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1081“…In this study, chitin extraction was carried out using the microwave-assisted extraction method by employing choline chloride (C(5)H(14)ClNO) and DL-malic acid (C₄H₆O₅) as the solvents. The inhibitory activity assay of chitin on the expression of NF-kappaB p65 was performed by using Western blot. …”
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1082por Lima, Katelene, Malmir, Maryam, Camões, Sérgio P., Hasan, Kamrul, Gomes, Samuel, Moreira da Silva, Isabel, Figueira, Maria Eduardo, Miranda, Joana P., Serrano, Rita, Duarte, Maria Paula, Silva, Olga“…The chemical screening of aqueous and hydroethanolic extracts of this medicinal plant revealed the presence of organic acids, iridoids, phenylethanoids, and flavonoids as the main classes of marker compounds, with malic acid, citric acid, and verbascoside being the main marker compounds identified. …”
Publicado 2023
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1083por Aliyeva, Naila, Nasibova, Aygun, Mammadov, Ziyaddin, Eftekhari, Aziz, Khalilov, Rovshan“…Among them, the most important are glucose-6-phosphate dehydrogenase (G6PDH, EC 1.1.1.49), malate dehydrogenase decarboxylating (DMDH, malic enzyme, EC 1.1.1.40) and NADP-isocitrate dehydrogenase (NADP-IDH, EC 1.1.1.42). …”
Publicado 2023
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1084IGF-I is a mitogen involved in differentiation-related gene expression in fetal rat brown adipocytesPublicado 1993“…They express constitutively early growth-related genes such as c-myc, c-fos, and beta-actin, tissue specific-genes such as the uncoupling protein (UCP) and the lipogenic marker malic enzyme (ME). Fetal brown adipocytes bear a high expression of insulin-like growth factor receptor (IGF-IR), and show a high affinity IGF-I specific-binding to its receptor, and a high number of binding sites per cell. …”
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1085“…RESULTS: Nineteen phosphate-solubilizing fluorescent Pseudomonas strains of P. fluorescens, P. poae, P. trivialis, and Pseudomonas spp. produced gluconic acid, oxalic acid, 2-ketogluconic acid, lactic acid, succinic acid, formic acid, citric acid and malic acid in the culture filtrates during the solubilization of tricalcium phosphate, Mussoorie rock phosphate, Udaipur rock phosphate and North Carolina rock phosphate. …”
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1086por Voznesenskaya, Elena V., Koteyeva, Nuria K., Edwards, Gerald E., Ocampo, Gilberto“…Portulaca umbraticola, clade Umbraticola, is NADP-malic enzyme (NADP-ME)-type C(4) species, while P. oleracea and P. molokiniensis in clade Oleracea are NAD-ME-type C(4) species, all having different forms of Atriplicoid-type leaf anatomy. …”
Publicado 2010
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1087por Amaral, Ana I., Teixeira, Ana P., Håkonsen, Bjørn I., Sonnewald, Ursula, Alves, Paula M.“…In addition, considerable fluxes through pyruvate carboxylase [PC; PC/pyruvate dehydrogenase (PDH) ratio = 0.5], malic enzyme (5% of the total pyruvate production), and catabolism of branched-chained amino acids (contributing with ∼40% to total acetyl-CoA produced) confirmed the significance of these pathways to astrocytic metabolism. …”
Publicado 2011
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1088por Wang, Yixing, Zeng, Xin, Iyer, Niranjani J., Bryant, Douglas W., Mockler, Todd C., Mahalingam, Ramamurthy“…Sequence analysis of closely related members of the NAD(+)-malic enzyme type C4 grasses such as the model system Setaria viridis can serve as a viable proxy for the switchgrass genome.…”
Publicado 2012
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1089por Zhang, Bei, Xue, Changhu, Hu, Xiaoqian, Xu, Jie, Li, Zhaojie, Wang, Jingfeng, Yanagita, Teruyoshi, Xue, Yong, Wang, Yuming“…The activities of hepatic lipogenic enzymes including fatty acid synthase (FAS), malic enzyme (ME) and glucose-6-phosphatedehydrogenase (G6PDH) were inhibited by SCC treatment. …”
Publicado 2012
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1090por Chaisawang, Montri, Verduyn, Cornelis, Chauvatcharin, Somchai, Suphantharika, Manop“…Assay of some enzymes critical for NADPH supply indicates that activity of glucose-6-phosphate dehydrogenase, the first enzyme in the HMP pathway, is far insufficient for the required NADPH-flux and malic enzyme must be a major source. Activity of the latter (ca. 300 mU/mg protein) far exceeds that in oleaginous fungi and yeast.…”
