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27801por Swart, Tarryn, Khan, Farrah D., Ntlantsana, Apelele, Laming, Dustin, Veale, Clinton G. L., Przyborski, Jude M., Edkins, Adrienne L., Hoppe, Heinrich C.“…The regulation of human Arf1 GTPase activity by ArfGEFs that stimulate GDP/GTP exchange and ArfGAPs that mediate GTP hydrolysis has attracted attention for the discovery of Arf1 inhibitors as potential anti-cancer agents. The malaria parasite Plasmodium falciparum encodes a Sec7 domain-containing protein - presumably an ArfGEF - and two putative ArfGAPs, as well as an Arf1 homologue (PfArf1) that is essential for blood-stage parasite viability. …”
Publicado 2020
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27802por Wondafrash, Dawit Zewdu, Desalegn, Tsion Zewdu, Yimer, Ebrahim M., Tsige, Arega Gashaw, Adamu, Betelhem Anteneh, Zewdie, Kaleab Alemayehu“…Hydroxychloroquine is an immunomodulatory drug that has been used for the treatment of malaria and autoimmune diseases. There is an emerging evidence that suggests its beneficial effect against diabetes mellitus. …”
Publicado 2020
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27803por Zhao, Yueyang, Long, Zhimin, Ding, Ya, Jiang, Tingting, Liu, Jiajun, Li, Yimin, Liu, Yuanjie, Peng, Xuehua, Wang, Kejian, Feng, Min, He, Guiqiong“…Dihydroartemisinin (DHA) is an active metabolite of sesquiterpene trioxane lactone extracted from Artemisia annua, which is used to treat malaria worldwide. DHA can activate autophagy, which is the main mechanism to remove the damaged cell components and recover the harmful or useless substances from eukaryotic cells and maintain cell viability through the autophagy lysosomal degradation system. …”
Publicado 2020
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27804por Wang, Xin, Liu, Min, Cai, Guo He, Chen, Yan, Shi, Xiao Chen, Zhang, Cong Cong, Xia, Bo, Xie, Bao Cai, Liu, Huan, Zhang, Rui Xin, Lu, Jun Feng, Zhu, Meng Qing, Yang, Shi Zhen, Chu, Xin Yi, Zhang, Dan Yang, Wang, Yong Liang, Wu, Jiang Wei“…Lactucin, a plant-derived natural small molecule, is known for anti-malaria and anti-hyperalgesia. The study is to investigate whether lactucin plays a key role in adipogenesis. …”
Publicado 2020
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27805por Oyen, David, Torres, Jonathan L., Aoto, Phillip C., Flores-Garcia, Yevel, Binter, Špela, Pholcharee, Tossapol, Carroll, Sean, Reponen, Sini, Wash, Rachael, Liang, Qi, Lemiale, Franck, Locke, Emily, Bradley, Allan, King, C. Richter, Emerling, Daniel, Kellam, Paul, Zavala, Fidel, Ward, Andrew B., Wilson, Ian A.“…Lasting protection has long been a goal for malaria vaccines. The major surface antigen on Plasmodium falciparum sporozoites, the circumsporozoite protein (PfCSP), has been an attractive target for vaccine development and most protective antibodies studied to date interact with the central NANP repeat region of PfCSP. …”
Publicado 2020
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27806por Munnur, Uma, Karnad, Dilip R., Bandi, Venkata D. P., Lapsia, Vijay, Suresh, Maya S., Ramshesh, Priya, Gardner, Michael A., Longmire, Stephen, Guntupalli, Kalpalatha K.“…They had higher APACHE II scores (median 16 vs 10), greater incidence of neurological (63 vs 36%), renal (50 vs 37%), and cardiovascular dysfunction (39 vs 29%). Severe malaria, viral hepatitis, cerebral venous thrombosis, and poisoning were common medical disorders. …”
Publicado 2005
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27807por Parola, Philippe, Soula, Georges, Gazin, Pierre, Foucault, Cedric, Delmont, Jean, Brouqui, Philippe“…RESULTS: A total of 613 patients were enrolled, including 364 migrants (59.4%), 126 travelers (20.6%), 37 visitors (6%), 24 expatriates (3.9%), and 62 patients (10.1%) who could not be classified. Malaria was the most common diagnosis (75.2%), with most cases (62%) acquired by migrants from the Comoros archipelago and who had traveled to these islands to visit friends and relatives. …”
Publicado 2006
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27808por Yao, Xueting, Ye, Fei, Zhang, Miao, Cui, Cheng, Huang, Baoying, Niu, Peihua, Liu, Xu, Zhao, Li, Dong, Erdan, Song, Chunli, Zhan, Siyan, Lu, Roujian, Li, Haiyan, Tan, Wenjie, Liu, Dongyang“…Hydroxychloroquine shares the same mechanism of action as chloroquine, but its more tolerable safety profile makes it the preferred drug to treat malaria and autoimmune conditions. We propose that the immunomodulatory effect of hydroxychloroquine also may be useful in controlling the cytokine storm that occurs late-phase in critically ill SARS-CoV-2 infected patients. …”
Publicado 2020
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27809por Rollier, Christine S., Spencer, Alexandra J., Sogaard, Karen Colbjorn, Honeycutt, Jared, Furze, Julie, Bregu, Migena, Gilbert, Sarah C., Wyllie, David, Hill, Adrian V. S.“…However, in primate studies, co-administration of a TRAM expressing adenovirus with a vaccine expressing the ME-TRAP malaria antigen had no significant effect on the immune responses. …”
Publicado 2020
