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27001por Dong, Yuxiang, Sonawane, Yogesh, Maher, Steven P., Zeeman, Anne-Marie, Chaumeau, Victor, Vantaux, Amélie, Cooper, Caitlin A., Chiu, Francis C. K., Ryan, Eileen, McLaren, Jenna, Chen, Gong, Wittlin, Sergio, Witkowski, Benoît, Nosten, François, Sriraghavan, Kamaraj, Kyle, Dennis E., Kocken, Clemens H. M., Charman, Susan A., Vennerstrom, Jonathan L.“…As 1 and all but one of its identified Phase I metabolites had no in vitro activity against P. vivax or P. cynomolgi liver-stage malaria parasites, we suggest that there may be additional unidentified active metabolites of 1 or that the exposure of 1 achieved in the reported unsuccessful clinical trial of this drug candidate was insufficient to kill the P. vivax hypnozoites.…”
Publicado 2022
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27002por Osoti, Victor, Akinyi, Mercy, Wamae, Kevin, Kimenyi, Kelvin M., de Laurent, Zaydah, Ndwiga, Leonard, Gichuki, Paul, Okoyo, Collins, Kepha, Stella, Mwandawiro, Charles, Kandie, Regina, Bejon, Philip, Snow, Robert W., Ochola-Oyier, Lynette Isabella“…Dried blood spots were obtained from a Plasmodium falciparum malaria survey in school children conducted across eight counties in western Kenya in 2019. …”
Publicado 2022
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27003“…Predominant species are vectors of disease: Culex pipiens, Cx. perexiguus, Cx. theileri, known vectors of West Nile virus, followed by Anopheles maculipennis s. l. and An. sergentii that are the main vectors of malaria in Morocco. Cx. pipiens and Cx. perexiguus reached the highest density in September, while Cx. theileri was found in large numbers in February and can therefore emerge in late winter and mid-spring. …”
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27004“…More recently, studies of other parasitic diseases such as cerebral malaria (CM) and onchocerciasis are yielding novel insights into the pathogenesis of parasite-associated epilepsy. …”
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27005por Wichers, Jan Stephan, Mesén-Ramírez, Paolo, Fuchs, Gwendolin, Yu-Strzelczyk, Jing, Stäcker, Jan, von Thien, Heidrun, Alder, Arne, Henshall, Isabelle, Liffner, Benjamin, Nagel, Georg, Löw, Christian, Wilson, Danny, Spielmann, Tobias, Gao, Shiqiang, Gilberger, Tim-Wolf, Bachmann, Anna, Strauss, Jan“…The obligate intracellular parasite Plasmodium falciparum, an agent of human malaria, relies on membrane transport proteins for the uptake of nutrients from the host, disposal of metabolic waste, exchange of metabolites between organelles, and generation and maintenance of transmembrane electrochemical gradients for its growth and replication within human erythrocytes. …”
Publicado 2022
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27006“…It offers a powerful tool to identify antimalarial drug resistance and can support malaria control and elimination globally.…”
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27007por Mufusama, Jean-Pierre, Feineis, Doris, Mudogo, Virima, Kaiser, Marcel, Brun, Reto, Bringmann, Gerhard“…The mbandakamines B(3) (3) and B(4) (4) displayed pronounced activities in vitro against the malaria parasite Plasmodium falciparum and the pathogen of African sleeping sickness, Trypanosoma brucei rhodesiense.…”
Publicado 2019
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27008por Sussmann, Rodrigo A. C., Gabriel, Heloisa B., Ríos, Alejandro García, Menchaca Vega, Danielle S., Yamaguchi, Lydia F., Doménech-Carbó, Antonio, Cebrián-Torrejón, Gerardo, Kimura, Emilia A., Kato, Massuo J., Bofill Verdaguer, Ignasi, Crispim, Marcell, Katzin, Alejandro M.“…Malaria is one of the most widespread parasitic diseases, especially in Africa, Southeast Asia and South America. …”
Publicado 2022
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27009por Alaa Eldin Refat, Lamis, O’Malley, Ciaran, Simmie, John M., McArdle, Patrick, Erxleben, Andrea“…[Image: see text] The identification and study of supramolecular synthons is a fundamental task in the design of pharmaceutical cocrystals. The malaria drug pyrimethamine (pyr) and the antibiotic trimethoprim (tmp) are both 2,4-diaminopyrimidine derivatives, providing the same C–NH(2)/N=C/C–NH(2) and C–NH(2)/N=C interaction sites. …”
Publicado 2022
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27010por Zhang, Mingying, Wu, Danbin, Xu, Jia, Liu, Lijuan, Jiao, Wei, Yu, Jiahui, Chen, Guangxing“…Dihydroarteannuin (DHA), the primary element of artemisinin extracted from the traditional Chinese herb Artemisia annua L., has been used in malaria treatment for a long time. Recently, many studies have indicated that DHA also exhibits potent anti-rheumatoid arthritis (RA) activity. …”
