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901por Urakawa, Susumu, Takamoto, Kouichi, Nakamura, Tomoya, Sakai, Shigekazu, Matsuda, Teru, Taguchi, Toru, Mizumura, Kazue, Ono, Taketoshi, Nishijo, Hisao“…Furthermore, the concentrations of eight metabolites, including branched-chain amino acids, carnitine, and malic acid, were significantly different between the LC + MT and LC groups. …”
Publicado 2015
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902por Gonzalez Malagon, Sandra G., Melidoni, Anna N., Hernandez, Diana, Omar, Bilal A., Houseman, Lyndsey, Veeravalli, Sunil, Scott, Flora, Varshavi, Dorsa, Everett, Jeremy, Tsuchiya, Yugo, Timms, John F., Phillips, Ian R., Shephard, Elizabeth A.“…Five proteins were down regulated in the liver of Fmo5(−/−) mice: aldolase B, ketohexokinase and cytosolic glycerol 3-phosphate dehydrogenase (GPD1) are involved in glucose or fructose metabolism and GPD1 also in production of glycerol 3-phosphate, a precursor of triglyceride biosynthesis; HMG-CoA synthase 1 is involved in cholesterol biosynthesis; and malic enzyme 1 catalyzes the oxidative decarboxylation of malate to pyruvate, in the process producing NADPH for use in lipid and cholesterol biosynthesis. …”
Publicado 2015
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903por Wang, Yan-Liang, Almvik, Marit, Clarke, Nicholas, Eich-Greatorex, Susanne, Øgaard, Anne Falk, Krogstad, Tore, Lambers, Hans, Clarke, Jihong Liu“…Barley showed a reduction in root length and root surface area and an increase in root-exuded malic acid under low-P conditions. Potato exuded relatively small amounts of OAs under low P, while there was a marked increase in root tips. …”
Publicado 2015
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904“…Alterations in the activities of enzymes of glucose metabolism (hexokinase, phosphofructokinase, pyruvate kinase, and glucose-6-phosphatase, fructose-1,6-bisphosphatase and glucose-6-phosphate dehydrogenase) and lipid metabolism (fatty acid synthase, malic enzyme and lipoprotein lipase) as observed in diabetic (D) rats were prevented with CMEEt administration. …”
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905por Krishnan, Michelle L., Wang, Zi, Silver, Matt, Boardman, James P., Ball, Gareth, Counsell, Serena J., Walley, Andrew J., Montana, Giovanni, Edwards, Anthony David“…Within the PPAR pathway, five genes were found by Graph Guided Group Lasso to be highly associated with the phenotype: aquaporin 7 (AQP7), malic enzyme 1, NADP(+)‐dependent, cytosolic (ME1), perilipin 1 (PLIN1), solute carrier family 27 (fatty acid transporter), member 1 (SLC27A1), and acetyl‐CoA acyltransferase 1 (ACAA1). …”
Publicado 2016
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906“…We show that differences in plant extract preparation and assay conditions are required to measure NADP-malic enzyme and phosphoenolpyruvate carboxylase (pH 8, Mg(2+), 22 °C) and phosphoenolpyruvate carboxykinase (pH 7, >2mM Mn(2+), no Mg(2+)) maximal activities accurately. …”
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907por Kujur, Alice, Upadhyaya, Hari D., Bajaj, Deepak, Gowda, C. L. L., Sharma, Shivali, Tyagi, Akhilesh K., Parida, Swarup K.“…Overall, combining high-resolution QTL mapping with genetic association analysis and differential expression profiling, delineated natural allelic variants in five candidate genes (encoding cytochrome-c-biosynthesis protein, malic oxidoreductase, NADH dehydrogenase iron-sulfur protein, expressed protein and bZIP transcription factor) regulating plant height in chickpea. …”
Publicado 2016
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908“…Higher relative fluxes through formyltetrahydrofolate ligase, phosphoenolpyruvate carboxylase, and malic enzyme led to higher biomass yield, while higher relative fluxes through pyruvate kinase and pyruvate dehydrogenase led to higher growth rate. …”
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909por Boğa, Mehmet, Ertaş, Abdulselam, Yılmaz, Mustafa Abdullah, Kızıl, Murat, Çeken, Bircan, Haşimi, Nesrin, Özden, Tuğba Yılmaz, Demirci, Serpil, Yener, İsmail, Deveci, Özcan“…Phenolic profile of V. pinetorum were qualified and quantified by UHPLC-ESI-MS/MS analysis. Malic acid (47250.61±2504.28 µg/g) and luteolin (7651.96±527.98 µg/g) were found as most abundant compounds for metanol and acetone extracts, respectively. …”
