression (3.0%) were the common health problems adolescents sought health care for. …”
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26783por Paul, Aditya S., Miliu, Alexandra, Paulo, Joao A., Goldberg, Jonathan M., Bonilla, Arianna M., Berry, Laurence, Seveno, Marie, Braun-Breton, Catherine, Kosber, Aziz L., Elsworth, Brendan, Arriola, Jose S. N., Lebrun, Maryse, Gygi, Steven P., Lamarque, Mauld H., Duraisingh, Manoj T.“…Asexual proliferation of the Plasmodium parasites that cause malaria follows a developmental program that alternates non-canonical intraerythrocytic replication with dissemination to new host cells. …”
Publicado 2020
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26784“…Piliostigma thonningii is traditionally used for the management of inflammation, malaria fever, rheumatism, and insanity, among other diseases caused by a disturbed redox state in the body. …”
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26785por Della Porta, Alessandra, Bornstein, Kasha, Coye, Austin, Montrief, Tim, Long, Brit, Parris, Mehruba Anwar“…DISCUSSION: Chloroquine and hydroxychloroquine are aminoquinoline derivatives widely used in the treatment of rheumatologic diseases including systemic lupus erythematosus and rheumatoid arthritis as well as for malaria prophylaxis. In early 2020, anecdotal reports and preliminary data suggested utility of hydroxychloroquine in attenuating viral loads and symptoms in patients with SARS-CoV-2 infection. …”
Publicado 2020
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26786por Lopes, Danielle de Sousa, dos Santos, Uener Ribeiro, Dos Anjos, Danielle Oliveira, da Silva Júnior, Lauro José Caires, de Paula, Vanderlúcia Fonseca, Vannier-Santos, Marcos André, Silva-Jardim, Izaltina, Castro-Gomes, Thiago, Pirovani, Carlos Priminho, Lima-Santos, Jane“…We have previously shown that a fungus from genus Trichoderma can be used for treating cerebral malaria in mouse models and inhibit biofilm formation. …”
Publicado 2020
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26787por Alves, Vinícius Santos, Leite-Aguiar, Raíssa, Silva, Joyce Pereira da, Coutinho-Silva, Robson, Savio, Luiz Eduardo Baggio“…In this review we discuss the beneficial or deleterious effects of various components of the purinergic signaling pathway in infectious diseases that affect the CNS, including human immunodeficiency virus (HIV-1) infection, herpes simplex virus type 1 (HSV-1) infection, bacterial meningitis, sepsis, cryptococcosis, toxoplasmosis, and malaria. We also provide a description of this signaling pathway in emerging viral infections with neurological implications such as Zika and SARS-CoV-2.…”
Publicado 2020
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26788“…Assessment of mefloquine plasma concentrations in treated mice showed that levels were reached which are close to serum concentrations that are achieved in humans during long-term malaria prophylaxis. Mefloquine might be applied in human AE patients as a salvage treatment. …”
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26789por Graef, Katy M., Okoye, Ifeoma, Ohene Oti, Naomi O., Dent, Jennifer, Odedina, Folakemi T.“…PURPOSE: In a dramatic reversal of longstanding trends, cancer now kills more Africans than malaria. Despite Africa’s growing cancer burden, individuals of African descent, notably those residing in Africa, remain drastically under-represented in cancer clinical trials. …”
Publicado 2020
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26790por Garten, Matthias, Beck, Josh R., Roth, Robyn, Tenkova-Heuser, Tatyana, Heuser, John, Istvan, Eva S., Bleck, Christopher K. E., Goldberg, Daniel E., Zimmerberg, Joshua“…The malaria parasite interfaces with its host erythrocyte (RBC) using a unique organelle, the parasitophorous vacuole (PV). …”
Publicado 2020
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26791Pyrethroid and Carbamate Resistance in Anopheles funestus Giles along Lake Kariba in Southern Zambiapor Chanda, Javan, Saili, Kochelani, Phiri, Foustina, Stevenson, Jennifer C., Mwenda, Mulenga, Chishimba, Sandra, Mulube, Conceptor, Mambwe, Brenda, Lungu, Christopher, Earle, Duncan, Bennett, Adam, Eisele, Thomas P., Kamuliwo, Mulakwa, Steketee, Richard W., Keating, Joseph, Miller, John M., Sikaala, Chadwick H.“…To prevent the development of resistance and reduce the underlying vectorial capacity of mosquitoes in areas targeted for malaria elimination, an effective integrated vector management strategy is needed.…”
