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26921por Mann, Lea, Lang, Markus, Schulze, Philipp, Halz, Jan Henrik, Csuk, René, Hoenke, Sophie, Seidel, Rüdiger W., Richter, Adrian“…Nα-2-thiophenoyl-d-phenylalanine-2-morpholinoanilide (MMV688845, IUPAC: N-(1-((2-morpholinophenyl)amino)-1-oxo-3-phenylpropan-2-yl)thiophene-2-carboxamide) from the Pathogen Box(®) library (Medicines for Malaria Ventures, MMV) is a promising lead compound for antimycobacterial drug development. …”
Publicado 2021
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26922por Onohuean, Hope, Alagbonsi, Abdullateef I., Usman, Ibe M., Iceland Kasozi, Keneth, Alexiou, Athanasios, Badr, Reem H., Batiha, Gaber El-Saber, Ezeonwumelu, Joseph O. C.“…Annona muricata and Khaya grandifoliola are ethnomedicinally used for the treatment of malaria and have been experimentally shown to have an anti-plasmodial effect, but the mechanisms involved are not fully understood. …”
Publicado 2021
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26923por Balaska, Sofia, Fotakis, Emmanouil Alexandros, Chaskopoulou, Alexandra, Vontas, John“…BACKGROUND: Phlebotomine sand flies are prominent vectors of Leishmania parasites that cause leishmaniasis, which comes second to malaria in terms of parasitic causative fatalities globally. …”
Publicado 2021
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26924por Min, Aung Myat, Saito, Makoto, Simpson, Julie A., Kennedy, Stephen H., Nosten, François H., McGready, Rose“…Despite this, histopathological chorioamnionitis, and funisitis (when examined) were commonly observed in preterm birth complicated by confirmed bacterial or viral, but not parasitic, infection. The presence of malaria parasites but not pigment in placenta was reported to increase the risk of PTB, but this finding was inconclusive. …”
Publicado 2021
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26925“…Standard questionnaire in assessing the household socio-economic status adapted from standard surveys, such as Nigeria Health and Demographic Survey and Malaria Indicator Survey, was administered on the household heads of each household every 2 years to monitor socio-economic advancement of the households. …”
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26926“…Artemisinin and its derivatives belong to a family of drugs approved for the treatment of malaria with known clinical safety and efficacy. In addition to its anti-malarial effect, artemisinin displays anti-viral, anti-inflammatory, and anti-cancer effects in vivo and in vitro. …”
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26927por Mohamed, Kassim Said, Abasse, Kassim Said, Abbas, Muhammad, Sintali, Dahiru Nasiru, Baig, Mirza Muhammad Faran Ashraf, Cote, Andre“…Additionally, the resurgence and emergence of old and new diseases such as cholera, chikungunya, malaria, HIV/AIDS as indicators of inadequate health services were most likely during political turmoil. …”
Publicado 2021
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26928“…In our preferred empirical model with household fixed effects, we find that health worker absenteeism reduces the odds that a patient seeks care in the public sector (OR = 0.65, 95% CI = 0.44–0.95) and receives malaria testing (OR = 0.73, 95% CI = 0.53–0.99) and increases the odds of paying out-of-pocket for treatment (OR = 1.41, 95% CI = 1.10–1.80). …”
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26929“…Climate change is one of the critical determinants affecting life cycles and transmission of most infectious agents, including malaria, cholera, dengue fever, hand, foot, and mouth disease (HFMD), and the recent Corona-virus pandemic. …”
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26930por Knudsen, Anne S., Björnsson, Kasper H., Bassi, Maria R., Walker, Melanie R., Kok, Andreas, Cristinoi, Bogdan, Jensen, Anja R., Barfod, Lea“…The highly conserved Plasmodium falciparum cysteine-rich protective antigen (PfCyRPA) is a key target for next-generation vaccines against blood-stage malaria. PfCyRPA constitute the core of a ternary complex, including the reticulocyte binding-like homologous protein 5 (PfRh5) and the Rh5-interacting protein (PfRipr), and is fundamental for merozoite invasion of erythrocytes. …”
Publicado 2021