Publicado 2012
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1091“…Cell lysate experiments showed significant MGO-dose dependent inhibition of glucose-6-phosphate-dependent enzymes and isocitrate dehydrogenase, but not malic enzyme. Analysis of intact cell or lysate proteins showed that arginine-derived hydroimidazolones were the predominant advanced glycation end-product (AGE) formed; lower levels of N (ε)-(carboxyethyl)lysine (CEL) and N (ε)-(carboxymethyl)lysine (CML) were also detected. …”
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1092por Lee, Byung Dae, Park, Je Min, Lee, Young Min, Moon, Eun Soo, Jeong, Hee Jeong, Chung, Young In, Rim, Hyo Deog“…OBJECTIVE: It was previously suggested that the malic enzyme 2 (ME2) as the candidate gene for psychosis in fine mapping of chromosome 18q21. …”
Publicado 2014
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1093“…Photosynthetic efficiency was probed by combining leaf gas-exchange measurements with carbon isotope discrimination and assaying the key carboxylases [ribulose-1,5-bisphosphate carboxylase/oxygenase (Rubisco) and phosphoenolpyruvate carboxylase (PEPC)] and decarboxylases [nicotinamide adenine dinucleotide phosphate malic enzyme (NADP-ME) and phosphoenolpyruvate carboxykinase (PEP-CK)] operating in maize leaves. …”
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1094por Bowsher, Alan W., Ali, Rifhat, Harding, Scott A., Tsai, Chung-Jui, Donovan, Lisa A.“…Species native to low nutrient soils and those native to high nutrient soils responded similarly to low nutrient treatments with increased exudation of organic acids (fumaric, citric, malic acids) and glucose, potentially as a mechanism to enhance nutrition acquisition. …”
Publicado 2016
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1095por Koteyeva, Nuria K., Voznesenskaya, Elena V., Berry, James O., Cousins, Asaph B., Edwards, Gerald E.“…In the C(4)-D domain, CO(2) released in the C(4) cycle via mitochondrial NAD-malic enzyme is refixed by Rubisco. Despite striking differences in origin and intracellular positioning of domains, these species show strong convergence in C(4) developmental patterns. …”
Publicado 2016
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1096“…The strain of Star. bacillaris produced the highest amount of glycerol and was able to metabolize all fructose and malic acid. Strains of M. pulcherrima and H. uvarum showed a low fermentation power (about 4%), while, L. thermotolerans, Star. …”
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1098por Hong, Moonju, Jung, Jeeyoun, Park, Hee-Sook, Lee, So Min, Jeong, Nam-Joo, Kim, Soon-Hee, Lee, Kyoung-Won, Lee, Ju-A, Kim, Myung-Sunny“…Increases in the levels of TCA cycle intermediate metabolites, such as 2-oxoglutaric acid, isocitric acid, and malic acid, in the serum of obese mice were significantly reversed after SFZYD treatment. …”
Publicado 2017
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1099por vel Szic, Katarzyna Szarc, Declerck, Ken, Crans, René A.J, Diddens, Jolien, Scherf, David B., Gerhäuser, Clarissa, Berghe, Wim Vanden“…In contrast to the DNA demethylating agent 5-aza-2’-deoxycytidine (DAC), WA treatment of MDA-MB-231 cells rather tackles an epigenetic cancer network through gene-specific DNA hypermethylation of tumor promoting genes including ADAM metallopeptidase domain 8 (ADAM8), urokinase-type plasminogen activator (PLAU), tumor necrosis factor (ligand) superfamily, member 12 (TNFSF12), and genes related to detoxification (glutathione S-transferase mu 1, GSTM1), or mitochondrial metabolism (malic enzyme 3, ME3). Gene expression and pathway enrichment analysis further reveals epigenetic suppression of multiple cancer hallmarks associated with cell cycle regulation, cell death, cancer cell metabolism, cell motility and metastasis. …”
Publicado 2017
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1100por Gao, Jiarong, Qin, Xiu-Juan, Jiang, Hui, Chen, Jin-Feng, Wang, Ting, Zhang, Ting, Xu, Shuang-Zhi, Song, Jun-Mei“…In serum, the metabolites identified included isoleucine, L-malic acid, α-copper, carnitine, hippuric acid, glutaric acid and glucose. …”
Publicado 2017
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