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27641por Early, Angela M., Lievens, Marc, MacInnis, Bronwyn L., Ockenhouse, Christian F., Volkman, Sarah K., Adjei, Samuel, Agbenyega, Tsiri, Ansong, Daniel, Gondi, Stacey, Greenwood, Brian, Hamel, Mary, Odero, Chris, Otieno, Kephas, Otieno, Walter, Owusu-Agyei, Seth, Asante, Kwaku Poku, Sorgho, Hermann, Tina, Lucas, Tinto, Halidou, Valea, Innocent, Wirth, Dyann F., Neafsey, Daniel E.“…Here, we combine these complementary approaches in an analysis of the malaria parasite Plasmodium falciparum using haplotype sequences from thousands of natural infections in sub-Saharan Africa. …”
Publicado 2018
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27642por Prado, Elizabeth L., Ashorn, Ulla, Phuka, John, Maleta, Kenneth, Sadalaki, John, Oaks, Brietta M., Haskell, Marjorie, Allen, Lindsay H., Vosti, Steve A., Ashorn, Per, Dewey, Kathryn G.“…Among subgroups of women with baseline low hemoglobin, poor iron status, or malaria, those who received LNS scored 0.4 to 0.7 SD higher than the IFA arm in verbal fluency. …”
Publicado 2017
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27643por Saraiva, Raúl G., Huitt-Roehl, Callie R., Tripathi, Abhai, Cheng, Yi-Qiang, Bosch, Jürgen, Townsend, Craig A., Dimopoulos, George“…This independent mode of action substantiates exploring a chromobacteria-based approach for malaria transmission-blocking.…”
Publicado 2018
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27644por Djègbè, Innocent, Akoton, Romaric, Tchigossou, Genevieve, Ahadji-Dabla, Koffi Mensah, Atoyebi, Seun Michael, Adéoti, Razack, Zeukeng, Francis, Ketoh, Guillaume Koffivi, Djouaka, Rousseau“…Background: To optimize the success of insecticide-based malaria control intervention, knowledge of the distribution of Anopheles gambiae species and insecticide resistance mechanisms is necessary. …”
Publicado 2018
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27645por Haenssgen, Marco J., Charoenboon, Nutcha, Althaus, Thomas, Greer, Rachel C., Intralawan, Daranee, Lubell, Yoel“…Anthropological and sociological research has illuminated the role and impact of rapid point-of-care malaria testing. This paper expands our knowledge about the social implications of non-malarial POCT, using the case study of a C-reactive-protein point-of-care testing (CRP POCT) clinical trial with febrile patients at primary-care-level health centres in Chiang Rai province, northern Thailand. …”
Publicado 2018
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27646por Zhang, Yongjie, den Braver-Sewradj, Shalenie P., den Braver, Michiel W., Hiemstra, Steven, Vermeulen, Nico P. E., van de Water, Bob, Commandeur, Jan N. M., Vos, J. C.“…Formation of the reactive amodiaquine quinoneimine (AQ-QI) and N-desethylamodiaquine quinoneimine (DEAQ-QI) plays an important role in the toxicity of the anti-malaria drug amodiaquine (AQ). Glutathione conjugation protects against AQ-induced toxicity and GSTP1 is able to conjugate its quinoneimine metabolites AQ-QI and DEA-QI with glutathione. …”
Publicado 2018
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27647por Lunev, Sergey, Butzloff, Sabine, Romero, Atilio R., Linzke, Marleen, Batista, Fernando A., Meissner, Kamila A., Müller, Ingrid B., Adawy, Alaa, Wrenger, Carsten, Groves, Matthew R.“…Malaria remains a major threat to human health, as strains resistant to current therapeutics are discovered. …”
Publicado 2018
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27648por Zhang, YiMin, Shao, Li, Zhou, Ning, Li, JianZhou, Chen, Yu, Lu, Juan, Wang, Jie, Chen, ErMei, Xie, ZhongYang, Li, LanJuan“…Seven Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways, cytokine-cytokine receptor interaction, hematopoietic cell lineage, lysosome, rheumatoid arthritis, malaria, and phagosome and pertussis pathways were mapped for DEGs in the failure group. …”
Publicado 2018
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27649“…Merozoite surface protein 7 (MSP-7) is a multigene family expressed during malaria blood-stage infection. MSP-7 forms complex with MSP-1 prior to merozoite egress from erythrocytes, and could affect merozoite invasion of erythrocytes. …”
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27650por Roth, Alison, Maher, Steven P., Conway, Amy J., Ubalee, Ratawan, Chaumeau, Victor, Andolina, Chiara, Kaba, Stephen A., Vantaux, Amélie, Bakowski, Malina A., Thomson-Luque, Richard, Adapa, Swamy Rakesh, Singh, Naresh, Barnes, Samantha J., Cooper, Caitlin A., Rouillier, Mélanie, McNamara, Case W., Mikolajczak, Sebastian A., Sather, Noah, Witkowski, Benoît, Campo, Brice, Kappe, Stefan H. I., Lanar, David E., Nosten, François, Davidson, Silas, Jiang, Rays H. Y., Kyle, Dennis E., Adams, John H.“…Malaria liver stages represent an ideal therapeutic target with a bottleneck in parasite load and reduced clinical symptoms; however, current in vitro pre-erythrocytic (PE) models for Plasmodium vivax and P. falciparum lack the efficiency necessary for rapid identification and effective evaluation of new vaccines and drugs, especially targeting late liver-stage development and hypnozoites. …”
