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4141por Kim, Dong-Wook, Min, Tae-Sun, Kim, Yoonha, Silva, Renato Rodrigues, Hyun, Hae-Nam, Kim, Ju-Sung, Kim, Kyung-Hwan, Kim, Hak-Jin, Chung, Yong Suk“…These simple but clear results imply that precision agriculture could be achieved even with a low-resolution camera in a cost-effective manner to reduce the pollution of underground water.…”
Publicado 2019
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4142“…Patients suffering from conditions such as paralysis, diabetes or rheumatoid arthritis could in the future be treated in a personalised manner using bioelectronic medicines (BEms) (Nat Rev Drug Discov 13:399–400, 2013, Proc Natl Acad Sci USA 113:8284–9, 2016, J Intern Med 282:37–45, 2017). …”
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4143“…The aim of this document is to facilitate the resumption of elective endoscopic activity in an efficient and safe manner. MATERIAL AND METHODS: A series of questions considered to be of clinical and logistical relevance were formulated. …”
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4144“…To address it, a deep learning framework based on auto-encoder, termed DeepAE, is proposed to elucidate high-dimensional transcriptomic profiling data in an encode–decode manner. Comparative experiments were conducted on nine transcriptomic profiling datasets to compare DeepAE with four benchmark methods. …”
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4145por Wang, Yingmei, Zhang, Shiqian, Wei, Lihui, Lin, Zhongqiu, Wang, Xinyu, Wang, Jianliu, Hua, Keqin, Cui, Manhua, Wang, Jiandong, Wang, Shixuan, Di, Wen, Wang, Yudong, An, Ruifang, Xi, Mingrong, Guo, Ruixia, Zhou, Qi, Xie, Xing, Xue, Fengxia“…We recommend that patients with gynecological malignancies should be managed in hierarchical and individualized manners in combination with local conditions related to COVID-19. …”
Publicado 2020
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4146“…The aim of this document is to facilitate the resumption of elective endoscopic activity in an efficient and safe manner. MATERIAL AND METHODS: A series of questions considered to be of clinical and logistical relevance were formulated. …”
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4147por Guillory, Xavier, Wolter, Madita, Leysen, Seppe, Neves, João Filipe, Kuusk, Ave, Genet, Sylvia, Somsen, Bente, Morrow, John Kenneth, Rivers, Emma, van Beek, Lotte, Patel, Joe, Goodnow, Robert, Schoenherr, Heike, Fuller, Nathan, Cao, Qing, Doveston, Richard G., Brunsveld, Luc, Arkin, Michelle R., Castaldi, Paola, Boyd, Helen, Landrieu, Isabelle, Chen, Hongming, Ottmann, Christian“…This X-ray crystallography driven study shows that the rim of the interface of individual 14-3-3 complexes can be targeted in a differential manner with fragments that represent promising starting points for the development of specific 14-3-3 PPI stabilizers.…”
Publicado 2020
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4148por Li, Yunzhan, Liu, Zehua, Li, Li, Lian, Wenhua, He, Yaohui, Khalil, Elbadry, Mäkilä, Ermei, Zhang, Wenzhong, Torrieri, Giulia, Liu, Xueyan, Su, Jingyi, Xiu, Yuanming, Fontana, Flavia, Salonen, Jarno, Hirvonen, Jouni, Liu, Wen, Zhang, Hongbo, Santos, Hélder A., Deng, Xianming“…Hence, the study proposes a potential mechanism for elucidating the altered immunogenicity of nanomaterials under pathological conditions, which might further offer insights to establish harmonized standards for assessing the biosafety of biomaterials in a disease‐specific or personalized manner.…”
Publicado 2020
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4149por Fang, Chengli, Li, Linyu, Zhao, Yihan, Wu, Xiaoxian, Philips, Steven J., You, Linlin, Zhong, Mingkang, Shi, Xiaojin, O’Halloran, Thomas V., Li, Qunyi, Zhang, Yu“…The MerR-family proteins represent a unique family of bacteria transcription factors (TFs), which activate transcription in a manner distinct from canonical ones. Here, we report a cryo-EM structure of a B. subtilis transcription activation complex comprising B. subtilis six-subunit (2αββ‘ωε) RNA Polymerase (RNAP) core enzyme, σ(A), a promoter DNA, and the ligand-bound B. subtilis BmrR, a prototype of MerR-family TFs. …”
Publicado 2020
