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27101por Herten, Pieter-Jan, Vlieghe, Erika, Bottieau, Emmanuel, Florence, Eric, Jorens, Philippe G“…The four historically most prevalent “tropical” diseases (malaria, enteric fever, dengue, and rickettsiosis) can present with single or multiple organ failure in a very similar manner, which makes differentiation based solely on clinical signs very difficult. …”
Publicado 2022
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27102por Walczak, Marta, Meister, Thomas R., Nguyen, Hoa Mai, Zhu, Yili, Besteiro, Sébastien, Yeh, Ellen“…While the structural features required for conserved autophagy functions of Atg8 are well established, little is known about the molecular changes that facilitated acquisition of divergent, nonautophagic functions of Atg8. The malaria parasite Plasmodium falciparum offers a unique opportunity to study nonautophagic functions of Atg8 family proteins because it encodes a single Atg8 homolog whose only essential function is in the inheritance of an unusual secondary plastid called the apicoplast. …”
Publicado 2023
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27103por Joerin-Luque, Iriel A., Sukow, Natalie Mary, Bucco, Isabela Dall’Oglio, Tessaro, Joana Gehlen, Lopes, Claudemira Vieira Gusmão, Barbosa, Ana Angélica Leal, Beltrame, Marcia H.“…Lastly, the prevalence of known malaria-adaptive African mutations and other African-specific variants discovered in quilombos, as well as the genetic bases of health-related traits, are discussed here, together with their implication for the health of populations of African descent. …”
Publicado 2023
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27104por Gjertsson, Inger, McGrath, Sarah, Grimstad, Kristoffer, Jonsson, Charlotte A, Camponeschi, Alessandro, Thorarinsdottir, Katrin, Mårtensson, Inga-Lill“…These cells are expanded in peripheral blood with age and during chronic inflammatory conditions such as viral infections, malaria, common variable immunodeficiency, and autoimmune diseases. …”
Publicado 2022
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27105por Jantausch, Barbara A., Bost, James E., Bhansali, Priti, Hefter, Yosefa, Greenberg, Isabella, Goldman, Ellen“…METHODS: Residents, fellows and students participated in an online, self-directed case-based vignette activity to learn malaria diagnosis and management. Pre and post-tests with multiple choice and open-ended case-based questions assessed knowledge and critical thinking. …”
Publicado 2023
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27106por Hassani, Danial, Taheri, Ayat, Fu, Xueqing, Qin, Wei, Hang, Liu, Ma, Yanan, Tang, Kexuan“…Artemisinin, derived from Artemisia annua, is currently used as the first-line treatment for malaria. However, wild-type plants have a low artemisinin biosynthesis rate. …”
Publicado 2023
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27107por Kande Betu Ku Mesu, Victor, Mutombo Kalonji, Wilfried, Bardonneau, Clélia, Valverde Mordt, Olaf, Ngolo Tete, Digas, Blesson, Séverine, Simon, François, Delhomme, Sophie, Bernhard, Sonja, Mahenzi Mbembo, Hélène, Mpia Moke, Christian, Lumeya Vuvu, Steven, Mudji E'kitiak, Junior, Akwaso Masa, Felix, Mukendi Ilunga, Melchias, Mpoyi Muamba Nzambi, Dieudonné, Mayala Malu, Tim, Kapongo Tshilumbwa, Serge, Botalema Bolengi, Franck, Nkieri Matsho, Mathieu, Lumbala, Crispin, Scherrer, Bruno, Strub-Wourgaft, Nathalie, Tarral, Antoine“…Exclusion criteria included severe malnutrition, inability to take medication orally, pregnant or breastfeeding women, any clinically important medical condition that could jeopardise patient safety or participation in the study, severely deteriorated general status, any contraindication to imidazole drugs, HAT treatment in the past 2 years, previous enrolment in the study or previous intake of fexinidazole, abnormalities on electrocardiogram that did not return to normal in pretreatment repeated assessments or were considered clinically important, QT interval corrected using Fridericia's formula of at least 450 ms, and patients not tested for malaria or not having received appropriate treatment for malaria or for soil-transmitted helminthiasis. …”
