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28041“…Advancement of inhibitors that target Plasmodium and Mycobacterial proteasomes is a means to improve treatment of malaria and tuberculosis. In addition, PIs may also synergize with current frontline agents support as resistance to conventional drugs continues to increase. …”
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28042por Tchouakui, Magellan, Oruni, Ambrose, Assatse, Tatiane, Manyaka, Claudine R., Tchoupo, Micareme, Kayondo, Jonathan, Wondji, Charles S.“…BACKGROUND: Insecticide resistance threatens the effectiveness of malaria vector control, calling for an urgent need to design suitable resistance management strategies. …”
Publicado 2022
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28043por Lopaticki, Sash, McConville, Robyn, John, Alan, Geoghegan, Niall, Mohamed, Shihab Deen, Verzier, Lisa, Steel, Ryan W. J., Evelyn, Cindy, O’Neill, Matthew T., Soler, Niccolay Madiedo, Scott, Nichollas E., Rogers, Kelly L., Goddard-Borger, Ethan D., Boddey, Justin A.“…Therefore, tryptophan C-mannosylation by DPY19 ensures TSR protein quality control at two lifecycle stages for successful transmission of the human malaria parasite.…”
Publicado 2022
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28044por Yu, SuE, Vassilev, Svetlan, Lim, Zhong Ri, Sivalingam, Jaichandran, Lam, Alan Tin Lun, Ho, Valerie, Renia, Laurent, Malleret, Benoit, Reuveny, Shaul, Oh, Steve Kah Weng“…Mature RBCs and reticulocytes, the immature counterparts of RBCs generated during erythropoiesis, could also find important applications in research, for example in malaria parasite infection studies. However, one major challenge is the lack of a high‐density culture platform for large‐scale generation of RBCs in vitro. …”
Publicado 2022
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28045por Rashidzadeh, Hamid, Zamani, Payam, Amiri, Mahdi, Hassanzadeh, Seyed Mehdi, Ramazani, Ali“…CONCLUSION: Based on these results, PCL–PEG–PCL micelles have a great potential to be the carrier for PLN for the malaria targeting.…”
Publicado 2022
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28046por Osanloo, Mahmoud, Firooziyan, Samira, Abdollahi, Abbas, Hatami, Shekoufeh, Nematollahi, Amene, Elahi, Narges, Zarenezhad, Elham“…OBJECTIVE: Microbial infections and mosquito-borne diseases such as malaria, with 627 k deaths in 2020, are still major public health challenges. …”
Publicado 2022
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28047por Heinberg, Adina, Amit-Avraham, Inbar, Mitesser, Vera, Simantov, Karina, Goyal, Manish, Nevo, Yuval, Kandelis-Shalev, Sofia, Thompson, Emilie, Dzikowski, Ron“…The virulence of Plasmodium falciparum, which causes the deadliest form of human malaria, is attributed to its ability to evade the human immune response. …”
Publicado 2022
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28048por Cutts, Julia C, O’Flaherty, Katherine, Zaloumis, Sophie G, Ashley, Elizabeth A, Chan, Jo Anne, Onyamboko, Marie A, Fanello, Caterina, Dondorp, Arjen M, Day, Nicholas P, Phyo, Aung Pyae, Dhorda, Mehul, Imwong, Mallika, Fairhurst, Rick M, Lim, Pharath, Amaratunga, Chanaki, Pukrittayakamee, Sasithon, Hien, Tran Tinh, Htut, Ye, Mayxay, Mayfong, Faiz, M Abdul, Takashima, Eizo, Tsuboi, Takafumi, Beeson, James G, Nosten, Francois, Simpson, Julie A, White, Nicholas J, Fowkes, Freya J I“…METHODS: In an artemisinin therapeutic efficacy study, antibodies to 12 pre-erythrocytic and erythrocytic P. falciparum antigens were measured in 118 children with uncomplicated P. falciparum malaria in the Democratic Republic of Congo (DRC) and compared with responses in patients from Asian sites, described elsewhere. …”
Publicado 2022
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28049por González-Olvera, Merit, Hernandez-Colina, Arturo, Himmel, Tanja, Eckley, Lindsay, Lopez, Javier, Chantrey, Julian, Baylis, Matthew, Jackson, Andrew P.“…In 2017, a mortality event affected Humboldt penguins at Chester Zoo (UK), which coincided with the diagnosis of avian malaria (AM) in some birds. AM is found worldwide wherever a competent mosquito vector is present, but the disease is particularly severe in penguins and other species that originate from non-endemic regions. …”
Publicado 2022
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28050por Tye, Mark A., Payne, N. Connor, Johansson, Catrine, Singh, Kritika, Santos, Sofia A., Fagbami, Lọla, Pant, Akansha, Sylvester, Kayla, Luth, Madeline R., Marques, Sofia, Whitman, Malcolm, Mota, Maria M., Winzeler, Elizabeth A., Lukens, Amanda K., Derbyshire, Emily R., Oppermann, Udo, Wirth, Dyann F., Mazitschek, Ralph“…In recent years, aminoacyl-tRNA synthetases, including prolyl-tRNA synthetase, have emerged as attractive targets for malaria chemotherapy. We describe the development of a single-step biochemical assay for Plasmodium and human prolyl-tRNA synthetases that overcomes critical limitations of existing technologies and enables quantitative inhibitor profiling with high sensitivity and flexibility. …”