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26931por Jakobowska, Iga, Becker, Frank, Minguzzi, Stefano, Hansen, Kerrin, Henke, Björn, Epalle, Nathan Hugo, Beitz, Eric, Hannus, Stefan“…Blocking lactate export in the parasitic protozoan Plasmodium falciparum is a novel strategy to combat malaria. We discovered small drug-like molecules that inhibit the sole plasmodial lactate transporter, PfFNT, and kill parasites in culture. …”
Publicado 2021
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26932por Delandre, Océane, Gendrot, Mathieu, Fonta, Isabelle, Mosnier, Joel, Benoit, Nicolas, Amalvict, Rémy, Gomez, Nicolas, Madamet, Marylin, Pradines, Bruno“…Background: Artemisinin-based combination therapy (ACT) was recommended to treat uncomplicated falciparum malaria. Unlike the situation in Asia where resistance to ACT has been reported, artemisinin resistance has not yet emerged in Africa. …”
Publicado 2021
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26933por Francis, Sheena, Frank, Chelsea, Buchanan, Luke, Green, Sean, Stennett-Brown, Roxann, Gordon-Strachan, Georgiana, Rubio-Palis, Yasmin, Grant, Charles, Alexander-Lindo, Ruby Lisa, Nwokocha, Chukwuemeka, Robinson, Dwight, Delgoda, Rupika“…Insect-transmitted NTDs include, but are not limited to, malaria, dengue and lymphatic filariasis. Control measures for these disease, are often ignored because of the associated cost. …”
Publicado 2021
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26934“…INTRODUCTION: Dengue and Malaria are the most important mosquito-borne viral diseases affecting humans. …”
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26935“…In Africa, medicinal plants are commonly used to treat malaria and other diseased conditions. The ethanolic leaf and twig extract of Faurea speciosa has been shown to possess promising antiplasmodial properties. …”
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26936por Dey, Dipta, Quispe, Cristina, Hossain, Rajib, Jain, Divya, Ahmed Khan, Rasel, Janmeda, Pracheta, Islam, Muhammad Torequl, Ansar Rasul Suleria, Hafiz, Martorell, Miquel, Daştan, Sevgi Durna, Kumar, Manoj, Taheri, Yasaman, Petkoska, Anka Trajkovska, Sharifi-Rad, Javad“…Koenig is traditionally used to treat various diseases including diarrhea, cholera, dysentery, fever, malaria, and viral infections, among others. To summarize critically the taxonomy, ethnomedicinal, phytochemistry, and pharmacological activities of X. granatum, information was collected from different databases. …”
Publicado 2021
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26937por Lobie, Tekle Airgecho, Roba, Aklilu Abrham, Booth, James Alexander, Kristiansen, Knut Ivan, Aseffa, Abraham, Skarstad, Kirsten, Bjørås, Magnar“…Public health priority programs that have faced drug-resistance challenges associated with diseases, such as tuberculosis, HIV, and malaria, have given less attention to risks attributable to the COVID-19 pandemic. …”
Publicado 2021
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26938por Jayaswal, Vivek, Ndo, Cyrille, Ma, Hsiu-Ching, Clifton, Bryan D, Pombi, Marco, Cabrera, Kevin, Cohuet, Anna, Mouline, Karine, Diabaté, Abdoulaye, Dabiré, Roch, Ayala, Diego, Ranz, José M“…The magnitude and functional patterns of intraspecific transcriptional variation in the anophelines, including those of sex-biased genes underlying sex-specific traits relevant for malaria transmission, remain understudied. As a result, how changes in expression levels drive adaptation in these species is poorly understood. …”
Publicado 2021
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26939por Akorli, Jewelna, Akorli, Esinam Abla, Tetteh, Seraphim Naa Afoley, Amlalo, Godwin Kwame, Opoku, Millicent, Pwalia, Rebecca, Adimazoya, Michelle, Atibilla, Dorcas, Pi-Bansa, Sellase, Chabi, Joseph, Dadzie, Samuel Kweku“…It indicates possible widespread among malaria vector species and warrants investigations into the symbiont’s diversity across sub-Saharan Africa.…”
Publicado 2021
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26940por Zhanel, George G., Zhanel, Michael A., Boreskie, Kevin F., Lynch, Joseph P., Karlowsky, James A.“…Hydroxychloroquine (HCQ), also known by its trade name Plaquenil®, has been used for over 50 years as a treatment for malaria, systemic lupus erythematosus, and rheumatoid arthritis. …”
Publicado 2021
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