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4150por Liu, Xinxin, Shi, Dandan, Guo, Lu, Zhou, Xiaoying, Shang, Mengmeng, Sun, Xiao, Meng, Dong, Zhao, Yading, Li, Jie“…CONCLUSION: These stable and safe CNDs may be a promising choice to achieve efficient ultrasound-mediated gene delivery to specific tissues in a spatiotemporally controlled manner.…”
Publicado 2021
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4151por Podwalski, Piotr, Szczygieł, Krzysztof, Tyburski, Ernest, Sagan, Leszek, Misiak, Błażej, Samochowiec, Jerzy“…It measures the diffusion of water molecules in tissues, which can occur either without restriction (i.e., in an isotropic manner) or limited by some obstacles, such as cell membranes (i.e., in an anisotropic manner). …”
Publicado 2020
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4152por Ivashenka, Alena, Wunder, Christian, Chambon, Valerie, Sandhoff, Roger, Jennemann, Richard, Dransart, Estelle, Podsypanina, Katrina, Lombard, Bérangère, Loew, Damarys, Lamaze, Christophe, Poirier, Francoise, Gröne, Hermann-Josef, Johannes, Ludger, Shafaq-Zadah, Massiullah“…According to the glycolipid-lectin (GL-Lect) hypothesis, the construction of tubular endocytic pits is driven in a glycosphingolipid-dependent manner by sugar-binding proteins of the galectin family. …”
Publicado 2021
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4153“…However, while personalized diabetes care has the potential to significantly improve outcomes in patients with diabetes in a safe and cost-effective manner, its wider application presents several challenges, especially in resource-strained settings. …”
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4154“…New approaches to stratify multiple myeloma patients based on prognosis and therapeutic decision-making, or prediction, are needed since patients are currently managed in a similar manner regardless of individual risk factors or disease characteristics. …”
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4155“…Here we proposed formalin-fixed, paraffin-embedded (FFPE) CTC block method, in combination manner with the hydrogel core-mediated CTC accumulation and conventional paraffin tissue block preparation. …”
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4156“…As a fast, accurate, inexpensive, portable, and scalable method, electrochemical biosensors are very promising for biomarker detection in matrices obtained in a non-invasive manner. This review summarises and compares the electrochemical biosensors for the detection of TNF-α in a non-invasive manner and highlights recent advances and future prospects in developing high-performance electrochemical platforms for noninvasive measurement of TNF-α.…”
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4157por Evans Ngwenah, Foncham, Sanda Antoine, Kada, Martin, Salah, Christopher, Tume, Mahamat, Oumar“…Finally, the crude polysaccharide-rich extract showed nitrite and hydrogen peroxide scavenging activity in a concentration-dependent manner. CONCLUSION: Polysaccharide-rich extract possesses immunomodulatory and antioxidant properties.…”
Publicado 2021
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4158“…In addition, fraxetin, in a dose-dependent manner, had the ability to combat the echocardiographic, histopathological, immunohistochemical, and electron microscopic changes induced by doxorubicin in cardiomyocytes. …”
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4159por Barrios, Vicente, Chowen, Julie A., Martín-Rivada, Álvaro, Guerra-Cantera, Santiago, Pozo, Jesús, Yakar, Shoshana, Rosenfeld, Ron G., Pérez-Jurado, Luis A., Suárez, Juan, Argente, Jesús“…Members of this axis, composed of various ligands, receptors, and binding proteins, are regulated in a tissue- and time-specific manner that requires precise control that is not completely understood. …”
Publicado 2021
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4160por Sun, Lue, Inaba, Yohei, Sogo, Yu, Morikawa, Kumi, Kunugita, Naoki, Chida, Koichi, Moritake, Takashi“…Recently, whole-blood antioxidant capacity (WBAC) has been reported to decrease in a dose-dependent manner after acute total body irradiation (TBI). However, changes in WBAC after localized and chronic irradiations have not been reported. …”
Publicado 2021
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