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  1. 3421
    “…The treatment of SiHa cells with PHE for 24 h suppressed colony formation in a dose-dependent manner, inhibited proliferation and inhibited cell motility. …”
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    The Inhibitory Effects of Phenolic and Terpenoid Compounds from Baccharis trimera in Siha Cells: Differences in Their Activity and Mechanism of Action
  2. 3422
    “…In this study, we evaluated the cytotoxic activity of vincristine, doxorubicin, temozolomide, panobinostat, toceranib, gemcitabine, cisplatin, fluorouracil, cyclophosphamide, and methotrexate on a CTVT cell line, determining that all drugs decreased the viability in a dose-dependent manner. Furthermore, they inhibit cellular migration in a time- and drug-dependent manner, as evaluated by the wound healing assay. …”
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    In vitro chemosensitivity of a canine tumor venereal transmissible cancer cell line
  3. 3423
    “…Morphogens determine cellular differentiation in many developing tissues in a concentration dependent manner. As a central model for gradient formation during animal development, Hedgehog (Hh) morphogens spread away from their source to direct growth and pattern formation in the Drosophila wing disc. …”
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    Drosophila hedgehog signaling range and robustness depend on direct and sustained heparan sulfate interactions
  4. 3424
    Publicado 1989
    “…Cs+ blocked inward current in a manner similar to that of Na+, but the former was much more potent. …”
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    Voltage-dependent block of cardiac inward-rectifying potassium current by monovalent cations
  5. 3425
    “…It inhibited the synthesis of RNA by recombinant HCV NS5B polymerase in a dose dependent manner. The CC(50 )value was 77 μM. The inhibition was in a noncompetitive manner with the substrate UTP. …”
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    Characterization of thiobarbituric acid derivatives as inhibitors of hepatitis C virus NS5B polymerase
  6. 3426
    “…Whether macrophages sense and respond to thermal signals in a manner which regulates their function in a specific manner is still not clear. …”
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    Opposing roles for heat and heat shock proteins in macrophage functions during inflammation: a function of cell activation state?
  7. 3427
    “…Homing endonucleases (HEs) are ancient selfish elements that catalyze double-stranded DNA breaks (DSB) in a highly specific manner. In this report, we show that the HEs Y2-I-AniI, I-CreI and I-SceI are all capable of catalyzing the excision of genomic segments from the Ae. aegypti genome in a heritable manner. …”
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    Germline excision of transgenes in Aedes aegypti by homing endonucleases
  8. 3428
    “…In describing motion events verbs of manner provide information about the speed of agents or objects in those events. …”
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    To Dash or to Dawdle: Verb-Associated Speed of Motion Influences Eye Movements during Spoken Sentence Comprehension
  9. 3429
    “…However, the Reinforcement Learning (RL) techniques that were used in previous studies to induce tutorial tactics are insufficient when encountering large problems and hence were used in offline manners. Therefore, we introduced a Genetic-Based Reinforcement Learning (GBML) approach to induce tutorial tactics in an online-learning manner without basing on any preexisting dataset. …”
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    Online Pedagogical Tutorial Tactics Optimization Using Genetic-Based Reinforcement Learning
  10. 3430
    “…Subsequently, the intracellular domain (ICD) of TβRI enters in an unknown manner into the nucleus, where it promotes the transcription of pro-invasive genes, such as MMP2 and MMP9. …”
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    APPL proteins promote TGFβ-induced nuclear transport of the TGFβ type I receptor intracellular domain
  11. 3431
    “…In this study, we present digital holographic microscopy (DHM) as a label-free, nonperturbing means to quantify lipid droplets in differentiating adipocytes in a robust medium- to high-throughput manner. Taking advantage of the high refractive index of lipid droplets, DHM can assess the production of intracellular lipid droplets by differences in phase shift in a quantitative manner. …”
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    High-throughput, nonperturbing quantification of lipid droplets with digital holographic microscopy
  12. 3432
    “…Similarly, T cell-derived extracellular vesicles modulate endothelial cell responses to vascular endothelial growth factor and tube formation in a CD47-dependent manner. Uptake of T cell derived extracellular vesicles by recipient endothelial cells globally alters gene expression in a CD47-dependent manner. …”
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    CD47-dependent immunomodulatory and angiogenic activities of extracellular vesicles produced by T cells
  13. 3433
    “…PIRE strongly inhibited the viability of the human nasopharyngeal carcinoma cells (NPC-TW 01 and NPC-TW 04) in a time- and dose-dependent manner. Migration of cancer cells was also suppressed by PIRE. …”
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    Ethanolic Extracts of Pluchea indica Induce Apoptosis and Antiproliferation Effects in Human Nasopharyngeal Carcinoma Cells
  14. 3434
    “…Our results indicated that VEGFR-1 regulated EGF-R expression to promote proliferation activity in a cell-autonomous-dependent manner.…”
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    VEGFR-1 Regulates EGF-R to Promote Proliferation in Colon Cancer Cells
  15. 3435
    “…These factors not only accelerate the growth of cancer cells in a cell-autonomous manner, but also stimulate non-malignant cells in the TME to generate a pro-tumorigenic niche in a non-cell-autonomous manner. …”
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    Tumor Milieu Controlled by RB Tumor Suppressor
  16. 3436
    por Li, Jing, Zhou, Peng
    Publicado 2020
    “…Unlike other Mandarin wh-words that correspond to a single meaning, zenme can be used to question either the manner or the cause of an event. Study 1 explored whether children understand that zenme is ambiguous between a causal and a manner reading. …”
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    Children’s Interpretation of Ambiguous wh-Adjuncts in Mandarin Chinese
  17. 3437
    “…Embedding ethical concepts into smart Internet-connected devices and making them behave in a more human-centred manner, i.e., ethically and in a socially acceptable manner, has received significant attention in the software industry. …”
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    Towards a Policy Development Methodology for Human-Centred IoT Collectives
  18. 3438
    “…The effect of extracellular β-(1→3), (1→6)-glucan, produced by Paenibacillus polymyxa JB115, on nitric oxide (NO) production in RAW264.7 macrophages was investigated. β-glucan induced the production of NO by RAW264.7 macrophages in a concentration- and time-dependent manner. Moreover, β-glucan stimulation increased the mRNA expression of iNOS, COX-2 and IL-6 in RAW264.7 macrophages in a concentration-dependent manner.…”
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    A novel β-glucan produced by Paenibacillus polymyxa JB115 induces nitric oxide production in RAW264.7 macrophages
  19. 3439
    por Parsons, J E
    Publicado 2000
    “…Department of Energy (DOE) is committed to conducting work efficiently and in a manner that ensures protection of the workers, public, and environment. …”
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    Fluor Hanford Integrated Safety Management System Phase II Verification Vol 1 and Vol 2
  20. 3440
    “…One manner in which arrhythmias originate is an ill-fated interaction of the regular electrical signal controlling the heartbeat, the sinus wave, with an ectopic stimulus. …”
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    Unstable eigenmodes are possible drivers for cardiac arrhythmias
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