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27901por Chaudhari, Ramesh, Tandel, Nikunj, Sahu, Kiran, Negi, Sushmita, Bashir, Hilal, Rupareliya, Arzu, Mishra, Ravi PN, Dalai, Sarat K., Tyagi, Rajeev K.“…Our results show significant IgG isotype subclass (IgG1and IgG3) response of specific antibody levels as well as cell-mediated immunity (CMI) activating factor (IFN-γ), a crucial player in conferring resistance to blood-stage malaria in mice receiving EL-PfMSP-Fu(24) through transdermal route as compared to the intramuscularly administered formulation. …”
Publicado 2021
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27902“…SIMPLE SUMMARY: Mosquitoes from the family Culicidae are vectors of numerous human diseases such as dengue, Zika, and West Nile fevers, malaria, and lymphatic filariasis. The availability of high-quality genome assemblies for mosquitoes assists in identifying genes responsible for important epidemiological traits such as vector competence, insecticide resistance, and mosquito behavior and stimulates a better understanding of the genetic structure of mosquito populations. …”
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27903“…Mosquitoes vector many pathogens that cause human disease, such as malaria that is caused by parasites in the genus Plasmodium. …”
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27904por Mbye, Haddijatou, Bojang, Fatoumata, Jawara, Aminata Seedy, Njie, Bekai, Mohammed, Nuredin Ibrahim, Okebe, Joseph, D’Alessandro, Umberto, Amambua-Ngwa, Alfred“…Monitoring of Plasmodium falciparum sensitivity to antimalarial drugs in Africa is vital for malaria elimination. However, the commonly used ex vivo/in vitro 50% inhibitory concentration (IC(50)) test gives inconsistent results for several antimalarials, while the alternative ring-stage survival assay (RSA) for artemisinin derivatives has not been widely adopted. …”
Publicado 2020
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27905por Bourgard, Catarina, Lopes, Stefanie C. P., Lacerda, Marcus V. G., Albrecht, Letusa, Costa, Fabio T. M.“…Plasmodium vivax is a world-threatening human malaria parasite, whose biology remains elusive. The unavailability of in vitro culture, and the difficulties in getting a high number of pure parasites makes RNA isolation in quantity and quality a challenge. …”
Publicado 2021
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27906por Coalson, Jenna E., Santos, Ellen M., Little, Ashley C., Anderson, Elizabeth J., Stroupe, Nancy, Agawo, Maurice, Hayden, Mary, Munga, Stephen, Ernst, Kacey C.“…Universal “coverage” with long-lasting insecticidal nets (LLINs) is recommended for malaria control in endemic areas, but ownership does not ensure usage. …”
Publicado 2020
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27907por Bates, François A., Duncan, Elizabeth H., Simmons, Monika, Robinson, Tanisha, Samineni, Sridhar, Strbo, Natasa, Villasante, Eileen, Bergmann-Leitner, Elke, Wijayalath, Wathsala“…METHODS: Changes in the global immune profile were evaluated in three different groups of rhesus macaques previously enrolled in dengue or malaria vaccine studies over six months after their last exposure. …”
Publicado 2021
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27908por Prasad, Shashanka K., Pradeep, Sushma, Shimavallu, Chandan, Kollur, Shiva Prasad, Syed, Asad, Marraiki, Najat, Egbuna, Chukwuebuka, Gaman, Mihnea-Alexandru, Kosakowska, Olga, Cho, William C., Patrick-Iwuanyanwu, Kingsley Chukwuemeka, Ortega Castro, Joaquín, Frau, Juan, Flores-Holguín, Norma, Glossman-Mitnik, Daniel“…Annona muricata, a tropical plant which has been extensively used in ethnomedicine to treat a wide range of diseases, from malaria to cancer. Interestingly, this plant has been reported to demonstrate significant antiviral properties against the human immunodeficiency virus, herpes simplex virus, human papilloma virus, hepatitis C virus and dengue virus. …”
Publicado 2021
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27909por Rogier, Eric, Nace, Doug, Dimbu, Pedro R., Wakeman, Brian, Pohl, Jan, Beeson, James G., Drakeley, Chris, Tetteh, Kevin, Plucinski, Mateusz“…This parametrization methodology allows direct comparison of Ig isotypes produced against various Plasmodium antigens following malaria infection, and the same methodology could be applied to other longitudinal serologic studies from P. falciparum or different pathogens. …”
Publicado 2021
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27910por Strong, Kathleen L, Pedersen, Jon, White Johansson, Emily, Cao, Bochen, Diaz, Theresa, Guthold, Regina, You, Danzhen, Requejo, Jennifer, Liu, Li“…The leading causes of disease for children under-5 remain preterm birth and infectious diseases, pneumonia, diarrhoea and malaria. For older children and adolescents, injuries become important causes of death as do interpersonal violence and self-harm. …”
Publicado 2021
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27911“…API also hinders the control and prevention of malaria as infected hosts serve as silent reservoirs for transmission of Plasmodium species in the community. …”
