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28641por Taxiarchi, Chrysanthi, Kranjc, Nace, Kriezis, Antonios, Kyrou, Kyros, Bernardini, Federica, Russell, Steven, Nolan, Tony, Crisanti, Andrea, Galizi, Roberto“…Although of high priority for the development of genetic tools to control malaria-transmitting mosquitoes, only a few germline-specific regulatory regions have been characterised to date and the presence of global regulatory mechanisms, such as dosage compensation and meiotic sex chromosome inactivation (MSCI), are mostly assumed from transcriptomic analyses of reproductive tissues or whole gonads. …”
Publicado 2019
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28642por Hailemeskel, Elifaged, Menberu, Temesgen, Shumie, Girma, Behaksra, Sinknesh, Chali, Wakweya, Keffale, Migbaru, Belachew, Mulualem, Shitaye, Getasew, Mohammed, Hussien, Abebe, Daniel, Ashine, Temesgen, Drakeley, Chris, Mamo, Hassen, Petros, Beyene, Bousema, Teun, Tadesse, Fitsum G., Gadisa, Endalamaw“…A country-wide assessment is recommended to clarify the implication of the observed level of variation in drug resistance markers on the efficacy of AL-based treatment against uncomplicated P. falciparum malaria.…”
Publicado 2019
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28643por Bamou, Roland, Sonhafouo-Chiana, Nadège, Mavridis, Konstantinos, Tchuinkam, Timoléon, Wondji, Charles S., Vontas, John, Antonio-Nkondjio, Christophe“…A key factor affecting malaria vector control efforts in Cameroon is the rapid expansion of insecticide resistance in Anopheles gambiae s.l (An. gambiae) populations; however, mechanisms involved in insecticide resistance in forest mosquito populations are still not well documented yet. …”
Publicado 2019
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28644por Paz-Soldan, Valerie A., Morrison, Amy C., Sopheab, Heng, Schwarz, Julia, Bauer, Karin M., Mckenney, Jennie L., Chhea, Chhorvann, Saphonn, Vonthanak, Khuon, Dyna, Hontz, Robert D., Gorbach, Pamina M.“…Defense Threat Reduction Agency Joint Science and Technology Office initiated a program to develop novel point-of-need diagnostic devices for surveillance of emerging infectious diseases including dengue, malaria, plague, and melioidosis. Prior to distribution of devices to observe their correct use among community members in Iquitos, Peru, and Phnom Penh, Cambodia, research was conducted to: 1) assess acceptability of use, including the motivation to use a rapid diagnostic test (RDT) before or instead of seeking care at a health facility, 2) explore comprehension of RDT use instructions, and 3) examine possible strategies for large scale RDT distribution and use at each site. …”
Publicado 2019
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28645por Wekesa Sifuna, Martin, Wambui, Milka, Kang'ethe Nganga, Joseph, Wainaina Kariuki, Daniel, Kimani, Francis Thuo, Muregi, Francis Wamakima“…Malaria is the eighth highest contributor to global disease burden with 212 million cases and 429,000 deaths reported in 2015. …”
Publicado 2019
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28646por Tomlinson, Sean, Carrington Yates, Henrietta, Oruni, Ambrose, Njoroge, Harun, Weetman, David, Donnelly, Martin J., Hof, Arjen E Van’t“…BACKGROUND: Malaria vector control and research rely heavily on monitoring mosquito populations for the development of resistance to public health insecticides. …”
Publicado 2019
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28647por Daré, Labanté Outcha, Bruand, Pierre-Emile, Gérard, Daniel, Marin, Benoît, Lameyre, Valerie, Boumédiène, Farid, Preux, Pierre-Marie“…The aim of this study was to estimate the pooled prevalence and pooled association measures of comorbidities between mental disorders (anxiety, depression, bipolar disorder, and schizophrenia) and neurotropic parasitic diseases (malaria, cysticercosis, toxoplasmosis, human African trypanosomiasis, Chagas disease, and human toxocariasis) in developing and emerging countries. …”
Publicado 2019
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28648por Kim, Jonathan, Tan, Yong Zi, Wicht, Kathryn J., Erramilli, Satchal K., Dhingra, Satish K., Okombo, John, Vendome, Jeremie, Hagenah, Laura M., Giacometti, Sabrina I., Warren, Audrey L., Nosol, Kamil, Roepe, Paul D., Potter, Clinton S., Carragher, Bridget, Kossiakoff, Anthony A., Quick, Matthias, Fidock, David A., Mancia, Filippo“…The emergence and spread of drug-resistant Plasmodium falciparum impedes global efforts to control and eliminate malaria. For decades, treatment relied on chloroquine (CQ), a safe and affordable 4-aminoquinoline that was highly effective against intra-erythrocytic asexual blood-stage parasites, until resistance arose in Southeast Asia and South America and spread worldwide(1). …”
Publicado 2019
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28649por Bao, Ruixia, Liu, Mengyang, Wang, Dan, Wen, Shaoshi, Yu, Haiyang, Zhong, Yi, Li, Zheng, Zhang, Yi, Wang, Tao“…The stems are traditionally used for the treatment of sexual insufficiency, fever, hypertension, and malaria. Furthermore, it has antidiabetic and anticancer activities. …”
Publicado 2019
