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27421“…BACKGROUND: Complement (C) is a crucial part of the innate immune system and becomes over activated during malaria, resulting in depletion of C components, especially those for lectin pathway (LP), thereby compromising the host's innate defense. …”
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27422por Noden, Bruce H., Tshavuka, Filippus I., van der Colf, Berta E., Chipare, Israel, Wilkinson, Rob“…BACKGROUND: The role of pathogen-mediated febrile illness in sub-Saharan Africa is receiving more attention, especially in Southern Africa where four countries (including Namibia) are actively working to eliminate malaria. With a high concentration of livestock and high rates of companion animal ownership, the influence of zoonotic bacterial diseases as causes of febrile illness in Namibia remains unknown. …”
Publicado 2014
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27423por Leong, F. Joel, Li, Ruobing, Jain, Jay Prakash, Lefèvre, Gilbert, Magnusson, Baldur, Diagana, Thierry T., Pertel, Peter“…This first-in-human randomized, double-blind, placebo-controlled, ascending-single and -multiple oral dose study was designed to evaluate the safety, tolerability, and pharmacokinetics in healthy volunteers of KAE609 (cipargamin; formerly NITD609), a spiroindolone now in trials for malaria treatment. It was studied in single-dose cohorts (1 to 300 mg, including one 30-mg food effect cohort) with 4 to 10 subjects in each cohort and in multiple-dose cohorts (10 to 150 mg once daily for 3 days) with 8 subjects in each cohort. …”
Publicado 2014
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27424por Lunga, Paul K, Qin, Xu-Jie, Yang, Xing W, Kuiate, Jules-Roger, Du, Zhi Z, Gatsing, Donatien“…(Sapindaceae) is an African woody vine, which is widely used in traditional medicine for the treatment of human malaria, erectile dysfunction and bacterial infections. …”
Publicado 2014
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27425por Lubinga, Solomon J, Jenny, Alisa M, Larsen-Cooper, Erin, Crawford, Jessica, Matemba, Charles, Stergachis, Andy, Babigumira, Joseph B“…We employ a cluster quasi-experimental design with pre-and post-samples and decision analytic modeling to examine access to and the use of medicines for malaria, pneumonia, and diarrhea for children less than 5 years of age. …”
Publicado 2014
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27426por Lee, Kang Pa, Park, Eun-Seok, Kim, Dae-Eun, Park, In-Sik, Kim, Jin Tack, Hong, Heeok“…BACKGROUND/OBJECTIVES: Artemisinin (AT), an active compound in Arternisia annua, is well known as an anti-malaria drug. It is also known to have several effects including anti-oxidant, anti-inflammation, and anti-cancer activities. …”
Publicado 2014
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27427“…The main research interest of my research group is the discovery and development of traditional herbal medicine for the treatment of two important tropical diseases, cholangiocarcinoma and malaria. As the time is quite limited, I am going to give you the summary of the conceptual framework and highlight some important findings which will illustrate how different approaches have been used or applied for the discovery of the promising candidates for these two diseases.…”
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27428por Wu, Kang, Fang, Hai, Lyu, Liang-Dong, Lowrie, Douglas B., Wong, Ka-Wing, Fan, Xiao-Yong“…Correlation on dataset from patients with AIDS or malaria was stronger for TMtb-iNet, indicating an involvement of TMtb-iNet in these chronic human infections. …”
Publicado 2014
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27429por Lawson, David W., Borgerhoff Mulder, Monique, Ghiselli, Margherita E., Ngadaya, Esther, Ngowi, Bernard, Mfinanga, Sayoki G. M., Hartwig, Kari, James, Susan“…However, Maasai children were less likely to report malaria and worm infections. Food insecurity was high throughout the study site, but particularly severe for the Maasai, and reflected in lower dietary intake of carbohydrate-rich staple foods, and fruits and vegetables. …”
Publicado 2014
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27430por Maliti, Deodatus, Ranson, Hilary, Magesa, Stephen, Kisinza, William, Mcha, Juma, Haji, Khamis, Killeen, Gerald, Weetman, David“…Population genetic structures of the two major malaria vectors Anopheles gambiae s.s. and An. arabiensis, differ markedly across Sub-Saharan Africa, which could reflect differences in historical demographies or in contemporary gene flow. …”
Publicado 2014
