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30001por Fasinu, Pius S, Tekwani, Babu L, Nanayakkara, NP Dhammika, Avula, Bharathi, Herath, HMT Bandara, Wang, Yan-Hong, Adelli, Vijender R, Elsohly, Mahmoud A, Khan, Shabana I, Khan, Ikhlas A, Pybus, Brandon S, Marcsisin, Sean R, Reichard, Gregory A, McChesney, James D, Walker, Larry A“…BACKGROUND: Primaquine, currently the only approved drug for the treatment and radical cure of Plasmodium vivax malaria, is still used as a racemic mixture. Clinical use of primaquine has been limited due to haemolytic toxicity in individuals with genetic deficiency in glucose-6-phosphate dehydrogenase. …”
Publicado 2014
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30002por Ogutu, Bernhards, Juma, Elizabeth, Obonyo, Charles, Jullien, Vincent, Carn, Gwenaelle, Vaillant, Michel, Taylor, Walter Robert John, Kiechel, Jean-René“…For QTcB, a parameter for ECG modifications, increases were modest and due to rising DAQ concentrations and falling heart rates as malaria resolved. Rapid parasite clearance rates and no resistant infections suggest effective pharmacokinetics of both formulations. …”
Publicado 2014
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30003por Sanghong, Rukpong, Junkum, Anuluck, Chaithong, Udom, Jitpakdi, Atchariya, Riyong, Doungrat, Tuetun, Benjawan, Champakaew, Daruna, Intirach, Jitrawadee, Muangmoon, Roongtawan, Chansang, Arpaporn, Pitasawat, Benjawan“…This study was carried out in Thailand to evaluate the repellency of Ligusticumsinense hexane extract (LHE) against laboratory Anopheles minimus and Aedes aegypti, the primary vectors of malaria and dengue fever, respectively. METHODS: Repellent testing of 25% LHE against the two target mosquitoes; An. minimus and Ae. aegypti, was performed and compared to the standard repellent, DEET, with the assistance of six human volunteers of either sex under laboratory conditions. …”
Publicado 2015
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30004por Guillotte, Micheline, Nato, Farida, Juillerat, Alexandre, Hessel, Audrey, Marchand, Françoise, Lewit-Bentley, Anita, Bentley, Graham A., Vigan-Womas, Inès, Mercereau-Puijalon, Odile“…BACKGROUND: Rosetting, namely the capacity of the Plasmodium falciparum-infected red blood cells to bind uninfected RBCs, is commonly observed in African children with severe malaria. Rosetting results from specific interactions between a subset of variant P. falciparum erythrocyte membrane protein 1 (PfEMP1) adhesins encoded by var genes, serum components and RBC receptors. …”
Publicado 2016
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30005“…The public health catastrophe of antimicrobial resistance in malaria has brought these constraints on evolution into a practical realm, with one proposed solution: withdrawing anti-malarial medication use in high resistance settings, built on the assumption that reverse evolution occurs readily enough that populations of pathogens may revert to their susceptible states. …”
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30006por Elfving, Kristina, Shakely, Deler, Andersson, Maria, Baltzell, Kimberly, Ali, Abdullah S., Bachelard, Marc, Falk, Kerstin I., Ljung, Annika, Msellem, Mwinyi I., Omar, Rahila S., Parola, Philippe, Xu, Weiping, Petzold, Max, Trollfors, Birger, Björkman, Anders, Lindh, Magnus, Mårtensson, Andreas“…BACKGROUND: Despite the fact that a large proportion of children with fever in Africa present at primary health care facilities, few studies have been designed to specifically study the causes of uncomplicated childhood febrile illness at this level of care, especially in areas like Zanzibar that has recently undergone a dramatic change from high to low malaria transmission. METHODS: We prospectively studied the aetiology of febrile illness in 677 children aged 2–59 months with acute uncomplicated fever managed by IMCI (Integrated Management of Childhood Illness) guidelines in Zanzibar, using point-of-care tests, urine culture, blood-PCR, chest X-ray (CXR) of IMCI-pneumonia classified patients, and multiple quantitative (q)PCR investigations of nasopharyngeal (NPH) (all patients) and rectal (GE) swabs (diarrhoea patients). …”
