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26841por Deribe, Kebede, Bakajika, Didier K, Zoure, Honorat Marie-Gustave, Gyapong, John O, Molyneux, David H, Rebollo, Maria P“…Vector control interventions conducted by other programmes, particularly malaria vector control, have had a profound effect in stopping transmission in some endemic countries in the region. …”
Publicado 2020
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26842por Gust, Juliane, Ponce, Rafael, Liles, W. Conrad, Garden, Gwenn A., Turtle, Cameron J.“…To provide insight into possible final common pathways of CNS inflammation, we place ICANS into the context of other systemic inflammatory conditions that are associated with neurologic dysfunction, including sepsis-associated encephalopathy, cerebral malaria, thrombotic microangiopathy, CNS infections, and hepatic encephalopathy. …”
Publicado 2020
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26843“…RESULTS: In total, 293 differentially expressed genes were identified and mainly enriched in cell cycle, ECM–receptor interaction, and malaria. In the PPI network, 36 hub genes were identified, of which 6 were found to play significant roles in carcinogenesis of NSCLC: CDC20, ECT2, KIF20A, MKI67, TPX2, and TYMS. …”
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26844por Midtgaard Eriksen, Camilla, Lauridsen Kujabi, Monica, Sulaiman Kanu, Aminata, Gulis, Gabriel“…In relation to the survey, the perceived causes of child mortality for ill children in the villages were mainly malaria (33.6%), diarrhea (11.6%), pneumonia (8.6%), and unknown (26%). …”
Publicado 2021
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26845por Rawat, Mukul, Kanyal, Abhishek, Sahasrabudhe, Aishwarya, Vembar, Shruthi Sridhar, Lopez-Rubio, Jose-Juan, Karmodiya, Krishanpal“…Plasmodium falciparum has evolved resistance to almost all front-line drugs including artemisinin, which threatens malaria control and elimination strategies. Oxidative stress and protein damage responses have emerged as key players in the generation of artemisinin resistance. …”
Publicado 2021
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26846“…Methods: We used several different monoclonal antibodies to test for Ago2 localisation in the human malaria parasite, P. falciparum and rodent P. berghei parasites. …”
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26847por Diallo, Bakary N’tji, Swart, Tarryn, Hoppe, Heinrich C., Tastan Bishop, Özlem, Lobb, Kevin“…Malaria elimination can benefit from time and cost-efficient approaches for antimalarials such as drug repurposing. …”
Publicado 2021
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26848por Mok, Sachel, Stokes, Barbara H., Gnädig, Nina F., Ross, Leila S., Yeo, Tomas, Amaratunga, Chanaki, Allman, Erik, Solyakov, Lev, Bottrill, Andrew R., Tripathi, Jaishree, Fairhurst, Rick M., Llinás, Manuel, Bozdech, Zbynek, Tobin, Andrew B., Fidock, David A.“…The emergence and spread of artemisinin resistance, driven by mutations in Plasmodium falciparum K13, has compromised antimalarial efficacy and threatens the global malaria elimination campaign. By applying systems-based quantitative transcriptomics, proteomics, and metabolomics to a panel of isogenic K13 mutant or wild-type P. falciparum lines, we provide evidence that K13 mutations alter multiple aspects of the parasite’s intra-erythrocytic developmental program. …”
Publicado 2021
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26849por Federizon, Jasmin, Feugmo, Conrard Giresse Tetsassi, Huang, Wei-Chiao, He, Xuedan, Miura, Kazutoyo, Razi, Aida, Ortega, Joaquin, Karttunen, Mikko, Lovell, Jonathan F.“…These were investigated using the his-tagged model antigen Pfs25, a protein antigen candidate for malaria transmission-blocking vaccines. Pfs25 was found to associate with the small molecule aquocobalamin, a form of vitamin B12 and a cobalt-containing corrin macrocycle, but without particle formation, enabling comparative assessment. …”
Publicado 2021
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26850“…Cross immunity because of past exposure to viral infections as well as malaria is likely to protect from the severe manifestations of disease. …”
