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  1. 61
    “…The optimal lipid production was obtained at 0.8% malic acid after 24 h of fermentation. Furthermore, in fed-batch bioreactors containing glucose as a carbon source supplemented with malic acid, the highest cell growth, and lipid production were achieved. …”
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    Enhanced lipid production by addition of malic acid in fermentation of recombinant Mucor circinelloides Mc-MT-2
  2. 62
    “…Binary complexes of α-hydroxy acids (L-Tartaric acid and L-Malic acid) with d-electron metal ions (copper, cobalt, nickel) were investigated. …”
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    Influence of d-Electron Divalent Metal Ions in Complex Formation with L-Tartaric and L-Malic Acids
  3. 63
    “…l-Malic acid is a C4-dicarboxylic acid and a potential key building block for a bio-based economy. …”
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    Enhanced l-Malic Acid Production by Aspergillus oryzae DSM 1863 Using Repeated-Batch Cultivation
  4. 64
    “…[Image: see text] NADP(+)-dependent malic enzyme 1 (ME1) decarboxylates malate to form pyruvate and NADPH in the cytoplasm, where it mediates diverse biological functions related to the generation of lipids and other cellular building blocks. …”
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    Discovery and Characterization of a Novel Allosteric Small-Molecule Inhibitor of NADP(+)-Dependent Malic Enzyme 1
  5. 65
    “…Here, indole in choline chloride‐malic acid deep eutectic solvent (DES) was studied as a function of water content, to identify solute interactions with the DES which affect heterocycle reactivity and selectivity, and as a proxy for biomolecule solvation. …”
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    Neutron Diffraction Study of Indole Solvation in Deep Eutectic Systems of Choline Chloride, Malic Acid, and Water
  6. 66
    “…Another enzyme catalyzing malate oxidation is malic enzyme (ME). We clarified which enzyme oxidizes malate that originates from the cyanobacterial TCA cycle using analyses focusing on ME and MDH. …”
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    Malic Enzyme, not Malate Dehydrogenase, Mainly Oxidizes Malate That Originates from the Tricarboxylic Acid Cycle in Cyanobacteria
  7. 67
    “…Ferrocenecarboxaldehyde and malic acid also prevented LPO less efficiently than folic acid. …”
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    Attenuation of hexaconazole induced oxidative stress by folic acid, malic acid and ferrocenecarboxaldehyde in an invertebrate model Bombyxmori
  8. 68
    “…We revealed the functional characterization of C4-NADP-malic enzyme (NADP-ME), extracted and partially purified from maize (Zea mays L. cv. …”
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    Regulation of NADP-Malic Enzyme Activity in Maize (Zea mays L.) under Salinity with Reference to Light and Darkness
  9. 69
    “…In contrast to non-neoplastic tissues, cancer cells utilize glucose mainly for production of basic cellular modules ‘(i.e. nucleotides, aminoacids, fatty acids). In cancer, Malic enzyme (ME) and ATP-citrate lyase (ACLY) are key enzymes linking aerobic glycolysis and fatty acid synthesis and may therefore be of biological and prognostic significance in non-small cell lung cancer (NSCLC). …”
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    Prognostic Value of Malic Enzyme and ATP-Citrate Lyase in Non-Small Cell Lung Cancer of the Young and the Elderly
  10. 70
    “…However, direct acid production is not favored as at a lowered pH value of pH 4.5 the malic acid titer decreased to only 9 ± 1 g L(−1). …”
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    Enhanced malic acid production from glycerol with high-cell density Ustilago trichophora TZ1 cultivations
  11. 71
    por Deng, Yu, Lin, Jia, Mao, Yin, Zhang, Xiaojuan
    Publicado 2016
    “…T. fusca muC obtained by adaptive evolution preferred yeast extract to ammonium sulfate for accumulating malic acid and ammonium sulfate for cell growth. …”
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    Systematic analysis of an evolved Thermobifida fusca muC producing malic acid on organic and inorganic nitrogen sources
  12. 72
    “…In this work, two types of CPT-conjugated polymers were synthesized based on poly(β-L-malic acid) (PMLA) derivatives. Folic acid (FA) was introduced into the polymers as tumor targeting group. …”
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    Preparation of Two Types of Polymeric Micelles Based on Poly(β-L-Malic Acid) for Antitumor Drug Delivery
  13. 73
    “…Malic enzyme 1 (ME1) regulates one of the main pathways that provide nicotinamide adenine dinucleotide phosphate (NADPH), which is essential for cancer cell growth through maintenance of redox balance and biosynthesis processes in the cytoplasm. …”
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    Inhibition of malic enzyme 1 disrupts cellular metabolism and leads to vulnerability in cancer cells in glucose-restricted conditions
  14. 74
    “…Bioinformatics analysis identified that miR-612 targeted the expression of malic enzyme 1 (ME1), and this was confirmed by western blot and luciferase reporter assay results. …”
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    Tumor-suppressing effects of microRNA-612 in bladder cancer cells by targeting malic enzyme 1 expression
  15. 75
    “…Malic enzyme 1 (ME1) is a multifunctional protein involved in glycolysis, the citric acid cycle, NADPH production, glutamine metabolism, and lipogenesis. …”
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    Expression of cytosolic malic enzyme (ME1) is associated with disease progression in human oral squamous cell carcinoma
  16. 76
    “…Key words:Xerostomia, malic acid, transplantation.…”
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    Effectiveness of a spray containing 1% malic acid in patients with xerostomia induced by graft-versus-host disease
  17. 77
    “…PURPOSE: Malic enzyme 1 (ME1) catalyzes malate to pyruvate and thus promotes glycolysis. …”
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    Malic Enzyme 1 Indicates Worse Prognosis in Breast Cancer and Promotes Metastasis by Manipulating Reactive Oxygen Species
  18. 78
    por Borhan, Azry, Yusuf, Suzana
    Publicado 2020
    “…As a starting material for the production of activated carbon (AC) by chemical activation using malic acid due to its biodegradable and non-toxic properties, rubber seed shell (RSS) was used as agricultural waste from rubber farming. …”
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    Activation of Rubber-Seed Shell Waste by Malic Acid as Potential CO(2) Removal: Isotherm and Kinetics Studies
  19. 79
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    Synthesis of Poly(Malic Acid) Derivatives End-Functionalized with Peptides and Preparation of Biocompatible Nanoparticles to Target Hepatoma Cells
  20. 80
    “…Mucor circinelloides, an oleaginous filamentous fungus, is gaining popularity due to its ability to synthesize significant amounts of lipids containing γ-linolenic acid (GLA) that have important health benefits. Malic enzyme (ME), which serves as the main source of NADPH in some fungi, has been found to regulate lipid accumulation in oleaginous fungi. …”
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    Role of Cytosolic Malic Enzyme in Oleaginicity of High-Lipid-Producing Fungal Strain Mucor circinelloides WJ11
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