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  1. 4361
    “…Rab35 localizes to the surface of oligodendroglia in a GTP-dependent manner, where it increases the density of vesicles, suggesting a function in docking or tethering. …”
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    Regulation of exosome secretion by Rab35 and its GTPase-activating proteins TBC1D10A–C
  2. 4362
    “…All heterozygous loss-of-function SIAE mutations tested were capable of functioning in a dominant negative manner. A homozygous secretion-defective polymorphic variant of SIAE was catalytically active, lacked the ability to function in a dominant negative manner, and was seen in 8 autoimmune subjects but in no control subjects. …”
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    Functionally defective germline variants of sialic acid acetylesterase in autoimmunity
  3. 4363
    “…In vitro data indicated that the VA extracts stimulated the proliferation of resting splenocytes and macrophages in a dose-dependent manner up to the highest concentration used (150 μg mL(−1)). …”
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    The Antiinfective Effects of Velvet Antler of Formosan Sambar Deer (Cervus unicolor swinhoei) on Staphylococcus aureus-Infected Mice
  4. 4364
    “…BACKGROUND: We previously reported that the primary tumour/vessel tumour/nodal tumour (PVN) classification is significantly superior to the UICC pTNM classification and the Nottingham Prognostic Index for accurately predicting the outcome of patients with invasive ductal carcinoma of the breast in a manner that is independent of the nodal status and the hormone receptor status. …”
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    Modified primary tumour/vessel tumour/nodal tumour classification for patients with invasive ductal carcinoma of the breast
  5. 4365
    “…Intraperitoneal (IP) morphine administration reversed mechanical allodynia and anxiety-like behavior in a dose-dependent manner. Gabapentin also partially reduced incision-evoked mechanical allodynia and anxiety-like behavior in a dose-dependent manner. …”
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    Surgical Incision Induces Anxiety-Like Behavior and Amygdala Sensitization: Effects of Morphine and Gabapentin
  6. 4366
    “…The weighted least-squares finite element method is used because it allows data to be assimilated in a very flexible manner so that accurate measurements are more closely matched with the numerical solution than less accurate data. …”
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    Weighted Least-Squares Finite Element Method for Cardiac Blood Flow Simulation with Echocardiographic Data
  7. 4367
    “…Similarly, there was no evidence for increased oxidative stress in muscle or liver when Sirt3 was ablated in a tissue-specific manner. These observations suggest that the mitochondrial hyperacetylation induced by Sirt3-deletion in a tissue specific manner is not necessarily linked to mitochondrial dysfunction and does not recapitulate the metabolic abnormalities observed in the germline Sirt3 knock-out mice.…”
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    Muscle or liver-specific Sirt3 deficiency induces hyperacetylation of mitochondrial proteins without affecting global metabolic homeostasis
  8. 4368
    “…These results suggest that SKL-NP modulates I(h) in indirect manner by the activation of a Gi-protein coupled receptor that decreases intracellular cAMP concentration. …”
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    A Novel Carbamoyloxy Arylalkanoyl Arylpiperazine Compound (SKL-NP) Inhibits Hyperpolarization-Activated Cyclic Nucleotide-Gated (HCN) Channel Currents in Rat Dorsal Root Ganglion Neurons
  9. 4369
    “…The naturally occurring polyamine spermidine (Spd) has recently been shown to promote longevity across species in an autophagy-dependent manner. Here, we demonstrate that Spd improves both survival and locomotor activity of the fruit fly Drosophila melanogaster upon exposure to the superoxide generator and neurotoxic agent paraquat. …”
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    Spermidine promotes stress resistance in Drosophila melanogaster through autophagy-dependent and -independent pathways
  10. 4370
    “…MetalPDB is updated monthly in an automated manner.…”
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    MetalPDB: a database of metal sites in biological macromolecular structures
  11. 4371
    “…In the present work, we noted that Angus-derived mature adipocytes extruded a majority of their cellular lipid droplets prior to cell division. In this manner, these cells are processing lipid in a manner observed in mature adipocytes isolated from swine tissue. …”
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    Like pigs, and unlike other breeds of cattle examined, mature Angus-derived adipocytes may extrude lipid prior to proliferation in vitro
  12. 4372
    “…With the development of nanomaterial-based nanodevices, it became inevitable to develop cost-effective and simple nanofabrication technologies enabling the formation of nanomaterial assembly in a controllable manner. Herein, we present suspended monolithic carbon single nanowires and nanomeshes bridging two bulk carbon posts, fabricated in a designed manner using two successive UV exposure steps and a single pyrolysis step. …”
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    Monolithic carbon structures including suspended single nanowires and nanomeshes as a sensor platform
  13. 4373
    “…Compounds 19–23 inhibited TNFα-stimulated NF-κB activation in a dose-dependent manner, with IC(50) values ranging from 0.75–8.30 μM. …”
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    Anti-Inflammatory and PPAR Transactivational Effects of Oleanane-Type Triterpenoid Saponins from the Roots of Pulsatilla koreana
  14. 4374
    “…BRCA1 interacts with DNA-PKcs in a cell cycle-regulated manner and this interaction is mediated by the tandem BRCT domain of BRCA1, but surprisingly in a phospho-independent manner. …”
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    BRCA1 modulates the autophosphorylation status of DNA-PKcs in S phase of the cell cycle
  15. 4375
    “…We therefore devised a mathematical model of the city’s hypothetical network of representatives as a formal proof of concept that widespread cooperation was realizable in a fully distributed manner. In the model, decisions become self-organized into globally optimal configurations even though local representatives behave and modify their relations in a rational and selfish manner. …”
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    Can Government Be Self-Organized? A Mathematical Model of the Collective Social Organization of Ancient Teotihuacan, Central Mexico
  16. 4376
    “…The Ank gene expression significantly increased when treated by transforming growth factor alpha 1 (TGF-β1) in a dose-dependent manner and decreased when treated by SB431542 (ALK inhibitor) in a dose-dependent manner. …”
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    Investigating Conversion of Endplate Chondrocytes Induced by Intermittent Cyclic Mechanical Unconfined Compression in Three-Dimensional Cultures
  17. 4377
    “…The results indicated that DHM could reduce ROS accumulation in a concentration-dependent manner. Additionally, with increasing concentrations of DHM, the expression of proteins that participate in the cell apoptosis program increased in a concentration-dependent manner. …”
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    A reduction in reactive oxygen species contributes to dihydromyricetin-induced apoptosis in human hepatocellular carcinoma cells
  18. 4378
    “…RESULTS: In this work we showed that Tat protein: i) by its N-terminal domain induces production of both IL-10 and TNF-α in a TLR4-MD2 dependent manner, ii) interacts specifically with TLR4-MD2 and MD2 with high affinity but not with CD14, iii) induces in vivo TNF-α and IL-10 in a TLR4 dependent manner. …”
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    HIV-1 Tat protein binds to TLR4-MD2 and signals to induce TNF-α and IL-10
  19. 4379
    “…Here, we describe a method to generate megakaryocytes (MKs) and functional platelets from iPSCs in a scalable manner under serum/feeder-free conditions. The method also permits the cryopreservation of MK progenitors, enabling a rapid “surge” capacity when large numbers of platelets are needed. …”
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    Scalable Generation of Universal Platelets from Human Induced Pluripotent Stem Cells
  20. 4380
    “…We report consistent individual differences which demonstrate a mixture of some observers who demonstrate coactive processing with other observers who process the dimensions in a parallel self-terminating manner.…”
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    Logical-rules and the classification of integral dimensions: individual differences in the processing of arbitrary dimensions
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