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27912A review of Cameroonian medicinal plants with potentials for the management of the COVID-19 pandemicpor Fongnzossie Fedoung, Evariste, Biwole, Achille Bernard, Nyangono Biyegue, Christine Fernande, Ngansop Tounkam, Marlene, Akono Ntonga, Patrick, Nguiamba, Véronique Priscille, Essono, Damien Marie, Forbi Funwi, Preasious, Tonga, Calvin, Nguenang, Guy Merlin, Kemeuze, Victor, Sonwa, Denis Jean, Tsabang, Nole, Bouelet, Isabelle Sandrine, Tize, Zra, Boum, Alexandre Teplaira, Momo Solefack, Marie Caroline, Betti, Jean Lagarde, Nouga Bissoue, Achille, Lehman, Leopold Gustave, Mapongmetsem, Pierre Marie, Nneme Nneme, Leandre, Ngono Ngane, Rosalie Annie, Ngogang Yonkeu, Jeanne“…Of these species, 30 contain confirmed antiCOVID-19 secondary metabolites, 90 are used traditionally to manage at least 3 common symptoms of COVID-19, 10 have immunostimulant activity, 52 have anti-inflamatory activity, 14 have antiviral properties and 78 species are documented as used to treat malaria. A PCA analysis showing cluster formatting among the recorded species indicates 4 groups of species and an array of possibility of using individual species or a combination of species for their complementary effects. …”
Publicado 2021
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27913por Sulistyowaty, Melanny Ika, Uyen, Nguyen Hoang, Suganuma, Keisuke, Chitama, Ben-Yeddy Abel, Yahata, Kazuhide, Kaneko, Osamu, Sugimoto, Sachiko, Yamano, Yoshi, Kawakami, Susumu, Otsuka, Hideaki, Matsunami, Katsuyoshi“…To the best of our knowledge, this is the first report on the bioactive “unnatural” natural products from the crude extract of A. galanga (L.) by chemical conversion and on its activities against causal pathogens of leishmaniasis, trypanosomiasis, and malaria.…”
Publicado 2021
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27914por Sbirkov, Yordan, Ivanova, Tsvetomira, Burnusuzov, Hasan, Gercheva, Kalina, Petrie, Kevin, Schenk, Tino, Sarafian, Victoria“…Atovaquone is a well-tolerated drug used in the clinic mainly against malaria. Being a ubiquinone analogue, this drug inhibits co-enzyme Q10 of the electron transport chain (ETC) affecting oxidative phosphorylation and cell metabolism. …”
Publicado 2021
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27915por Cao, Shuhui, Wang, Yue, Li, Jingwen, Ling, Xuxinyi, Zhang, Yao, Zhou, Yan, Zhong, Hua“…The analysis of the GO biological process revealed that these DEGs were mainly enriched in wound healing, in response to wounding, cell migration, cell motility, and regulation of cell motility, while the KEGG pathway analysis found that these DEGs were mainly enriched in proteoglycans in cancer, bladder cancer, malaria, tyrosine kinase inhibitor resistance in Epidermal Growth Factor Receptor (EGFR), and the ERBB signaling pathway. …”
Publicado 2021
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27916por Rocamora, Frances, Gupta, Purva, Istvan, Eva S., Luth, Madeline R., Carpenter, Emma F., Kümpornsin, Krittikorn, Sasaki, Erika, Calla, Jaeson, Mittal, Nimisha, Carolino, Krypton, Owen, Edward, Llinás, Manuel, Ottilie, Sabine, Goldberg, Daniel E., Lee, Marcus C. S., Winzeler, Elizabeth A.“…[Image: see text] In malaria, chemical genetics is a powerful method for assigning function to uncharacterized genes. …”
Publicado 2021
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27917por Papadimos, Thomas J., Soghoian, Samara E., Nanayakkara, Prabath, Singh, Sarman, Miller, Andrew C., Saddikuti, Venkataramanaiah, Jayatilleke, Achala Upendra, Dubhashi, Siddharth P., Firstenberg, Michael S., Dutta, Vibha, Chauhan, Vivek, Sharma, Pushpa, Galwankar, Sagar C., Garg, Manish, Taylor, Nicholas, Stawicki, Stanislaw P.“…Many regional health-care systems faced at least one wave of overwhelming COVID-19 case surges, and still face the possibility of a new wave of infections on the horizon, potentially in combination with other endemic diseases such as influenza, dengue, tuberculosis, and malaria. In this context, the need for an effective and scientifically informed leadership to sustain and improve global capacity to ensure international health security is starkly apparent. …”
Publicado 2020
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27918por Lee, Alice U., Jackson, Kathy, Tekoaua, Rosemary, Lee, Caroline, Huntley, Margaret Sue, Hilmers, David C.“…Mortality attributable to this disease exceeds that from HIV, tuberculosis and malaria combined in this region. CONTEXT: CHB is a major health problem in the Pacific island nation of Kiribati. …”
Publicado 2020
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27919por Macharia, Peter M, Joseph, Noel K, Sartorius, Benn, Snow, Robert W, Okiro, Emelda A“…Most factors in Western and South-East Kenya recorded moderate intervention coverage although having a high infection prevalence of both HIV and malaria. CONCLUSION: The heterogeneous estimates necessitates prioritisation of the marginalised counties to achieve health equity and improve child survival uniformly across the country. …”
Publicado 2021
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27920por Mirahmadi, Hadi, Safari, Tahere, Metanat, Malihe, Tabatabaei, Seyed Mehdi, Mehravaran, Ahmad, Raeghi, Saber“…Because PvAMA-1 is noticeable as vaccine candidate antigen, these documents provide valuable information for the development of malaria vaccine.…”
Publicado 2020
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