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28650por Flores-Garcia, Yevel, Herrera, Sonia M., Jhun, Hugo, Pérez-Ramos, Daniel W., King, C. Richter, Locke, Emily, Raghunandan, Ramadevi, Zavala, Fidel“…However, much of the work on CSP and immunity has been developed based on studies using rodent or non-human primate CSP antigens, which may not be entirely translatable to CSP expressed by human malaria parasites, especially considering the host specificity of the different species. …”
Publicado 2019
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28651por Michels, Luana Roberta, Maciel, Tamara Ramos, Nakama, Kelly Ayumi, Teixeira, Flavia Elizabete Guerra, de Carvalho, Felipe Barbosa, Gundel, André, de Araujo, Bibiana Verlindo, Haas, Sandra Elisa“…CONCLUSION: Cationic nanocapsules modified the pharmacology of QN, presenting a potential alternative for malaria treatment.…”
Publicado 2019
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28652“…BACKGROUND: Malaria remains to be one of the deadliest infectious diseases and imposes substantial financial and social costs in the world. …”
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28653“…Seven in ten of these deaths are due to acute respiratory infections (mostly pneumonia), diarrhea, measles, malaria or malnutrition. The WHO Department of Child and Adolescent Health and Development (CAH), in collaboration with eleven other WHO programmes and UNICEF, has responded to this challenge by developing the Integrated Management of Childhood Illness (IMCI) strategy. …”
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28654Acute and subchronic oral toxicity assessments of Combretum micranthum (Combretaceae) in Wistar ratspor Kpemissi, Mabozou, Metowogo, Kossi, Melila, Mamatchi, Veerapur, Veeresh P., Negru, Mihai, Taulescu, Marian, Potârniche, Adrian-Valentin, Suhas, Doddamavattur Shivalingaiah, Puneeth, Tumbadi Adinarayanashetty, Vijayakumar, Sachidananda, Eklu-Gadegbeku, Kwashie, Aklikokou, Kodjo“…BACKGROUND: Combretum micranthum (CM) (Combretaceae) is widely used in traditional medicine throughout West Africa for the treatment of diabetes, hypertension, inflammation, malaria and liver ailments. In our recent research we demonstrated that CM has nephroprotective potentials in diabetes mellitus, hypertension and renal disorders. …”
Publicado 2020
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28655“…Yet, NTDs were estimated to affect close to 2 billion people at the turn of the millennium, with a collective burden equivalent to HIV/AIDS, tuberculosis, or malaria. A global response was therefore warranted. …”
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28656por de Souza, Helen Paredes, de Oliveira, Wanessa Tenório Gonçalves Holanda, dos Santos, Jefferson Pereira Caldas, Toledo, João Paulo, Ferreira, Isis Polianna Silva, de Sousa Esashika, Suely Nilsa Guedes, de Lima, Tatiane Fernandes Portal, de Sousa Delácio, Amanda“…The following incidence rates were mapped: dengue, acute Chagas disease, schistosomiasis, Hansen's disease, hepatitis A, cutaneous leishmaniasis, visceral leishmaniasis, leptospirosis, malaria, and tuberculosis. The analyses were performed for the period from 2010 to 2017 based on a synthetic indicator calculated as the mean of mean incidence coefficients for each disorder, normalized by the mean and standard deviation during the period of analysis. …”
Publicado 2020
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28657por Nomura, Shuhei, Yoneoka, Daisuke, Tanaka, Shiori, Makuuchi, Ryoko, Sakamoto, Haruka, Ishizuka, Aya, Nakamura, Haruyo, Kubota, Anna, Shibuya, Kenji“…Five GDB disease groups were significantly and relatively well-funded compared to their contributions to Japan’s DALY, including neglected tropical diseases and malaria (funding vs DALY = 1.7% vs 0.0%, p<0.01) and neoplasms (28.5% vs 19.2%, p<0.001). …”
Publicado 2020
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28658por Viswasam, Nikita, Lyons, Carrie E., MacAllister, Jack, Millett, Greg, Sherwood, Jennifer, Rao, Amrita, Baral, Stefan D.“…Phase 2 was a review of 23 different types of documents released between January 2009 –January 2019, with a focus on the US President’s Emergency Plan for AIDS Relief (PEPFAR) and The Global Fund to Fight AIDS, Tuberculosis and Malaria investments, for evidence of stakeholder engagement in PSE studies, as well as key population PSE research utilization to inform HIV programming and international HIV investments. …”
Publicado 2020
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28659por Singh, Om P., Nanda, Nutan, Chandra, Dinesh, Jha, Deepa, Adak, Tridibes, Dua, Virendra K., Subbarao, Sarala K.“…This assay will be useful in studies related to bionomics of members of the Fluviatilis Complex in their role in malaria transmission.…”
Publicado 2020
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28660Probe-based multiplex qPCR identifies blood-meal hosts in Anopheles mosquitoes from Papua New Guineapor Keven, John B., Artzberger, Georgia, Gillies, Mary L., Mbewe, Rex B., Walker, Edward D.“…This paper describes a molecular probe-based quantitative PCR for identifying blood-meal hosts in Anopheles malaria vectors from Papua New Guinea. METHODS: TaqMan oligonucleotide probes targeting specific regions of mitochondrial or nuclear DNA of the three primary Anopheles blood-meal hosts, humans, pigs and dogs, were incorporated into a multiplex, quantitative PCR which was optimized for sensitivity and specificity. …”
Publicado 2020
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