Publicado 2016
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30007por Wu, Yang, Cruz, Laura N., Szestak, Tadge, Laing, Gavin, Molyneux, Gemma R., Garcia, Celia R. S., Craig, Alister G.“…CONCLUSION: A protein element in the human malaria parasite that responds to external cues, including the pro-inflammatory cytokine TNF have been discovered. …”
Publicado 2016
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30008por Nunes, Rodrigo Dutra, Romeiro, Nelilma Correia, De Carvalho, Hugo Tremonte, Moreira, Jean Ribeiro, Sola-Penna, Mauro, Silva-Neto, Mário Alberto C., Braz, Glória Regina Cardoso“…Aedes, Anopheles and Culex are dengue, malaria and filariasis vectors, respectively, and are shown to have this distinct characteristic in phosphofructokinase control. …”
Publicado 2016
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30009por Chang, Xuelian, Zhong, Daibin, Lo, Eugenia, Fang, Qiang, Bonizzoni, Mariangela, Wang, Xiaoming, Lee, Ming-Chieh, Zhou, Guofa, Zhu, Guoding, Qin, Qian, Chen, Xiaoguang, Cui, Liwang, Yan, Guiyun“…BACKGROUND: Anopheles sinensis is one of the most abundant vectors of malaria and other diseases in Asia. Vector control through the use of insecticides is the front line control method of vector-borne diseases. …”
Publicado 2016
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30010por Bandje, Kossiwa, Naissant, Bernina, Bigey, Pascal, Lohezic, Murielle, Vayssières, Marlène, Blaud, Magali, Kermasson, Laetitia, Lopez-Rubio, José-Juan, Langsley, Gordon, Lavazec, Catherine, Deloron, Philippe, Merckx, Anaïs“…BACKGROUND: The asexual intra-erythrocytic multiplication of the malaria parasite Plasmodium falciparum is regulated by various molecular mechanisms. …”
Publicado 2016
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30011por Chersich, Matthew F., Blaauw, Duane, Dumbaugh, Mari, Penn-Kekana, Loveday, Dhana, Ashar, Thwala, Siphiwe, Bijlmakers, Leon, Vargas, Emily, Kern, Elinor, Becerra-Posada, Francisco, Kavanagh, Josephine, Mannava, Priya, Mlotshwa, Langelihle, Becerril-Montekio, Victor, Footman, Katharine, Rees, Helen“…Studies on health systems or promotion; community-based activities; and haemorrhage, hypertension, HIV/STIs and malaria were included. Following review of 35,078 titles and abstracts, 2292 full-text publications were included. …”
Publicado 2016
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30012por Younis, Tahira, Khan, Muhammad Rashid, Sajid, Moniba, Majid, Muhammad, Zahra, Zartash, Shah, Naseer Ali“…(Oleaceae) are used traditionally in the treatment of internal wounds, bone fracture, pain, jaundice, malaria and in pneumonia. These ailments involve protective and essential mechanisms of the organism in response to infection, injury and trauma. …”
Publicado 2016
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30013por Huang, Bo, Wang, Qi, Deng, Changsheng, Wang, Jianhua, Yang, Tao, Huang, Shiguang, Su, Xin-zhuan, Liu, Yajun, Pan, Longhua, Li, Guoming, Li, Di, Zhang, Hongying, Bacar, Afane, Abdallah, Kamal Said, Attoumane, Rachad, Mliva, Ahamada M. S. A., Zheng, Shaoqin, Xu, Qin, Lu, Fangli, Guan, Yezhi, Song, Jianping“…BACKGROUND: In Comoros, the widespread of chloroquine (CQ)-resistant Plasmodium falciparum populations was a major obstacle to malaria control, which led to the official withdrawal of CQ in 2004. …”
Publicado 2016
