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401por Wu, Qiushuang, Medina, Santiago Gerardo, Kushawah, Gopal, DeVore, Michelle Lynn, Castellano, Luciana A, Hand, Jacqelyn M, Wright, Matthew, Bazzini, Ariel Alejandro“…This work provides definitive evidence that translation strongly affects mRNA stability in a codon-dependent manner in human cells.…”
Publicado 2019
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402por O'Connell, Meghan E., Sridharan, Divya, Driscoll, Tristan, Krishnamurthy, Ipsita, Perry, Wick G., Applewhite, Derek A.Enlace del recurso
Publicado 2019
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404por Ziegler, Maren, Grupstra, Carsten G. B., Barreto, Marcelle M., Eaton, Martin, BaOmar, Jaafar, Zubier, Khalid, Al-Sofyani, Abdulmohsin, Turki, Adnan J., Ormond, Rupert, Voolstra, Christian R.“…Here we show that bacterial community structure responds in a coral host-specific manner upon cross-transplantation between reef sites with differing levels of anthropogenic impact. …”
Publicado 2019
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405por Prior, Kimberley F., O’Donnell, Aidan J., Rund, Samuel S. C., Savill, Nicholas J., van der Veen, Daan R., Reece, Sarah E.“…Host sickness behaviours vary in pathogen species-specific manners but the influence of pathogen intraspecific variation is rarely studied. …”
Publicado 2019
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406por Schmidtner, Anna K., Slattery, David A., Gläsner, Joachim, Hiergeist, Andreas, Gryksa, Katharina, Malik, Victoria A., Hellmann-Regen, Julian, Heuser, Isabella, Baghai, Thomas C., Gessner, André, Rupprecht, Rainer, Di Benedetto, Barbara, Neumann, Inga D.“…Minocycline markedly increased relative abundance of Lachnospiraceae and Clostridiales Family XIII, families known for their butyrate production, with a corresponding increase and positive correlation in plasma 3-OH-butyrate levels in a trait-dependent manner. Thus, our data suggest that the antidepressant effect of minocycline is sex- and trait-dependent, associated with a reduced microglial number in the prefrontal cortex, and with changes in microbial composition and their metabolites. …”
Publicado 2019
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407por Edén, Desirée, Panagiotou, Grigorios, Mokhtari, Dariush, Eriksson, Jan W., Åberg, Mikael, Siegbahn, Agneta“…TF expression was confirmed in 3T3-L1 adipocytes, and both cell types were found to be procoagulant in a TF/FVIIa-dependent manner. FXa was generated without FVIIa added to the coagulation assay, and active site-inhibited FVIIa blocked FXa formation, supporting our finding of FVII production by human primary adipocytes. …”
Publicado 2019
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408por Srikantan, Subramanya, Deng, Yilun, Cheng, Zi-Ming, Luo, Anqi, Qin, Yuejuan, Gao, Qing, Sande-Docor, Glaiza-Mae, Tao, Sifan, Zhang, Xingyu, Harper, Nathan, Shannon, Chris E., Fourcaudot, Marcel, Li, Zhi, Kasinath, Balakuntalam S., Harrison, Stephen, Ahuja, Sunil, Reddick, Robert L., Dong, Lily Q., Abdul-Ghani, Muhammad, Norton, Luke, Aguiar, Ricardo C. T., Dahia, Patricia L. M.Enlace del recurso
Publicado 2019
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409The Fracture Callus Is Formed by Progenitors of Different Skeletal Origins in a Site‐Specific Mannerpor Wang, Yongmei, Chen, Ling, Kang, Misun, Ling, Lin, Tian, Faming, Won‐Kim, Sun Hee, Ho, Sunita, Bikle, Daniel D.Enlace del recurso
Publicado 2019
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410por Pati, Sthitapranjya, Salvi, Sonali S., Kallianpur, Mamata, Vaidya, Bhupesh, Banerjee, Antara, Maiti, Sudipta, Clement, James P., Vaidya, Vidita A.“…Designer receptors exclusively activated by designer drugs (DREADD)-based chemogenetic tools are extensively used to manipulate neuronal activity in a cell type-specific manner. Whole-cell patch-clamp recordings indicate membrane depolarization, coupled with increased neuronal firing rate, following administration of the DREADD ligand, clozapine-N-oxide (CNO) to activate the Gq-coupled DREADD, hM3Dq. …”
Publicado 2019
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411por Lee, Shuen Yee, Mac Aogáin, Micheál, Fam, Kai Deng, Chia, Kar Ling, Binte Mohamed Ali, Nur A’tikah, Yap, Margaret M. C., Yap, Eric P. H., Chotirmall, Sanjay H., Lim, Chin LeongEnlace del recurso
Publicado 2019
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414por Cunanan, Joanna, Deacon, Erin, Cunanan, Kristina, Yang, Zifan, Ask, Antje, Morikawa, Lily, Todorova, Ekaterina, Bridgewater, Darren“…In wild type kidney explants, quercetin treatment resulted in abnormal branching morphogenesis and nephrogenesis in a dose dependent manner. In wild type embryonic kidneys, quercetin reduced nuclear beta-catenin expression and decreased expression of beta-catenin target genes Pax2, Six2, and Gdnf, which are essential for kidney development. …”
Publicado 2020
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416por Maillet, Sarah, Fernandez, Juliette, Decourcelle, Mathilde, El Koulali, Khadija, Blanchet, Fabien P., Arhel, Nathalie J., Maarifi, Ghizlane, Nisole, Sébastien“…Given the well-known influence of these cellular factors on the stability of HIV-1 cores, we investigated the effect of Daxx on the cytoplasmic fate of incoming cores and found that Daxx prevented HIV-1 uncoating in a SIM-dependent manner. Altogether, our findings suggest that, by recruiting TNPO3, TRIM5α, and TRIM34 and possibly other proteins onto incoming HIV-1 cores through a SIM-dependent interaction with CA-bound CypA, Daxx increases their stability, thus preventing uncoating and reverse transcription. …”
Publicado 2020
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417por Deville, Sara Sofia, Vehlow, Anne, Förster, Sarah, Dickreuter, Ellen, Borgmann, Kerstin, Cordes, Nils“…Mechanistically, synemin forms a protein complex with DNA-PKcs through its C-terminal tail domain for determining DNA repair processes upstream of this enzyme in an ATM-dependent manner. Our study discovers a critical function of the intermediate filament protein, synemin in the DNA damage response, fundamentally supporting the concept of cytoarchitectural elements as co-regulators of nuclear events.…”
Publicado 2020
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418por Lafuente-Barquero, Juan, García-Rubio, Maria Luisa, Martin-Alonso, Marta San, Gómez-González, Belén, Aguilera, Andrés“…We show that unscheduled and recombinogenic DNA:RNA hybrids that trigger the SSA event are formed in cis during transcription and in a Rad51-independent manner. We found no evidence that such hybrids form in trans and in a Rad51-dependent manner.…”
Publicado 2020
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419por Budweiser, StephanEnlace del recurso
Publicado 2020
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420por Phipps, Kara L., Ganti, Ketaki, Jacobs, Nathan T., Lee, Chung-Young, Carnaccini, Silvia, White, Maria C., Manandhar, Miglena, Pickett, Brett E., Tan, Gene S., Ferreri, Lucas M., Perez, Daniel R., Lowen, Anice C.Enlace del recurso
Publicado 2020
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