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29661por Kayange, Neema M., Mazuguni, Nicholaus, Hokororo, Adolfine, Muiruri, Charles, Reis, Karl, Kidenya, Benson R., Mazigo, Humphrey D.“…Venous blood was obtained for estimation of creatinine level and for malaria diagnosis. The primary outcomes were the prevalence of renal abnormalities, defined by the presence of low estimated glomerular filtration rate (eGFR), proteinuria or microalbuminuria, and hematuria in urine. …”
Publicado 2020
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29662por Aviles, Erica I., Rotenberry, Rachel D., Collins, C. Mathilda, Dotson, Ellen. M., Benedict, Mark Q.“…Their use has substantial potential to contribute to a greater understanding of the bio-ecology of this important malaria vector. Rhodamine B has the advantage that it appears to be permanent and is less easily confused with auto-fluorescence. …”
Publicado 2020
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29663por De Luca, Pietro, Scarpa, Alfonso, De Bonis, Egidio, Cavaliere, Matteo, Viola, Pasquale, Gioacchini, Federico Maria, Ralli, Massimo, Ettore, Cassandro, Claudia, Cassandro“…Chloroquine (CQ) and hydroxychloroquine (HCQ) are typically used in the treatment of rheumatoid arthritis, systemic lupus erythematosus and malaria; they have been considered for off-label and compassionate use in several countries against moderate to severe cases of COVID-19 and there's actually a massive demand of these two drugs. …”
Publicado 2021
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29664por Hodoameda, Peter, Duah-Quashie, Nancy Odurowah, Hagan, Charles Oheneba, Matrevi, Sena, Abuaku, Benjamin, Koram, Kwadwo, Quashie, Neils Ben“…This study investigated the host and parasite genetic factors affecting the susceptibility of the malaria parasite to ACT partner drugs. METHODS: Archived samples from 240 patients age ≤ 9 years participating in anti-malarial drug resistance survey in Ghana, and given artemether with lumefantrine (AL) or artesunate with amodiaquine (AA), were selected and analysed. …”
Publicado 2020
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29665por Pinthong, Nattapon, Limudomporn, Paviga, Vasuvat, Jitlada, Adisakwattana, Poom, Rattaprasert, Pongruj, Chavalitshewinkoon-Petmitr, Porntip“…BACKGROUND: The emergence of artemisinin-resistant malaria parasites highlights the need for novel drugs and their targets. …”
Publicado 2020
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29666por Pathak, Ashish, Mårtensson, Andreas, Gawariker, Sudhir, Sharma, Ashish, Diwan, Vishal, Purohit, Manju, Ursing, Johan“…BACKGROUND: Artesunate plus sulfadoxine–pyrimethamine (ASP) is first-line treatment for uncomplicated Plasmodium falciparum malaria in most of India, except for six North-eastern provinces where treatment failure rates were high. …”
Publicado 2020
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29667por Tam, Dao Ngoc Hien, Tawfik, Gehad Mohamed, El-Qushayri, Amr Ehab, Mehyar, Ghaleb Muhammad, Istanbuly, Sedralmontaha, Karimzadeh, Sedighe, Tu, Vo Linh, Tiwari, Ranjit, Van Dat, Truong, Nguyen, Phuong Thuy Viet, Hirayama, Kenji, Huy, Nguyen Tien“…BACKGROUND: Despite noticeable improvement in anti-malarial treatment, rapid growth of resistant malaria strains points out the need for continuous development of novel anti-malarials to fight the disastrous infection. …”
Publicado 2020
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29668por Hung, Yuen W., Hoxha, Klesta, Irwin, Bridget R., Law, Michael R., Grépin, Karen A.“…Overall, the majority of the studies identified were from Sub-Saharan Africa and were published within the last 5 years. Malaria and maternal health were the most commonly studied health conditions, although a number of other health conditions and health services were also explored. …”
Publicado 2020
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29669por El Chamy Maluf, Sarah, Icimoto, Marcelo Yudi, Melo, Pollyana Maria Saud, Budu, Alexandre, Coimbra, Rita, Gazarini, Marcos Leoni, Carmona, Adriana Karaoglanovic“…BACKGROUND: The intra-erythrocytic development of the malaria parasite Plasmodium falciparum depends on the uptake of a number of essential nutrients from the host cell and blood plasma. …”
Publicado 2020
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29670por Kemibala, Elison E., Mafra-Neto, Agenor, Saroli, Jesse, Silva, Rodrigo, Philbert, Anitha, Ng’habi, Kija, Foster, Woodbridge A., Dekker, Teun, Mboera, Leonard E. G.“…While these odour sources are normally spatio-temporally segregated in a mosquito’s life history, here this study explored to what extent a combination of flower- and human-mimicking synthetic volatiles would attract the malaria vector Anopheles gambiae sensu stricto (s.s.) …”
Publicado 2020
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29671“…Enriched pathways of the upregulated DEGs included extracellular matrix (ECM) receptor interaction, focal adhesion, human papillomavirus infection, malaria, and cell adhesion molecules. The downregulated DEGs were mainly enriched in ascorbate and aldarate metabolism, arginine and proline metabolism, endocrine- and other factor-regulated calcium reabsorption, mineral absorption and longevity regulating pathway, and multiple species signaling pathway. …”
