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6“…Malic enzymes have high cofactor selectivity. An isoform-specific distribution of residues 314, 346, 347 and 362 implies that they may play key roles in determining the cofactor specificity. …”
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7por Oswald, Florian, Dörsam, Stefan, Veith, Nicolas, Zwick, Michaela, Neumann, Anke, Ochsenreither, Katrin, Syldatk, Christoph“…The overall conversion of CO and H(2) into malic acid was calculated to be 3.5 g malic acid per mol of consumed syngas or 0.22 g malic acid per gram of syngas.…”
Publicado 2016
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8por Cheng, Chiao-Pei, Huang, Li-Chun, Chang, Yung-Lung, Hsieh, Ching-Hsuan, Huang, Shih-Ming, Hueng, Dueng-Yuan“…We performed a preliminary analysis of data obtained from Gene Expression Omnibus profiles and determined that malic enzyme 2 (ME2) expression was positively associated with WHO grade in human primary gliomas. …”
Publicado 2016
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9“…Thus, the mitochondrial malic enzyme functionally couples the mitochondria with aerobic glycolysis in osteoblasts.…”
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10por Harding, Christopher John, Cadby, Ian Thomas, Moynihan, Patrick Joseph, Lovering, Andrew Lee“…Bacterial hybrid malic enzymes (MaeB grouping, multidomain) catalyse the transformation of malate to pyruvate, and are a major contributor to cellular reducing power and carbon flux. …”
Publicado 2021
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12“…The ΔFUM1Ckr_fum + mae1 and ΔFUM1(ss)Ckr_fum + mae1 strains converted extracellular malic acid into 0.98 and 1.11 g/L fumaric acid under aerobic conditions.…”
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13por Gómez-Moreno, Gerardo, Guardia, Javier, Aguilar-Salvatierra, Antonio, Cabrera-Ayala, Maribel, Maté-Sánchez de-Val, José E., Calvo-Guirado, José L.“…Objectives: Assessing the clinical effectiveness of a topical sialogogue on spray (malic acid, 1%) in the treatment of xerostomia induced by antihypertensive drugs. …”
Publicado 2013
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14“…We show that p53 represses the expression of the tricarboxylic acid cycle (TCA cycle)-associated malic enzyme 1 (ME1) and malic enzyme 2 (ME2). Both MEs are important for NADPH production, lipogenesis, and glutamine metabolism, with ME2 having a more profound effect. …”
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15por Gerrard Wheeler, Mariel Claudia, Arias, Cintia Lucía, Righini, Silvana, Badia, Mariana Beatriz, Andreo, Carlos Santiago, Drincovich, María Fabiana, Saigo, Mariana“…Malic enzymes (ME) catalyze the decarboxylation of malate generating pyruvate, CO(2) and NADH or NADPH. …”
Publicado 2016
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16por Trichez, Debora, Auriol, Clément, Baylac, Audrey, Irague, Romain, Dressaire, Clémentine, Carnicer-Heras, Marc, Heux, Stéphanie, François, Jean Marie, Walther, Thomas“…However, as malate can be a precursor for specialty chemicals, such as 2,4-dihydroxybutyric acid, that require additional cofactors NADP(H) and ATP, we set out to reengineer Escherichia coli for Krebs cycle-dependent production of malic acid that can satisfy these requirements. RESULTS: We found that significant malate production required at least simultaneous deletion of all malic enzymes and dehydrogenases, and concomitant expression of a malate-insensitive PEP carboxylase. …”
Publicado 2018
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17“…In this study, the structure, reaction mechanism, and digestibility of wrinkled pea starch with malic acid and heat–moisture treatment (HMT) are investigated. …”
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18Induction of Erythroid Differentiation in Human Erythroleukemia Cells by Depletion of Malic Enzyme 2“…Malic enzyme 2 (ME2) is a mitochondrial enzyme that catalyzes the conversion of malate to pyruvate and CO(2) and uses NAD as a cofactor. …”
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19“…The cytosolic NADP(+)-dependent malic enzyme (c-NADP-ME) has a dimer-dimer quaternary structure in which the dimer interface associates more tightly than the tetramer interface. …”
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