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  1. 3541
    “…In the presence of a subthreshold concentration (5.5 mM) of glucose, PMA hyperpolarized β-cells in a concentration-dependent manner (0.8–240 nM), even in the presence of BIM. …”
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    Phorbol ester impairs electrical excitation of rat pancreatic beta-cells through PKC-independent activation of K(ATP) channels
  2. 3542
    “…It acted in an autocrine/paracrine manner, resulting in mitochondrial dysfunction and an upregulation of inflammatory and fibrotic genes. …”
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    Sex-specific metabolic functions of adipose Lipocalin-2
  3. 3543
    “…Immunohistochemical results showed that the expression of endoplasmic reticulum stress (ERS) characteristic proteins 78 kDa glucose-regulated protein 78 (GRP78) and C/EBP homologous protein (CHOP) increased in a concentration-dependent manner. CCK-8 results suggested that ART could inhibit fibroblast viability in a concentration- and time-dependent manner. …”
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    Artesunate prevents knee intraarticular adhesion via PRKR-like ER kinase (PERK) signal pathway
  4. 3544
    “…RESULTS: AKBA significantly inhibited the proliferation of gastric cancer cells in a dose- and time-dependent manner, inhibited migration in a time-dependent manner, and induced apoptosis in a dose-dependent manner in vitro; it also inhibited tumor growth in vivo. …”
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    Acetyl-11-keto-β-boswellic acid inhibits proliferation and induces apoptosis of gastric cancer cells through the phosphatase and tensin homolog /Akt/ cyclooxygenase-2 signaling pathway
  5. 3545
    “…Additionally, while treatment with 3–12 ng/ml VEGF further induced retrotransposition frequency in a dose-dependent manner (up to 40.3%), pre-incubation with tinzaparin (2 IU/ml) for 0.5–4 h reduced this frequency to 18.3% in a time-dependent manner, confirmed by analogous results in NIH3T3 fibroblasts. …”
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    Tinzaparin inhibits VL30 retrotransposition induced by oxidative stress and/or VEGF in HC11 mouse progenitor mammary cells: Association between inhibition of cancer stem cell proliferation and mammosphere disaggregation
  6. 3546
    “…Herein, we demonstrate that Tbet suppresses IL-17A and Th17 differentiation both in vitro and in vivo in a cell-intrinsic manner, and that in fact, Tbet is not necessary for EAE induction. …”
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    IFNγ inhibits Th17 differentiation and function via Tbet-dependent and Tbet-independent mechanisms
  7. 3547
    “…Thermal injuries in young children involving the buttocks, perineum, and lower limbs raise suspicion of child abuse. Determining the manner of death and ruling out homicide in a fatal case of scalding remains a challenge for forensic practitioners. …”
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    Case Report: Medicolegal evaluation in a pediatric case of fatal scald injury from rural Nepal
  8. 3548
    “…This pilot study investigates whether compensatory mechanisms utilized in the production of speech sounds with a given target constriction location vary systematically depending on target manner of articulation. The data reveal that compensatory strategies used to produce target alveolar segments vary systematically as a function of target manner of articulation in subtle yet meaningful ways. …”
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    Variation in compensatory strategies as a function of target constriction degree in post-glossectomy speech
  9. 3549
    “…During the postpartum period, Tie2 signalling could be involved in vascular maturation at the endometrium in a ligand-independent manner, with marked reduction of VEGF-A, VEGFR2 and PR expressions. …”
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    VEGF-A regulated by progesterone governs uterine angiogenesis and vascular remodelling during pregnancy
  10. 3550
    “…Although detection rate for near-threshold acoustic stimuli appears to vary in an inverted U-shaped manner for some subjects, it varies in a U-shaped manner or in other manners for other subjects. …”
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    Inconsistent effects of stochastic resonance on human auditory processing
  11. 3551
    “…Through molecular engineering of the DNA sequences and their nano-/microscale architectures, the precursors self-assemble in a controlled manner to produce soft hydrogels in an efficient, cost-effective, and highly tunable manner. …”
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    Programmable all-DNA hydrogels based on rolling circle and multiprimed chain amplification products
  12. 3552
    “…We and others have reported that rheumatoid arthritis (RA) synovial T cells can activate human monocytes/macrophages in a contact-dependent manner to induce the expression of inflammatory cytokines, including tumour necrosis factor alpha (TNFα). …”
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    T-cell contact-dependent regulation of CC and CXC chemokine production in monocytes through differential involvement of NFκB: implications for rheumatoid arthritis
  13. 3553
    por Hackenbrock, Charles R.
    Publicado 1966
    “…On transition to State III, a dramatic change in the manner of folding of the inner membrane takes place. …”
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    ULTRASTRUCTURAL BASES FOR METABOLICALLY LINKED MECHANICAL ACTIVITY IN MITOCHONDRIA : I. Reversible Ultrastructural Changes with Change in Metabolic Steady State in Isolated Liver Mitochondria
  14. 3554
    “…Endogenous TRAF2 and MLK3 associate with each other in response to TNF-α treatment in a time-dependent manner. The association between MLK3 and TRAF2 mediates MLK3 activation and competition with the TRAF2 deletion mutant that binds to MLK3 attenuates MLK3 kinase activity in a dose dependent manner, upon TNF-α treatment. …”
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    TRAF2-MLK3 interaction is essential for TNF-α-induced MLK3 activation
  15. 3555
    “…These data demonstrate that non-TRs can activate some TREs in a spatially regulated manner, whereas other TREs respond only to the known TRs, which also read out activity in a spatially regulated manner. …”
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    Analysis of Thyroid Response Element Activity during Retinal Development
  16. 3556
    “…Upon stress, Gcn5 is recruited to promoters and coding sequences of stress genes in a Sty1- and Atf1-dependent manner, causing both an enhanced acetylation of histone H3 and nucleosome eviction. …”
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    Gcn5 facilitates Pol II progression, rather than recruitment to nucleosome-depleted stress promoters, in Schizosaccharomyces pombe
  17. 3557
    “…ESB increased the cGMP levels of rabbit corpus cavernosum in a concentration-dependent manner without changes in cAMP levels. In a perfusion model of penile tissue, ESB also relaxed penile corpus cavernosum smooth muscle in a dose-dependent manner. …”
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    Effect of an Ethanol Extract of Scutellaria baicalensis on Relaxation in Corpus Cavernosum Smooth Muscle
  18. 3558
    “…CCT assists folding of actin, tubulin, and numerous other cellular proteins in an ATP-dependent manner. The catalytic cooperativity of ATP binding/hydrolysis in CCT occurs in a sequential manner different from concerted cooperativity as shown for GroEL. …”
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    Functional Subunits of Eukaryotic Chaperonin CCT/TRiC in Protein Folding
  19. 3559
    “…Validated circadian exons were regulated in a tissue-dependent manner and were present in genes with circadian transcript abundance. …”
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    Regulation of alternative splicing by the circadian clock and food related cues
  20. 3560
    “…SIO treatment induced strong S and G(2)/M phase cell cycle arrest in a dose-dependent manner in DU-145 and LNCaP. In contrast, SIO treatment induced strong Sub G(1) and G(0)/G(1) phase cell cycle arrest in a dose-dependent manner in PC-3. …”
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    Sepia Ink Oligopeptide Induces Apoptosis in Prostate Cancer Cell Lines via Caspase-3 Activation and Elevation of Bax/Bcl-2 Ratio
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