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  1. 3401
    por Jung, Marc, Pfeifer, Gerd P
    Publicado 2015
    “…We explore mechanisms that could facilitate DNA methylation changes in a site-specific manner and highlight a model in which region-specific DNA hypermethylation during aging is facilitated in a competitive manner by destabilization of the Polycomb repressive complex.…”
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    Aging and DNA methylation
  2. 3402
    por Jafarpour, Saber, Lewis, Andrew D
    Publicado 2014
    “…The presentation of this material in the real analytic setting is new, as is the manner in which the various hypotheses are unified using functional analysis. …”
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    Time-varying vector fields and their flows
  3. 3403
    “…We, therefore, developed the HouseKeepR algorithm to rapidly analyse multiple gene expression datasets in a disease-specific manner and rank HK gene candidates according to stability in an unbiased manner. …”
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    Un-biased housekeeping gene panel selection for high-validity gene expression analysis
  4. 3404
    “…Furthermore, the viral fluorescence intensities were inhibited by SPS in a dose-dependent manner when the viruses or cells were preincubated with SPS. …”
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    Efficacy of sodium polyanethol sulfonate on herpes simplex virus-1 infection in vitro
  5. 3405
    por Funai, Katsuhiko, Cartee, Gregory D.
    Publicado 2009
    “…CONCLUSIONS: These data suggest that 1) insulin stimulates glucose transport and phosphorylation of AS160 and TBC1D1 in a PI 3-kinase/Akt–dependent manner, 2) contraction stimulates PAS-AS160 (but not PAS-TBC1D1 or glucose transport) in a PI 3-kinase/Akt–dependent manner, and 3) contraction stimulates PAS-TBC1D1 and glucose transport (but not PAS-AS160) in an AMPK-dependent manner.…”
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    Inhibition of Contraction-Stimulated AMP-Activated Protein Kinase Inhibits Contraction-Stimulated Increases in PAS-TBC1D1 and Glucose Transport Without Altering PAS-AS160 in Rat Skeletal Muscle
  6. 3406
    “…The MTT cell viability data revealed that treatment with phenolic rich extracts at 75 ~ 175 μg/ml significantly inhibited the viability and proliferation of cells, and these effects occurred in a concentration-dependent manner and time dependent manner (P < 0.01). RESULTS: The phenolic rich extracts can induce apoptosis of SiHa cells, can increase the apoptosis rate in a concentration-dependent manner and time dependent manner (P < 0.01). …”
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    Anti-carcinogenic effects of the phenolic-rich extract from abnormal Savda Munziq in association with its cytotoxicity, apoptosis-inducing properties and telomerase activity in human cervical cancer cells (SiHa)
  7. 3407
    “…Thus, the later apparently rapid increase of suicides reflected steadily improving classification of manner of death, as well as a more fundamental increase in the suicide rate.…”
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    The Impact of Improving Suicide Death Classification in South Korea: A Comparison with Japan and Hong Kong
  8. 3408
    “…GBPs, induced in a type I IFN-dependent manner, are required for the F. novicida-mediated AIM2-inflammasome pathway. …”
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    IFN-γ extends the immune functions of Guanylate Binding Proteins to inflammasome-independent antibacterial activities during Francisella novicida infection
  9. 3409
    “…While male and female control flies (no MeHg) and flies fed with lower concentrations of MeHg (28.25, 56.5 µM) copulated in a normal manner, male and female flies exposed to higher concentrations of MeHg (113, 226, and 339 µM) did not copulate. …”
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    Methylmercury Exposure Induces Sexual Dysfunction in Male and Female Drosophila Melanogaster
  10. 3410
    por Wang, Xin, Mao, Rongyan, Chen, Weiwei
    Publicado 2018
    “…RESULTS: ox-LDL incubation reduced the viability of BMECs by inducing cell apoptosis in a concentration-dependent manner. ROCK activity was also elevated by ox-LDL incubation in BMECs in a concentration-dependent manner. …”
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    FSD-C10 Shows Therapeutic Effects in Suppressing oxidized low-density lipoprotein (ox-LDL)-Induced Human Brain Microvascular Endothelial Cells Apoptosis via Rho-Associated Coiled-Coil Kinase (ROCK)/Mitogen-Activated Protein Kinase (MAPK) Signaling
  11. 3411
    “…Moreover, we found that GEF increased HA synthase 1 (HAS1) expression in a time-dependent manner. We also found that GEF stimulates collagen release and the expression of collagen 1, 3, and 7 synthases in a time-dependent manner. …”
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    Ginseng Gintonin Enhances Hyaluronic Acid and Collagen Release from Human Dermal Fibroblasts Through Lysophosphatidic Acid Receptor Interaction
  12. 3412
    “…The single processing unit exchanges control messages with nodes via the switch, while the nodes exchange data packets among themselves using a wireless medium in a distributed manner. The main disadvantage of the traditional testbed is that, despite the network being distributed in nature, decisions are made in a centralized manner. …”
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    A Distributed Testbed for 5G Scenarios: An Experimental Study
  13. 3413
    “…The ability to sense and use the body parts in an organized and differentiated manner is a precursor of body knowledge in infancy. …”
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    Development of body knowledge as measured by arm differentiation in infants: From global to local?
