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27061por Alves, Américo J. S., Alves, Nuno G., Bártolo, Inês, Fontinha, Diana, Caetano, Soraia, Prudêncio, Miguel, Taveira, Nuno, Pinho e Melo, Teresa M. V. D.“…These eight compounds also showed nanomolar activity against HIV-2, and six of them displayed micromolar antiplasmodial activity against both the hepatic and the blood stages of infection by malaria parasites, in agreement with the lead molecule’s bioactivity profile. …”
Publicado 2022
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27062por Assies, Roxanne, Snik, Ilse, Kumwenda, Mercy, Chimalizeni, Yamikani, Langton, Josephine, van Woensel, Job B M, Doctor, Allan, Calis, Job C J“…Important etiologies included gastroenteritis, sepsis, malaria and severe anemia, which often coincided. …”
Publicado 2022
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27063por Lapp, Zena, Obala, Andrew A., Abel, Lucy, Rasmussen, David A., Sumner, Kelsey M., Freedman, Elizabeth, Taylor, Steve M., Prudhomme-O’Meara, Wendy“…Taken together, our observations provide evidence for the mosquito vector acting as a reservoir of sequence diversity in malaria parasite populations.…”
Publicado 2022
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27064por Carrasquilla, Manuela, Drammeh, Ndey F., Rawat, Mukul, Sanderson, Theo, Zenonos, Zenon, Rayner, Julian C., Lee, Marcus C. S.“…The repeated emergence of antimalarial drug resistance in Plasmodium falciparum, including to the current frontline antimalarial artemisinin, is a perennial problem for malaria control. Next-generation sequencing has greatly accelerated the identification of polymorphisms in resistance-associated genes but has also highlighted the need for more sensitive and accurate laboratory tools to profile current and future antimalarials and to quantify the impact of drug resistance acquisition on parasite fitness. …”
Publicado 2022
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27065“…These 26 species are involved in the circulation of seven MBDs in North Africa, including two parasitic infections (malaria and filariasis) and five viral infections (WNV, RVF, DENV, SINV and USUV). …”
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27066por Võ, Tuấn Cường, Trinh, Nguyen Thi Minh, Lê, Hương Giang, Kang, Jung-Mi, Yoo, Won Gi, Quang, Huynh Hong, Na, Byoung-Kuk“…It has been extensively studied as a leading vivax-malaria-vaccine candidate. In this study, the genetic polymorphism and natural selection of pvcsp in P. vivax isolates collected from the Central Highlands, Vietnam were analyzed to understand the genetic structure of the parasite circulating in the endemic area and to provide baseline information for effective vaccine development based on the protein. …”
Publicado 2022
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27067“…Analysis of keywords revealed the dominance of research topics with keywords such as HIV/AIDS, Tuberculosis, Malaria, Obesity, Hypertension, risk factors, infection, mortality, amongst others. …”
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27068por Charoenkwan, Phasit, Schaduangrat, Nalini, Lio, Pietro, Moni, Mohammad Ali, Chumnanpuen, Pramote, Shoombuatong, Watshara“…The iAMAP-SCM predictor is anticipated to assist experimental scientists in the high-throughput identification of potential AMAP candidates for the treatment of malaria and other clinical applications.…”
Publicado 2022
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27069“…Myosin B (MyoB) is a class 14 myosin expressed in all invasive stages of the malaria parasite, Plasmodium falciparum. It is not associated with the glideosome complex that drives motility and invasion of host cells. …”
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27070por Wang, Haixia“…Objective: Dihydroartemisinin (DHA) is an active metabolite of artemisinin and its derivatives, which is a potent drug extensively applied in clinical treatment of malaria. The antitumor properties of DHA have received increasing attention. …”
Publicado 2022
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27071por Chen, Kaiying, Ponnusamy, Loganathan, Mouhamadou, Chouaïbou S., Fodjo, Behi Kouadio, Sadia, Gba Christabelle, Affoue, France Paraudie Kouadio, Deguenon, Jean M., Roe, R. Michael“…Anopheles coluzzii is in the Anopheles gambiae sensu lato (s.l.) species complex and important in the transmission of malaria. The total 16S rRNA reads were assigned to 34 phyla, 73 orders, 325 families, and 700 genera. …”
Publicado 2022