Publicado 2020
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26792por Stevenson, Alex, Kirresh, Ali, Conway, Samuel, White, Laura, Ahmad, Mahmood, Little, Callum“…Despite having reasonable safety profiles in the treatment of malaria and certain autoimmune conditions, both drugs are known to have potential cardiotoxic side effects. …”
Publicado 2020
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26793por Makhoba, Xolani H, Viegas Jr, Claudio, Mosa, Rebamang A, Viegas, Flávia P D, Pooe, Ofentse J“…This review will discuss the potential impact of multi-target drug approach on various complex diseases with focus on malaria, tuberculosis (TB), diabetes and neurodegenerative diseases as the main representatives of multifactorial diseases. …”
Publicado 2020
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26794por Molnár, Petra, Orbán, Ágnes, Izrael, Richard, Babai, Réka, Marton, Lívia, Butykai, Ádám, Karl, Stephan, Vértessy, Beáta G., Kézsmárki, István“…Emergence of resistant Plasmodium species makes drug efficacy testing a crucial part of malaria control. Here we describe a novel assay for sensitive, fast and simple drug screening via the magneto-optical detection of hemozoin, a natural biomarker formed during the hemoglobin metabolism of Plasmodium species. …”
Publicado 2020
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26795por Kam, Yiu‐Wing, Ahmed, Mohamed Yousif, Amrun, Siti Naqiah, Lee, Bernett, Refaie, Tarik, Elgizouli, Kamla, Fong, Siew‐Wai, Renia, Laurent, Ng, Lisa FP“…Nonetheless, eight disease‐specific immune mediators were identified as potential biomarkers for dengue (MIP‐1α, MCP‐1), malaria (TNF‐α), streptococcal and meningococcal (eotaxin, GRO‐α, RANTES, SDF‐1α and PIGF‐1) infections, with high specificity and sensitivity profiles. …”
Publicado 2020
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26796“…The larvicidal activity of the bags treated with pectin-cedar wood nanocapsules was assessed against malaria vector, Anopheles culicifacies and 98% mortality was recorded till 4 weeks, this suggests its potential and hassle free applications in controlling mosquito vector.…”
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26797por Xu, Yi, Baylink, David J., Chen, Chien-Shing, Reeves, Mark E., Xiao, Jeffrey, Lacy, Curtis, Lau, Eric, Cao, Huynh“…Anti-viral infection. Anti-malaria and anti-systemic lupus erythematosus (SLE). 2. …”
Publicado 2020
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26798por Calina, Daniela, Hartung, Thomas, Docea, Anca Oana, Spandidos, Demetrios A., Egorov, Alex M., Shtilman, Michael I., Carvalho, Felix, Tsatsakis, Aristidis“…Besides, the fact that obtaining vaccines faster through deliberate infection studies of healthy people has greater benefits than risks, has been demonstrated by obtaining other vaccines in other historical pandemics such as: smallpox, influenza, malaria, typhoid fever, Dengue fever and Zika. CONCLUSIONS: One possibility to shorten the time required for the development of COVID-19 vaccines is to reduce clinical phases II and III by using human challenge studies through eliberate infection of healthy volunteers with SARS-CoV-2 after administration of the candidate vaccine. …”
Publicado 2020
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26799por Chen, Li, Chen, Haiyan, Dong, Shan, Huang, Wei, Chen, Li, Wei, Yuan, Shi, Liping, Li, Jinying, Zhu, Fengfeng, Zhu, Zhu, Wang, Yiyang, Lv, Xiuxiu, Yu, Xiaohui, Li, Hongmei, Wei, Wei, Zhang, Keke, Zhu, Lihong, Qu, Chen, Hong, Jian, Hu, Chaofeng, Dong, Jun, Qi, Renbin, Lu, Daxiang, Wang, Huadong, Peng, Shuang, Hao, Guang“…It has been suggested that chloroquine (CQ) and hydroxychloroquine (HCQ), which were primarily employed as prophylaxis and treatment for malaria, could be used to treat COVID-19. CQ and HCQ may be potential inhibitors of SARS-CoV-2 entry into host cells, which are mediated via the angiotensin-converting enzyme 2 (ACE2), and may also inhibit subsequent intracellular processes which lead to COVID-19, including damage to the cardiovascular (CV) system. …”
Publicado 2020
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26800“…BACKGROUND: The alarming spread of parasite resistance to current antimalarial agents is threatening malaria controlling efforts. This, consequently, urged the scientific community to discover novel antimalarial drugs. …”
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