Publicado 2021
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27108por Rashpa, Ravish, Klages, Natacha, Schvartz, Domitille, Pasquarello, Carla, Brochet, Mathieu“…Malaria-causing parasites of the Plasmodium genus undergo multiple developmental phases in the human and the mosquito hosts, regulated by various post-translational modifications. …”
Publicado 2023
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27109por Nimmagadda, Nikitha, Khillare, Kishor M, Satpathy, Prasanna Kumar, Gowda, Bharath S, Narayana, Varun, Gopal, Prashant, Tripathy, Srikanth, Athavale, Prachi V“…Biochemical, hematologic (total and differential cell counts), and immunologic measurements (rapid malaria, dengue, Leptospira, and viral hepatitis antigen antibodies) were performed. …”
Publicado 2023
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27110por Nguyen, William, Dans, Madeline G., Currie, Iain, Awalt, Jon Kyle, Bailey, Brodie L., Lumb, Chris, Ngo, Anna, Favuzza, Paola, Palandri, Josephine, Ramesh, Saishyam, Penington, Jocelyn, Jarman, Kate E., Mukherjee, Partha, Chakraborty, Arnish, Maier, Alexander G., van Dooren, Giel G., Papenfuss, Tony, Wittlin, Sergio, Churchyard, Alisje, Baum, Jake, Winzeler, Elizabeth A., Baud, Delphine, Brand, Stephen, Jackson, Paul F., Cowman, Alan F., Sleebs, Brad E.“…Consistent with other cyt b targeted antimalarials, WJM228 prevented pre-erythrocytic parasite and male gamete development and reduced asexual parasitemia in a P. berghei mouse model of malaria. Correcting the limited aqueous solubility and the high susceptibility to cyt b Q(o) site resistant parasites found in the clinic will be major obstacles in the future development of the 3-oxadiazole quinolone antimalarial class.…”
Publicado 2023
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27111Most common reasons for primary care visits in low- and middle-income countries: A systematic reviewpor Bigio, Jacob, MacLean, Emily, Vasquez, Nathaly Aguilera, Huria, Lavanya, Kohli, Mikashmi, Gore, Genevieve, Hannay, Emma, Pai, Madhukar, Adam, Pierrick“…The top five diagnoses were uncomplicated hypertension, upper respiratory tract infection, type 2 diabetes, malaria and health maintenance/prevention. No psychological symptoms were among the top 10 pooled RFEs. …”
Publicado 2022
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27112por Harish, Vinyas, Buajitti, Emmalin, Burrows, Holly, Posen, Joshua, Bogoch, Isaac I., Corbeil, Antoine, Gubbay, Jonathan B., Rosella, Laura C., Morris, Shaun K.“…In this ecological study of over 170,000 unique tests from Public Health Ontario’s laboratory, we reviewed all laboratory-reported cases of malaria, dengue, chikungunya, and enteric fever in Ontario, Canada between 2008–2020 to identify high-resolution geographical clusters for potential targeted pre-travel prevention. …”
Publicado 2023
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27113por Mehata, Abhishesh Kumar, Setia, Aseem, , Vikas, Malik, Ankit Kumar, Hassani, Rym, Dailah, Hamad Ghaleb, Alhazmi, Hassan A., Albarraq, Ahmed A., Mohan, Syam, Muthu, Madaswamy S.“…However, various randomized or human clinical trials have been underway for TPGS-based drug delivery systems for multiple diseases such as pneumonia, malaria, ocular disease, keratoconus, etc. In this review, we have emphasized in detail the review of the nanotheranostics and targeted drug delivery approaches premised on TPGS. …”