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27072por Porto-Pedrosa, Maria Luiza Mundim, de Miranda, Camila Dutra Moreira, Lopes, Mateus Eustáquio, Nakagaki, Brenda Naemi, Mafra, Kassiana, de Paula, Cristina Maria Pinto, Diniz, Ariane Barros, Costa, Karen Marques de Oliveira, Antunes, Maisa Mota, Oliveira, André Gustavo, Balderas, Robert, Lopes, Rodrigo Pestana, Menezes, Gustavo Batista“…Also, we revealed how infections – using a model of malaria - can change the spleen immune profile in adults and infants, which could become the key to understanding different severity grades of infection. …”
Publicado 2022
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27073por Bazant, Eva, McPhillips-Tangum, Carol, Shrestha, Sumitra Devi, G S, Preetha, Khera, Ajay, Nic Lochlainn, Laura, Habtamu, Esmael, Patel, Vivek I, Muhire, Gladys, Saarlas, Kristin N“…Planning is critical to the implementation of effective health campaigns, including those related to neglected tropical diseases, malaria, vitamin A supplementation and vaccine-preventable diseases, including polio, measles and meningitis. …”
Publicado 2022
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27074por Vittor, Amy Y., Laporta, Gabriel Zorello, Sallum, Maria Anice Mureb, Walker, Robert T.“…Further adding to the existential struggle of indigenous tribes, malaria and SARS-Coronavirus-2 are wreaking havoc on these vulnerable populations. …”
Publicado 2021
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27075“…RESULTS: Totally 110076 cases of VBDs reported in Ardabil Province during the past 18 years including malaria, visceral leishmaniasis (VL), cutaneous leishmaniasis (CL), Crimean Congo hemorrhagic fever (CCHF), tick–borne relapsing fever (TRF), pediculosis, scorpionism, scabies and anthrax. …”
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27076por Dens, Stefanie, Nieto-Sanchez, Claudia, De Los Santos, Mario, Hawer, Thomas, Haile, Asgedom, Solari, Karla, Cisneros, Jesus, Vega, Victor, Solomon, Kalkidan, Addissie, Adamu, Yewhalaw, Delenasaw, Otero, Larissa, Grietens, Koen Peeters, Verdonck, Kristien, Van Acker, Maarten“…We introduce the use of drawings in two interdisciplinary projects conducted in the field of global public health: first, a study about the heterogeneous burden of tuberculosis and COVID-19 in Lima, Peru, and second, a study about urban malaria in Jimma, Ethiopia. In both cases, drawings such as maps, plans, and sections were used to analyze spatial factors present in the urban context at different scales: from the scale of the territory, the city, and the district, to the neighborhood and the household. …”
Publicado 2022
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27077por Hussain, Tahir, Linera-Gonzalez, Jose, Beck, John M., Fierro, Manuel A., Mair, Gunnar R., Smith, Ryan C., Beck, Josh R.“…During vertebrate infection, obligate intracellular malaria parasites develop within a parasitophorous vacuole, which constitutes the interface between the parasite and its hepatocyte or erythrocyte host cells. …”
Publicado 2022
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27078por Puumala, Emily, Zaslaver, Olga, Chen, Amy, Duncan, Dustin, Fogal, Meea, Shapiro, Rebecca S., Mazhab-Jafari, Mohammad T., Whitesell, Luke, Montenegro-Burke, J. Rafael, Robbins, Nicole, Cowen, Leah E.“…Here, we endeavored to identify compounds with novel bioactivity against C. auris from the Medicines for Malaria Venture’s Pathogen Box library. Of the five hits identified, the trisubstituted isoxazole MMV688766 emerged as the only compound displaying potent fungicidal activity against C. auris, as well as other evolutionarily divergent fungal pathogens. …”
Publicado 2022
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27079por Najm, Rania, Hamie, Maguy, Berry-Sterkers, Laurence, Lebrun, Maryse, El Hajj, Hiba, Lamarque, Mauld H.“…IMPORTANCE Toxoplasma gondii belongs to the Apicomplexa phylum, which comprises more than 5,000 species, among which is Plasmodium falciparum, the notorious agent of human malaria. Intriguingly, the Apicomplexa genomes encode at least one phosphatase closely related to the bacterial Schewanella phosphatase, or Shelph. …”
Publicado 2022
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27080por Takahashi, Maria Beatriz, Teixeira, Aline Florencio, Nascimento, Ana Lucia Tabet Oller“…The symptoms are similar to those of flu-like diseases, such as dengue, yellow fever, and malaria, which can result in a misleading clinical diagnosis. …”
Publicado 2022
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