Publicado 2022
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28051por Wen, Sihua, Zhang, Xiaofei, Wu, Yanan, Yu, Shangshang, Zhang, Wei, Liu, Ding, Yang, Kai, Sun, Jing“…It is astringent and hemostatic, and it is used for treating malaria, preventing dysentery, detoxification, and as a tonic for deficiency. …”
Publicado 2022
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28052por Patatt, Fernanda Soares Aurélio, Sampaio, André Luiz Lopes, Tauil, Pedro Luiz, Oliveira, Carlos Augusto Costa Pires de“…OBJECTIVE: To verify the incidence of hearing loss in neonates who have no other associated risk indicators, born to mothers treated for malaria during pregnancy. METHODS: A retrospective, quantitative cohort study was developed at Hospital de Base Dr. …”
Publicado 2019
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28053por Zhou, Yonglin, Liu, Baichen, Chu, Xiuling, Su, Jianqing, Xu, Lei, Li, Li, Deng, Xuming, Li, Dan, Lv, Qianghua, Wang, Jianfeng“…Due to the generally safe profile of specialized malaria medication administration in humans, artemisinin derivatives are a promising class of multi-target inhibitors on bacterial resistance and virulence that can be used to extend the usage life of colistin and to tackle the inevitability of serious bacterial infection with colistin.…”
Publicado 2022
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28054“…Increasing life expectancy, outbreaks like COVID-19, and the endemic nature of diseases like dengue, malaria have underscored its importance. Therefore, this study was carried out to assess hesitancy and the factors influencing the uptake of vaccines in adults. …”
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28055“…BACKGROUND: Despite available, inexpensive and effective treatments, malaria, diarrhoea, and pneumonia still contribute the majority of the global burden of childhood morbidity and mortality. …”
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28056“…Regression models were created, and a t-test for differences between means was applied for monthly or yearly clustered data compared to pre-COVID-19 data. Tests for malaria parasite, Mycobacterium tuberculosis, rifampicin resistance, blood group, blood count, and histology showed a statistically significant decrease in 2020, followed by a partial recovery in 2021. …”
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28057por Arias-Alpízar, Kevin, Sánchez-Cano, Ana, Prat-Trunas, Judit, Sulleiro, Elena, Bosch-Nicolau, Pau, Salvador, Fernando, Oliveira, Inés, Molina, Israel, Sánchez-Montalvá, Adrián, Baldrich, Eva“…As a proof-of-concept, the μPAD has been applied to the quantitative detection of Plasmodium falciparum lactate dehydrogenase (Pf-LDH), a biomarker of malaria infection. In this system, detection is based on a single-step magneto-immunoassay that consists of a single 5-min incubation of the lysed blood sample with immuno-modified magnetic beads (MB), detection antibody, and an enzymatic signal amplifier (Poly-HRP). …”
Publicado 2022
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28058por Panchal, Shital S., Mishra, Umang, Kothari, Charmy, Kothari, Vijay, Dalai, Sarat, Mecwan, Marcellin, Chaudhary, Shrishma, Sharma, Juhi, Shah, Priyanka“…Microscopy was used to screen samples for malaria. RESULTS: Of the 300 children analyzed, 87.7% were anemic, 239 children were mildly anemic, 20 were moderately anemic and 4 were severely anemic. …”
Publicado 2022
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28059por Dass, Swati, Mather, Michael W., Morrisey, Joanne M., Ling, Liqin, Vaidya, Akhil B., Ke, Hangjun“…The mitochondrion of malaria parasites is an attractive antimalarial drug target, which require mitoribosomes to translate genes encoded in the mitochondrial (mt) DNA. …”
Publicado 2022
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28060por Jimenez, Jose L., Marr, Linsey C., Randall, Katherine, Ewing, Edward Thomas, Tufekci, Zeynep, Greenhalgh, Trish, Tellier, Raymond, Tang, Julian W., Li, Yuguo, Morawska, Lidia, Mesiano‐Crookston, Jonathan, Fisman, David, Hegarty, Orla, Dancer, Stephanie J., Bluyssen, Philomena M., Buonanno, Giorgio, Loomans, Marcel G. L. C., Bahnfleth, William P., Yao, Maosheng, Sekhar, Chandra, Wargocki, Pawel, Melikov, Arsen K., Prather, Kimberly A.“…This miasmatic paradigm was challenged in the mid to late 19th century with the rise of germ theory, and as diseases such as cholera, puerperal fever, and malaria were found to actually transmit in other ways. …”
Publicado 2022
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