Publicado 2022
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27011por Ngole, Mamy, Race, Valerie, Mbayabo, Gloire, Lumbala, Paul, Songo, Cathy, Lukusa, Prosper Tshilobo, Devriendt, Koenraad, Matthijs, Gert, Lumaka, Aimé“…In limited resource countries, these tests face limitations including cost, low sensitivity due to recurrent transfusions in endemic malaria region, and interference from fetal hemoglobin in neonatal diagnostic. …”
Publicado 2022
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27012“…Species most frequently studied were those incriminated in malaria transmission, whereas relevant vectors such as Aedes aegypti, Ae. albopictus, and Haemagogus janthinomys were surprisingly neglected. …”
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27013por Herrera-Calderon, Oscar, Chavez, Haydee, Enciso-Roca, Edwin Carlos, Común-Ventura, Pablo Williams, Hañari-Quispe, Renan Dilton, Figueroa-Salvador, Linder, Loyola-Gonzales, Eddie, Pari-Olarte, Josefa Bertha, Aljarba, Nada H., Alkahtani, Saad, Batiha, Gaber El-Saber“…On the other hand, Aedes aegypti is the main vector of several tropical diseases and the transmitter of yellow fever, chikungunya, malaria, dengue, and Zika virus. In this study, the aim was to investigate the antioxidant activity in vitro and the insecticidal activity in silico, in the presence of the mosquito juvenile hormone-binding protein (mJHBP) from Aedes aegypti, of the essential oil from S. molle leaves. …”
Publicado 2022
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27014por Ledger, Kimberly J., Innocent, Hanna, Lukhele, Sifiso M., Dorleans, Rayann, Wisely, Samantha M.“…Previous research has shown that even when malaria has been dramatically reduced, unexplained acute febrile illnesses persist and may be explained by the serological evidence of rickettsiae in humans. …”
Publicado 2022
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27015por Jaramillo Ponce, José R., Kapps, Delphine, Paulus, Caroline, Chicher, Johana, Frugier, Magali“…In Plasmodium, the causative agent of malaria, the tRNA import protein (tRip), is a membrane protein that participates in tRNA trafficking; we show that tRip also functions as an AIMP. …”
Publicado 2022
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27016por Avalos-Padilla, Yunuen, Georgiev, Vasil N., Lantero, Elena, Pujals, Silvia, Verhoef, René, N. Borgheti-Cardoso, Livia, Albertazzi, Lorenzo, Dimova, Rumiana, Fernàndez-Busquets, Xavier“…Overall, our results increase the knowledge on the underlying molecular mechanisms during malaria pathogenesis and demonstrate that ESCRT-III P. falciparum proteins participate in EV production.…”
Publicado 2021
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27017por Teixeira, Ana Rafaela, Pérez-Cabezas, Begoña, Costa, David M., Sá, Mónica, Golba, Sylvain, Sefiane-Djemaoune, Hélèna, Ribeiro, Joana, Kaneko, Izumi, Iwanaga, Shiroh, Yuda, Masao, Tsuji, Moriya, Boscardin, Silvia Beatriz, Amino, Rogerio, Cordeiro-da-Silva, Anabela, Tavares, Joana“…Malaria is a major public health concern, as a highly effective human vaccine remains elusive. …”
Publicado 2022
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27018por Dako-Gyeke, Phyllis, Asampong, Emmanuel, Opoku-Mensah, Kwabena, Tabong, Philip Teg-Nefaah, Awor, Phyllis, Tucker, Joseph D“…These submissions can be put into three main themes: technology and strengthening (eg, mHealth for cervical cancer screening, video directly observed therapy), inclusiveness and reaching the marginalised (people with disability and infertility) and data utilisation for project improvement (seasonal calendar to reduce morbidity and mortality of children under 5 for malaria, diarrhoea and pneumonia). CONCLUSION: In conclusion, this study shows that solutions to local problems exist. …”
Publicado 2022
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27019por Panda, Sujogya Kumar, Gazim, Zilda Cristiani, Swain, Shasank S., Bento, Marisa Cassia Vieira de Araujo, Sena, Jéssica da Silva, Mukazayire, Marie Jeanne, Van Puyvelde, Luc, Luyten, Walter“…In folk medicine it may be used as an infusion to treat respiratory problems, cough, headache, stomach pain, diarrhea, fever, malaria, and dengue; and in the form of compresses it is applied for the relief of headaches and toothaches. …”
Publicado 2022
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27020por Carod-Artal, Francisco Javier“…Pathological findings of cerebral malaria include diffuse cerebral edema, perivascular ring hemorrhages, white matter necrosis, parenchyma petechial hemorrhages, occlusion of brain vessels, and sequestration of infected erythrocytes in cortical and perforating arteries. …”
Publicado 2008
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