Publicado 2023
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27114por Amang à Ngnoung, Gabrielle Ange, Sidjui, Lazare S., Leutcha, Peron B., Nganso Ditchou, Yves O., Tchokouaha, Lauve R. Y., Herbette, Gaëtan, Baghdikian, Beatrice, Kowa, Theodora K., Soh, Desire, Kemzeu, Raoul, Poka, Madan, Demana, Patrick H., Siwe Noundou, Xavier, Tchinda, Alembert T., Fekam Boyom, Fabrice, Lannang, Alain M., Nyassé, Barthélemy“…Antrocaryon klaineanum is traditionally used for the treatment of back pain, malaria, female sterility, chlamydiae infections, liver diseases, wounds, and hemorrhoid. …”
Publicado 2023
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27115por Pollegioni, Paola, Persampieri, Tania, Minuz, Roxana L., Bucci, Alessandro, Trusso, Alessandro, Martino, Salvatore Di, Leo, Chiara, Bruttini, Marco, Ciolfi, Marco, Waldvogel, Ann‐Marie, Tripet, Frédéric, Simoni, Alekos, Crisanti, Andrea, Müller, Ruth“…The development of genetically modified mosquitoes (GMM) and their subsequent field release offers innovative approaches for vector control of malaria. A non‐gene drive self‐limiting male‐bias Ag(PMB)1 strain has been developed in a 47‐year‐old laboratory G3 strain of Anopheles gambiae s.l. …”
Publicado 2022
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27116por Rosillo, Stefano R., Dimbu, Pedro Rafael, Cândido, Ana Luisa M., Oh, Je-Hoon Michael, Ferreira, Carolina Miguel, Nieto Andrade, Benjamin, Labuda, Sarah, Horth, Roberta, Kelley, Julia, Morais, Joana F. M., Fortes, Filomeno, Martins, José Franco, Talundzic, Eldin, Pluciński, Mateusz M.“…Sulfadoxine-pyrimethamine (SP) is used for prevention of malaria in pregnant women in Angola. We sequenced the Plasmodium falciparum dihydrofolate reductase (pfdhfr) and dihydropteroate synthase (pfdhps) genes, implicated in SP resistance, in samples collected during a 2019 study of artemisinin-based combination therapy efficacy in Benguela, Lunda Sul, and Zaire provinces. …”
Publicado 2023
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27117por Fotoran, Wesley L., da Silva, Jamile Ramos, Glitz, Christiane, Ferreira, Luís Carlos de Souza, Wunderlich, Gerhard“…Conclusion: Intradermal delivery of cationic lipid-encapsulated samRNA constructs is a feasible approach for developing future malaria vaccines.…”
Publicado 2023
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27118por Ewendt, Franz, Schmitt, Marvin, Kluttig, Alexander, Kühn, Julia, Hirche, Frank, Kraus, Frank B., Ludwig-Kraus, Beatrice, Mikolajczyk, Rafael, Wätjen, Wim, Bürkner, Paul-Christian, Föller, Michael, Stangl, Gabriele I.“…Eryptosis is characterized by cell shrinkage, membrane blebbing, and cell membrane phospholipid disorganization and associated with diseases such as sepsis, malaria or iron deficiency, and impaired microcirculation. …”
Publicado 2023
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27119“…For instance, allocation of the new malaria vaccine among sub-Saharan African countries should be based not on reciprocity to countries that participated in research, but on maximally reducing serious illness and deaths, especially among infants and children.…”
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27120por Arwati, Heny, Lestarisa, Trylianti, Augustina, Indria, Rohmah, Etik Ainun, Subekti, Sri, Keman, Soedjajadi, Dachlan, Yoes Prijatna“…CONCLUSION: Low allelic variation of Pfmsp-1 and Pfmsp-2 genes with monogenotype indicated the low intensity of malaria transmission among gold miners in the studied areas. …”
Publicado 2023
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