  14. 3414
    “…The treatment of Obac (1 and 10 μM) increased wound healing and migration rates in a dose-dependent manner. Alkaline phosphatase (ALP) staining and activity showed that Obac (1 and 10 μM) enhanced early osteoblast differentiation in a dose-dependent manner. …”
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    Limonoid Triterpene, Obacunone Increases Runt-Related Transcription Factor 2 to Promote Osteoblast Differentiation and Function
  15. 3415
    “…Besides advantages of common in vitro techniques, there is a growing demand for in vivo information based on imaging techniques that allow to screen antibiotic candidates in a dynamic manner. Gathering information from imaging data in a reproducible manner, robust data processing and analysis workflows demand advanced (semi-)automation and data management to increase reproducibility. …”
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    Antibiotic Drug screening and Image Characterization Toolbox (A.D.I.C.T.): a robust imaging workflow to monitor antibiotic stress response in bacterial cells in vivo
  16. 3416
    “…The importance of willingness to behave in an environmentally responsible manner was 0.1562, the importance of innovative behaviour was 0.1404, and the perceived behavioural control was 0.1322. …”
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    Predictive Analysis of the Pro-Environmental Behaviour of College Students Using a Decision-Tree Model
  17. 3417
    “…Results: M2 macrophage direct contact induced a higher proliferation and invasion in PCa cells when compared with noncontact coculture manner. In direct contact manner, NOTCH1 pathway was greatly activated in PCa cells, induced by elevated γ-secretase activity and higher coactivator MAML2 expression. …”
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    Tumor-associated macrophages in direct contact with prostate cancer cells promote malignant proliferation and metastasis through NOTCH1 pathway
  18. 3418
    “…The results of the present study demonstrated that apigenin inhibits ACC-2 cell growth in a dose- and time-dependent manner. Treatment with apigenin also induced apoptosis and G(2)/M-phase arrest in a dose- and time-dependent manner. …”
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    Apigenin inhibits the proliferation of adenoid cystic carcinoma via suppression of glucose transporter-1
  19. 3419
    “…In the present study, echistatin inhibited cell proliferation, migration, invasion, and adhesion of 143B-LM4 cells. 143B-LM4 cell proliferation decreased after treatment with echistatin in a time-dependent and dose-dependent manner (P <0.01). In vitro migration and invasion of 143B-LM4 cells were also inhibited by echistatin in a dose-dependent manner (P <0.01, respectively). …”
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    Disintegrin targeting of an α(v)β(3) integrin-over-expressing high-metastatic human osteosarcoma with echistatin inhibits cell proliferation, migration, invasion and adhesion in vitro
  20. 3420
    “…The results indicated that Biochanin A significantly inhibited the growth of SK-Mel-28 cells in a dose and time dependent manner. Treatment of the cells with Biochanin A induced apoptosis in a dose dependent manner. …”
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    Biochanin A induces anticancer effects in SK-Mel-28 human malignant melanoma cells via induction of apoptosis, inhibition of cell invasion and modulation of NF-κB and MAPK signaling pathways
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