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30014por Denoeud-Ndam, Lise, Dicko, Alassane, Baudin, Elisabeth, Guindo, Ousmane, Grandesso, Francesco, Diawara, Halimatou, Sissoko, Sibiri, Sanogo, Koualy, Traoré, Seydou, Keita, Sekouba, Barry, Amadou, de Smet, Martin, Lasry, Estrella, Smit, Michiel, Wiesner, Lubbe, Barnes, Karen I., Djimde, Abdoulaye A., Guerin, Philippe J., Grais, Rebecca F., Doumbo, Ogobara K., Etard, Jean-François“…METHODS: Children under 5 years of age with uncomplicated P. falciparum malaria were enrolled between November 2013 and January 2015 in Mali and Niger, one third with uncomplicated SAM and two thirds without. …”
Publicado 2016
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30015por Deribew, Amare, Tessema, Gizachew Assefa, Deribe, Kebede, Melaku, Yohannes Adama, Lakew, Yihunie, Amare, Azmeraw T., Abera, Semaw F., Mohammed, Mesoud, Hiruye, Abiy, Teklay, Efrem, Misganaw, Awoke, Kassebaum, Nicholas“…Under-5 mortality rates due to measles, diarrhea, malaria, protein-energy malnutrition, and iron-deficiency anemia declined by more than two-thirds between 1990 and 2013. …”
Publicado 2016
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30016por Swai, Johnson K., Finda, Marceline F., Madumla, Edith P., Lingamba, Godfrey F., Moshi, Irene R., Rafiq, Mohamed Y., Majambere, Silas, Okumu, Fredros O.“…Open eaves [RR (95% CI) 1.15 (1.08–1.23), P < 0.05] and absence of window shutters [RR (95% CI) 2.10 (1.91–2.31), P < 0.05] increased catches of malaria vectors. All Anopheles mosquitoes caught were negative for Plasmodium. …”
Publicado 2016
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30017por McCarthy, James S, Lotharius, Julie, Rückle, Thomas, Chalon, Stephan, Phillips, Margaret A, Elliott, Suzanne, Sekuloski, Silvana, Griffin, Paul, Ng, Caroline L, Fidock, David A, Marquart, Louise, Williams, Noelle S, Gobeau, Nathalie, Bebrevska, Lidiya, Rosario, Maria, Marsh, Kennan, Möhrle, Jörg J“…METHODS: Healthy participants aged 18–55 years were enrolled in a two-part study: part 1, a single ascending dose (25–1200 mg), double-blind, randomised, placebo-controlled study, and part 2, an open-label, randomised, active-comparator controlled study, in which participants were inoculated with Plasmodium falciparum induced blood-stage malaria (IBSM) and treated with DSM265 (150 mg) or mefloquine (10 mg/kg). …”
Publicado 2017
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30018por Marwa, Karol J., Njalika, Agnes, Ruganuza, Deodatus, Katabalo, Deogratias, Kamugisha, Erasmus“…The leading illness/symptoms which led to self-medication among pregnant women attending clinic were malaria 56 (32.56%, morning sickness 44 (25.55%) and headache 33(19.19%). …”
Publicado 2018
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30019por Bastiaens, Guido J. H., Tiono, Alfred B., Okebe, Joseph, Pett, Helmi E., Coulibaly, Sam A., Gonçalves, Bronner P., Affara, Muna, Ouédraogo, Alphonse, Bougouma, Edith C., Sanou, Guillaume S., Nébié, Issa, Bradley, John, Lanke, Kjerstin H. W., Niemi, Mikko, Sirima, Sodiomon B., d’Alessandro, Umberto, Bousema, Teun, Drakeley, Chris“…We assessed the safety of low-dose PQ in combination with artemether-lumefantrine (AL) or dihydroartemisinin-piperaquine (DP) in G6PDd African males with asymptomatic P. falciparum malaria. METHODS AND FINDINGS: In Burkina Faso, G6PDd adult males were randomized to treatment with AL alone (n = 10) or with PQ at 0.25 (n = 20) or 0.40 mg/kg (n = 20) dosage; G6PD-normal males received AL plus 0.25 (n = 10) or 0.40 mg/kg (n = 10) PQ. …”
Publicado 2018
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30020por Dorkenoo, Monique Ameyo, Bronzan, Rachel, Yehadji, Degninou, Tchalim, Mawèke, Yakpa, Kossi, Etassoli, Santrao, Adjeloh, Poukpessi, Maman, Issaka, Sodahlon, Yao“…METHODS: The routine surveillance established in 2010 consisted of a network of 47 laboratories, which searched for Wuchereria bancrofti microfilaria on nocturnal blood smears collected for malaria diagnosis and an additional network of 20 peripheral health facilities, which collected dried blood spots and tested them for Og4C3 antigen. …”
Publicado 2018
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