Publicado 2018
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27651por Anselmetti, Yoann, Duchemin, Wandrille, Tannier, Eric, Chauve, Cedric, Bérard, Sèverine“…We use ADseq to provide improved assemblies and a genome history made of duplications, losses, gene translocations, rearrangements, of 18 complete Anopheles genomes, including several important malaria vectors. We also provide additional support for a differentiated mode of evolution of the sex chromosome and of the autosomes in these mosquito genomes. …”
Publicado 2018
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27652por Vofo, Brice N., Ngankam, Gaelle V. F., Ngwasiri, Calypse A., Atem, Jeannine A., Aminde, Leopold N.“…BACKGROUND: Endemic Burkitt’s lymphoma is found predominantly in malaria holoendemic zones, typically in the tropical rain forest of Africa. …”
Publicado 2018
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27653por Colmenarejo, Gonzalo, Lozano, Sonia, González-Cortés, Carolina, Calvo, David, Sanchez-Garcia, Juliana, Matilla, Jesús-Luís Presa, Leroy, Didier, Rodrigues, Janneth“…Plasmodium falciparum Standard Membrane Feeding Assay (PfSMFA) is the current gold standard mosquito based confirmatory transmission blocking (TrB) assay for human malaria. However, owing to its complexity only selected gametocytocidal molecules are progressed into SMFA. …”
Publicado 2018
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27654Detailed Phytochemical Analysis of High- and Low Artemisinin-Producing Chemotypes of Artemisia annuapor Czechowski, Tomasz, Larson, Tony R., Catania, Theresa M., Harvey, David, Wei, Cenxi, Essome, Michel, Brown, Geoffrey D., Graham, Ian A.“…Chemical derivatives of artemisinin, a sesquiterpene lactone produced by Artemisia annua, are the active ingredient in the most effective treatment for malaria. Comprehensive phytochemical analysis of two contrasting chemotypes of A. annua resulted in the characterization of over 80 natural products by NMR, more than 20 of which are novel and described here for the first time. …”
Publicado 2018
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27655“…Background: Growing insecticide resistance and changes in biting and resting behavior of malaria vectors threaten efficacy of insecticide treated nets and indoor residual spraying. …”
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27656por Tijani, Muyideen K., Reddy, Sreenivasulu B., Langer, Christine, Beeson, James G., Wahlgren, Mats, Nwuba, Roseangela I., Persson, Kristina E. M.“…Individuals with higher exposure to malaria produced antibodies with higher affinity to both antigens. …”
Publicado 2018
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27657por Rogerio, Kamilla Rodrigues, Carvalho, Leonardo J M, Domingues, Luiza Helena Pinto, Neves, Bruno Junior, Moreira, José Teófilo, Castro, Rosane Nora, Bianco, Cesare, Daniel-Ribeiro, Claudio Tadeu, Andrade, Carolina Horta, Graebin, Cedric Stephan“…BACKGROUND: Malaria is responsible for 429,000 deaths per year worldwide, and more than 200 million cases were reported in 2015. …”
Publicado 2018
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27658por Adams, Emily Rebecca, Schoone, Gerard, Versteeg, Inge, Gomez, Maria Adelaida, Diro, Ermias, Mori, Yasuyoshi, Perlee, Desiree, Downing, Tim, Saravia, Nancy, Assaye, Ashenafi, Hailu, Asrat, Albertini, Audrey, Ndung'u, Joseph Mathu, Schallig, Henk“…To calculate analytical specificity, 100 clinical samples and isolates from fever-causing pathogens, including malaria parasites, arboviruses, and bacteria, were tested. …”
Publicado 2018
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27659por Amambua-Ngwa, Alfred, Jeffries, David, Amato, Roberto, Worwui, Archibald, Karim, Mane, Ceesay, Sukai, Nyang, Haddy, Nwakanma, Davis, Okebe, Joseph, Kwiatkowski, Dominic, Conway, David J., D’Alessandro, Umberto“…This is probably the first evidence of directional selection on Pfnfs or linked loci by lumefantrine. Given the declining malaria transmission, the consequent loss of population immunity, and sustained drug pressure, it is important to monitor Gambian P. falciparum populations for further signs of adaptation.…”
Publicado 2018
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27660por Fregonese, Federica“…More recently, CABs have been adopted and used in other fields of medical research, such as malaria. CABs are not without limitations, however, and there is little research on the effectiveness of their use in achieving community protection and participation. …”
Publicado 2018
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