Publicado 2016
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910por Dörsam, Stefan, Kirchhoff, Jennifer, Bigalke, Michael, Dahmen, Nicolaus, Syldatk, Christoph, Ochsenreither, Katrin“…Furthermore, effects of substances to malic acid production were analyzed and compounds were categorized regarding their properties in three groups of toxicity. …”
Publicado 2016
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911“…The results of our analysis identified a promising epilepsy candidate gene for follow-up sequencing: malic enzyme 2 (ME2; min p < 0.0084).…”
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912por Chong, Teik Min, Chen, Jian-Woon, See-Too, Wah-Seng, Yu, Choo-Yee, Ang, Geik-Yong, Lim, Yan Lue, Yin, Wai-Fong, Grandclément, Catherine, Faure, Denis, Dessaux, Yves, Chan, Kok-Gan“…Phenotype microarray analysis has demonstrated that this strain can utilize several organic acids including lactic acid, succinic acid, malic acid, citric acid and fumaric acid as sole growth substrates. …”
Publicado 2017
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913Metabolic Effects of Acibenzolar-S-Methyl for Improving Heat or Drought Stress in Creeping Bentgrass“…Metabolite profiling identified a number of amino acids, organic acids, and sugars which were differentially accumulated between ASM treated and untreated plants under heat or drought stress, including aspartic acid, glycine, citric acid, malic acid, and the sugars glucose, and fructose. …”
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914por Charbonnier, Teddy, Le Coq, Dominique, McGovern, Stephen, Calabre, Magali, Delumeau, Olivier, Aymerich, Stéphane, Jules, Matthieu“…Screening a genome-wide transposon mutant library, we find that an active malic enzyme replenishing the pyruvate pool is required for this repression. …”
Publicado 2017
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915“…Secreted pathogen effectors block the metabolic coenzyme NADP-malic enzyme, inhibiting the transfer of electrons to the NADPH oxidases (RBOHs) responsible for ROS generation. …”
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916“…DUSP6 was predicted to exhibit genetic interactions with other hypermethylated DEGs such as malic enzyme 3 and ST3 β-galactoside α-2,3-sialyltransferase 5; TNXB was predicted to be co-expressed with a set of hypermethylated DEGs, including EPH receptor B6, aldehyde dehydrogenase 1 family, member L1 and glutathione peroxidase 3. …”
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917por Gao, Lei, Zhao, Shengjie, Lu, Xuqiang, He, Nan, Zhu, Hongju, Dou, Junling, Liu, Wenge“…The results suggested that soluble sugar consist of fructose, glucose and sucrose while malic-, citric-, and oxalic acids are the primary organic acids in watermelon fruit. …”
Publicado 2018
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918“…The levels of succinic acid and malic acid in the ginseng extract fermented with S. bayanus as well as the levels of lactic acid, malonic acid, and hydroxypruvic acid in the ginseng extract fermented with lactic acid bacteria (L. plantarum and L. mesenteroide) were the highest. …”
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919por Wu, Li, Zhao, Jiayu, Cao, Kexin, Liu, Xiao, Cai, Hao, Wang, Jiaqi, Li, Weidong, Chen, Zhipeng“…Furthermore, the suppressive effect of α-KG on ATP synthase plays an important role in the low levels of oxidative phosphorylation in SMMC-7721 cells; this effect could be strengthened by the metabolic poison methotrexate and reversed by l-(−)-malic acid, an accelerator of the malate-aspartate cycle. …”
Publicado 2018
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920por Guo, Rui, Shi, LianXuan, Jiao, Yang, Li, MingXia, Zhong, XiuLi, Gu, FengXue, Liu, Qi, Xia, Xu, Li, HaoRu“…In JD17, the prolonged drought stress induced a progressive accumulation of osmolytes, including proline, sucrose, fructose, mannose and malic acid. This research extended our understanding of the mechanisms involved in wheat seedling drought tolerance; this study also demonstrated that gas chromatography–mass spectrometry metabolomics could be an effective approach to understand the drought effects on plant biochemistry.…”
Publicado 2018
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