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27431por Tiendrebeogo, Regis W, Adu, Bright, Singh, Susheel K, Dodoo, Daniel, Dziegiel, Morten H, Mordmüller, Benjamin, Nébié, Issa, Sirima, Sodiomon B, Christiansen, Michael, Theisen, Michael“…BACKGROUND: Unbiased flow cytometry-based methods have become the technique of choice in many laboratories for high-throughput, accurate assessments of malaria parasites in bioassays. A method to quantify live parasites based on mitotracker red CMXRos was recently described but consistent distinction of early ring stages of Plasmodium falciparum from uninfected red blood cells (uRBC) remains a challenge. …”
Publicado 2014
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27432por Shahin, Ilan, Sohal, Raman, Ginther, John, Hayden, Leigh, MacDonald, John A., Mossman, Kathryn, Parikh, Himanshu, McGahan, Anita, Mitchell, Will, Bhattacharyya, Onil“…Compared to 1,068 single-country programs, we find that trans-nationally scaled programs are more donor-reliant; more likely to focus on targeted health needs such as HIV/AIDS, TB, malaria, or family planning rather than provide more comprehensive general care; and more likely to engage in activities that support healthcare services rather than provide direct clinical care. …”
Publicado 2014
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27433“…METHODS: Data on social networks and research use were collected from seventy policy actors across three health policy cases in Burkina Faso (child health, malaria, and HIV). Networks were graphed for actors’ interactions, their provision of, and request for research evidence. …”
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27434por Siccardi, Marco, Olagunju, Adeniyi, Seden, Kay, Ebrahimjee, Farid, Rannard, Steve, Back, David, Owen, Andrew“…PURPOSE: To treat malaria, HIV-infected patients normally receive artemether (80 mg twice daily) concurrently with antiretroviral therapy and drug-drug interactions can potentially occur. …”
Publicado 2013
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27435por Henriques, Gisela, Hallett, Rachel L., Beshir, Khalid B., Gadalla, Nahla B., Johnson, Rachel E., Burrow, Rebekah, van Schalkwyk, Donelly A., Sawa, Patrick, Omar, Sabah A., Clark, Taane G., Bousema, Teun, Sutherland, Colin J.“…BACKGROUND: The efficacy of artemisinin-based combination therapy (ACT) for Plasmodium falciparum malaria may be threatened by parasites with reduced responsiveness to artemisinins. …”
Publicado 2014
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27436por Islamuddin, Mohammad, Chouhan, Garima, Want, Muzamil Y., Tyagi, Maujiram, Abdin, Malik Z., Sahal, Dinkar, Afrin, Farhat“…Visceral leishmaniasis (VL), the second-most dreaded parasitic disease after malaria, is currently endemic in 88 countries. Dramatic increases in the rates of infection, drug resistance, and non-availability of safe vaccines have highlighted the need for identification of novel and inexpensive anti-leishmanial agents from natural sources. …”
Publicado 2014
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27437por Chitnumsub, Penchit, Jaruwat, Aritsara, Riangrungroj, Pinpunya, Ittarat, Wanwipa, Noytanom, Krittikar, Oonanant, Worrapoj, Vanichthanankul, Jarunee, Chuankhayan, Phimonphan, Maenpuen, Somchart, Chen, Chun-Jung, Chaiyen, Pimchai, Yuthavong, Yongyuth, Leartsakulpanich, Ubolsree“…Plasmodium parasites, the causative agent of malaria, rely heavily on de novo folate biosynthesis, and the enzymes in this pathway have therefore been explored extensively for antimalarial development. …”
Publicado 2014
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27438por Okombo, John, Kamau, Alice W., Marsh, Kevin, Sutherland, Colin J., Ochola-Oyier, Lynette Isabella“…These findings highlight the importance of continual surveillance and characterization of parasite genotypes as indicators of the therapeutic efficacy of antimalarials, particularly in the context of changes in malaria treatment policy.…”
Publicado 2014
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27439por Tambwe, Mgeni Mohamed, Mbeyela, Edgar Mtaki, Massinda, Brian Migamyo, Moore, Sarah Jane, Maia, Marta Ferreira“…BACKGROUND: Malaria vector control is in need of new tools to face its current challenges such as the spread of pyrethroid-resistance and the increase of outdoor feeding mosquitoes. …”
Publicado 2014
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27440por Green, Justin A, Patel, Apurva K, Patel, Bela R, Hussaini, Azra, Harrell, Emma J, McDonald, Mirna J, Carter, Nick, Mohamed, Khadeeja, Duparc, Stephan, Miller, Ann K“…Tafenoquine is being developed for relapse prevention in Plasmodium vivax malaria. This Phase I, single-blind, randomized, placebo- and active-controlled parallel group study investigated whether tafenoquine at supratherapeutic and therapeutic concentrations prolonged cardiac repolarization in healthy volunteers. …”
Publicado 2014
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