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27221por Wakaguri, Hiroyuki, Suzuki, Yutaka, Sasaki, Masahide, Sugano, Sumio, Watanabe, Junichi“…BACKGROUND: Apicomplexan parasites are causative agents of various diseases including malaria and have been targets of extensive genomic sequencing. …”
Publicado 2009
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27222por Smargiasso, Nicolas, Gabelica, Valérie, Damblon, Christian, Rosu, Frédéric, De Pauw, Edwin, Teulade-Fichou, Marie-Paule, Rowe, J Alexandra, Claessens, Antoine“…The var gene family encodes PfEMP1, the parasite's major variant antigen and adhesin expressed at the surface of infected erythrocytes, that plays a key role in malaria pathogenesis and immune evasion. The ability of the PQS found in the upstream regions of group B var genes (UpsB-Q) to form stable G-quadruplex structures in vitro was confirmed using (1)H NMR, circular dichroism, UV spectroscopy, and thermal denaturation experiments. …”
Publicado 2009
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27223por Sissoko, Mahamadou S., Dabo, Abdoulaye, Traoré, Hamidou, Diallo, Mouctar, Traoré, Boubacar, Konaté, Drissa, Niaré, Boubacar, Diakité, Moussa, Kamaté, Bourama, Traoré, Abdrahamane, Bathily, Aboudramane, Tapily, Amadou, Touré, Ousmane B., Cauwenbergh, Sarah, Jansen, Herwig F., Doumbo, Ogobara K.“…BACKGROUND: This study was conducted to determine the efficacy of the antimalarial artemisinin-based combination therapy (ACT) artesunate +sulfamethoxypyrazine/pyrimethamine (As+SMP), administered in doses used for malaria, to treat Schistosoma haematobium in school aged children. …”
Publicado 2009
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27224por Katwere, Michael, Kambugu, Andrew, Piloya, Theresa, Wong, Matthew, Hendel-Paterson, Brett, Sande, Merle A, Ronald, Allan, Katabira, Elly, Were, Edward M, Menten, Joris, Colebunders, Robert“…Thirty-two (18%) had other diagnoses (malaria, bacteraemia, etc.). No aetiology could be elucidated in 28 persons (15%). …”
Publicado 2009
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27225“…The root (35.8%) was the most commonly used plant part. The category: malaria, fever and headache had the highest 0.82 ICF. …”
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27226“…New technology and experience gained with other species of insect pests has encouraged a reassessment of the use of the sterility principle as part of integrated control of malaria vectors. Significant technical and logistic hurdles will need to be overcome to develop the technology and make it effective to suppress selected vector populations, and its application will probably be limited to specific ecological situations. …”
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27227por Leite, Ney Ribeiro, Krogh, Renata, Xu, Wei, Ishida, Yuko, Iulek, Jorge, Leal, Walter S., Oliva, Glaucius“…We crystallized AaegOBP1 and determined its three-dimensional structure at 1.85 Å resolution by molecular replacement based on the structure of the malaria mosquito OBP, AgamOBP1, the only mosquito OBP structure known to date. …”
Publicado 2009
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27228por Vezenegho, Samuel B, Bass, Chris, Puinean, Mirel, Williamson, Martin S, Field, Linda M, Coetzee, Maureen, Koekemoer, Lizette L“…BACKGROUND: The malaria vector and non-vector species of the Anopheles funestus group are morphologically very similar and accurate identification is required as part of effective control strategies. …”
Publicado 2009
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27229por Hodel, Eva Maria, Ley, Serej D, Qi, Weihong, Ariey, Frédéric, Genton, Blaise, Beck, Hans-Peter“…BACKGROUND: In order to provide a cost-effective tool to analyse pharmacogenetic markers in malaria treatment, DNA microarray technology was compared with sequencing of polymerase chain reaction (PCR) fragments to detect single nucleotide polymorphisms (SNPs) in a larger number of samples. …”
Publicado 2009
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27230por Ghanchi, Najia K, Mårtensson, Andreas, Ursing, Johan, Jafri, Sana, Bereczky, Sándor, Hussain, Rabia, Beg, Mohammad A“…The genetic diversity and allelic distribution found in this study is similar to previous reports from India and Southeast Asian countries with low malaria endemicity.…”
Publicado 2010