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27810por Tiash, Snigdha, Saunders, Jake, Hart, Christopher J.S., Ryan, John H., Riches, Andrew G., Skinner-Adams, Tina S.“…To improve the health and well-being of millions of people world-wide, new anti-Giardia drugs with different modes of action to currently used drugs are required. The Medicines for Malaria Venture's Pathogen Box, a collection of bio-active compounds specifically chosen to stimulate infectious disease drug discovery, represents an opportunity for the discovery of new anti-Giardia agents. …”
Publicado 2020
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27811“…Large-scale programs against these diseases, for example malaria, dengue and African trypanosomiasis, include vector control, and assessing the impact of this intervention requires frequent and extensive monitoring of disease vector abundance. …”
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27812por Boutayeb, A.“…In parallel, 10.1007/978-0-387-78665-0_5343 such as HIV/AIDS, malaria, tuberculosis, acute respiratory infections and diarrheal disease are causing high mortality rates especially in low and middle income countries. …”
Publicado 2010
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27813por Giersing, Birgitte K., Vekemans, Johan, Nava, Samantha, Kaslow, David C., Moorthy, Vasee“…Since the previous meeting, significant progress has been made with regulatory approvals of the first malaria and dengue vaccines, and the first phase III trials of a respiratory syncytial virus (RSV) vaccine candidate has started in the elderly and pregnant women. …”
Publicado 2019
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27814por Asmerom, Demoze, Hailu, Gebremedhin Solomon, Yimer, Ebrahim M., Bitew, Helen, Kahsay, Getu“…Aloe adigratana is one of the endemic Aloe species in Ethiopia where the leaf latex of the plant is traditionally used for the treatment of various pathogenic conditions such as wound, dandruff, malaria, and diabetes. In spite of such claims, there was no scientific study done so far. …”
Publicado 2020
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27815por Lee, Ba-Wool, Ha, Ji-Hye, Shin, Han-Gyo, Jeong, Seong-Hun, Jeon, Da-Bin, Kim, Ju-Hong, Park, Ji-Young, Kwon, Hyung-Jun, Jung, Kyungsook, Lee, Woo-Song, Kim, Hyeon-Young, Kim, Sung-Hwan, Jang, Hyun-Jae, Ryu, Young-Bae, Lee, In-Chul“…Spiraea prunifolia var. simpliciflora (SP) is traditionally used as an herbal remedy to treat fever, malaria, and emesis. This study aimed to evaluate the anti-oxidative and anti-inflammatory properties of the methanol extract of SP leaves in tumor necrosis factor (TNF)-α-stimulated NCI-H292 cells and in a lipopolysaccharide (LPS)-induced acute lung injury (ALI) mouse model. …”
Publicado 2020
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27816“…This requirement also enables mosquitoes to serve as efficient vectors to acquire and potentially transmit a multitude of mosquito-borne diseases, most notably malaria. Recent studies suggest that mosquito immunity is stimulated following a blood meal, independent of infection status. …”
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27817“…Moreover, Chloroquine and hydroxychloroquine, drugs used to treat malaria and arthritis, respectively, were recommended by the National Health Commission of the People's Republic of China for treatment of COVID-19. …”
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27818por Arwati, Heny, Hapsari, Windya T., Wardhani, Kartika A., Aini, Kholida N., Bahalwan, Ramadhani R., Wardhani, Puspa, Sandhika, Willy“…AIM: The aim of this study was to investigate the toxicity of goat bile in BALB/c mice since some Indonesian people consume raw goat gallbladder to treat malaria and increase stamina. MATERIALS AND METHODS: Acute toxicity test was done in six groups of BALB/c mice using 100%, 50%, 25%, 12.5%, and 6.75% of goat bile and negative control. …”
Publicado 2020
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27819por Verity, Robert, Aydemir, Ozkan, Brazeau, Nicholas F., Watson, Oliver J., Hathaway, Nicholas J., Mwandagalirwa, Melchior Kashamuka, Marsh, Patrick W., Thwai, Kyaw, Fulton, Travis, Denton, Madeline, Morgan, Andrew P., Parr, Jonathan B., Tumwebaze, Patrick K., Conrad, Melissa, Rosenthal, Philip J., Ishengoma, Deus S., Ngondi, Jeremiah, Gutman, Julie, Mulenga, Modest, Norris, Douglas E., Moss, William J., Mensah, Benedicta A., Myers-Hansen, James L., Ghansah, Anita, Tshefu, Antoinette K., Ghani, Azra C., Meshnick, Steven R., Bailey, Jeffrey A., Juliano, Jonathan J.“…The Democratic Republic of the Congo (DRC) harbors 11% of global malaria cases, yet little is known about the spatial and genetic structure of the parasite population in that country. …”
Publicado 2020
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27820por Gugliandolo, Enrico, Palma, Ernesto, Peritore, Alessio Filippo, Siracusa, Rosalba, D’Amico, Ramona, Fusco, Roberta, Licata, Patrizia, Crupi, Rosalia“…Artemisinin derivatives are currently the most widely used drugs for the treatment of malaria, especially for their excellent safety profile and low cost. …”
Publicado 2020
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