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26851por Tipthara, Phornpimon, Kobylinski, Kevin C., Godejohann, Markus, Hanboonkunupakarn, Borimas, Roth, Alison, Adams, John H., White, Nicholas J., Jittamala, Podjanee, Day, Nicholas P. J., Tarning, Joel“…Mass drug administration of ivermectin has been proposed as a possible malaria elimination tool. Ivermectin exhibits a mosquito‐lethal effect well beyond its biological half‐life, suggesting the presence of active slowly eliminated metabolites. …”
Publicado 2021
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26852por Martínez-de la Puente, Josué, Gutiérrez-López, Rafael, Díez-Fernández, Alazne, Soriguer, Ramón C., Moreno-Indias, Isabel, Figuerola, Jordi“…Here, we used a wild avian malaria-mosquito assemblage model to experimentally test the role of vector microbiota on the cost of infection and their consequences for parasite development. …”
Publicado 2021
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26853por Adam, Ruqayya, Mukhtar, Muhammad M., Abubakar, Umar F., Damudi, Hajara A., Muhammad, Abdullahi, Ibrahim, Sulaiman S.“…Suspicion of failure in the effectiveness of artemisinin-based combination therapies (currently the first-line treatment of malaria, worldwide) is leading to the unofficial use of alternative antimalarials, including chloroquine and sulfadoxine/pyrimethamine, across northern Nigeria. …”
Publicado 2021
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26854“…Although used as a drug in the combinatorial therapy to treat malaria, the use of mefloquine is not highly recommended because of its adverse effects in humans. …”
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26855“…Icosahedral multimers are being evaluated for vaccination against malaria, HIV and cancer. For enzymes, Spy technology has increased resilience, promoted substrate channelling, and assembled hydrogels for continuous flow biocatalysis. …”
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26856por Moreira, Danilo Reymão, Uberti, Ana Carolina Musa Gonçalves, Gomes, Antonio Rafael Quadros, Ferreira, Michelli Erica Souza, da Silva Barbosa, Aline, Varela, Everton Luiz Pompeu, Dolabela, Maria Fani, Percário, Sandro“…Inhibition of brain iNOS by dexamethasone caused a decrease in parasitemia and increased the survival rate of infected animals, suggesting that NO synthesis may stimulate a series of compensatory redox effects that, if overstimulated, may be responsible for the onset of severe forms of malaria.…”
Publicado 2021
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26857por Habtewold, Tibebu, Sharma, Aayushi A., Wyer, Claudia A. S., Masters, Ellen K. G., Windbichler, Nikolai, Christophides, George K.“…Malaria parasites develop as oocysts in the mosquito for several days before they are able to infect a human host. …”
Publicado 2021
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26858por Pholcharee, Tossapol, Oyen, David, Flores-Garcia, Yevel, Gonzalez-Paez, Gonzalo, Han, Zhen, Williams, Katherine L., Volkmuth, Wayne, Emerling, Daniel, Locke, Emily, Richter King, C., Zavala, Fidel, Wilson, Ian A.“…The most advanced P. falciparum circumsporozoite protein-based malaria vaccine, RTS,S/AS01 (RTS,S), confers partial protection but with antibody titers that wane relatively rapidly, highlighting the need to elicit more potent and durable antibody responses. …”
Publicado 2021
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26859por Inzaule, Seth C, Tessema, Sofonias K, Kebede, Yenew, Ogwell Ouma, Ahmed E, Nkengasong, John N“…Global disease control programmes, including those for tuberculosis, malaria, HIV, foodborne pathogens, and antimicrobial resistance, also recommend genomics-based surveillance as an integral strategy towards control and elimination of these diseases. …”
Publicado 2021
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26860por Alemneh, Derebe“…Five medicinal plants were recorded with the highest healing potential value for malaria, asthma, tapeworm, cough, and stomach ulcer. …”
Publicado 2021
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