“…By leveraging in-house data collected over a decade, we have developed a virtual screening cascade for malaria and tuberculosis drug discovery comprising 15 models for key decision-making assays ranging from whole-cell phenotypic screening and cytotoxicity to aqueous solubility, permeability, microsomal metabolic stability, cytochrome inhibition, and cardiotoxicity. …”
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“…Included studies suggest evidence-based interventions effectively to reduce the common morbidities associated with sickle cell disease such as stroke, vaso-occlusive crisis, acute chest syndrome, severe anaemia and malaria infection. Evidence-based interventions also improve survival among study participants. …”
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“…Schistosomiasis is a human parasitic disease caused by the Schistosoma species and is recognised in public health as second to malaria in terms of its socioeconomic impact on humans. …”
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“…We aimed to determine the feasibility of a Test-Treat-Track-Test-Treat (5T) strategy in two low-prevalence villages; the 5T strategy has been successfully implemented in diseases such as malaria. A total of 200 school children aged 6–12 years were randomly selected from two schools and tested for Schistosoma mansoni infection using the point-of-care circulating cathodic antigen test. …”
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“…INTRODUCTION: Geographical mobility, the movement of individuals or populations, may increase an individual’s risk of acquiring or transmitting infectious diseases, including HIV, tuberculosis, malaria and COVID-19. Many studies have collected information on short-term mobility through self-reported travel histories or using GPS trackers, but there has been no consistent conceptualisation and operationalisation of such geographical mobility in global health research. …”
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“…We find robust results on malaria: risk perception was significantly influenced by the risk perception of the reference group across different definitions of the reference group, hinting at the existence of social norms. …”
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“…Here, we studied the effects of dihydroartemisinin (DHA), an artemisinin derivative used to treat malaria, on conjugation. DHA inhibited the conjugation of the IncI2 and IncX4 plasmids carrying the mobile colistin resistance gene (mcr-1) by more than 160-fold in vitro in Escherichia coli, and more than two-fold (IncI2 plasmid) in vivo in a mouse model. …”
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“…The infectious foci were urinary tract infections (29.4%), pneumopathies (28.7%), malaria (21.3%), skin infections (13.2%) and the undetermined focus (7.3%). …”
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“…A substantial proportion of primary care, mother, child and malaria services are available through non-public providers across all 27 LICs. …”
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“…Medical effects include malnutrition, malaria, diarrhea, heat stress, exacerbations of chronic conditions, infectious disease outbreaks, trauma, and death. …”
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“…This species is also a likely vector for Usutu virus, avian malaria (Plasmodium spp.), and parasitic heartworms (Dirofilaria spp.). …”
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“…For SDG 3; Good health and well-being, there are improvements in certain segments: reduction in the infant mortality rate (2.8/1,000 from 2020) and mortality rate among children under 5 (3.7/1,000 from 2020) and reduction in the tuberculosis and malaria incidence. Numerous challenges are mainly reflected in the inequality of access and quality of health services, the high prevalence of current tobacco use among those over 15 years, and low air quality. …”
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“…When the SDG indicators were requested by the UN and WHO, Norway was able to deliver 26 of the 28 indicators (93%) on the UN list, though some indicators, such as 3.3.3 (Malaria incidence), were regarded as unnecessary. …”
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“…The lethal malaria parasite Plasmodium falciparum needs to constantly respond and adapt to changes within the human host in order to survive and transmit. …”
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“…Here we report the discovery of a previously uncharacterized gene (sex chromosome activation (SOA)) as a master regulator of DC in the malaria mosquito Anopheles gambiae. Sex-specific alternative splicing prevents functional SOA protein expression in females. …”
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“…We collected stool, venous blood (for hemoglobin and malaria rapid tests), anthropometric measurements, and administered a questionnaire on Water Access Sanitation and Hygiene (WASH) practices. …”
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“…MOL's in vitro antibabesial activity was enhanced when administrated simultaneously with either diminazene aceturate (DA) or MMV665875 compound from malaria box. In mice infected by B. microti, a combination of MOL and a low dose of DA (12.5 mg·kg(−1)) resulted in a significant (P < 0.05) reduction in B. microti growth. …”
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“…Evaluation included blood cultures, malaria rapid diagnostic tests, and urinary lipoarabinomannan testing for tuberculosis. …”
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“…Other specific terms such as “malaria,” “dengue,” “Zika,” or any infectious disease were included in the dictionary and mapped to “fever.” …”
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“…BACKGROUND AND AIM: Malaria is a global health issue causing substantial morbidity and mortality. …”
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