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29672por Bala, Usaini, Ajumobi, Olufemi, Umar, Amina, Adewole, Adefisoye, Waziri, Ndadilnasiya, Gidado, Saheed, Mohammed, Audu B., Uhomoibhi, Perpetua, Muhammad, Basheer, Ismail, Munira, Kachur, Stephen Patrick, Cash, Shelby, Asamoa, Kwame“…We updated the MHFL and assessed service delivery parameters in the Malaria Frontline Project implementing areas in Kano and Zamfara States. …”
Publicado 2020
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29673“…Independent predictors of time to recovery were play stimulation (AHR=1.93, 95% CI: 1.23–3.03), vaccination status (AHR=2.26, 95% CI: 1.12–4.57), tuberculosis (AHR= 0.48, 95% CI: 0.27–0.87), malaria (AHR=0.34,95% CI:0.13–0.88), use of amoxicillin (AHR=1.54, 95% CI: 0.008–2.34), deworming (AHR=1.8, 95% CI: 1.18–2.73), and shock (AHR=0.18, 95% CI: 0.05–0.59). …”
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29674por Tang, Jingyi, Chisholm, Scott A., Yeoh, Lee M., Gilson, Paul R., Papenfuss, Anthony T., Day, Karen P., Petter, Michaela, Duffy, Michael F.“…BACKGROUND: The malaria parasite Plasmodium falciparum has an unusually euchromatic genome with poorly conserved positioning of nucleosomes in intergenic sequences and poorly understood mechanisms of gene regulation. …”
Publicado 2020
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29675por Chida, Afiya Razia, Ravi, Samathmika, Jayaprasad, Suvratha, Paul, Kiran, Saha, Jaysmita, Suresh, Chinjusha, Whadgar, Saurabh, Kumar, Naveen, Rao K, Raksha, Ghosh, Chaitali, Choudhary, Bibha, Subramani, Suresh, Srinivasan, Subhashini“…Malaria remains a major healthcare risk to growing economies like India, and a chromosome-level reference genome of Anopheles stephensi is critical for successful vector management and understanding of vector evolution using comparative genomics. …”
Publicado 2020
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29676por Adamu, Auwal, Jada, Mahmoud Suleiman, Haruna, Hauwa Mohammed Sani, Yakubu, Bassa Obed, Ibrahim, Mohammed Auwal, Balogun, Emmanuel Oluwadare, Sakura, Takaya, Inaoka, Daniel Ken, Kita, Kiyoshi, Hirayama, Kenji, Culleton, Richard, Shuaibu, Mohammed Nasir“…The present study was designed and performed to provide genetic epidemiological data of the prevalence of N86Y-Y184F-D1246Y SNPs in Plasmodium falciparum multidrug resistance 1 (pfmdr1) in the malaria hotspot of Northern Nigeria. METHODS: Plasmodium falciparum-positive blood samples on Whatman-3MM filter papers were collected from 750 symptomatic patients from four states (Kano, Kaduna, Yobe and Adamawa) in Northern Nigeria, and genotyped via BigDye (v3.1) terminator cycle sequencing for the presence of three SNPs in pfmdr1. …”
Publicado 2020
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29677por Puhl, Ana C., Fritch, Ethan James, Lane, Thomas R., Tse, Longping V., Yount, Boyd L., Sacramento, Carol Queiroz, Tavella, Tatyana Almeida, Costa, Fabio Trindade Maranhão, Weston, Stuart, Logue, James, Frieman, Matthew, Premkumar, Lakshmanane, Pearce, Kenneth H., Hurst, Brett L., Andrade, Carolina Horta, Levi, James A., Johnson, Nicole J., Kisthardt, Samantha C., Scholle, Frank, Souza, Thiago Moreno L., Moorman, Nathaniel John, Baric, Ralph S., Madrid, Peter, Ekins, Sean“…We have previously repurposed pyronaridine, tilorone and quinacrine (from malaria, influenza, and antiprotozoal uses, respectively) as inhibitors of Ebola and Marburg virus in vitro in HeLa cells and of mouse adapted Ebola virus in mouse in vivo. …”
Publicado 2020
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29678por Huang, Tzu-En, Deng, Yi-Ning, Hsu, Jui-Ling, Leu, Wohn-Jenn, Marchesi, Elena, Capobianco, Massimo L., Marchetti, Paolo, Navacchia, Maria Luisa, Guh, Jih-Hwa, Perrone, Daniela, Hsu, Lih-Ching“…Dihydroartemisinin (DHA), the main active metabolite of artemisinin derivatives, is a well-known drug for the treatment of malaria. Previous studies have demonstrated that DHA exhibits antitumor effects toward a variety of human cancers and has a potential for repurposing as an anticancer drug. …”
Publicado 2020
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29679por Richardson, Elise A., Abruzzo, Nicole O., Taylor, Caitlin E., Stevens, Bruce R., Cuda, James P., Weeks, Emma N. I.“…These findings are important as they show the potential for DL-methionine and the combination of DL-methionine with BTI to be used as a larvicide against Anopheles mosquitoes, which are responsible for transmitting malaria. ABSTRACT: Mosquito larvicides can reduce mosquito populations at the source, potentially decreasing biting rates and pathogen transmission. …”
Publicado 2020
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29680por Costello, Varea H, Tribble, David, Eickhoff, Christa, Tilley, Drake H, Utz, Gregory, Telu, Kalyani, Ganesan, Anuradha, Fraser, Jamie, Lalani, Tahaniyat“…Younger travelers were more likely engage in risk behaviors (e.g. consume poorly cooked meat or seafood (16% vs 9%) or street vendor food (26% vs 8.6%), wade in fresh water (24% vs. 18%), and non-compliance with malaria prophylaxis (22% vs 12%) (p< 0.05). Older travelers had a lower incidence of TD (18% vs 24%), and a higher proportion of cases with loose stool or mild TD that did not interfere with daily activities (63% vs. 51%) (p< 0.05). …”
Publicado 2020
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