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  1. 3561
    “…Curcumin inhibited cell growth in a dose-dependent manner. CNE1 and CNE2 cells tended to be arrested at the S or G(2)/M cell cycle stages following curcumin treatment and the levels of ROS increased in a time-dependent manner. …”
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    Enhanced inhibitory effect of curcumin via reactive oxygen species generation in human nasopharyngeal carcinoma cells following purple-light irradiation
  2. 3562
    “…The best characterized member of the ING family, ING1, interacts with the proliferating cell nuclear antigen (PCNA) in a UV-inducible manner. ING1 also interacts with members of the 14-3-3 family leading to its cytoplasmic relocalization. …”
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    ING1 induces apoptosis through direct effects at the mitochondria
  3. 3563
    “…In conclusion, hypoxia regulates the invasion of brain cancer cells in vitro in a TLR9-dependent manner, which is considered to be associated with a complex expression pattern of TLR9-regulated mediators and inhibitors of invasion.…”
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    Hypoxia regulates Toll-like receptor-9 expression and invasive function in human brain cancer cells in vitro
  4. 3564
    por Boetzer, Marten, Pirovano, Walter
    Publicado 2014
    “…RESULTS: Here we propose a novel hybrid assembly methodology that aims to scaffold pre-assembled contigs in an iterative manner using PacBio RS long read information as a backbone. …”
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    SSPACE-LongRead: scaffolding bacterial draft genomes using long read sequence information
  5. 3565
    “…Cohesin is loaded onto DNA by the Scc2/NIPBL-Scc4/MAU2-loading complex in a manner that depends on the adenosine triphosphatase (ATPase) activity of cohesin’s Smc1 and Smc3 subunits. …”
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    Cohesin’s ATPase Activity Couples Cohesin Loading onto DNA with Smc3 Acetylation
  6. 3566
    “…Our methods were able to identify distinct signaling pathways for rat and human cells in a data-driven manner, based on the facts that rat and human cells exhibited distinct transcriptomic and proteomics responses to a common set of stimuli. …”
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    Modeling Signal Transduction from Protein Phosphorylation to Gene Expression
  7. 3567
    “…EGCG inhibited the proliferation of CNE2 cells in a concentration-dependent manner (P<0.05) and blocked the cell cycle progression of the cells. …”
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    Effects of epigallocatechin gallate on the proliferation and apoptosis of the nasopharyngeal carcinoma cell line CNE2
  8. 3568
    “…YB-1 secretion occurs in a cell type-specific manner. Whereas macrophages actively secret YB-1, dendritic cells maintain it predominantly in the cytoplasm even in response to LPS. …”
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    Differential Control of Interleukin-6 mRNA Levels by Cellular Distribution of YB-1
  9. 3569
    “…The present study was performed to investigate the molecular mechanism by which t10, c12-CLA stimulates ATF3 expression and apoptosis in human colorectal cancer cells. t10, c12-CLA increased an apoptosis in human colorectal cancer cells in dose dependent manner. t10, c12-CLA induced ATF3 mRNA and luciferase activity of ATF3 promoter in a dose-dependent manner. …”
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    ATF3 Mediates Anti-Cancer Activity of Trans-10, cis-12-Conjugated Linoleic Acid in Human Colon Cancer Cells
  10. 3570
    “…To extend this work in an unbiased manner, we used 2D gel electrophoresis and mass spectroscopy for protein identification. …”
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    Senescent cancer-associated fibroblasts secrete active MMP-2 that promotes keratinocyte dis-cohesion and invasion
  11. 3571
    “…In contrast, NPR-C mRNA was expressed in an antiphase manner with nadir in the active period (P=0.007). …”
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    Diurnal gene expression of lipolytic natriuretic peptide receptors in white adipose tissue
  12. 3572
    “…Δ(age) was associated with cancer incidence in a ‘J-shaped’ manner for subjects examined pre-2003, and with cancer mortality in a time-varying manner. …”
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    Blood Epigenetic Age may Predict Cancer Incidence and Mortality
  13. 3573
    “…Aloe-emodin treatment stimulated the accumulation of cartilage nodules in a dose-dependent manner. ATDC5 cells were treated with aloe-emodin and stained with alcian blue. …”
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    Aloe-Emodin Induces Chondrogenic Differentiation of ATDC5 Cells via MAP Kinases and BMP-2 Signaling Pathways
  14. 3574
    “…Furthermore, S43126 at [10(−5)M] increased Ca(2+) oscillation, [Ca(2+)] and (45)Ca(2+) uptake in a time and dose-dependent manner. Moreover, Western blot analysis of treated samples showed that S43126 caused an increased protein expression of IRAS as well as phosphorylation of both ERK1/2 and PKB in a concentration-dependent manner. …”
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    Novel I(1)-Imidazoline Agonist S43126 Augment Insulin Secretion in Min6 Cells
  15. 3575
    “…Therefore, Ire1 uniquely regulates fungal development and differentiation in an Hxl1-independent manner.…”
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    Unique roles of the unfolded protein response pathway in fungal development and differentiation
  16. 3576
    “…Furthermore, caffeine may act directly on Leydig cells and interfere with testosterone production in a dose-related manner, consequently delaying onset of sexual maturation.…”
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    Dose- and time-related effects of caffeine on the testis in immature male rats
  17. 3577
    por Heba, Mahi, Faraz, Sana, Banerjee, Sugato
    Publicado 2017
    “…Shankhpushpi reduced both alcohol dependence and withdrawal in a GABAA-dependent manner, thus showing anti-addictive potential. SUMMARY: Shankhpushpi prevented ethanol withdrawal anxiety and alcohol addiction in a GABA(A)-dependent manner. …”
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    Effect of Shankhpushpi on Alcohol Addiction in Mice
  18. 3578
    “…MCP30 blocks Ishikawa H cells from progressing between the S-phase and the G2/M-phase in a time- and concentration-dependent manner. Western blotting revealed that MCP30 treatment decreased the levels of P-AKT in a dose-dependent manner. …”
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    Effect of Momordica charantia protein on proliferation, apoptosis and the AKT signal transduction pathway in the human endometrial carcinoma Ishikawa H cell line in vitro
  19. 3579
    “…CGRP significantly increased the amplitude of EPSCs mediated by NMDA-Rs in a manner dependent on protein kinase A activation, but not that mediated by alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptors, in concentration-dependent and antagonist-sensitive manners. …”
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    Potentiation of NMDA receptor-mediated synaptic transmission at the parabrachial-central amygdala synapses by CGRP in mice
  20. 3580
    “…Shikonin inhibited TPC-1 cell migration and invasion in a dose-dependent manner. The methylation of PTEN was suppressed by shikonin, which also reduced the expression of DNMT1 in a dose-dependent manner, and increased the expression of PTEN. …”
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    Shikonin Inhibites Migration and Invasion of Thyroid Cancer Cells by Downregulating DNMT1
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