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27231por Lin, Enmoore, Kiniboro, Benson, Gray, Laurie, Dobbie, Stuart, Robinson, Leanne, Laumaea, Annemarie, Schöpflin, Sonja, Stanisic, Danielle, Betuela, Inoni, Blood-Zikursh, Melinda, Siba, Peter, Felger, Ingrid, Schofield, Louis, Zimmerman, Peter, Mueller, Ivo“…BACKGROUND: Where P. vivax and P. falciparum occur in the same population, the peak burden of P. vivax infection and illness is often concentrated in younger age groups. Experiences from malaria therapy patients indicate that immunity is acquired faster to P. vivax than to P. falciparum challenge. …”
Publicado 2010
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27232por Mair, Gunnar R., Lasonder, Edwin, Garver, Lindsey S., Franke-Fayard, Blandine M. D., Carret, Céline K., Wiegant, Joop C. A. G., Dirks, Roeland W., Dimopoulos, George, Janse, Chris J., Waters, Andrew P.“…Therefore, translational repression may offer avenues as a target for the generation of transmission blocking strategies and contribute to limiting the spread of malaria.…”
Publicado 2010
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27233“…BACKGROUND: Plasmodium falciparum is the main causative agent of malaria. Of the 5 484 predicted genes of P. falciparum, about 57% do not have sufficient sequence similarity to characterized genes in other species to warrant functional assignments. …”
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27234por Spicer, Neil, Aleshkina, Julia, Biesma, Regien, Brugha, Ruairi, Caceres, Carlos, Chilundo, Baltazar, Chkhatarashvili, Ketevan, Harmer, Andrew, Miege, Pierre, Murzalieva, Gulgun, Ndubani, Phillimon, Rukhadze, Natia, Semigina, Tetyana, Walsh, Aisling, Walt, Gill, Zhang, Xiulan“…To address this deficit, we review primary data from seven country studies on the effects of three GHIs on coordination of HIV/AIDS programmes: the Global Fund to Fight AIDS, Tuberculosis and Malaria, the President's Emergency Plan for AIDS Relief (PEPFAR), and the World Bank's HIV/AIDS programmes including the Multi-country AIDS Programme (MAP). …”
Publicado 2010
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27235por Gadalla, Nahla B, Elzaki, Salah Eldin, Mukhtar, Ebtihal, Warhurst, David C, El-Sayed, Badria, Sutherland, Colin J“…Dynamic within-host changes in the relative abundance of both sensitive and resistant Plasmodium falciparum parasites were examined in a cohort of chloroquine-treated patients presenting with uncomplicated falciparum malaria, using a novel allele-specific quantitative approach. …”
Publicado 2010
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27236“…BACKGROUND: In the human malaria parasites Plasmodium falciparum, histone modifications have been implicated in the transcriptional regulation. …”
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27237por Koehler, Rebecca N., Walsh, Anne M., Sanders-Buell, Eric E., Eller, Leigh Anne, Eller, Michael, Currier, Jeffrey R., Bautista, Christian T., Wabwire-Mangen, Fred, Hoelscher, Michael, Maboko, Leonard, Kim, Jerome, Michael, Nelson L., Robb, Merlin L., McCutchan, Francine E., Kijak, Gustavo H.“…A vast number of infectious diseases affect East Africa, including HIV/AIDS, malaria, and tuberculosis, but the HLA genetic diversity in this region remains incompletely described. …”
Publicado 2010
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27238“…CONCLUSIONS: A detailed quantitative analysis of a batchwise magnetic fractionation process for malaria infected erythrocytes using high gradient magnetic fractionation columns was performed. …”
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27239por Kang, Jung-Mi, Moon, Sung-Ung, Kim, Jung-Yeon, Cho, Shin-Hyeong, Lin, Khin, Sohn, Woon-Mok, Kim, Tong-Soo, Na, Byoung-Kuk“…BACKGROUND: Merozoite surface protein-1 (MSP-1) and MSP-2 of Plasmodium falciparum are potential vaccine candidate antigens for malaria vaccine development. However, extensive genetic polymorphism of the antigens in field isolates of P. falciparum represents a major obstacle for the development of an effective vaccine. …”
Publicado 2010
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27240“…RESULTS: Here we have applied high confidence function predictions from our automated prediction system, PFP, to three genome sequences, Escherichia coli, Saccharomyces cerevisiae, and Plasmodium falciparum (malaria). The number of annotated genes is increased by PFP to over 90% for all of the genomes. …”
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