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  1. 3201
    por Guan, Hua, Tian, Kun, Luo, Wei, Li, Mingfei
    Publicado 2023
    “…In conclusion, these findings highlight the oncogenic role of METTL3-induced circMYO1C in PDAC tumorigenesis via an m(6)A-dependent manner, inspiring a novel strategy to explore PDAC epigenetic therapy.…”
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  2. 3202
    “…Prolonged exposure to 25-OHC caused cell death and enhanced celecoxib-induced cell death in a cell-type dependent manner. The lack of uniform response by the three endothelial cell types examined suggests that our model system of primary cultures of bmLECs, bmVECs, and bmAECs may aid the evaluation of celecoxib in inhibiting proliferation of different types of tumour-associated endothelial cells.…”
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  3. 3203
    por Bandi, Nora, Vassella, Erik
    Publicado 2011
    “…RESULTS: In the present study, we demonstrate that miR-34a and miR-15a/16 act synergistically to induce cell cycle arrest in a Rb-dependent manner. In contrast, no synergistic effect of these miRNAs was observed for apoptosis. …”
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  4. 3204
    “…Single nucleotide polymorphisms rs2519184, rs8234, and rs10798 were associated in an allele-specific manner with QTc and symptom occurrence. Patients with the derived SNP variants on their mutated KCNQ1 allele had shorter QTc and fewer symptoms, while the opposite was also true: patients with the derived SNP variants on their normal KCNQ1 allele had significantly longer QTc and more symptoms. …”
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  5. 3205
  6. 3206
    “…We found that IL-27 inhibits in vitro tumor growth of human melanomas and greatly enhances the expression of TNF-related apoptosis inducing ligand (TRAIL) in a dose-dependent manner. Neutralizing antibody against TRAIL partly but significantly blocked the IL-27–mediated inhibition of tumor growth. …”
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  7. 3207
  8. 3208
  9. 3209
  10. 3210
  11. 3211
  12. 3212
    “…This study revealed that BaP, as a component of PM(2.5), induces pulmonary injury by activating PLA2 and elevating lysophosphatidylcholine (LPC) in a Ca(2+)-dependent manner in the alveolar type II cells.…”
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  13. 3213
  14. 3214
  15. 3215
    “…TAK-875 decreased viability of 2D and 3D cultures of HepG2, a human hepatocarcinoma cell line, in concentration- (>50 μM) and time-dependent manners, both of which corresponded with ROS generation. …”
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  16. 3216
    “…Grb2-associated binder (Gab) family proteins are multi-site docking proteins, which expand cytokine-induced signal transduction in a spatial- and time-dependent manner by coordinating the recruitment of proteins involved in mitogen activated protein kinase (MAPK)/extracellular-signal regulated kinase (ERK) and phosphatidyl-inositol-3-kinase (PI3K) signalling. …”
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  17. 3217
  18. 3218
  19. 3219
  20. 3220
    “…What’s more, A. caviae resulted in NF-κB p65 nuclear translocation partly in a TLR2-dependent manner. Blocking NF-κB using BAY 11-7082 almost completely inhibited NLRP3 inflammasome first signal pro-IL-1β expression. …”
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